Binding polynomial in molecular self-assembly

In the present work the concept of a binding polynomial is revisited for the most widely used case of self-assembly of identical molecular units and results in the re-construction of a link to the grand partition function of such a system. It is found that if the self-assembly process is not pronounced (i.e., the product of the equilibrium constant and the monomer concentration is close to zero), the binding polynomial has the meaning of a molecular partition function that is given by the summation over energy levels of any molecule in the system. In other cases the concept of a binding polynomial may be misleadin

АКТУАЛЬНІ АСПЕКТИ ТРАНСФОРМАЦІЇ ЕКОНОМІЧНИХ ВІДНОСИН: КРИПТОВАЛЮТИ ТА ЇХНЄ ПРАВОВЕ РЕГУЛЮВАННЯ

The article is devoted to the analysis of transformation of economic relations due to the emergence of such phenomenon as cryptocurrency. It is substantiated that its appearance is connected with the development of the information society, the formation of the virtual economy and the spread of digitization processes in all spheres of economic activity. It is proved that despite the innovative nature of the revolutionary character and the considerable potential for stimulating radical changes in the sphere of economic relations and economic model of modern society, the cryptocurrency is a confirmation of the evolution of money. From the point of view of the theory of money, the ability of cryptocurrency to perform the functions of money (measures of value, means of payment and medium of exchange, accumulation, world money), as well as new specific functions — social, regulatory, indicative and others, — have been proved. Analysis of the practice of cryptocurrencies spread gave the opportunity to reveal their characteristic features on grounds of the format of money, unit of account, legal status, money creation, stability of payment, mechanism of exchange, regulation and supervision, risks, etc. In addition, the positive properties of cryptocurrencies and their possible negative effects are identified. It is emphasized that the adoption and active spread of cryptocurrencies leads to the transformation of economic relations, and more precisely, the objective formation of a new system of economic relations as a compensator of the negative manifestations of a modern economic society, which, at the same time, has exacerbated to some extent the threats to the traditional monetary system. This is confirmed by the tendencies of the development of the cryptocurrency market, changes in the position of the central banks of the countries of the world from rigid rejection to the development of national cryptocurrencies, including in Ukraine. The problematic aspects of determining the legal status of cryptocurrencies in the regulation of cryptocurrency in Ukraine from the point of view of civil-law relations and relatively criminal-law context have been identified. It is concluded that it is necessary to determine the legal status of cryptocurrency in Ukraine, taking into account the position of the leading countries of the world.Присвячено аналізовi трансформації економічних відносин внаслідок появи такого феномену, як криптовалюта. Обґрунтовано, що її виникнення пов’язано з розвитком інформаційного суспільства, формуванням віртуальної економіки та поширенням процесів цифровізації в усі сфери економічної діяльності. Доведено, що незважаючи на інноваційність революційного характеру та значний потенціал щодо стимулювання радикальних змін у сфері економічних відносин і економічної моделі сучасного суспільства, криптовалюта є підтвердженням еволюції грошей.  З позиції теорії грошей доведено можливість криптовалюти виконувати функції грошей (міри вартості, засобу обігу та засобу платежу, нагромадження, світові гроші), а також нові специфічні функції — соціальну, регуляторну, індикативну та інші. Аналіз практики поширення криптовалют дозволив виявити їхні характерні особливості за ознаками формату грошей, одиниці обліку, правового статусу, емісії, стабільність розрахунків, механізм обміну, регулювання i нагляду, ризиків тощо. Крім того, визначено позитивні властивості криптовалют i можливі їхні негативні ефекти. Наголошено, що прийняття і активне поширення криптовалют зумовимо трансформацію економічних відносин, а точніше — об’єктивне формування нової системи економічних відносин як компенсатора негативних проявів сучасного економічного суспільства, яка водночас певною мірою посилила загрози для традиційної монетарної системи. Це підтверджують тенденції розвитку криптовалютного ринку, зміни позиції центральних банків країн світу від неприйняття до розробки національних криптовалют, у тому числі в Україні. Виявлено проблемні аспекти визначення правового статусу криптовалют регулювання криптовалюти в Україні з позиції цивільно-правових відносин і щодо кримінально-правового контексту. Зроблено висновок, що необхідно визначити правовий статус криптовалюти в Україні, враховуючи позицію провідних країн світу

Sociological diagnostics of crowdsourcing technology in the practice of regional management

The article proposes a methodology for identifying and analyzing the technology of crowdsourcing, examines the main stages of the formation, and analyzes the implementation of crowdsourcing technology into the practice of regional managemen

Land Resources of Alagirskii District As a Factor of Sustainable Development of the Agro-industrial Complex

The most important condition for the rational organization of the territory is the formation of a morphological appearance, which is distinguished by high productivity, ecological diversity, aesthetic appeal, and will satisfy sanitary and hygienic requirements. The use of land resources in the Alagirskii District of the Republic of North Ossetia-Alania and the development of measures for rational organization of the territory, with the creation of an effective system of land use, evaluation criteria of environmental reliability, social acceptability, economic efficiency and compliance with the legal regime of land use, are a necessary condition for the rational use of land. In this work, materials of land inventory for 2016–2018, data of the committee of land and property relations of the district, statistical data on the effectiveness of agricultural land were used. The developed data allows to establish the optimal ratio of natural ecosystems and agro-ecosystems for this natural-agricultural zone, to establish optimal areas of arable and forage lands that need improvement based on the landscape features of the territory for stability and development of agricultural production

FEATURES OF THE OIL AND GAS POLICY OF THE UNITED STATES OF AMERICA

The scientific article is devoted to the study of the features of the oil and gas policy of the United States of America. The authors considered the organizational and economic structure of the oil and gas industry, state policy and taxation in the oil and gas complex, problems and prospects for its development

Prospects for the Digitalization of the Educational Environment

Развитие цифровых технологий в сфере образования диктуется стремительным развитием общества. В процессе цифровизации изменяется как структура обучения, так и организация учебного процесса. В статье рассматривается актуальность проблемы современных технологий в системе образования.The development of digital technologies in education is dictated by the rapid development of society. In the process of digitalization, both the structure of training and the organization of the educational process change. This article describes the relevance of the problems of modern technologies in the education system

MORPHOGENESIS OF KNEE HYALINE CARTILAGE DURING INTRAARTICULAR INJECTION OF PLATELET-RICH AUTOLOGOUS PLASMA AND/OR HYALURONIC ACID PREPARATION IN RATS WITH EXPERIMENTAL OSTEOARTHRITIS

According to current concepts, the influence of autologous platelet-rich plasma (PRP) and high molecular hyaluronates (HA) on the repair of hyaline cartilage during its inflammatory and degenerative changes has been insufficiently studied yet. The objective of the work was to evaluate the morphological changes in the structure of hyaline cartilage in experimental osteoarthritis after intra-articular injection of PRP and/or HA. Material and methods. The authors used 50 adult rats of Wistar line, weighing 250±2,2 g., distributed into five groups of 10 animals (two control and three experimental groups). An experimental gonarthosis was simulated on four groups of animals. Animals of the first experimental group received intra-articular injection of PRP, the second group – HA, the third – both PRP and HA. Results. No morphological signs of degenerative and inflammatory changes in the first control group were identified. Following osteoarthritis simulation the articular cartilage thinned to 121±20,4 microns (p<0,05) and the volume fraction of chondrocyte decreased to 1,2±0,6% (p<0,05). The authors observed an uneven coloration of collagen fibers with severe tinctorial properties disorder of the articular cartilage matrix. After the RPR introduction the authors observed tickening of the articular cartilage up to 275±18,9 micron (p<0,05) and the volume fraction of chondrocytes up to 18,4±2,0% (p<0,05). The contour of the cartilage surface became smoother with the formation of a cell-free zone. Collagen fibers demonstrated a uniform distribution, tinctorial properties of cartilage matrix in all areas were preserved, no signs of inflammation were noted. After HA introduction the authors observed thickening of the cartilage plate up to 264±21,3 microns (p<0,05) and the volume fraction of chondrocytes up to 11,6±1,2% (p<0,05). The surface of the cartilage featured uneven contours due to multiple areas of pulping. Uneven tinctorial properties of cartilage matrix, thickness and orientation of collagen fibres were retained. No signes of inflammation were observed. After the combined consecutive application of PRP and HA cartilage thickness increased up to 268±15,3 microns (p<0,05) and the volume fraction of chondrocytes increased up to 12,7±0,9% (p<0,05). Individual portions of pulping on the cartilage surface were observed. Tinctorial properties of the cartilage matrix were preserved; the focal uneven staining of collagen fibers in the basal zone was observed. No signs of inflammation were noted. Conclusion. During osteoarthritis simulation in knee joints of experimental Wistar line rats the authors observed severe structural changes in articular hyaline cartilage including complete destruction accompanied by vascular proliferation and granulomatous inflammation. Intraarticular injections of PRP, HA as well as PRP in combination with HA during the simulation of osteoarthrosis were accompanied by a decrease in the severity of degenerative and dystrophic processes and improval of tinctorial properties of articular cartilage matrix. Sole application of PRP or consecutive application of PRP followed by HA were observed as having the more significant reparative effect on articular cartilage as compared to HA

Molecular alterations in the culture of lung cancer cells H1299 after exposure to high doses of ionizing radiation

Objective To study the copy number of genes-components of signaling cascades involved in DNA repair, cell cycle regulation and apoptosis under the influence of high doses of ionizing radiation.Material and Мethods The study was carried out on a culture of H1299 non-small cell lung cancer cells. Cell lines were cultured in a Binder incubator (Germany) for 24 h (at 37 °C, 5% CO2 ), and then the groups were divided into therapeutic and control. The first one was irradiated with a NovalisTx, Varian linear accelerator at doses from 18 to 24 Gy, the second was not exposed to radiation. During the study, we monitored cell viability and evaluated apoptotic activity, then each sample was amplified in two iterations. During the study, cell viability was monitored, apoptotic activity was assessed, and then each sample was amplified in two replicates. The relative copy number of genetic loci was determined by Real-Time qPCR (RT-qPCR).Results When comparing the relative copy number in the genetic loci of the H1299 non-small cell lung cancer cell culture after exposure to a high dose of ionizing radiation, a statistically significant decrease in the relative copy number of the CASP3 and RBBP8 genes was found, which may indicate a decrease in the potential of caspase-mediated tumor repopulation and an increase in the radiosensitivity of tumor cells.Conclusion Exposure to high doses of ionizing radiation leads to a detrimental effect on tumor cells and allows to overcome one of the mechanisms of radioresistance – tumor cell repopulation

Analysis of tuberculosis incidence among health workers in the Dnepropetrovsk region.

The purpose of our study was to conduct a comparative analysis of tuberculosis incidence among healthcare workers in the general medical service departments and anti-tubercular departments in the Dnipropetrovsk region for the period from 2008 to 2017, analysis of the professional, clinical structure of tuberculosis cases for 2015-2017. Despite the decrease in the incidence of tuberculosis inUkraine,  the incidence of morbidity among medical workers in the Dnipropetrovsk region remains unfavorable. Over the past 3 years, 155 employees of health facilities have been infected with tuberculosis, including 134 from the institutions of the general medical profile and 21 employees of the anti-TB clinics. The risk group consists of representatives of scrub staff and nursing staff, as well as auxiliary (other) personnel, regardless of the profile of the medical institution. It was established that the morbidity of the staff of the institutions of the community network and the clinical structure of cases of tuberculosis is unfavorable with a high proportion of destructive changes in the lungs, bacterial discharge, less specific gravity of cases detected during prophylactic examinations

Analysis of tuberculosis incidence among health workers in the Dnepropetrovsk region.

The purpose of our study was to conduct a comparative analysis of tuberculosis incidence among healthcare workers in the general medical service departments and anti-tubercular departments in the Dnipropetrovsk region for the period from 2008 to 2017, analysis of the professional, clinical structure of tuberculosis cases for 2015-2017. Despite the decrease in the incidence of tuberculosis inUkraine,  the incidence of morbidity among medical workers in the Dnipropetrovsk region remains unfavorable. Over the past 3 years, 155 employees of health facilities have been infected with tuberculosis, including 134 from the institutions of the general medical profile and 21 employees of the anti-TB clinics. The risk group consists of representatives of scrub staff and nursing staff, as well as auxiliary (other) personnel, regardless of the profile of the medical institution. It was established that the morbidity of the staff of the institutions of the community network and the clinical structure of cases of tuberculosis is unfavorable with a high proportion of destructive changes in the lungs, bacterial discharge, less specific gravity of cases detected during prophylactic examinations