Lagrangian trajectories, residual currents and rectification process in the Northern Gulf of California

"Considering a semi-implicit approximation of the Coriolis terms, a numerical solution of the vertically integrated equations of motion is proposed. To test the two-dimensional numerical model, several experiments for the calculation of Euler, Stokes and Lagrange residual currents in the Gulf of California were carried out. To estimate the Lagrangian residual current, trajectories of particles were also simulated. The applied tidal constituents were M2, S2, K2, N2, K1, P1 and O1. At spring tides, strong tidal velocities occur in the northern half of the gulf. In this region of complex geometry, depths change from a few meter in the northern shelf zone to more than 3000 m in the southern part. In the archipelago region, the presence of islands alters amplitude and direction of tidal currents producing a rectification process which is reflected in a clockwise circulation around Tiburón Island in the Lagrangian residual current. The rectification process is explained by the superposition of the Euler and Stokes residual currents. Residual current patterns show several cyclonic and anticyclonic gyres in the Northern Gulf of California. Numerical experiments for individual and combinations of several tidal constituents revealed a large variability of Lagrangian trajectories.

Secretion Mechanism across Wall

Yeast organisms are widely explored by humans for different biotechnological applications. During their growth, they need to adapt and interact themselves with the environment medium. For this purpose, organisms uptake nutrients and at the same time secrete different molecules include proteins to extracellular medium. This phenomenon requires the use of specialized structures to regulate entry and exit of molecules called transporters. Two transporters, namely Proteins and Vesicles, are specialized in translocating molecules in and out across the wall. The knowledge of these systems is important and served to bring novel applications of yeast. Taking together, this book chapter is divided into two parts: at first, it primarily accounts on few examples of protein (carbohydrates and peroxisome proteins) and vesicle (intracellular and extracellular vesicles) transporters of yeasts. Second, it deals with the recent advances of yeast applications in diverse area of science

Mixed carbonate-siliciclastic contourite drift deposits associated with the entrance of an Atlantic-Mediterranean corridor (late Miocene, southwest Spain)

Carbonate contourite drifts are poorly documented in the onshore record because of the difficulty of implementing diagnostic criteria for their recognition. Accordingly, little is known about the relative position of carbonate drifts with respect to ancient carbonate platforms, seaways and shallow passages within the context of palaeoceanography. This study presents a fossil example of mixed carbonate-siliciclastic drift cropping out in a quarry in Osuna (Sevilla province, southern Spain) at the northern end of the Guadalhorce Corridor, a Miocene strait connecting the Mediterranean Sea and the Atlantic Ocean in the Betic Cordillera. Based on the facies and sedimentary structures, the studied succession is divided into three units: 1) the lower unit, Unit 1, is a 33-m thick succession of large carbonate bodieswithmega cross-stratification pointing to the southeast and secondarily to the northwest interpreted as a contourite drift; 2) the intermediate Unit 2 is a 0.5–2-m thick terrigenous conglomerate body eroding the top of Unit 1; and 3) the uppermost Unit 3 consists of a 6-m thick siliciclasticdominated succession with herringbone cross-stratification and a dominant direction of the structures to the northwest interpreted as tidal deposits. The large-scale sediment bodies with mega cross-beds, the presence of reactivation surfaces with grain-size changes, and the unidirectionality of the structures were diagnostic for the recognition of Unit 1 as drift deposits. The dominant sedimentary structures pointing to the southeast in the drift were generated by Atlantic inflow into the Mediterranean. This challenges the classical “siphon” model for the Atlantic-Mediterranean water-mass circulation pattern for this age. The conglomerates of Unit 2 evidence regional uplift of the southernmargin of the Guadalquivir Basin that promoted a change in the depositional mode from a bottom-current dominated (Unit 1) to a tide-dominated environment (Unit 3) after the closure of the Guadalhorce Corridor in the Messinian.Juan de la Cierva Project (Ministerio de Ciencia, Innovacion y Universidades) JC2019042375-I project SECAMARA PGC2018099391-B-100Junta de Andalucia European Commission RNM-19

Presentación de un caso de enteropatía sprue-like secundaria a olmesartán

A 64-year-old male patient hospitalised because of weight loss and chronic diarrhea. He had been previously on treatment with olmesartan. Outpatient studies including complete blood and stool tests, abdominal ultrasound and CT scan were normal. The diagnosis of sprue like disease in the context of olmersatan treatment was made upon the results of endoscopies with biopsies and the good clinical response once the medication was discontinued. The patient is asymptomatic two years later.Varón de 64 años que ingresa en nuestro hospital por síndrome constitucional secundario a diarrea crónica. En tratamiento previo durante un año con olmesartán. Una amplia batería de pruebas complementarias, que incluyeron estudio analítico y microbiología de heces, así como ecografía y tomografía computarizada (TC) abdominal no aportaron información de la etiología en medio ambulatorio. Por persistencia del cuadro, con marcada pérdida de peso y deshidratación, se decide estudio en medio hospitalario. El antecedente del tratamiento con olmesartán, así como la realización de endoscopias digestivas alta y baja con toma de muestra para biopsia, orientaron al diagnóstico de esprue-like por olmesartán, circunstancia que se corroboró con la desaparición de la sintomatología tras la retirada del fármaco. Dos años después, el paciente ha recuperado su peso y permanece asintomático

NURSES' evidence-based practice competence and hospital practice environment after specific training under the best practice spotlight organization® programme. A cross sectional study

Producción CientíficaThe aim of the study was to evaluate the impact of a specific training within the framework of the Best Practice Spotlight Organization® programme, on nurses' evidence-based practice competence and the practice environment in two hospitals. The study sample were 204 nurses working at medical and surgical inpatient units at two hospitals involved in the Best Practice Spotlight Organization® programme. They were classified into two groups: those who had received specific training within the framework of the programme, called trained-champions (n = 66), and those who had not yet received training, control group (n = 138). The trained-champions exhibited better evidence-based practice competence values than the control group in all dimensions (p < 0.001), with a higher difference in means in the “Utilisation” dimension (−0.80; CI:-0.99,-0.60) and the “Knowledge” dimension (−0.63; CI:-0.88,-0.38). The conclusions are that Specific EBP training within the framework of the Best Practice Spotlight Organization® programme has succeeded in nurses (trained-champions) obtaining better EBP competence than others without this training

Geomorphological record of extreme wave events during Roman times in the Guadalquivir estuary (gulf of cadiz, SW Spain): An archaeological and paleogeographical approach

Analysis of the geological record has made it possible to delimit for theGuadalquivir estuary the traces of extreme wave events (EWEs) during the Roman period in the Iberian Peninsula (218 BCE to 476 CE). The largest event occurred in the 2nd-3rd century CE. It generated clearly visible erosive effects in the coastal barriers, including washover fans and erosional scarps. In the inner estuary, however, the effects were minor: crevasse splays that broke levees and cheniers, as well as a residual sedimentary lag. The significant development of the spits protected the inner estuary from the marine incursion, which only caused a water level rise with low-regime waves. Correlation of the geomorphological and sedimentary marks left by this event with the archaeological and geological evidence of other events recognized elsewhere in the Gulf of Cadiz effectively argues for a tsunami as to the nature of the 2nd-3rd century CE event. Yet this and the other identified EWEs in the Guadalquivir estuary during the pre-Roman and the Roman period all fit a model of paleogeographic evolution dominated by processes of coastal progradation and estuarine infilling. Radiocarbon dating, geomorphological analysis, and historical references fail to warrant the so-called '218-209 BCE' Atlantic tsunami, as hypothesized in the received scientific literature. In pre-Roman and Roman times, human occupation at the mouth of the Guadalquivir River was strongly influenced by various geodynamic processes, the location of the settlements being contingent upon dependable, fast communication with the sea and, above all, upon adequate protection from EWEs, on the leeward side of spits. Progressive progradation of these coastal barriers combined with the gradual infilling of the estuary to make navigation to open sea increasingly difficult and, eventually, to result in the abandonment of settlements

Pathological changes of renal biopsy in Sjögren Syndrome

We are presenting the case of a 53-year-old woman with a history of Sjögren syndrome and a secondary antiphospholipid syndrome admitted at the Nephrology department for the evaluation of renal failure. The patient was initially diagnosed with tubulointerstitial nephritis and subsequently a membranoproliferative type I glomerulonephritis, secondary to cryoglobulins during the course of the disease. Repeated renal biopsies were required to confirm the diagnosis

The role of neo-tectonics in the sedimentary infilling and geomorphological evolution of the Guadalquivir estuary (Gulf of Cadiz, SW Spain) during the Holocene.

Spain) has yielded new evidence regarding the sedimentary infilling and geomorphological evolution of the Guadalquivir estuary during the Holocene. The sedimentation and geomorphological disposition have been strongly conditioned by neotectonic activity along a set of SW-NE alignments, interrupted by other alignments that follow E-W and NW-SE directions. The most conspicuous of the SW-NE alignments is the Torre Carbonero-Marilópez Fault (TCMF). South of this fault, the estuary experienced a marked subsidence from about 4000 to 2000 cal. yr BP through a series of sedimentary sequences of retrogradation and aggradationwithin the context of relative sea-level rise. From c. 2000 cal. yr BP to the present the subsidence has remained relatively dormant, with progradation of the littoral systems and infilling of the marshland progressing within a context of sea-level stability. Our results reveal that neotectonic activity is a critical factor thatmust also be reckonedwith in any attempt to understand the Holocene geomorphological evolution in the Guadalquivir estuary

Biological properties and potential of compounds extracted from red seaweeds

Macroalgae have been recently used for different applications in the food, cosmetic and pharmaceutical industry since they do not compete for land and freshwater against other resources. Moreover, they have been highlighted as a potential source of bioactive compounds. Red algae (Rhodo- phyta) are the largest group of seaweeds, including around 6000 different species, thus it can be hypoth- esized that they are a potential source of bioactive compounds. Sulfated polysaccharides, mainly agar and carrageenans, are the most relevant and exploited compounds of red algae. Other potential molecules are essential fatty acids, phycobiliproteins, vitamins, minerals, and other secondary metabolites. All these compounds have been demonstrated to exert several biological activities, among which antioxidant, anti- inflammatory, antitumor, and antimicrobial properties can be highlighted. Nevertheless, these properties need to be further tested on in vivo experiments and go in-depth in the study of the mechanism of action of the specific molecules and the understanding of the structure–activity relation. At last, the extraction technologies are essential for the correct isolation of the molecules, in a cost-effective way, to facilitate the scale-up of the processes and their further application by the industry. This manuscript is aimed at describing the fundamental composition of red algae and their most studied biological properties to pave the way to the utilization of this underused resource.The research leading to these results was supported by MICINN supporting the Ramoón y Cajal grant for M.A. Prieto (RYC-2017-22891); by Xunta de Galicia for supporting the program EXCELENCIA-ED431F 2020/12, the pre-doctoral grants of P. Garcia-Oliveira (ED481A-2019/295) and M. Carpena (ED481A 2021/313). Authors are grateful to Ibero-American Program on Science and Technology (CYTED—AQUA-CIBUS, P317RT0003) and to the Bio Based Industries Joint Undertaking (JU) under grant agreement No 888003 UP4HEALTH Project (H2020-BBI- JTI-2019) that supports the work of P. Garcia-Perez and C. Lourenço-Lopes. The JU receives support from the European Union’s Horizon 2020 research and innovation program and the Bio Based Industries Consortium. The project SYSTEMIC Knowledge hub on Nutrition and Food Security, has received funding from national research funding parties in Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF), Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEI) in a joint action of JPI HDHL, JPI-OCEANS and FACCE-JPI launched in 2019 under the ERA-NET ERA-HDHL (n° 696295).info:eu-repo/semantics/publishedVersio

Carcinoma anaplásico del tiroides

Female patient, 44 years of age, with a palpable mass in the right breast, supraclavicular lymph nodes and tumor in the left adrenal gland. She was admitted to hospital and evolved unfavorably. She was hypotensive, with abdominal pain despite painkillers. She also began with episodes of disorientation. At the eleventh day of admission she started sweating profusely and showed marked deterioration of the general condition. It was necessary to call the doctor on guard duty. When arriving to bed, the patient had a cardiac arrest and, despite resuscitation measures, the patient was declared deceased. With the necropsy, it was found, as the underlying cause of death, an anaplastic thyroid carcinoma with multiple metastases to organ and systems.Paciente femenina de 44 años de edad con una masa palpable en mama derecha, adenopatías supraclaviculares y tumor en la glándula suprarrenal izquierda que ingresó y evolucionó desfavorablemente; estaba hipotensa y con dolor abdominal a pesar de los analgésicos, además comenzó con episodios de desorientación. Al onceno día de su ingreso comenzó con sudoración profusa y toma marcada del estado general y fue necesario localizar a la guardia médica; al llegar al lecho la enferma cae en paro cardiorespiratorio y, a pesar de las medidas de reanimación cardiopulmonar, la paciente fue declarada fallecida. En la necropsia se constató como causa básica de la muerte un carcinoma anaplásico del tiroides con múltiples metástasis a sistemas y órganos