Impact of nitrogen fertilization on guinea grass (Panicum maximum, Jacq) in the humid premountain forest in the Department of Tolima.

P?ginas 17-21El objetivo del trabajo de investigaci?n fue evaluar la respuesta de diferentes dosis (0, 100, 150 y 300 kg/ha) de nitr?geno en la producci?n de pasto guinea (Panicum maximum, Jacq). Los resultados servir?n para establecer una recomendaci?n t?cnico-econ?mica viable de fertilizaci?n para la producci?n de esta gram?nea bajo condiciones de bosque h?medo sub-andino. El dise?o experimental utilizado fue bloques completos al azar con las cuatro dosis de nitr?geno mencionadas. Se aplic? 246 y 60 kg ha/a?o de CaCO3 y K2 O, respectivamente para correcci?n del pH. La producci?n y el porcentaje de materia seca en el forraje fueron medidos en los tres cortes realizados a intervalos de 28 d?as. Los cortes presentaron efecto significativo (P<0,01) en la producci?n y porcentaje de materia seca. La mayor producci?n de materia seca se encontr? en el corte dos (56 d?as) con 0,23 kg/m2 y el m?ximo porcentaje de MS se encontr? en el corte tres (84 d?as) con 21,4%; mientras que la fertilizaci?n de 300 kg N/ha/a?o present? el mayor rendimiento productivo de la gram?nea. La mayor rentabilidad financiera fue encontrada en el testigo (0 kg N/ha/a?o).ABSTRACT. The goal of this study was to evaluate different levels of nitrogen fertilization (0, 100, 150 and 300 kg/ha/year) on the production of Guinea grass (Panicum maximum). The results should support a viable technical-economical recommendation of fertilization for the production of this grass under sub-Andean humid forest conditions. An experimental design of randomized blocks was used, with four treatments of nitrogen fertilization. It was also applied to all plots 246 and 60 kg/ha/yearof CaCO3 and K2O as pH corrective inputs. The production and percentage of dry mater were evaluated in all three cuttings, which were carried out every 28 days. The cutting presented a significant effect (P<0.01) in the production and percentage of dry matter. The highest dry matter production was found in the second cutting (56 days) with 0.23 kg/m2; and the highest dry matter percentage was found in the third cutting (84 days) with 21%; whereas, the fertilization with 300kg N/ha/year showed the highest grass productivity. The greatest financial profitability was found in the control treatment (0 kg N/ha/year)

Higgs Boson Phenomenology in a Simple Model with Vector Resonances

In this paper we consider a simple scenario where the Higgs boson and two vector resonances are supposed to arise from a new strong interacting sector. We use the ATLAS measurements of the dijet spectrum to set limits on the masses of the resonances. Additionally we compute the Higgs boson decay to two photons and found, when compare to the Standard Model prediction, a small excess which is compatible with ATLAS measurements. Finally we make prediction for Higgs-strahlung processes for the LHC running at 14 TeV

Impacto de la fertilización nitrogenada sobre el pasto guinea (Panicum maximum, Jacq) en el bosque húmedo premontano en el Departamento del Tolima

El objetivo del trabajo de investigación fue evaluar la respuesta de diferentes dosis (0, 100, 150 y 300 kg/ha) denitrógeno en la producción de pasto guinea (Panicum maximum, Jacq). Los resultados servirán para establecer unarecomendación técnico-económica viable de fertilización para la producción de esta gramínea bajo condiciones debosque húmedo sub-andino. El diseño experimental utilizado fue bloques completos al azar con las cuatro dosis denitrógeno mencionadas. Se aplicó 246 y 60 kg ha/año de CaCO3 y K2O, respectivamente para corrección del pH.La producción y el porcentaje de materia seca en el forraje fueron medidos en los tres cortes realizados a intervalosde 28 días. Los cortes presentaron efecto significativo (P&lt;0,01) en la producción y porcentaje de materia seca. Lamayor producción de materia seca se encontró en el corte dos (56 días) con 0,23 kg/m2 y el máximo porcentaje deMS se encontró en el corte tres (84 días) con 21,4%; mientras que la fertilización de 300 kg N/ha/año presentó elmayor rendimiento productivo de la gramínea. La mayor rentabilidad financiera fue encontrada en el testigo (0 kgN/ha/año)

Social media sites users' choice between utilitarian and informational reinforcers assessed using temporal discounting

Objective: This study provides a first approach to the use of the Multiple-Choice Procedure in social media networks use, as well as empirical evidence for the application of the Behavioral Perspective Model to digital consumption behavior in young users in conjunction with a methodology based on behavioral economics. Participants/methods: The participants were part of a large university in Bogotá, Colombia, and they received an academic credit once they completed the online questionnaire. A total of 311 participants completed the experiment. Of the participants, 49% were men with a mean age of 20.6 years (SD = 3.10, Range = 15–30); 51% were women with a mean age of 20.2 years (SD = 2.84, Range = 15–29). Results: Among the total participants, 40% reported that they used social networks between 1 and 2 h a day, 38% between 2 and 3 h, 16% for 4 h or more, and the remaining 9% used them for 1 h or less per day. The factorial analysis of variance (ANOVA) allowed us to identify a statistically significant effect of the delay of the alternative reinforcer, that is, the average crossover points were higher when the monetary reinforcer was delayed 1 week, compared to the immediate delivery of the monetary reinforcer. There was no statistically significant effect of the interaction between the magnitude of the reinforcer and the delay time of the alternative reinforcer. Conclusions: This study supports the relative reinforcing value of an informational reinforcement consequence such as social media use, which is sensitive to both the magnitude of reinforcement and the delay in delivery as individual factors. The findings on reinforcer magnitude and delay effects are consistent with previous research that have applied behavioral economics to the study of non-substance-related addictions

In Vitro and In Vivo Biological Activity of Ruthenium 1,10-Phenanthroline-5,6-dione Arene Complexes

Funding Information: We are grateful to Fundação para a Ciência e a Tecnologia, I.P., through MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020, UIDP/04612/2020) and LS4FUTURE Associated Laboratory (LA/P/0087/2020). The NMR spectrometers at CERMAX are integrated in the national NMR Network and partially supported through project 022162. Oscar A. Lenis-Rojas acknowledge national funds through FCT, POPH-Programa Operacional Potencial Humano, and FSE (European Social Fund) for the CEEC 2017 Initiative. Additionally, this work is financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. Publisher Copyright: © 2022 by the authors.Ruthenium(II) arene complexes exhibit promising chemotherapeutic properties. In this study, the effect of the counter anion in Ru(II) complexes was evaluated by analyzing the biological effect of two Ru(II) p-cymene derivatives with the 1,10-phenanthroline-5,6-dione ligand of general-formula [(η6-arene)Ru(L)Cl][X] X = CF3SO3 (JHOR10) and PF6 (JHOR11). The biological activity of JHOR10 and JHOR11 was examined in the ovarian carcinoma cell line A2780, colorectal carcinoma cell line HCT116, doxorubicin-resistant HCT116 (HCT116-Dox) and in normal human dermal fibroblasts. Both complexes JHOR10 and JHOR11 displayed an antiproliferative effect on A2780 and HCT116 cell lines, and low cytotoxicity in fibroblasts. Interestingly, JHOR11 also showed antiproliferative activity in the HCT116-Dox cancer cell line, while JHOR10 was inactive. Studies in A2780 cells showed that JHOR11 induced the production of reactive oxygen species (ROS) that trigger autophagy and cellular senescence, but no apoptosis induction. Further analysis showed that JHOR11 presented no tumorigenicity, with no effect in the cellular mobility, as evaluated by thye wound scratch assay, and no anti- or pro-angiogenic effect, as evaluated by the ex-ovo chorioallantoic membrane (CAM) assay. Importantly, JHOR11 presented no toxicity in chicken and zebrafish embryos and reduced in vivo the proliferation of HCT116 injected into zebrafish embryos. These results show that these are suitable complexes for clinical applications with improved tumor cell cytotoxicity and low toxicity, and that counter-anion alteration might be a viable clinical strategy for improving chemotherapy outcomes in multidrug-resistant (MDR) tumors.publishersversionpublishe

Evaluation of the in vitro and in vivo efficacy of ruthenium polypyridyl compounds against breast cancer

[Abstract] The clinical success of cisplatin, carboplatin, and oxaliplatin has sparked the interest of medicinal inorganic chemistry to synthesize and study compounds with non-platinum metal centers. Despite Ru(II)–polypyridyl complexes being widely studied and well established for their antitumor properties, there are not enough in vivo studies to establish the potentiality of this type of compound. Therefore, we report to the best of our knowledge the first in vivo study of Ru(II)–polypyridyl complexes against breast cancer with promising results. In order to conduct our study, we used MCF7 zebrafish xenografts and ruthenium complexes [Ru(bipy)2(C12H8N6-N,N)][CF3SO3]2Ru1 and [{Ru(bipy)2}2(μ-C12H8N6-N,N)][CF3SO3]4Ru2, which were recently developed by our group. Ru1 and Ru2 reduced the tumor size by an average of 30% without causing significant signs of lethality when administered at low doses of 1.25 mg·L−1. Moreover, the in vitro selectivity results were confirmed in vivo against MCF7 breast cancer cells. Surprisingly, this work suggests that both the mono- and the dinuclear Ru(II)–polypyridyl compounds have in vivo potential against breast cancer, since there were no significant differences between both treatments, highlighting Ru1 and Ru2 as promising chemotherapy agents in breast cancer therapy.Xunta de Galicia; ED431C 2018/39Portugal. Fundação para a Ciência e a Tecnologia; PEst 2015-2020Portugal. Fundação para a Ciência e a Tecnologia; UID/Multi/04349/2013Portugal. Fundação para a Ciência e a Tecnologia; RECI/QEQ-QIN/0189/2012Portugal. Fundação para a Ciência e a Tecnologia; UID/QUI/00100/2020Portugal. Fundação para a Ciência e a Tecnologia; UIDP/04378/2020Portugal. Fundação para a Ciência e a Tecnologia; UIDB/04378/2020Portugal. Fundação para a Ciência e a Tecnologia; LA/P/0140/202

Inserción laboral y empleabilidad de egresados universitarios de la Macro Región Centro del Perú

Objective. Was to determine the level of labor insertion of university graduates from the Macro Region of Central Peru. Method. The design was non-experimental; the research level was descriptive; The instrument used was the Labor Insertion questionnaire for university administration graduates, developed based on the perspective of Gómez-Cartolín (2015) which had 27 items, the dimensions were employability (with 15 items), and the employability dimension (12 items), the sample consisted of 315 university graduates from the Central Macro Region of Peru. Results. In the Junín region, 21.9% were men, and 22.5% were women; in Pasco 7.0% were men and 19.7% were women; In Huánuco 4.4% were men and 24.4% were women, making a total of 33.3% men and 66.7% women in the regions that make up the Central Macro Region of Peru. Conclusion. Labor insertion of the administration graduates of the Central Macro Region of Peru was medium, which indicates that they are working in activities related to their professional career, predominantly financial organizations.Objetivo. Determinar el nivel de inserción laboral de los egresados universitarios de la Macro Región del Centro del Perú. Métodos. La investigación fue de diseño no experimental y nivel descriptivo; el instrumento empleado fue el cuestionario de inserción laboral a egresados universitarios de Administración, desarrollado en base a la perspectiva de Gómez-Cartolín (2015) que constó de 27 ítems referidos a las dimensiones: empleabilidad (con 15 ítems) y ocupabilidad (12 ítems). La muestra estuvo conformada por 315 egresados universitarios de la Macro Región Centro del Perú. Resultados. En la región Junín, el 21,9 % eran varones, y el 22,5 % mujeres; en Pasco, el 7 % eran varones y el 19,7 % mujeres; en Huánuco 4,4 % eran varones y el 24,4 % mujeres; lo que hace un total de 33,3 % de varones y 66,7 % de mujeres en las regiones que conforman la Macro Región Centro del Perú. Conclusión. El nivel perceptual de inserción laboral de los egresados de Administración de la Macro Región Centro del Perú fue medio, lo cual indica que se encuentran laborando en actividades afines a su carrera profesional, predominando las organizaciones financieras

GENERALIZED URTICARIA AS A VASCULITIC MANIFESTATION IN A PATIENT WITH SARS-CoV-2 INFECTION: A CASE REPORT IN COLOMBIA

Skin manifestations have been reported in up to 20% of cases of SARS-CoV-2 infection, including morbilliform rash (22%), pernio-like acral lesions (18%), urticaria (16%), and macular erythema (13%). It is believed that in the case of SARS-CoV-2 infection, the mechanism involved is an inflammatory response that generates immune dysregulation, vascular congestion, vasculitis, vascular thrombosis, or neoangiogenesis. This case study, present the case of a patient with no previous history of urticarial reactions, autoimmune diseases, or exposure to medications who develops generalized urticaria lasting more than 24 hours and who was diagnosed with SARS-CoV-2 infection by RT-PCR with a nasopharyngeal swab. We suggest in this patient vasculitic urticaria as a manifestation of SARS-CoV-2 infection