Preferences for efficiency, rather than preferences for morality, drive cooperation in the one-shot Stag-Hunt game

Recent work highlights that cooperation in the one-shot Prisoner's dilemma (PD) is primarily driven by moral preferences for doing the right thing, rather than social preferences for equity or efficiency. To our knowledge, nothing is known on whether moral preferences affect cooperation in the Stag-Hunt Game (SHG). Cooperation in the SHG fundamentally differs from cooperation in the PD in that it is not costly, but risky: players have no temptation to deviate from the cooperative outcome, but cooperation only pays off if the other player cooperates. Here we provide data from two experiments (total N = 523) to investigate SHG cooperation. Contrary to what has been observed for the PD, we find that SHG cooperation is primarily driven by preferences for efficiency, rather than moral preferences for doing the right thing

Bilateral osteochondral defects of the patellae in an 11-year-old girl

Osteochondral defect or osteochondritis dissecans (OCD) of the knee usually affects young, active populations. It is a challenging diagnosis as patients typically present with poorly localised activity-related pain, which is non-specific and covers many differentials. We present an active 11-year-old girl with bilateral osteochondral defects of the patellae: a rare clinical disorder which was affecting her sporting activities. She had a 12-month history of bilateral anterior knee pain before the diagnosis was achieved with appropriate imaging. Her pain significantly improved with activity modification and physiotherapy. Follow-up will require outpatient clinic assessment and imaging to determine if non-operative management continues to be successful or surgery may be required. This case report emphasises the importance of appropriate high index of suspicion when managing patients with non-specific knee pain. It also demonstrates the importance of judicious use of imaging to avoid a missed or delayed diagnosis

Photospheric structure of an extended penumbra

The photospheric structure of an extended penumbra belonging to a complex spot observed near disk center is investigated by means of the inversion of the full Stokes vector of two Fe I lines at 1.56 μm. An attempt is made to classify the observed Stokes V profiles in terms of their shapes. It turns out that about 28% of the profiles have abnormal shapes indicative of two different magnetic-field components within the resolution element. The spatial distribution of abnormal Stokes V profiles is studied. It is found that such profiles are evenly distributed in the penumbra, without any particular tendency to concentrate near the so-called neutral line. Anomalous profiles are not only seen in the outer penumbra and beyond, but also in the middle part of it. A Milne-Eddington–like inversion is carried out first, revealing a smooth picture of the spatial distribution of magneticfield vector and velocities along the line of sight. In particular, dark spines with stronger and more vertical magnetic fields are seen to coexist with nearly horizontal magnetic fields throughout the penumbra. A full inversion allowing for gradients of the atmospheric parameters along the line of sight indicates the existence of cool magnetic tubes returning back to the solar surface (inclination angles greater than 90◦) and carrying the largest material flows

Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain

<p>Abstract</p> <p>Background</p> <p>The presence of EGFR kinase domain mutations in a subset of NSCLC patients correlates with the response to treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Although most EGFR mutations detected are short deletions in exon 19 or the L858R point mutation in exon 21, more than 75 different EGFR kinase domain residues have been reported to be altered in NSCLC patients. The phenotypical consequences of different EGFR mutations may vary dramatically, but the majority of uncommon EGFR mutations have never been functionally evaluated.</p> <p>Results</p> <p>We demonstrate that the relative kinase activity and erlotinib sensitivity of different EGFR mutants can be readily evaluated using transfection of an YFP-tagged fragment of the EGFR intracellular domain (YFP-EGFR-ICD), followed by immunofluorescence microscopy analysis. Using this assay, we show that the exon 20 insertions Ins770SVD and Ins774HV confer increased kinase activity, but no erlotinib sensitivity. We also show that, in contrast to the common L858R mutation, the uncommon exon 21 point mutations P848L and A859T appear to behave like functionally silent polymorphisms.</p> <p>Conclusion</p> <p>The ability to rapidly obtain functional information on EGFR variants of unknown relevance using the YFP-EGFR-ICD assay might prove important in the future for the management of NSCLC patients bearing uncommon EGFR mutations. In addition, our assay may be used to determine the response of resistant EGFR mutants to novel second-generation TKIs.</p

Propuesta de alfabetización mediática ante los estereotipos de género en los medios de comunicación: resultados y valoración de “rostros de mujer”

Educating today's society requires moving towards to new forms of literacy that promote a critical attitude towards the media, as a responsibility shared by various actors. In this paperwork, we propose an innovative resource to improve media education, aimed at different groups, addressing gender stereotypes that appear in different media of communication through the virtual chat rooms called "Faces of Women". Below you can find the results obtained after its implementation, and the evaluation of a group of experts who have been interviewed. The results allow us to make progress towards achieving citizenship media, which interacts with the media, critically analyzing messages and screens, due to the development of media skills

Propuesta de alfabetización mediática ante los estereotipos de género en los medios de comunicación: resultados y valoración de “rostros de mujer”

Educating today's society requires moving towards to new forms of literacy that promote a critical attitude towards the media, as a responsibility shared by various actors. In this paperwork, we propose an innovative resource to improve media education, aimed at different groups, addressing gender stereotypes that appear in different media of communication through the virtual chat rooms called "Faces of Women". Below you can find the results obtained after its implementation, and the evaluation of a group of experts who have been interviewed. The results allow us to make progress towards achieving citizenship media, which interacts with the media, critically analyzing messages and screens, due to the development of media skills

Conectar con el público: diseño estratégico de las comunidades de usuarios por la TV

The challenges of human interaction go through the basic need to connect. TV digitization resulted in a converged environment that strengthens the "de-massification of the mass media". The increasingly personalized, targeted, shared and commented consumption require strategies to connect directly to each user, while seeking his own connection with other public and with the media. This article is part of the strategic interests of the user communities in the converging TV, especially among the millennial audience. We conclude that have barely yet developed its potential and opens an avenue of discussion to improve the connection between the transmedia programming and audiences

Conectar con el público: diseño estratégico de las comunidades de usuarios por la TV

The challenges of human interaction go through the basic need to connect. TV digitization resulted in a converged environment that strengthens the "de-massification of the mass media". The increasingly personalized, targeted, shared and commented consumption require strategies to connect directly to each user, while seeking his own connection with other public and with the media. This article is part of the strategic interests of the user communities in the converging TV, especially among the millennial audience. We conclude that have barely yet developed its potential and opens an avenue of discussion to improve the connection between the transmedia programming and audiences

Preparation of Dipteran Larvae for Scanning Electron Microscopy with Special Reference to Myiasigen Dipteran Species

Although controversy exists concerning the role of chemical fixatives in scanning electron microscopy (SEM) studies of Dipteran larvae, we have observed that filtered 10% formaldehyde solution gives excellent results as a preservative. After immersing in vivo in formaldehyde, the larvae material is preserved for prolonged periods (up to 8 months), before examination with SEM. As a fixative, formaldehyde preserves the structure of the larval cuticle and produces no visible artifacts. Moreover, postfixation is not necessary. Due to pecularities of the way of life of Wohlfahrtia magnifica (principally the accumulations of necrotic tissue, purulent particles, and other types of substances that often adhere to the numerous spines of larvae), this species must be cleaned before examination by SEM. Manual cleaning with alternating bidistilled water and 0.9% saline solution proved to be a rapid, easy and inexpensive method that gave good results. Both lyophilization drying and critical point drying were used before sputtering the material. While lyophilization drying proved to be the most effective method for instars II and III, critical point drying was the best technique for study of specimens belonging to instar I. The optimum time for drying and conditions for lyophilization and sputter-coating with gold were determined experimentally. Samples were mounted on SEM stubs with double-sided adhesive and silver conductive paint. The method proposed is easy and effective for the SEM study of larvae myiasis-producing diptera

Investigation of Spray Angle Measurement Techniques

The in-cylinder fluid-dynamic processes of fuel injection and air entrainment influence the structure and shape of evolving fuel sprays, which can subsequently alter the ignition, combustion and pollutant formation processes in diesel engines. Different spray angle detection methods have been used in the literature to investigate the global and local spray characteristics. In this work, the five most widely used diesel spray angle detection methods were identified, and used to evaluate the characteristic features of each detection method: methods with a detection range based on the spray penetration length, methods with a fixed detection range in the near and far-field spray region, triangular-based methods, and methods based on averaging local data points. The sprays were acquired from our spray chamber and processed with different thresholding techniques to explore the differences between spray angle detection methods. All five methods generated a similar global trend of spray angle variation for temporally evolving sprays over the complete injection period. However, the actual spray angle values detected by each method were not always comparable. The differences in spray angle values between the different detection methods were larger during the early start of injection, and these differences systematically decreased as the spray approached a steady-state. The methods that detected the angle in the far-field demonstrated lower spatiotemporal variability when compared to the methods that detected the angle in the near-field. An assessment ofthecomparabilitybetweenangledetectionmethodswasmadeandtheoutcomeprovidesguidanceforthe selection of the spray angle detection method.Engineering and Physical Sciences Research Council in the UK (EPSRC