Relevance of Social, Economic, and Environmental Impacts on Residents’ Satisfaction with the Public Administration of Tourism

Those in charge of tourism destinations face the need to create tourism development models compatible with the essence of the localities that they manage. These models have to be sustainable, both environmentally and socially, and also must become drivers of the local economy. However, tourists also generate negative impacts in the locality which, when they are perceived by the residents, can give rise to a rejection of visitors. Hence, improving the tourism management is necessary. This is why to know the residents’ perceptions about the impacts of tourism is essential. Moreover, measuring the impact effects on their satisfaction with the public administration of the destination can be of great usefulness. This study falls into this research line, as it proposes a model to measure these impacts and their effect on satisfaction. To do so, an empirical study is performed among residents in the city of Seville (southern Spain, one of the most visited destinations in the world), based on subjective economic, social, and environmental indicators. The results show that the citizens value three types of impacts, the social impact coming after the economic impact as to its influence on their satisfaction with the administration. Based on this, we postulate that the efforts made to attract events to the city, or to improve connections to access a broader market, must be approached as public procurements in which selection criteria that are compatible with the destination’s positioning and strategy prevail. Social and environmental criteria should be considered among these criteria

Effect of agro-climatic conditions on near infrared spectra of extra virgin olive oils

Authentication of extra virgin olive oil requires fast and cost-effective analytical procedures, such as near infrared spectroscopy. Multivariate analysis and chemometrics have been successfully applied in several papers to gather qualitative and quantitative information of extra virgin olive oils from near infrared spectra. Moreover, there are many examples in the literature analysing the effect of agro-climatic conditions on food content, in general, and in olive oil components, in particular. But the majority of these studies considered a factor, a non-numerical variable, containing this meteorological information. The present work uses all the agro-climatic data with the aim of highlighting the linear relationships between them and the near infrared spectra. The study begins with a graphical motivation, continues with a bivariate analysis and, finally, applies redundancy analysis to extend and confirm the previous conclusions.Peer Reviewe

La inscripción registral facultativa en las compras ventas de bienes inmuebles, según sentencias de casación Perú 2009 – 2019

Debido a que el tráfico inmobiliario, ha suscitado conflictos y que se han materializado en procesos judiciales, en los que en muchos casos se ha recurrido a la casación para deslindar los derechos controvertidos, es por ello que fue de interés la manera en que incide la inscripción registral facultativa en las compras ventas de bienes inmuebles, según sentencias de casación Perú 2009-2019. El tipo de investigación es la aplicada, y el diseño de investigación empleado es el correlacional descriptivo así mediante los resultados se ha podido determinar que la inscripción registral facultativa incide de diversas maneras en las compras ventas de inmuebles así el 50% de los encuestados, considera que las compras ventas que se realizaron bajo el criterio de la consensualidad con documentos privados previsto en el art. 949 del C.C., generan procesos judiciales; por otro lado el 97% de los encuestados están de acuerdo en que a pesar que la inscripción es facultativa en las compras ventas de inmuebles, los sujetos titulares que actúan de buena fe solicitan la inscripción registral por seguridad jurídica, cumpliendo con el otorgamiento de la escritura pública a fin de acceder a créditos por la certeza, y porque les da tranquilidad psicológica, demostrando que en la realidad a pesar que la inscripción es facultativa en la práctica es como si fuera constitutiva, asimismo se obtuvo resultados cualitativos con sentencias de casación y con la entrevista a cinco expertos en derecho registral y notarial en donde el 60% estuvieron de acuerdo con la inscripción obligatoria tratándose de compras ventas de inmuebles, lo que sería una solución idónea siendo necesario un cambio a favor de un sistema dual de inscripción constitutiva no convalidante con lo que se evitaría conflictos judiciales

Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice

Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models. Firstly, its anti-inflammatory activity was evaluated in LPS-stimulated THP-1 macrophages and TNF-α-stimulated HaCaT keratinocytes, and its antioxidant activity in UVB-irradiated HaCaT cells. Next, in vitro and ex vivo permeation studies were developed to determine the most suitable formulation for in vivo FX topical application. Then, we evaluated the effects of a FX-containing cream on TPA-induced epidermal hyperplasia in mice, as well as on UVB-induced acute erythema in hairless mice. Our results confirmed the in vitro reduction of TNF-α, IL-6, ROS and LDH production. Since the permeation results showed that cream was the most favourable vehicle, FX-cream was elaborated. This formulation effectively ameliorated TPA-induced hyperplasia, by reducing skin edema, epidermal thickness, MPO activity and COX-2 expression. Moreover, FX-cream reduced UVB-induced erythema through down-regulation of COX-2 and iNOS as well as up-regulation of HO-1 protein via Nrf-2 pathway. In conclusion, FX, administered in a topical formulation, could be a novel natural adjuvant for preventing exacerbations associated with skin inflammatory pathologies as well as protecting skin against UV radiation

Fucoxanthin and Rosmarinic Acid Combination Has Anti-Inflammatory Effects through Regulation of NLRP3 Inflammasome in UVB-Exposed HaCaT Keratinocytes

Excessive exposure to ultraviolet (UV) radiation is the main risk factor to develop skin pathologies or cancer because it encourages oxidative condition and skin inflammation. In this sense, strategies for its prevention are currently being evaluated. Natural products such as carotenoids or polyphenols, which are abundant in the marine environment, have been used in the prevention of oxidative stress due to their demonstrated antioxidant activities. Nevertheless, the anti-inflammatory activity and its implication in photo-prevention have not been extensively studied. Thus, we aimed to evaluate the combination of fucoxanthin (FX) and rosmarinic acid (RA) on cell viability, apoptosis induction, inflammasome regulation, and anti-oxidative response activation in UVB-irradiated HaCaT keratinocytes. We demonstrated for the first time that the combination of FX and RA (5 µM RA plus 5 µM FX, designated as M2) improved antioxidant and anti-inflammatory profiles in comparison to compounds assayed individually, by reducing UVB-induced apoptosis and the consequent ROS production. Furthermore, the M2 combination modulated the inflammatory response through down-regulation of inflammasome components such as NLRP3, ASC, and Caspase-1, and the interleukin (IL)-1β production. In addition, Nrf2 and HO-1 antioxidant genes expression increased in UVB-exposed HaCaT cells pre-treated with M2. These results suggest that this combination of natural products exerts photo-protective effects by down-regulating NRLP3-inflammasome and increasing Nrf2 signalling pathway.Junta de Andalucía, Consejería de Innovación, Ciencia y Empresa-POLFANAT-P12-AGR-430Portugal, Fundação para a Ciência e a Tecnologia (FCT)-CESAM-UID/AMB/50017/2019Portugal, Fundação para a Ciência e a Tecnologia (FCT)-CEECIND/04050/2017Universidad de Sevilla "V Plan Propio US-PPI2015-1.5"

Vocational profile in Health Sciences Students, enrolled in first-year at University of Malaga (Spain): differences by degree.

Objectives: This study aimed to determine certain characteristics about the vocational profile of college students, especially if we consider the situation of transition that is taking place currently in college with the implementation of the European Higher Education Area (EHEA). Participants: Students enrolled in first grade of Health Sciences at University of Malaga (Spain) in Nursing, Physiotherapy, Podiatry and Occupational Therapy. The population comprised 272 participants (90%), of a 300 total sample of Health Sciences students with a mean age of 19 years (SD=1.8). Methodology: It was a descriptive and a cross sectional study. Students were asked to fill out an on-line questionnaire in May 2011. It was a vocational interests scale adapted into Spanish by a cross-cultural study. The dimensions were: Leadership, Organization, Altruism, Creativity, Analysis, Production, Adventure, and Erudition. The differences between the four groups of students have been checked by Anova. Results: The vocational profile among Health Sciences students showed significant differences. By degree, the most altruistic were Physiotherapy students (F=3.022, p= 0.030), being also the most adventurous (F=3.658, p=0.013). The most creative were Nursing students (F=3.578, p=0.014) and also the most erudite (F=5.527, p=0.001). Conclusions: These results could be useful in order to study the development of competences that are necessary for finding a job, work with patients and work as a member of multidisciplinary group. Also, we are collecting data every day in order to know the variance with respect the academic year (longitudinal study).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Representaciones familiares sobre la obesidad infantil en dos municipalidades de la Habana

Las representaciones alimentarias en la población constituyen un importante elemento para efectuar valoraciones acertadas sobre desórdenes alimentarios como el sobrepeso y la obesidad. Se realizo un estudio cualitativo a padres e hijos procedentes de escuelas de dos municipalidades de La Habana, Cuba. Se identificaron los niños sobrepeso y obesos por antropometría. Se aplicaron cuestionarios sobre estilos de vida y pruebas sobre la imagen corporal. Se realizaron grupos de discusión y encuestas a los padres. Se utilizó el método de la triangulación para analizar los resultados. El objetivo del trabajo es la identificación de las representaciones que posee la familia sobre los trastornos alimentarios con énfasis en la obesidad. Las discusiones grupales contribuyeron al acercamiento de esta complejidad que, por sus características requiere un enfoque multidisciplinario. Entre las manifestaciones más representativas se observó que existe problemas de autoestima y socialización, imagen corporal, no aceptación de la obesidad, poco conocimiento sobre la alimentación saludable y otros hábitos de vida beneficiosos. Se evidenció la poca percepción de riesgo de algunas familias sobre las consecuencias de la obesidad aunque cuando la identifican buscan ayuda profesional. La escuela y otros escenarios son adecuados para promover conductas saludables para disminuir el sobrepeso y la obesidad

Morphine induces endocytosis of neuronal μ-opioid receptors through the sustained transfer of Gα subunits to RGSZ2 proteins

<p>Abstract</p> <p>Background</p> <p>In general, opioids that induce the recycling of μ-opioid receptors (MORs) promote little desensitization, although morphine is one exception to this rule. While morphine fails to provoke significant internalization of MORs in cultured cells, it does stimulate profound desensitization. In contrast, morphine does promote some internalization of MORs in neurons although this does not prevent this opioid from inducing strong antinociceptive tolerance.</p> <p>Results</p> <p>In neurons, morphine stimulates the long-lasting transfer of MOR-activated Gα subunits to proteins of the RGS-R7 and RGS-Rz subfamilies. We investigated the influence of this regulatory process on the capacity of morphine to promote desensitization and its association with MOR recycling in the mature nervous system. In parallel, we also studied the effects of [D-Ala², <it>N</it>-MePhe⁴, Gly-ol⁵] encephalin (DAMGO), a potent inducer of MOR internalization that promotes little tolerance. We observed that the initial exposure to icv morphine caused no significant internalization of MORs but rather, a fraction of the Gα subunits was stably transferred to RGS proteins in a time-dependent manner. As a result, the antinociception produced by a second dose of morphine administered 6 h after the first was weaker. However, this opioid now stimulated the phosphorylation, internalization and recycling of MORs, and further exposure to morphine promoted little tolerance to this moderate antinociception. In contrast, the initial dose of DAMGO stimulated intense phosphorylation and internalization of the MORs associated with a transient transfer of Gα subunits to the RGS proteins, recovering MOR control shortly after the effects of the opioid had ceased. Accordingly, the recycled MORs re-established their association with G proteins and the neurons were rapidly resensitized to DAMGO.</p> <p>Conclusion</p> <p>In the nervous system, morphine induces a strong desensitization before promoting the phosphorylation and recycling of MORs. The long-term sequestering of morphine-activated Gα subunits by certain RGS proteins reduces the responses to this opioid in neurons. This phenomenon probably increases free Gβγ dimers in the receptor environment and leads to GRK phosphorylation and internalization of the MORs. Although, the internalization of the MORs permits the transfer of opioid-activated Gα subunits to the RGSZ2 proteins, it interferes with the stabilization of this regulatory process and recycled MORs recover the control on these Gα subunits and opioid tolerance develops slowly.</p

Incidencia de los procesos de aprendizaje en los niños y niñas con déficit de atención en la primera infancia, realizada en el año 2015 en El Centro de Desarrollo Estrellita del municipio de la Estrella.

La sistematización es un proceso que ha permitido organizar e identificar los objetivos de la práctica educativa que tiene como título “LA INCIDENCIA DE LOS PROCESOS DE APRENDIZAJES EN LOS NIÑOS Y NIÑAS CON TRANSTORNO DE DÉFICIT DE ATENCIÓN EN LA PRIMERA INFANCIA” . Este trabajo de sistematización genera en una práctica que se realizó desde una simple pregunta, permite que los objetivos inicialmente planteados en la práctica se cuestionen y se logre descubrir en realidad lo que se alcanzó y que pudo fallar para el cumplimiento de los objetivos. En el C.D.I LA ESTRELLITA del municipio de la estrella Antioquia, da lugar una propuesta de práctica la misma que una vez es planteada es considerad de importancia y buen aporte pedagógico y social el trabajo con niños y niñas con TDHA en la institución es llevado a la realidad. Pensando en obtener nuevos aprendizajes y poder apoyar más la educación infantil y en especial a los estudiantes que requieren un mayor acompañamiento o de una atención especial para que puedan explorar todas sus capacidades y no sentir que son diferentes sino más bien puedan crecer como niños y niñas que son especiales pero desde el real sentido de ser especial que sea sinónimo de algo muy bueno y no ser apartados de sus pares tan solo por pensar o actuar de una forma no esperada, poder estudiar y observar de cerca los hallazgos de esta práctica, los errores serán usados en un futuro como armas para dar mejores resultados y brinda la oportunidad de mejorar la perspectiva de lo que significa tener TDHA al igual que a padres, docentes y comunidad en generar les permitirá conocer cómo actuar con estos niños y así aportar a su desarrollo y no destruir sus futuros transmitiéndoles sus propias frustraciones.Corporación universitaria Minuto de Dio

Sistema de indicadores de clima organizacional para potenciar el desempeño laboral

La investigación presenta como objetivo evaluar la incidencia del clima organizacional en el desempeño de los trabajadores y directivos de una instalación turística. Se utiliza la metodología cualitativa, para ello se proponen de tres etapas, empleando las siguientes técnicas: análisis histórico-lógico de la bibliografía relacionada con la temática, revisión de documentos oficiales, observación, cuestionarios y entrevista. Se obtuvo como conclusiones los indicadores que conforman el sistema: estructura, responsabilidad, recompensa, desafío, relaciones y estándares