El sentido de la angustia en el mundo técnico

Este trabajo pretende caracterizar la angustia como fenómeno del mundo técnico en el horizonte histórico de sentido del mundo contemporáneo. Una perspectiva fundamental para esclarecer el nuevo malestar de la civilización en la era técnica. Con este propósito se analizará la productividad hermenéutica de la angustia en relación con la técnica y su significado ontológicoexistencial. Así, se mostrará en qué sentido la angustia patológica puede entenderse como interpretación caída y apropiación impropia de la angustia existencial; y también el modo en que la angustia existencial, constitutiva del existir, actúa como un auténtico dispositivo de supervivencia en el Gestell. This paper endeavors to characterize Angst as a phenomenon pertaining to the technical world within the historical sense-horizon of the contemporary world; a perspective which provides a crucial insight on the new malaise of civilization in the technical age. With a view to this purpose, the hermeneutic productivity of Angst will be analyzed in its relationship to technique and its ontological-existential significance. This will shed light on the sense in which pathological Angst can be understood as a fallen interpretation and an improper appropriation of existential Angst, and also on the way in which existential Angst, constitutive of existence, acts in fact as an genuine device for survival within Gestell

Feasibility of Thorium Fuel Cycles in a Very High Temperature Pebble-Bed Hybrid System

Nuclear energy presents key challenges to be successful as a sustainable energy source. Currently, the viability of the use thorium-based fuel cycles in an innovative nuclear energy generation system is being investigated in order to solve these key challenges. In this work, the feasibility of three thorium-based fuel cycles (232Th-233U, 232Th-239Pu, and 232Th-U) in a hybrid system formed by a Very High Temperature Pebble-Bed Reactor (VHTR) and two Pebble-Bed Accelerator Driven Systems (ADSs) was evaluated using parameters related to the neutronic behavior such as nuclear fuel breeding, minor actinide stockpile, the energetic contribution of each fissile isotope, and the radiotoxicity of the long lived wastes. These parameters were used to compare the fuel cycles using the well-known MCNPX ver. 2.6e computational code. The results obtained confirm that the 232Th-233U fuel cycle is the best cycle for minimizing the production of plutonium isotopes and minor actinides. Moreover, the inclusion of the second stage in the ADSs demonstrated the possibility of extending the burnup cycle duration and reducing the radiotoxicity of the discharged fuel from the VHTR.Received: 09 February 2015; Revised: 12 May 2015; Accepted: 20 May 201

Improving Urban Public Operation: Experience Of Rostov-On-Don (Russia)

This paper estimates experience of development of urban public transport in city Rostov-on- Don, Russia. The main aims of policy of municipal authorities on reforming public transport are analysed. The integrated decision of a problem included achievement of the following purposes: creation most appropriate structure of management of city public transport, change of form of ownership of public transport operators, improvement of competition on the entry of market of transport services, optimization of a routes network of public transport.Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

P5509The use of three-dimensional echocardiography to measure left ventricular ejection fraction would increase the number of patients with indication to receive implantable cardioverter defibrillators

n/

Phase Separation Based on U(1) Slave-boson Functional Integral Approach to the t-J Model

We investigate the phase diagram of phase separation for the hole-doped two dimensional system of antiferromagnetically correlated electrons based on the U(1) slave-boson functional integral approach to the t-J model. We show that the phase separation occurs for all values of J/t, that is, whether $0 < J/t < 1$ or $J/t \geq 1$ with J, the Heisenberg coupling constant and t, the hopping strength. This is consistent with other numerical studies of hole-doped two dimensional antiferromagnets. The phase separation in the physically interesting J region, $0 < J/t \lesssim 0.4$ is examined by introducing hole-hole (holon-holon) repulsive interaction. We find from this study that with high repulsive interaction between holes the phase separation boundary tends to remain robust in this low $J$ region, while in the high J region, J/t > 0.4, the phase separation boundary tends to disappear.Comment: 4 pages, 2 figures, submitted to Phys. Rev.

Photo--assisted current and shot noise in the fractional quantum Hall effect

The effect of an AC perturbation on the shot noise of a fractional quantum Hall fluid is studied both in the weak and the strong backscattering regimes. It is known that the zero-frequency current is linear in the bias voltage, while the noise derivative exhibits steps as a function of bias. In contrast, at Laughlin fractions, the backscattering current and the backscattering noise both exhibit evenly spaced singularities, which are reminiscent of the tunneling density of states singularities for quasiparticles. The spacing is determined by the quasiparticle charge $\nu e$ and the ratio of the DC bias with respect to the drive frequency. Photo--assisted transport can thus be considered as a probe for effective charges at such filling factors, and could be used in the study of more complicated fractions of the Hall effect. A non-perturbative method for studying photo--assisted transport at $\nu=1/2$ is developed, using a refermionization procedure.Comment: 14 pages, 6 figure

Vortices in superfluid trapped Fermi gases at zero temperature

We discuss various aspects of the vortex state of a dilute superfluid atomic Fermi gas at T=0. The energy of the vortex in a trapped gas is calculated and we provide an expression for the thermodynamic critical rotation frequency of the trap for its formation. Furthermore, we propose a method to detect the presence of a vortex by calculating the effect of its associated velocity field on the collective mode spectrum of the gas

Síndrome de retirada post-ibrutinib en un caso de macroglobulinemia de Waldenstrom

Poster [PC-041] Introducción: El tratamiento de la Macroglobulinemia de Waldenstrom (MW) en primera línea está basado en inmunoquimioterapia. Sin embargo las recaídas y resistencia al Rituximab son frecuentes, por lo que se necesitan otras terapias. Ibrutinib (IB) ha demostrado en varios estudios eficacia. Su discontinuación temporal puede ser necesaria para manejar toxicidades. Presentamos un caso de suspensión de IB en una MW, debido a un episodio de fibrilación auricular, con un cuadro clínico de inicio abrupto con sintomatología y recaída clínico-analítica, compatible con “Síndrome de retirada” en MW recientemente descrito (Castillo JJ, Haematologica 2018). Paciente: y Métodos: Varón de 70 años que estaba siendo tratado de Polimialgia reumática con corticoides. En Enero de 2012 se diagnostica de MW, con de neuropatía periférica (PN). ENG compatible con PN sensitivo- motora; IgM: 814 mg/dl: 1ª línea (Marzo 2012): Rituximabx4 con discreta mejoría. En Junio de 2013 cuadro de Leishmaniasis. En Enero de 2014 progresión de la PN con IgM de 2940 mg/dl : 2ª línea con Rituximabx4 sin apenas mejoría. En Noviembre 2014, clínica de PN, Hb: 10g/dl, IgM: 3790 mg/dl: 3ª línea con DRCx6 con escasa mejoría. En Enero de 2016 empeoramiento importante de la PN (marcha atáxica, hiporreflexia, impotencia), Hb:10, 2 g/dl, IgM 2900 mg/dl, infiltración MO del 60%, MYD88 +, ENG compatible. En Marzo 2016: 4ª línea con IB 420 mg/día. Mejoría rápida (días) de la clínica con descenso de la IgM en torno a 400 mg/dl que se mantiene y ascenso de la HB a valores normales (VGPR). En Diciembre de 2017 episodio de ACxFA sintomática. Se retira IB y se realiza cardioversión con Aminodarona y Apixaban. A los 3 días ingreso por fiebre, quebrantamiento general y reaparición brusca del cuadro neurológico. Analítica aumento rápido e intenso de la IgM (hasta 6490 mg/dl) y anemización (Hb: 8, 5 g/dl). Se reintroduce el IB con mejoría clínica súbita, descenso de la IgM y recuperación paulatina de la Hb (Fig1). Resultados: En la serie publicada de 114 discontinuados, lo presentaron 22 (20%). Se caracterizaba por un cuadro de fiebre, quebrantamiento general, sudoración y artralgias, que ocurría rápidamente tras la discontinuación. De estos, 7 pacientes presentaron también criterios de progresión de la enfermedad con incremento de la IgM (de 796 mg/dl a 1909 mg/dl) y anemización. Nuestro caso se comportó así, con una subida de la Ig M mucho más evidente y progresión clínico-analítica. En la publicación, como le ocurría a nuestro paciente, ocurría más en los pacientes que habían hecho una óptima respuesta al IB. La etiopatogenia no está aclarada, pero se atribuye a un síndrome de liberación de citoquinas (CXCL13 entre otras), con reversión rápida del efecto del fármaco e incremento brusco de la IgM. Nuestro paciente, al tener una respuesta óptima, tuvo un cuadro analítico de subida de la IgM mucho más grave que la publicada. Conclusiones: Presentamos el que creemos es la primera descripción de un Síndrome de retirada de Ibrutinib en MW de nuestro país. El cuadro desapareció al reintroducir el fármaco, una vez controlado el efecto adverso. Manejar y prevenir las toxicidades en pacientes sometidos a IB, es clave para evitar discontinuaciones, no perder eficacia y minimizar este u otros tipos de reacciones

Study of the B^0 Semileptonic Decay Spectrum at the Upsilon(4S) Resonance

We have made a first measurement of the lepton momentum spectrum in a sample of events enriched in neutral B's through a partial reconstruction of B0 --> D*- l+ nu. This spectrum, measured with 2.38 fb**-1 of data collected at the Upsilon(4S) resonance by the CLEO II detector, is compared directly to the inclusive lepton spectrum from all Upsilon(4S) events in the same data set. These two spectra are consistent with having the same shape above 1.5 GeV/c. From the two spectra and two other CLEO measurements, we obtain the B0 and B+ semileptonic branching fractions, b0 and b+, their ratio, and the production ratio f+-/f00 of B+ and B0 pairs at the Upsilon(4S). We report b+/b0=0.950 (+0.117-0.080) +- 0.091, b0 = (10.78 +- 0.60 +- 0.69)%, and b+ = (10.25 +- 0.57 +- 0.65)%. b+/b0 is equivalent to the ratio of charged to neutral B lifetimes, tau+/tau0.Comment: 14 page, postscript file also available at http://w4.lns.cornell.edu/public/CLN