‘Choicest unguents’: molecular evidence for the use of resinous plant exudates in late Roman mortuary rites in Britain

YesResinous substances were highly prized in the ancient world for use in ritual contexts. Details gleaned from classical literature indicate that they played a significant role in Roman mortuary rites, in treatment of the body and as offerings at the tomb. Outside of Egypt, however, where research has shown that a range of plant exudates were applied as part of the mummification process, resins have rarely been identified in the burial record. This is despite considerable speculation regarding their use across the Roman Empire. Focusing on one region, we investigated organic residues from forty-nine late Roman inhumations from Britain. Using gas chromatographyemass spectrometry and the well-attested biomarker approach, terpenic compounds were characterized in fourteen of the burials analysed. These results provided direct chemical evidence for the presence of exudates from three different plant families: coniferous Pinaceae resins, Mediterranean Pistacia spp. resins (mastic/terebinth) and exotic Boswellia spp. gum-resins (frankincense/olibanum) from southern Arabia or beyond. The individuals accorded this rite had all been interred with a package of procedures more elaborate than the norm. These findings illuminate the multiplicity of roles played by resinous substances in Roman mortuary practices in acting to disguise the odour of decomposition, aiding temporary soft-tissue preservation and signifying the social status of the deceased. Nevertheless, it was their ritual function in facilitating the transition to the next world that necessitated transportation to the most remote outpost of the late Roman Empire, Britain.R.C.B is supported by a PhD studentship from the Art and Humanities Research Council (43019R00209)

Local time and the pricing of time-dependent barrier options

A time-dependent double-barrier option is a derivative security that delivers the terminal value $\phi(S_T)$ at expiry $T$ if neither of the continuous time-dependent barriers b_\pm:[0,T]\to \RR_+ have been hit during the time interval $[0,T]$. Using a probabilistic approach we obtain a decomposition of the barrier option price into the corresponding European option price minus the barrier premium for a wide class of payoff functions $\phi$, barrier functions $b_\pm$ and linear diffusions $(S_t)_{t\in[0,T]}$. We show that the barrier premium can be expressed as a sum of integrals along the barriers $b_\pm$ of the option's deltas \Delta_\pm:[0,T]\to\RR at the barriers and that the pair of functions $(\Delta_+,\Delta_-)$ solves a system of Volterra integral equations of the first kind. We find a semi-analytic solution for this system in the case of constant double barriers and briefly discus a numerical algorithm for the time-dependent case.Comment: 32 pages, to appear in Finance and Stochastic

Small-Scale Vertical Movements of Summer Flounder Relative to Diurnal, Tidal, and Temperature Changes

Observation of animal movements on small spatial scales provides a means to understand how large-scale species distributions are established from individual behavioral decisions. Small-scale vertical movements of 14 Summer Flounder Paralichthys dentatus residing in Chesapeake Bay were observed by using depth data collected with archival tags. A generalized linear mixed model was employed to examine the relationship between these vertical movements and environmental covariates such as tidal state, time of day, lunar phase, and temperature. Vertical movements increased with warming water temperatures, and this pattern was most apparent at night and during rising and falling tides. Fish generally exhibited greater vertical movements at night, but the difference between vertical movements in the day and those at night decreased as fish increased in size. Results from this study fill a void in understanding the small-scale movements of Summer Flounder and could be incorporated into individual-based models to investigate how species distributions develop in response to environmental conditions

Spectrum of non-Hermitian heavy tailed random matrices

Let (X_{jk})_{j,k>=1} be i.i.d. complex random variables such that |X_{jk}| is in the domain of attraction of an alpha-stable law, with 0< alpha <2. Our main result is a heavy tailed counterpart of Girko's circular law. Namely, under some additional smoothness assumptions on the law of X_{jk}, we prove that there exists a deterministic sequence a_n ~ n^{1/alpha} and a probability measure mu_alpha on C depending only on alpha such that with probability one, the empirical distribution of the eigenvalues of the rescaled matrix a_n^{-1} (X_{jk})_{1<=j,k<=n} converges weakly to mu_alpha as n tends to infinity. Our approach combines Aldous & Steele's objective method with Girko's Hermitization using logarithmic potentials. The underlying limiting object is defined on a bipartized version of Aldous' Poisson Weighted Infinite Tree. Recursive relations on the tree provide some properties of mu_alpha. In contrast with the Hermitian case, we find that mu_alpha is not heavy tailed.Comment: Expanded version of a paper published in Communications in Mathematical Physics 307, 513-560 (2011

Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways

The epithelial Na+ channel (ENaC) regulates airway surface hydration. In mouse airways, ENaC is composed of three subunits, α, β, and γ, which are differentially expressed (α &gt; β &gt; γ). Airway-targeted overexpression of the β subunit results in Na+ hyperabsorption, causing airway surface dehydration, hyperconcentrated mucus with delayed clearance, lung inflammation, and perinatal mortality. Notably, mice overexpressing the α- or γ-subunit do not exhibit airway Na+ hyperabsorption or lung pathology. To test whether overexpression of multiple ENaC subunits produced Na+ transport and disease severity exceeding that of βENaC-Tg mice, we generated double (αβ, αγ, βγ) and triple (αβγ) transgenic mice and characterized their lung phenotypes. Double αγENaC-Tg mice were indistinguishable from WT littermates. In contrast, double βγENaC-Tg mice exhibited airway Na+ absorption greater than that of βENaC-Tg mice, which was paralleled by worse survival, decreased mucociliary clearance, and more severe lung pathology. Double αβENaC-Tg mice exhibited Na+ transport rates comparable to those of βENaC-Tg littermates. However, αβENaC-Tg mice had poorer survival and developed severe parenchymal consolidation. In situ hybridization (RNAscope) analysis revealed both alveolar and airway αENaC-Tg overexpression. Triple αβγENaC-Tg mice were born in Mendelian proportions but died within the first day of life, and the small sample size prevented analyses of cause(s) of death. Cumulatively, these results indicate that overexpression of βENaC is rate limiting for generation of pathological airway surface dehydration. Notably, airway co-overexpression of β- and γENaC had additive effects on Na+ transport and disease severity, suggesting dose dependency of these two variables

Theoretical study of incoherent phi photoproduction on a deuteron target

We study the photoproduction of phi mesons in deuteron, paying attention to the modification of the cross section from bound protons to the free ones with the aim of comparing with recent results at LEPS. For this purpose we take into account Fermi motion in single scattering and rescattering of the phi to account for phi absorption on a second nucleon as well as the rescattering of the proton. We find that the contribution of the double scattering is much smaller than the typical cross section of gamma p to phi p in free space, which implies a very small screening of the phi production in deuteron. The contribution from the proton rescattering, on the other hand, is found to be not negligible compared to the cross section of gamma p to phi p in free space, and leads to a moderate reduction of the phi photoproduction cross section on a deuteron at forward angles if LEPS set up is taken into account. The Fermi motion allows contribution of the single scattering in regions forbidden by phase space in the free case. In particular, we find that for momentum transferred squared close to the maximum value, the Fermi motion changes drastically the shape of d sigma / dt, to the point that the ratio of this cross section to the free one becomes very sensitive to the precise value of t chosen, or the size of the bin used in an experimental analysis. Hence, this particular region of t does not seem the most indicated to find effects of a possible phi absorption in the deuteron. This reaction is studied theoretically as a function of t and the effect of the experimental angular cuts at LEPS is also discussed, providing guidelines for future experimental analyses of the reaction.Comment: 17 pages, 16 figure

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

Contains fulltext : 177329.pdf (Publisher’s version ) (Open Access

A Preliminary Assessment of Silver Nanoparticle Inhibition of Monkeypox Virus Plaque Formation

The use of nanotechnology and nanomaterials in medical research is growing. Silver-containing nanoparticles have previously demonstrated antimicrobial efficacy against bacteria and viral particles. This preliminary study utilized an in vitro approach to evaluate the ability of silver-based nanoparticles to inhibit infectivity of the biological select agent, monkeypox virus (MPV). Nanoparticles (10–80 nm, with or without polysaccharide coating), or silver nitrate (AgNO3) at concentrations of 100, 50, 25, and 12.5 μg/mL were evaluated for efficacy using a plaque reduction assay. Both Ag-PS-25 (polysaccharide-coated, 25 nm) and Ag-NP-55 (non-coated, 55 nm) exhibited a significant (P ≤ 0.05) dose-dependent effect of test compound concentration on the mean number of plaque-forming units (PFU). All concentrations of silver nitrate (except 100 μg/mL) and Ag-PS-10 promoted significant (P ≤ 0.05) decreases in the number of observed PFU compared to untreated controls. Some nanoparticle treatments led to increased MPV PFU ranging from 1.04- to 1.8-fold above controls. No cytotoxicity (Vero cell monolayer sloughing) was caused by any test compound, except 100 μg/mL AgNO3. These results demonstrate that silver-based nanoparticles of approximately 10 nm inhibit MPV infection in vitro, supporting their potential use as an anti-viral therapeutic

Reuse of cell culture inserts for in vitro human primary airway epithelial cell studies

To the Editor: Humanprimary bronchial epithelial (HBE) cells have a long history in respiratory research. With the establishment of protocols for expansion of primary airway epithelial cells with conditionally reprogrammed cell methods (1, 2), cellular redifferentiation using air–liquid interface (ALI) conditions on porous membranes, and lentiviral infection and CRISPR/Cas9-mediated transduction and gene knockdown technologies (3, 4), the use of HBE cell cultures for respiratory research has greatly expanded

Rings and bars: unmasking secular evolution of galaxies

Secular evolution gradually shapes galaxies by internal processes, in contrast to early cosmological evolution which is more rapid. An important driver of secular evolution is the flow of gas from the disk into the central regions, often under the influence of a bar. In this paper, we review several new observational results on bars and nuclear rings in galaxies. They show that these components are intimately linked to each other, and to the properties of their host galaxy. We briefly discuss how upcoming observations, e.g., imaging from the Spitzer Survey of Stellar Structure in Galaxies (S4G), will lead to significant further advances in this area of research.Comment: Invited review at "Galaxies and their Masks", celebrating Ken Freeman's 70-th birthday, Sossusvlei, Namibia, April 2010. To be published by Springer, New York, editors D.L. Block, K.C. Freeman, & I. Puerari; minor change