Functional Genomics Profiling of Bladder Urothelial Carcinoma MicroRNAome as a Potential Biomarker.

Though bladder urothelial carcinoma is the most common form of bladder cancer, advances in its diagnosis and treatment have been modest in the past few decades. To evaluate miRNAs as putative disease markers for bladder urothelial carcinoma, this study develops a process to identify dysregulated miRNAs in cancer patients and potentially stratify patients based on the association of their microRNAome phenotype to genomic alterations. Using RNA sequencing data for 409 patients from the Cancer Genome Atlas, we examined miRNA differential expression between cancer and normal tissues and associated differentially expressed miRNAs with patient survival and clinical variables. We then correlated miRNA expressions with genomic alterations using the Wilcoxon test and REVEALER. We found a panel of six miRNAs dysregulated in bladder cancer and exhibited correlations to patient survival. We also performed differential expression analysis and clinical variable correlations to identify miRNAs associated with tobacco smoking, the most important risk factor for bladder cancer. Two miRNAs, miR-323a and miR-431, were differentially expressed in smoking patients compared to nonsmoking patients and were associated with primary tumor size. Functional studies of these miRNAs and the genomic features we identified for potential stratification may reveal underlying mechanisms of bladder cancer carcinogenesis and further diagnosis and treatment methods for urothelial bladder carcinoma

Implantation de Stradivarius à Genève

L’objectif principal de ce travail est de proposer un plan marketing pour l’implantation de Stradivarius, à Genève. Stradivarius est une entreprise espagnole de prêt-à-porter féminin qui compte sept-cent quatre-vingt points de vente dans quarante-cinq pays. Friande des magasins de prêt-à-porter et trouvant que Genève manque de diversité dans l’industrie du textile, j’ai trouvé intéressant de proposer ce projet. Ce projet s’adresse, principalement, à une clientèle féminine jeune, de classe moyenne, aimant s’habiller tendance et à la mode. Très soucieuse de leur apparence, l’implantation d’un nouveau concept, leur permettra d’agrandir leur collection personnelle et de s’approprier d’un nouveau style venu d’Espagne. Stradivarius proposera à sa clientèle une large gamme de produit à la pointe de la mode qui sera renouvelée toutes les deux semaines. La clientèle se rendra dans un magasin accueillant avec un personnel qui sera à l’écoute des demandes et conseilleront aux mieux la clientèle. Préalablement au plan marketing, une analyse de l’environnement externe, une analyse de la concurrence et une étude du marché du prêt-à-porter ont été effectué, afin d’analyser le secteur de l’industrie, ainsi que les coutumes d’achat et l’attractivité de Stradivarius sur le marché genevois. Puis, un plan marketing détaillé a été effectué, afin d’orienter la stratégie du projet. Les différentes recommandations qui ressortent de ce travail sont les suivants : Apporter une valeur ajoutée aux yeux de la clientèle par le service du personnel qui doit être irréprochable et à l’écoute de la clientèle la création d’une collection exclusive pour le marché genevois Communiquer l’implantation par le lieu d’implantation qui est très important pour le succès de Stradivarius la communication avant l’événement (publicité ciblée sur Facebook, petites affiches dans les magasins appartenant à Inditex (Zara, Massimo Dutti, Bershka), annonces sur le site officiel de Stradivarius

Practical residue curve map analysis applied to solvent recovery in non-ideal binary mixtures by batch distillation processes

Batch distillation inherent advantages has initiated recent search for process feasibility rules enabling the separation of azeotropic or difficult zeotropic binary mixtures thanks to the addition of an entrainer. A systematic procedure enabling to find suitable process and eventually suitable entrainer for the separation of zeotropic or azeotropic binary mixture is described. It brings together into practical use batch distillation process feasibility rules, chemical affinity insight and thermodynamic data analysis available in the literature. The procedure has been implemented in a wizard computer tool and is illustrated on the separation of the water – acetonitrile binary homoazeotrope. Through this tool, all possible 224 feasibility rules and 326 batch distillation sequence processes are checked systematically for each entrainer

Testing OPE for ghosts, gluons and αs\alpha_s

We present here our results on extracting Wilson coefficients from different quantities such as ghost and gluon propagators which are calculated by means of Lattice QCD. The results confirm the validity of our method for the calculation of the strong coupling constant as well as allow to estimate the range of momenta where OPE is applicable.Comment: arXiv admin note: substantial text overlap with arXiv:1301.759

Heuristic algorithms for a vehicle routing problem with simultaneous delivery and pickup and time windows in home health care

International audienceThis paper addresses a vehicle scheduling problem encountered in home health care logistics. It concerns the delivery of drugs and medical devices from the home care company's pharmacy to patients' homes, delivery of special drugs from a hospital to patients, pickup of bio samples and unused drugs and medical devices from patients. The problem can be considered as a special vehicle routing problem with simultaneous delivery and pickup and time windows, with four types of demands: delivery from depot to patient, delivery from a hospital to patient, pickup from a patient to depot and pickup from a patient to a medical lab. Each patient is visited by one vehicle and each vehicle visits each node at most once. Patients are associated with time windows and vehicles with capacity. Two mixed-integer programming models are proposed. We then propose a Genetic Algorithm (GA) and a Tabu Search (TS) method. The GA is based on a permutation chromosome, a split procedure and local search. The TS is based on route assignment attributes of patients, an augmented cost function, route re-optimization, and attribute-based aspiration levels. These approaches are tested on test instances derived from existing VRPTW benchmarks

Impacts of The Radiation Environment At L2 On Bolometers Onboard The Herschel Space Observatory

We present the effects of cosmic rays on the detectors onboard the Herschel satellite. We describe in particular the glitches observed on the two types of cryogenic far- infrared bolometer inside the two instruments PACS and SPIRE. The glitch rates are also reported since the launch together with the SREM radiation monitors aboard Herschel and Planck spacecrafts. Both have been injected around the Lagrangian point L2 on May 2009. This allows probing the radiation environment around this orbit. The impacts on the observation are finally summarized.Comment: 8 pages, 13 figures, 2 images, Author Keywords: Bolometers, Infrared detectors, cryogenics, radiation effects, submillimeter wave technology IEEE Terms: Bolometers, Detectors, Instruments, Picture archiving and communication systems, Protons, Silicon, Space vehicles; Radiation and Its Effects on Components and Systems (RADECS), 2011 12th European Conference. Conference location: Sevilla. Date of Conference: 19-23 Sept. 2011. Session H: Radiation Environment: Space, Atmospheric and Terrestrial (PH2

From graph theory and geometric probabilities to a representative width for three-dimensional detonation cells

We present a model for predicting a representative width for the three-dimensional cells observed on detonation fronts in reactive gases. Its physical premise is that the dynamics of the transverse waves of irregular cells obeys a stochastic process both stationary and ergodic and produces the same burnt mass per unit of time as the average planar steady ZND process. Graph theory then defines an ideal cell whose grouping is equivalent to the actual 3D cellular front, geometric probabilities determine the mean burned fraction that parameterizes the model, and ZND calculations close the problem with the time-position relationship of a fluid element in the ZND reaction zone. The model is limited to detonation reaction zones whose sole ignition mechanism is adiabatic shock compression, such as those of the mixtures with H2, C3H8 or C2H4 as fuels considered in this work. Indeed, the comparison of their measured and calculated widths shows an agreement better than or within the accepted experimental uncertainties, depending on the quality of the chemical kinetic scheme used for the ZND calculations. However, the comparison for CH4:O2 mixtures shows high overestimates, indirectly confirming that the detonation reaction zones in these mixtures certainly include other ignition mechanisms contributing to the combustion process, such as turbulent diffusion. In these situations, the cell mean width derived from longitudinal soot recordings shows a very large scatter and may thus not be a relevant detonation characteristic length. The model is easily implementable as a post-process of ZND profiles and provides fast estimates of the cell width, length and reaction time.Comment: Extended versio