ReCon: Revealing and Controlling PII Leaks in Mobile Network Traffic

It is well known that apps running on mobile devices extensively track and leak users' personally identifiable information (PII); however, these users have little visibility into PII leaked through the network traffic generated by their devices, and have poor control over how, when and where that traffic is sent and handled by third parties. In this paper, we present the design, implementation, and evaluation of ReCon: a cross-platform system that reveals PII leaks and gives users control over them without requiring any special privileges or custom OSes. ReCon leverages machine learning to reveal potential PII leaks by inspecting network traffic, and provides a visualization tool to empower users with the ability to control these leaks via blocking or substitution of PII. We evaluate ReCon's effectiveness with measurements from controlled experiments using leaks from the 100 most popular iOS, Android, and Windows Phone apps, and via an IRB-approved user study with 92 participants. We show that ReCon is accurate, efficient, and identifies a wider range of PII than previous approaches.Comment: Please use MobiSys version when referencing this work: http://dl.acm.org/citation.cfm?id=2906392. 18 pages, recon.meddle.mob

Readily accessible sp3-rich cyclic hydrazine frameworks exploiting nitrogen fluxionality

Increased molecular complexity correlates with improved chances of success in the drug development process. Here, a strategy for the creation of sp3-rich, non-planar heterocyclic scaffolds suitable for drug discovery is described that obviates the need to generate multiple stereogenic centers with independent control. Asymmetric transfer hydrogenation using a tethered Ru-catalyst is used to efficiently produce a range of enantiopure cyclic hydrazine building blocks (up to 99% ee). Iterative C–N functionalization at the two nitrogen atoms of these compounds produces novel hydrazine and hydrazide based chemical libraries. Wide chemical diversification is possible through variation in the hydrazine structure, use of different functionalization chemistries and coupling partners, and controlled engagement of each nitrogen of the hydrazine in turn. Principal Moment of Inertia (PMI) analysis of this small hydrazine library reveals excellent shape diversity and three-dimensionality. NMR and crystallographic studies confirm these frameworks prefer to orient their substituents in three-dimensional space under the control of a single stereogenic center through exploitation of the fluxional behavior of the two nitrogen atoms

The NexSTEM Program: A Community Assets Program that Fosters the Next Generation of STEM Leaders

Underrepresentation in science, technology, engineering, and mathematics (STEM) fields by individuals with low socioeconomic status (SES) is a long-standing concern. Funded in late 2018, the NexSTEM Program (the “Program”) is a National Science Foundation multi-institution consortia S-STEM grant-funded program at Illinois Wesleyan University (IWU), Illinois State University (ISU), and Heartland Community College (HCC) with the goal of reducing barriers for low SES students from Central Illinois enrolling in and completing STEM degree programs at the three institutions and identifying effective, and sustainable, programmatic components. To help address barriers, the Program awards 2- and 4-year scholarships to academically successful students with significant financial need, and pairs the scholarships with multi-level mentoring, academic supports, and hands-on STEM research project involvement beginning in the first semester of college for both 2-year and 4-year students. Uniquely, HCC students who want to transfer to IWU or ISU can take their scholarship with them as they complete their 4-year STEM degree. The Program has now onboarded 2 cohorts of largely Pell-eligible first year students pursuing an eligible STEM major at one of the three IHEs. This presentation will discuss program structure, interim outcomes related to the current cohorts, and implications for the efficacy of this model in improving retention and representation in STEM

Bis(2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hydr­oxy)meth­yl}piperidin-1-ium) tetra­chloridodiphenyl­stannate(IV)

In the title salt, (C17H17F6N2O)2[Sn(C6H5)2Cl4], the complete anion is generated by crystallograaphic inversion symmetry, giving a trans-SnC2Cl4 octa­hedral coordination geometry for the metal atom. In the cation, the quinoline residue is almost normal to the other atoms, so that the ion has an L-shaped conformation [the C—C—C—C torsion angle linking the fused-ring systems is 100.9 (7)°]; the six-membered piperidin-1-ium ring has a chair conformation. An intra­molecular N—H⋯O inter­action occurs. In the crystal, N—H⋯Cl and O—H⋯Cl hydrogen bonds link the components into a supra­molecular chain propagating along the a axis. C—H⋯Cl inter­actions are also present

Increasing Dominance - the Role of Advertising, Pricing and Product Design

Despite the empirical relevance of advertising strategies in concentrated markets, the economics literature is largely silent on the effect of persuasive advertising strategies on pricing, market structure and increasing (or decreasing) dominance. In a simple model of persuasive advertising and pricing with differentiated goods, we analyze the interdependencies between ex-ante asymmetries in consumer appeal, advertising and prices. Products with larger initial appeal to consumers will be advertised more heavily but priced at a higher level - that is, advertising and price discounts are strategic substitutes for products with asymmetric initial appeal. We find that the escalating effect of advertising dominates the moderating effect of pricing so that post-competition market shares are more asymmetric than pre-competition differences in consumer appeal. We further find that collusive advertising (but competitive pricing) generates the same market outcomes, and that network effects lead to even more extreme market outcomes, both directly and via the effect on advertising

Climacteric Lowers Plasma Levels of Platelet-Derived Microparticles: A Pilot Study in Pre-versus Postmenopausal Women

Background: Climacteric increases the risk of thrombotic events by alteration of plasmatic coagulation. Up to now, less is known about changes in platelet-(PMP) and endothelial cell-derived microparticles (EMP). Methods: In this prospective study, plasma levels of microparticles (MP) were compared in 21 premenopausal and 19 postmenopausal women. Results: No altered numbers of total MP or EMP were measured within the study groups. However, the plasma values of CD61-exposing MP from platelets/megakaryocytes were higher in premenopausal women (5,364 x 10(6)/l, range 4,384-17,167) as compared to postmenopausal women (3,808 x 10(6)/l, range 2,009-8,850; p = 0.020). This differentiation was also significant for the subgroup of premenopausal women without hormonal contraceptives (5,364 x 10(6)/l, range 4,223-15,916; p = 0.047; n = 15). Furthermore, in premenopausal women, higher plasma levels of PMP exposing CD62P were also present as compared to postmenopausal women (288 x 10(6)/l, range 139-462, vs. 121 x 10(6)/l, range 74-284; p = 0.024). This difference was also true for CD63+ PMP levels (281 x 10(6)/l, range 182-551, vs. 137 x 10(6)/l, range 64-432; p = 0.015). Conclusion: Climacteric lowers the level of PMP but has no impact on the number of EMP in women. These data suggest that PMP and EMP do not play a significant role in enhancing the risk of thrombotic events in healthy, postmenopausal women. Copyright (C) 2012 S. Karger AG, Base

Congenital deficiency reveals critical role of ISG15 in skin homeostasis

Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous nonsense mutation in the ISG15 gene, leading to unstable ISG15 protein lacking the functional domain. We characterized ISG15(-/-) dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells. ISG15-deficient cells exhibited the expected hyperinflammatory phenotype, but also dysregulated expression of molecules critical for connective tissue and epidermis integrity, including reduced collagens and adhesion molecules, but increased matrix metalloproteinases. ISG15(-/-) fibroblasts exhibited elevated ROS levels and reduced ROS scavenger expression. As opposed to hyperinflammation, defective collagen and integrin synthesis was not rescued by conjugation-deficient ISG15. Cell migration was retarded in ISG15(-/-) fibroblasts and HaCaT keratinocytes, but normalized under ruxolitinib treatment. Desmosome density was reduced in an ISG15(-/-) 3D epidermis model. Additionally, there were loose architecture and reduced collagen and desmoglein expression, which could be reversed by treatment with ruxolitinib/doxycycline/TGF-beta 1. These results reveal critical roles of ISG15 in maintaining cell migration and epidermis and connective tissue homeostasis, whereby the latter likely requires its conjugation to yet unidentified targets