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Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization

A limited repertoire of PPP family of serine/threonine phosphatases with a highly conserved catalytic domain acts on thousands of protein targets to orchestrate myriad central biological roles. A major structural reorganization of human calcineurin, a ubiquitous Ser/Thr PPP regulated by calcium and calmodulin and targeted by immunosuppressant drugs cyclosporin A and FK506, is unveiled here. The new conformation involves trans- to cis- isomerization of proline in the SAPNY sequence, highly conserved across PPPs, and remodels the main regulatory site where NFATc transcription factors bind. Transitions between cis- and trans- conformations may involve peptidyl prolyl isomerases such as cyclophilin A and FKBP12, which are known to physically interact with and modulate calcineurin even in the absence of immunosuppressant drugs. Alternative conformations in PPPs provide a new perspective on interactions with substrates and other protein partners and may foster development of more specific inhibitors as drug candidates

Radium-223 dichloride: a new paradigm in the treatment of prostate cancer

Review[Abstract] Radionuclides have been widely used for cancer treatment. Recently, new research about radium-223 dichloride has been conducted in prostate cancer, which reveals that it is the first radiopharmaceutical to demonstrate an improvement in overall survival and time to first symptomatic skeletal event in patients with castration resistant prostate cancer with symptomatic bone metastases. This fact has created a new paradigm in the treatment of prostate cancer landscape, where only chemotherapy and hormone therapy had a role, while β-emitters had been confined exclusively to the role of pain relief with no impact on survival. The aim of this review is to outline current treatment approaches for advanced prostate cancer with a focus on the role of radium-223 dichloride, reviewing patients' profile that make them suitable to therapy and chances for further studies

Videojuegos, e-sports y sedentarismo. ¿Una correlación positiva o negativa? Video games, e-sports and sedentary lifestyle. Positive or negative correlation?

El uso diario del tiempo puede considerarse un juego de suma cero. Por tanto, el tiempo dedicado a la realización de actividad física y al uso de las TIC puede ser considerado tiempo sustitutivo: si se dedica más tiempo a un tipo, el tiempo dedicado otras actividades se verá resentido. La imagen estereotipada de los jugadores de videojuegos o los seguidores de e-sports se asocia a comportamientos sedentarios y hábitos poco saludables y alejados del mundo del deporte. Sin embargo, ¿es eso cierto? Para poder contrastar la hipótesis contactamos con la Asociación para la investigación de medios de comunicación (AIMC) y nos facilitaron datos de individuos de 14 o más años, residentes en hogares de España, obteniendo una muestra es de 9806 entrevistas en 2021. El 33,99% de la población española mayor de 14 años practica deporte de forma semanal. Este porcentaje aumenta al 39,82% entre los jugadores de videojuegos y alcanza el 48,85% entre los seguidores de los e-sports. Estos porcentajes aumentan significativamente entre los jugadores y seguidores de videojuegos deportivos superando el 56% en ambos casos.  Por tanto, se puede rechazar la idea de sedentarismo entre los jugadores de e-sports. Para eliminar si este efecto viene condicionado por la variable edad de los individuos y no por su participación en videojuegos y e-sports, los resultados muestran cómo, para todos los cortes de edad, los porcentajes de individuos que practican deporte son superiores entre los jugadores o seguidores del mundo de los e-sports, rechazando la hipótesis inicial

Effect of eSport sponsorship on brands: an empirical study applied to youth

This paper contributes to the understanding of sponsorship in eSports, shedding light on an enormously important topic that has been little explored in academia. ESport is growing internationally, mainly due to the easy access to technology, but also as a response to access to different competitions on the part of the general public, and especially youth. The objective of this paper is to investigate the effect that eSport sponsorship has on the health of a brand sponsoring a competition. The field work was carried out by means of a questionnaire distributed among the Internet population, differentiating between children in the age bracket 8 and 14 years and youth between 15 and 25 years, with a total of 1,619 responses. The questionnaire measured the health of the brand through analysing the variables related to the purchase funnel and the brand's advertising campaigns. The results suggest that sponsoring an eSports league has positive effects on the brand. The study also contributes some findings that are applicable to managers in the area of marketing, suggesting some future related lines of research

Cerramientos multicapas ligeros en el concurso solar Decathlon 2007

El constante crecimiento de consumo energético en todos los sectores, siendo el caso particular el de las edificaciones que consumen una tercera parte del consumo total. Todo ello surge como consecuencia del crecimiento económico y del aumento de las exigencias de las condiciones de confort, además de utilizar energías fósiles. Si se estudia el consumo energético en las edificaciones, se puede ver que el mayor consumo se genera en climatización con un 46%, luego el agua caliente con 21%, electrodomésticos 16%, cocina 10% e iluminación 7%. Desde la década de los setenta, ha surgido una creciente demanda social por un crecimiento sostenible, originado por una parte por la crisis energética iniciada con el conflicto de Medio Oriente y por otra parte por un cada vez mayor y mejor análisis de la repercusión en el ambiente de nuestras actividades. Esto ha llevado a actuaciones de ámbito mundial como son: El Protocolo de Montreal, AGENDA 21, propone el desarrollo de las energías renovables, disminuir los impactos sobre la salud y el medio ambiente de la producción y consumo de energía y el fomento de una educación hacia el desarrollo sostenible. El Programa 21 de la ONU, plantea el control de aquellas substancias que producen el agotamiento de la capa de ozono. El Protocolo de Kyoto, cuyo objetivo es la disminución de las emisiones de Gases de Efecto Invernadero, en especial del CO2. Dando respuesta a estas actuaciones mundiales la Unión Europea ha desarrollado normativas, tendentes a la mejora de la eficiencia energética y a la seguridad y diversificación de los suministros. Así ha desarrollado: La Directiva 93/76 de 13.09.93 (SAVE), El Libro Verde, La Directiva 2002/91. En España las actuaciones se han presentado con: Código Técnico de la Edificación, Documento Básico “Ahorro de Energía” y Real Decreto 47/2007, por el que se aprueba el procedimiento básico para la certificación de eficiencia energética de edificios. Este certificado deberá incluir información objetiva sobre las características energéticas de los edificios de forma que se pueda valorar y comparar su eficiencia energética, con el fin de favorecer la promoción de edificios de alta eficiencia energética y las inversiones en ahorro de energía. Como respuesta a toda esta serie de normativas para la mejora del consumo energético se tiene, por un lado es el empleo de las energías renovables, como la solar fotovoltaica, solar térmica, eólica, hidráulica, biomasa, geotérmica,… y por otro mejorar el diseño y construcción de los edificios usando cerramientos eficientes, como los multicapa y aún mejor los multicapa ligeros, ya que generan mejores prestaciones en término de confort y ahorro energético

Recombinant AMP/Polypeptide Self-Assembled Monolayers with Synergistic Antimicrobial Properties for Bacterial Strains of Medical Relevance

Producción CientíficaNosocomial infections are one of the most frequent causes of indwelling biomedical device failure. In this regard, the use of antibiofilm nanocoatings based on antimicrobial peptides (AMPs) is a promising alternative to prevent multiresistant biofilm infections. However, the limitations of chemical production impede the large-scale development of advanced antimicrobial materials that improve the properties of AMPs. Herein, we present a multifunctional modular design for the recombinant coproduction of self-assembled monolayers (SAMs) based on AMPs and elastin-like recombinamers (ELRs), which combine the antimicrobial properties of a designer AMP, GL13K, and low-fouling activity of an ELR in a synergistic manner. The inclusion of a grafting domain intended for oriented tethering onto surfaces allowed the recombinant polymers to be covalently immobilized onto model gold surfaces. The antibiofilm properties against two of the bacterial strains most frequently responsible for indwelling medical device-associated infections, namely Staphylococcus epidermidis and Staphylococcus aureus, were then evaluated. GL13K peptide was found to provide antibiofilm properties to the surface, with these being synergistically enhanced by the antifouling effect of the ELR. This new design offers a promising tool for the development of advanced AMP-based nanocoatings for medical devices with powerful and enhanced features.Comisión Europea (project NMP-2014-646075)Ministerio de Economía, Industria y Competitividad (project PCIN-2015-010 / MAT2015-68901-R / MAT2016-78903-R)Junta de Castilla y León (project VA317P18

Influence of the flow split ratio on the position of the main atrial vortex: implications for stasis on the left atrial appendage

Background: Despite the recent advances in computational fluid dynamics (CFD) techniques applied to blood flow within the left atrium (LA), the relationship between atrial geometry, flow patterns, and blood stasis within the left atrial appendage (LAA) remains unclear. A better understanding of this relationship would have important clinical implications, as thrombi originating in the LAA are a common cause of stroke in patients with atrial fibrillation (AF). Aim: To identify the most representative atrial flow patterns on a patient-specific basis and study their influence on LAA blood stasis by varying the flow split ratio and some common atrial modeling assumptions. Methods: Three recent techniques were applied to nine patient-specific computational fluid dynamics (CFD) models of patients with AF: a kinematic atrial model to isolate the influence of wall motion because of AF, projection on a universal LAA coordinate system, and quantification of stagnant blood volume (SBV). Results: We identified three different atrial flow patterns based on the position of the center of the main circulatory flow. The results also illustrate how atrial flow patterns are highly affected by the flow split ratio, increasing the SBV within the LAA. As the flow split ratio is determined by the patient's lying position, the results suggest that the most frequent position adopted while sleeping may have implications for the medium- and long-term risks of stroke.Comment: Accepted manuscript, 21 pages, 10 figures, 5 table

FICARAM-15 Cruise Report 20th March – 22nd May 2013 on board BIO Hespérides by the Group FICARAM

54 páginas, 19 figuras, 3 anexosThe FICARAM-15 is the fifteenth repetition of a section conducted in 1994. This section is part of the international program GOSHIP (http://www.go-ship.org/CruisePlans.html) to develop a globally coordinated network of sustained hydrographic sections as part of the global ocean/climate observing system. The objective of the FICARAM-15 cruise is to investigate the temporal evolution of the anthropogenic carbon and evaluate the CO2 absorption capacity of the South Atlantic region, the Equatorial zone, and the subtropical region of Azores-Gibraltar in the North Atlantic. This cruise is supported by the CATARINA project funded by the Ministry of Economy and Competitiveness (CTM2010-17141) and is part of the European Union FP7 project CARBOCHANGE (http://carbochange.b.uib.no/). The objective of FICARAM-15 cruise is framed in the CATARINA project conducted by the tasks I.2.1 (air-sea CO2 exchange) I.3 (ventilation of water masses), I.4.1 (zonal variability of N2O and CH4), I.4.2 (anthropogenic carbon storage), I.4.4 (saturation horizon of calcium carbonate along the section) and I.5.4 (evolution of the acidification rates). Another component of the FICARAM-15 cruise aims to examine the biological and biogeochemical mechanisms that hinder total dissolved organic carbon (DOC) remineralisation in marine systems, taking a multidisciplinary perspective and applying many different approaches. This is the global objective of the Spanish project DOREMI (CTM2012-34294) that joins this FICARAM-15 cruise.During the FICARAM cruise the physical oceanography group was responsible for collecting the following data sets: CTD and XBT data; vessel-mounted ADCP and lowered ADCP; continuous thermosalinograph. Physical oceanographers participated in the cruise financed through Project “Tipping Corners in the Meridional Overturning Circulation” (TIC-MOC), CTM2011-28867. The FICARAM-15 cruise was organized in two phases with a common sampling. LEG 1: From Punta Arenas (Chile) to Recife (Brazil): 62 stations. Chief Scientist: Aida F. Ríos, PI of CATARINA project LEG 2: From Recife (Brazil) to Cartagena (Spain): 46 stations Chief Scientist: Celia Marrasé, PI of DOREMI project This report contains the sampling of all the variables at each station along the FICARAM section, as well as the analysis of the biogeochemical variables and the preliminary results. The principal investigator of the DOREMI project produced another report with the common sampling section, showing the analysis and results of the experiments on dissolved organic matter carried out on board.This cruise is supported by the CATARINA project funded by the Ministry of Economy and Competitiveness (CTM2010-17141) and is part of the European Union FP7 project CARBOCHANGE (http://carbochange.b.uib.no/)Peer reviewe

Perilesional injections of autologous fat graft in burn healing

Introduction: Burns are devastating injuries and the appearance of hypertrophic scars is a frequent complication. The classic treatment of dermal burns offers unaesthetic results in healing; however, the literature reports that autologous fat grafts favor revascularization, epithelialization, and aesthetic improvement. Objective: To determine the results of the application of perilesional injections of autologous fat graft in patients with dermal burns. Methods: A quasi-experimental study was performed, without randomization. A non-probabilistic test was used and the sample was made up of 40 patients in 2 groups: Group I with 20 subjects who underwent injections of autologous fat and the classic burn cure and in Group II 20 subjects with only the classic burn cure. The variables mean epithelialization time, presence of unsightly scars, appearance of keloids and hypertrophic scars were evaluated. Results: The patients in group I, with injections of fat graft, had a mean epithelialization time of 10 days less than the 14 days in group II. In addition, less unsightly scars appeared and a lower tendency to the appearance of keloids and hypertrophic scars. Finally, the patients in the group had a lower score on the Patient and Observer Scar Assessment Scale (POSAS) scale. Conclusions: Perilesional autologous fat graft injections reduce the appearance of unsightly scars, decreasing epithelialization time and improving the vascularization, pigmentation, thickness, relief, elasticity and surface of the scar