Prevalência de lesão cardíaca em pacientes hipertensos diabéticos e não-diabéticos.

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Clínica Médica

Avaliação de marcadores inflamatórios e de metabolismo ósseo em pacientes com espondilite anquilosante

A Espondilite Anquilosante (EA) é uma doença inflamatória crônica auto-imune cuja patogênese ainda não está totalmente esclarecida, mas se sabe que além da inflamação, há a neoformação óssea, que determina importante dano estrutural. Objetivos: 1) Avaliar a resposta inflamatória e a neoformação óssea de pacientes com EA por meio da dosagem de marcadores pró-inflamatórios (TNF-a, IL-1ß, IL-6, IL-17, MPO, ADA e NOx) e de metabolismo ósseo (FAO, OP e DKK- 1). 2) Comparar as concentrações séricas dos marcadores próinflamatórios e dos marcadores de metabolismo ósseo entre controles, pacientes portadores de EA sem medicação, em uso somente de agentes anti- TNF-a por pelo menos 12 semanas e pacientes portadores de EA em uso somente de fármacos anti-inflamatórios não hormonais (AINHs) por pelo menos 4 semanas. 3) Correlacionar os marcadores próinflamatórios (TNF-a, IL-1ß, IL-6, IL-17, MPO, ADA e NOx) e os marcadores de metabolismo ósseo (FAO, OP e DKK-1) nos pacientes com EA com os questionários clínicos: BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), BASFI (Bath Ankylosing Spondylitis Functional Index) e BASMI (Bath Ankylosing Spondylitis Metrology Index). Métodos: As concentrações séricas de TNF-a, IL-1ß, IL-6, IL-17, MPO, ADA, NOx, FAO, OP e DKK-1 foram mensurados em 52 pacientes com EA, sem medicamentos, tratados com AINHs ou com anti- TNF-a e em 26 controles saudáveis utilizando-se testes colorimétricos e/ou de enzimaimunoensaio (ELISA). A atividade e gravidade da doença EA foram determinadas por meio dos questionários BASDAI, BASFI e BASMI. Resultados: Comparados aos controles, os pacientes com EA apresentaram concentrações mais elevadas de TNF-a (p = 0,014), NOx (p = 0,0003), FAO (p 0,05). Houve correlação positiva entre os níveis séricos de ADA e BASDAI (r = 0,286, p = 0,044), e correlação negativa entre os níveis de OP e BASFI (r = -0,323, p = 0,022). Conclusão: os pacientes com EA sem medicação apresentaram diferenças significativas nas concentrações de NOx, FAO e OP, em comparação aos controles, e parece que estes marcadores não se alteram com o tratamento específico. A ADA parece estar relacionada com atividade de doença em pacientes com EA.Abstract : Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, who pathogenesis is still not completely understood.It is known that, in addition to inflammation, there is new bone formation, that determines major structural damages. Objectives: 1) To evaluate the inflammatory response and bone formation in patients with AS through the measurement of proinflammatory markers (TNF-a, IL-1ß, IL-6, IL-17, MPO, ADA and NOx) and bone metabolism (BAP, OP and DKK-1). 2) To compare the serum concentration of proinflammatory markers and bone metabolism markers among controls, patients with AS without medication, patients using only anti-TNF-a agents for at least 12 weeks and patients with AS treated with nonsteroidal anti-inflammatory drugs (NSAIDs) continuously for at least 4 weeks. 3) To correlate the proinflammatory (TNF-a, IL-1ß, IL-6, IL-17, MPO, ADA and NOx) and bone metabolism (BAP, OP and DKK-1) markers in AS patients with clinical questionnaires: BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), BASFI (Bath Ankylosing Spondylitis Functional Index), and BASMI (Bath Ankylosing Spondylitis Metrology Index). Methods: The serum levels of TNF-a, IL-1ß, IL-6, IL-17, MPO, ADA, NOx, BAP, OP and DKK-1 were measured in 52 patients with AS without medication , treated with NSAIDs or anti-TNF-a and in 26 healthy controls . The activity and severity of AS were determined by the questionnaires BASDAI, BASFI and BASMI. Results: Compared to controls, patients with AS had higher levels of TNF-a (p = 0.0147), NOx (p = 0.0003), BAP (p 0.05). There was a positive correlation between serum levels of ADA and BASDAI (r = 0,286, p = 0,044) and a negative correlation between OP and BASFI (r = -0,323, p = 0,022). Conclusion: AS patients without medication presented significant differences on levels of NOx, BAP and OP in comparison to control patients, and it seems that these markers expression do not change with specific treatment. ADA seems to be related with disease activity in AS patients

DESFOCANDO A LUZ DA DESABILIDADE: REPERCUSSÕES RELATIVAS AO CONHECIMENTO DO CORPO E O CONTEXTO DA PESSOA COM DEFICIÊNCIA NA EDUCAÇÃO

Resumo: Entremeio a complexidade das relações sociais, traçando recorte histórico, o conhecimento sobre o corpo emergia esboçando tratamento instrumental e mecanicista. Tratamento este, subjetivamente para forja-los eficientemente e teoricamente perfeitos. Entre repercussões relativas ao conhecimento do corpo, destaca-se a terminologia desabilidade, de forma a exemplificar sua concepção. Enfatizam-se referências específicas a cerca da problematização relativa à qualidade da educação destinada a pessoa com deficiência, de forma inerente à promoção de possíveis mudanças em atitudes relacionadas à diversidade, além da incorporação do conhecimento fomentado por trocas de experiências de mundo para sujeitos típicos e àtipicos, onde tornaren-se responsáveis e protagonistas da transformação social.Palavras-chave: Conhecimento do Corpo, Pessoa Com Deficiência, Educação Inclusiva, Desabilidade

Peripheral odontogenic keratocyst : report of two new cases and review of the literature

Peripheral odontogenic keratocyst (POKC) is a rare soft tissue entity showing the same histological characteristics of odontogenic keratocyst. Herein, we report two cases of POKC affecting the gingiva/alveolar mucosa. Case 1. A 43-year-old female was referred for evaluation of a painless well-defined nodular, sessile, non-tender swelling in the right maxillary buccal gingiva. No radiological alterations were observed. The patient was submitted to excisional biopsy and histological diagnosis was POKC. There were no signs of local recurrence after a 4-year follow-up. Case 2. A 63-year-old female was referred for evaluation of a painless well-defined nodular, sessile, yellowish swelling in the anterior mandibular alveolar mucosa. No radiological alterations were observed. The patient was submitted to excisional biopsy and histological diagnosis was POKC. Patient recovery was uneventful but she did not return for follow-up. POKC should be considered in the differential diagnosis of gingival cystic swellings and can be managed through conservative surgery

Sueño, cronotipo, ansiedad, personalidad, calidad de vida y rendimiento académico en adolescentes universitarios

Introduction: Little is known about the relationship of physiological parameters of sleep with personality and Academic Performance in university students. Objective: To explore the relationship between sleep, chronotype, anxiety, personality, quality of life, and academic performance in college adolescents. Materials and methods: The study was quantitative, observational-exploratory and Cross-sectional. Accumulated Academic Performance (RAA), physiological sleep parameters, sleep quality index, chronotype, personality, anxiety and quality of life in university students were explored. Comparison and multiple linear regression were performed. Results: In a sample of 27 university students, the following were found: significant positive correlations between AAR and Sex, and Duration of sleep; variance for Age, Standard Deviation of sleep, Anxiety, Attention to Norms, and Sensitivity; Significant effect in Age and Standard Deviation of Sleep, on the variance of the RAA (p= .007) with 39.1% to 50.8% of causality (R2a= .391; R2= .508). Conclusion: The RAA in youth is moderated by sleep duration and Standard Deviation of sleep activity is sensitive to identify significant changes in the RAA. The sleep quality index, chronotype, personality, anxiety and quality of life are not likely to identify significant effects on the RAA in students. Introducción: se sabe poco de la relación de parámetros fisiológicos del sueño con la personalidad y el rendimiento académico en estudiantes universitarios. Objetivo: Explorar la relación entre sueño, cronotipo, ansiedad, personalidad, calidad de vida y rendimiento académico en adolescentes universitarios. Método: el estudio fue de corte cuantitativo, observacional transversal. Se exploró el rendimiento académico acumulado (RAA), los parámetros fisiológicos del sueño, índice de calidad de sueño, cronotipo, personalidad, ansiedad y calidad de vida en estudiantes universitarios. Se realizó comparación y regresión lineal múltiple. Resultados: en una muestra de 27 estudiantes universitarios, se encontraron: correlaciones significativas positivas entre RAA y sexo y duración del sueño; varianza para edad, del sueño, ansiedad, atención a normas y sensibilidad; efecto significativo en edad y desviación estándar del sueño, sobre la varianza del RAA (p=0,001) con 39,1% a 50,8% de causalidad (R2a=0,39; R2=0,51). Conclusiones: el RAA en jóvenes es moderado por la duración del sueño y de la actividad de sueño es sensible para identificar cambios significativos en el RAA. El índice de calidad de sueño, cronotipo, personalidad, ansiedad y calidad de vida no son susceptibles de identificar efectos significativos en el RAA en estudiantes.&nbsp

Desempenho do catalisador KF-SiO2 na síntese de biodiesel

A procura por fontes renováveis de energia vem aumentando a cada ano, e neste cenário o biodiesel vem recebendo crescente atenção. O biodiesel pode ser produzido pela reação de transesterificação ou alcoólise, sendo que neste processo óleos vegetais e/ou gorduras reagem com um álcool de cadeia curta, geralmente metanol ou etanol. As reações ocorrem na presença de um catalisador, seja este ácido, básico ou enzimático, podendo ser homogêneo ou heterogêneo. Tradicionalmente é obtido pela transesterificação na presença de um catalisador homogêneo alcalino, frequentemente NaOH ou KOH, sendo estes não recuperáveis e passíveis de formação de subprodutos indesejáveis (sabão), contribuindo para a elevação de custos e geração de resíduos. O propósito deste trabalho foi produzir ésteres metílicos a partir do óleo de soja por uma rota alternativa, utilizando um catalisador heterogêneo, devido às vantagens conferidas ao processo produtivo, como facilidade na separação do biodiesel do meio reacional, ausência de reações paralelas e possibilidade de reuso do catalisador em novas reações. Dentre os inúmeros catalisadores heterogêneos, foi sintetizada a peneira molecular mesoporosa MCM-41 a base de sílica de acordo com o método descrito por Grün. Após a síntese das peneiras foi realizado o tratamento com um sal inorgânico, o fluoreto de potássio (KF), a fim de se obter catalisadores mais estáveis. Os materiais sólidos preparados foram caracterizados por diferentes técnicas, como a Microscopia Eletrônica de Varredura (MEV), Difratometria de Raios-X (DRX) e Análise Termogravimétrica (ATG). Já os ésteres metílicos foram analisados por Ressonância Magnética Nuclear de Hidrogênio (RMN 1H). Os resultados indicaram que o material foi sintetizado corretamente e a taxa de conversão em ésteres metílicos foi elevada (94,8%), além disso, apresentaram maior estabilidade, tornando-se promissores catalisadores heterogêneos para a utilização em reações de transesterificação

Ultrastructural features of agouti (Dasyprocta aguti) preantral follicles cryopreserved using dimethyl sulfoxide, ethylene glycol and propanediol

The objective was to develop an efficient protocol for cryopreservation of agouti (Dasyprocta aguti) ovarian tissue. Agouti ovarian fragments were placed, for 10 min, in a solution containing MEM and fetal bovine serum plus 1.5 M dimethyl sulfoxide (DMSO), ethylene glycol (EG) or propanediol (PROH); some of those fragments were subsequently cryopreserved in a programmable freezer. After exposure and/or thawing, all samples were fixed in Carnoy prior to histological analysis. To evaluate ultrastructure, follicles from the control and all cryopreserved treatments were fixed in Karnovsky and processed for transmission electron microscopy. After exposure and freezing, there was a significant decrease in the percentage of morphologically normal preantral follicles in all treatments when compared to the control (92.67 ± 2.79, mean ± SD). However, there were no significant difference when the exposure and freezing procedures were compared using the same cryoprotectant. Moreover, there was no significant difference among cryoprotectants at the time of exposure (DMSO: 64.7 ± 3.8; EG: 70.7 ± 11.2, PROH: 63.3 ± 8.5) or after freezing (DMSO: 60.6 ± 3.6, EG: 64.0 ± 11.9; PROH: 62.0 ± 6.9). However, only follicles frozen with PROH had normal ultrastructure. In conclusion, preantral follicles enclosed in agouti ovarian tissue were successfully cryopreserved using 1.5 M PROH, with satisfactory maintenance of follicle morphology and ultrastructure

Frontal electroencephalographic (EEG) activity and mediumship: a comparative study between spiritist mediums and controls

Mediumship and spirit possession are cultural phenomena found worldwide. The Spiritism, popular in Brazil, is a religious tradition that emphasizes mediumship. The “absorption hypothesis” (the association of marked increases in focused attention with concomitant decreases in self-awareness) is one of the neuropsychological explanatory theories for these experiences. We measured electroencephalographic (EEG) spectral power in frontal electrodes within theta, alpha and beta bandwidths, as well as cross-regional cortical coherences, in female Spiritist experienced mediums (n = 10) and in female non-medium control subjects from the same religious context (n = 10). Scalp EEG signals were captured simultaneously from participants in each of the two groups in three different moments: before, during and immediately after mediumistically speaking. Compared to non-medium controls, the mediums had greater beta power on some electrodes in all phases of the experiment, greater theta power on one electrode at the communication phase and greater alpha power on one electrode at the post-communication phase. No condition effects (within-group comparisons) were detected in any group. No group effects were noted for cross regional cortical coherences. No ictal EEG pattern was observed, except for one participant in the mediums group. These findings support the hypothesis that absorption could have a mechanistic role in anomalous sensorial experiences such as mediumship. The coherence pattern in mediums during the anomalous experience differed from prior studies on pathological dissociation and on hypnotic states. Cognitive control processes seem to be engaged during the anomalous sensorial experiences

Knowledge of the population of the northern state of Espírito Santo and Northeast of the state of Minas Gerais on Herpes Viruses and Perspectives of Care of Dentistry

This study aimed to measure the level of knowledge of HZV in northern municipalities in the state of Espirito Santo and Northeast of Minas Gerais in order to analyze and compare the variables investigated on the herpes virus. Specifically aims to understand the perception of this population about the forms of contagion, activating factors of the virus and the mechanism of access to information. Therefore, we carried out a literature review and research linked to it through the study method of approach to the case. In selected areas, individuals from 10 cities in the North of the Holy Spirit and Northeast of Minas Gerais, participated answering structured questionnaire. The results showed that a significant percentage have little information or complete ignorance about the disease, modes of transmission and its consequences for health. Much of the sample is unaware of the importance of the dentist to provide information and to treat cold sores, in addition to a lack of health services have been observed to provide information about the disease, its clinical signs and prevention, through educational activities for the population and 19% of the population has herpes labialis. Thus, it is concluded that most educational measures should be carried out, understanding that the greater the knowledge, the lower the infection rates, leading individuals to prevent and to treat when detected the expression of pathogenic signals. in addition to a lack of health services have been observed to provide information about the disease, its clinical signs and prevention, through educational activities for the population and 19% of the population has herpes labialis. Thus, it is concluded that most educational measures should be carried out, understanding that the greater the knowledge, the lower the infection rates, leading individuals to prevent and to treat when detected the expression of pathogenic signals. in addition to a lack of health services have been observed to provide information about the disease, its clinical signs and prevention, through educational activities for the population and 19% of the population has herpes labialis. Thus, it is concluded that most educational measures should be carried out, understanding that the greater the knowledge, the lower the infection rates, leading individuals to prevent and to treat when detected the expression of pathogenic signals