44 research outputs found
Efficacy of Anakinra in Refractory Adult-Onset Still's Disease: Multicenter Study of 41 Patients and Literature Review
Adult-onset Still's disease (AOSD) is often refractory to standard therapy. Anakinra (ANK), an interleukin-1 receptor antagonist, has demonstrated efficacy in single cases and small series of AOSD. We assessed the efficacy of ANK in a series of AOSD patients. Multicenter retrospective open-label study. ANK was used due to lack of efficacy to standard synthetic immunosuppressive drugs and in some cases also to at least 1 biologic agent. Forty-one patients (26 women/15 men) were recruited. They had a mean age of 34.4 ± 14 years and a median [interquartile range (IQR)] AOSD duration of 3.5 [2-6] years before ANK onset. At that time the most common clinical features were joint manifestations 87.8%, fever 78%, and cutaneous rash 58.5%. ANK yielded rapid and maintained clinical and laboratory improvement. After 1 year of therapy, the frequency of joint and cutaneous manifestations had decreased to 41.5% and to 7.3% respectively, fever from 78% to 14.6%, anemia from 56.1% to 9.8%, and lymphadenopathy from 26.8% to 4.9%. A dramatic improvement of laboratory parameters was also achieved. The median [IQR] prednisone dose was also reduced from 20 [11.3-47.5] mg/day at ANK onset to 5 [0-10] at 12 months. After a median [IQR] follow-up of 16 [5-50] months, the most important side effects were cutaneous manifestations (n = 8), mild leukopenia (n = 3), myopathy (n = 1), and infections (n = 5). ANK is associated with rapid and maintained clinical and laboratory improvement, even in nonresponders to other biologic agents. However, joint manifestations are more refractory than the systemic manifestations
Physical conditions and chemical abundances in photoionized nebulae from optical spectra
This chapter presents a review on the latest advances in the computation of
physical conditions and chemical abundances of elements present in photoionized
gas H II regions and planetary nebulae). The arrival of highly sensitive
spectrographs attached to large telescopes and the development of more
sophisticated and detailed atomic data calculations and ionization correction
factors have helped to raise the number of ionic species studied in
photoionized nebulae in the last years, as well as to reduce the uncertainties
in the computed abundances. Special attention will be given to the detection of
very faint lines such as heavy-element recombination lines of C, N and O in H
II regions and planetary nebulae, and collisionally excited lines of
neutron-capture elements (Z >30) in planetary nebulae.Comment: Book Chapter. 31 pages. 6 Figures. Accepted for publication in the
book "Reviews in Frontiers of Modern Astrophysics: From Space Debris to
Cosmology" (eds Kabath, Jones and Skarka; publisher Springer Nature) funded
by the European Union Erasmus+ Strategic Partnership grant "Per Aspera Ad
Astra Simul" 2017-1-CZ01-KA203-03556
Análisis preliminar del contenido alergénico del polen de variedades de olivo de Portugal
2 páginas.-- Comunicación presentada al XVI Simposio Internacional de Palinología de la A.P.L.E. celebrado en Mallorca (España) en Septiembre del 2008.Este trabajo ha sido financiado por los proyectos BFU 2004-00601/BFI (MEC), P06-AGR-01791 (Junta de Andalucía) y 2007PT0039 (CSIC/Fundaçao para a ciencia e a tecnología).Peer reviewe