Dehumanization of socioeconomically disadvantaged groups decreases support for welfare policies via perceived wastefulness

Low-socioeconomic status (SES) groups are sometimes depicted as money wasters who live on welfare. Previous research has also found that low-SES groups are also animalized. We expand previous findings (Sainz et al., 2019) by examining the consequences that animalization has on support for social welfare policies (e.g., unemployment, housing) and governmental control of low-SES groups’ spending. We explored the mediating role of perceived wastefulness (i.e., the perception that low-SES people lack the ability to properly administer their budget) in the relationships between animalization and support for welfare policies and governmental control measures. In three correlation studies, 1a to 1c, we examined the relationships between these variables in three countries: The United Kingdom, the United States, and Spain. From our results, animalizing low-SES groups seem to negatively predict support for public policies and positively predict support for governmental control via the perception that low-SES people are unable to manage their finances. Finally, in two experimental studies, 2a and 2b, we directly manipulated the humanness of a low-SES group (animalized vs. humanized) and measured its effects on perceptions of the group’s wastefulness, support for social welfare policies, and support for governmental control over the group’s expenses. Results indicated that animalizing low-SES groups reduced support for social welfare by activating the impression that low-SES people are poor financial managers (Study 2a), but also that animalizing low-SES groups increased support for governmental control via perceived wastefulness (Studies 2a–b). We discuss the role of animalization in denying aid to those in need."Programa de movilidad para jovenes doctorandos CEI-BIOTIC" (University of Granada CEI-BIOTIC

Spectral behavior of a low-cost all-fiber component based on untapered multifiber unions

Untapered multifiber unions are reported to show a spectral behavior similar to the tapered ones. Their oscillatory behavior does not depend on the biconical regions. This suggests a novel way to make low-cost all-fiber devices with applications as passive components such as optical filters and wavelength multiplexers/demultiplexers. Two types of multimode fibers have been studied and information about the index profile influence has been obtained. Polarization insensitivity and temperature stability have been observed

Spectral behavior of a low-cost all-fiber component based on untapered multifiber unions

Untapered multifiber unions are reported to show a spectral behavior similar to the tapered ones. Their oscillatory behavior does not depend on the biconical regions. This suggests a novel way to make low-cost all-fiber devices with applications as passive components such as optical filters and wavelength multiplexers/demultiplexers. Two types of multimode fibers have been studied and information about the index profile influence has been obtained. Polarization insensitivity and temperature stability have been observed

Proceso de Auditoría de los Estados Financieros Consolidados de un grupo de sociedades

A través de un “papel” de cinco o seis hojas, el auditor expresa la opinión sobre las cuentas anuales de una sociedad o un grupo y, dicha opinión puede tener consecuencias muy importantes.Detrás del informe de auditoría se encuentran: dedicación, esfuerzo, profesionalidad y, sobre todo, muchas horas de trabajo para asegurarse que la opinión de auditoría es la adecuada.A través de la realización de un caso práctico real, el cual pude formar parte en la realización de las prácticas, vamos a tratar de explicar cada una de las distintas fases que conllevan a la emisión del informe de un grupo, las cuales difieren en algunos aspectos, de la de los estados financieros individuales.<br /

Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics

Recent advances in the field of nanotechnology such as nanoencapsulation offer new biomedical applications, potentially increasing the scope and efficacy of therapeutic drug delivery. In addition, the discovery and development of novel biocompatible polymers increases the versatility of these encapsulating nanostructures, enabling chemical properties of the cargo and vehicle to be adapted to specific physiological requirements. Here, we evaluate the capacity of various polymeric nanostructures to encapsulate various antibiotics of different classes, with differing chemical structure. Polymers were sourced from two separate derivatives of poly(methyl vinyl ether-alt-maleic anhydride) (PMVE/MA): an acid (PMVE/MA-Ac) and a monoethyl ester (PMVE/MA-Es). Nanoencapsulation of antibiotics was attempted through electrospinning, and nanoparticle synthesis through solvent displacement, for both polymers. Solvent incompatibilities prevented the nanoencapsulation of amikacin, neomycin and ciprofloxacin in PMVE/MA-Es nanofibers. However, all compounds were successfully loaded into PMVE/MA-Es nanoparticles. Encapsulation efficiencies in nanofibers reached approximately 100% in all compatible systems; however, efficiencies varied substantially in nanoparticles systems, depending on the tested compound (14%–69%). Finally, it was confirmed that both these encapsulation processes did not alter the antimicrobial activity of any tested antibiotic against Staphylococcus aureus and Escherichia coli, supporting the viability of these approaches for nanoscale delivery of antibioticsThis research was funded by the Spanish Ministerio de Economía y Competitividad, grant numbers MAT-2017-86805-R and MAT-2014-53282-R,and Spanish Ministerio de Ciencia e Innovación (MCI)—Agencia Estatal de Investigación (AEI)/Fondo Europeo de Desarrollo Regional (FEDER), grant number RTI2018-101969-J-I0

Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies

Prostate cancer, as one of the most prevalent malignancies in males, exhibits an approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events and mutations, including the accumulation of oncometabolites, underpin the genesis and progression of this cancer type. Despite growing research demonstrating the pivotal role of oncometabolites in supporting various cancers, including prostate cancer, the root causes of their accumulation, especially in the absence of enzymatic mutations, remain elusive. Consequently, identifying a tangible therapeutic target poses a formidable challenge. In this review, we aim to delve deeper into the implications of oncometabolite accumulation in prostate cancer. We center our focus on the consequential epigenetic alterations and impacts on cancer stem cells, with the ultimate goal of outlining novel therapeutic strategies

¿Es Vicia un buen antecesor de la soja?

La adopción de vicia como cultivo de servicio se ha incrementado en los últimos años en la Argentina. Sin embargo, aún es necesario generar más información respecto a la elección de fechas de siembra y de secado, y de cómo puede incidir el cultivo de servicio en la disponibilidad de agua y nutrientes en el suelo para cultivos sucesores como la soja.EEA BalcarceFil: Rodríguez, María Pía. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Rodríguez, María Pía. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Rodríguez, María Pía. Agencia Nacional de Promoción Científica y Tecnológica.Fil: Carciocchi, Walter. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Carciochi, Walter. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Carciochi, Walter. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Crespo, Cecilia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Crespo, Cecilia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Crespo, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Sainz Rozas, Hernán Rene. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Sainz Rozas, Hernán Rene. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Sainz Rozas, Hernán Rene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Barbieri, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina.Fil: Barbieri, Pablo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina.Fil: Barbieri, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function

Abstract Background: Leptin and nitric oxide (NO) on their own participate in the control of non-shivering thermogenesis. However, the functional interplay between both factors in this process has not been explored so far. Therefore, the aim of the present study was to analyze the impact of the absence of the inducible NO synthase (iNOS) gene in the regulation of energy balance in ob/ob mice. Methods and Findings: Double knockout (DBKO) mice simultaneously lacking the ob and iNOS genes were generated, and the expression of molecules involved in the control of brown fat cell function was analyzed by real-time PCR, western-blot and immunohistochemistry. Twelve week-old DBKO mice exhibited reduced body weight (p,0.05), decreased amounts of total fat pads (p,0.05), lower food efficiency rates (p,0.05) and higher rectal temperature (p,0.05) than ob/ob mice. Ablation of iNOS also improved the carbohydrate and lipid metabolism of ob/ob mice. DBKO showed a marked reduction in the size of brown adipocytes compared to ob/ob mutants. In this sense, in comparison to ob/ob mice, DBKO rodents showed an increase in the expression of PR domain containing 16 (Prdm16), a transcriptional regulator of brown adipogenesis. Moreover, iNOS deletion enhanced the expression of mitochondria-related proteins, such as peroxisome proliferatoractivated receptor c coactivator-1 a (Pgc-1a), sirtuin-1 (Sirt-1) and sirtuin-3 (Sirt-3). Accordingly, mitochondrial uncoupling proteins 1 and 3 (Ucp-1 and Ucp-3) were upregulated in brown adipose tissue (BAT) of DBKO mice as compared to ob/ob rodents. Conclusion: Ablation of iNOS improved the energy balance of ob/ob mice by decreasing food efficiency through an increase in thermogenesis. These effects may be mediated, in part, through the recovery of the BAT phenotype and brown fat cell function improvement

Valor de la PET en la recurrencia del cáncer de próstata con PSA < 5 ng/ml

We intend to evaluate the usefulness of PET scans in diagnosing recurrent prostate cancer after a curative attempt using radical treatment. MATERIAL AND METHODS: 92 consecutive prostate cancer patients in biochemical progression following radical surgery (63) or radiation treatment (29) were studied with positron emission tomography (PET). In all cases two scans were performed in the same day (11C-choline and 18F-FDG). PET efficacy was evaluated both globally (by employing the results achieved with both 11C-choline and 18F-FDG) and using both radiotracers independently to detect recurrence in patients with biochemical progression. For this purpose, we used comparison of means for k-independent samples, 2 x 2 and 2 x X contingency tables and ROC curves. RESULTS: 1. Global PET: there is evidence of PET alteration regarding the PSA level (P=.003): the clinical stage (P=.01). There are no statistically significant PET alterations regarding the affected biopsy (uni or bilateral), surgical margins, pathological stage and time to progression. ROC curve PET-PSA is statistically significant (P< .0001) permitting calculation of different cut-off points, with a specificity of 91% (highest) for a PSA of 4.3 ng/ml. 2. PET 18FDG: the area under the ROC curve is statistically significant (P< .0001) with a specificity of 91% for a PSA of 6.51 ng/ml. 3. PET 11choline: the area under the ROC curve is statistically significant (P< .0001) with a specificity of 91% for a PSA of 5.15 ng/ml. CONCLUSIONS: PET is a useful tool for diagnosing prostate cancer recurrence after a curative attempt using radical treatment