Estudiantes de medicina y profesionales de la salud como autores del libro Angiostrongylus cantonensis. Emergencia en América. Un reto a imitar

Este trabajo esta encaminado a dar a conoser un el tarabajo de dos estudiantes de medicina

Frequency Analysis of a 64x64 Pixel Retinomorphic System with AER Output to Estimate the Limits to Apply onto Specific Mechanical Environment

The rods and cones of a human retina are constantly sensing and transmitting the light in the form of spikes to the cortex of the brain in order to reproduce an image in the brain. Delbruck’s lab has designed and manufactured several generations of spike based image sensors that mimic the human retina. In this paper we present an exhaustive timing analysis of the Address-Event- Representation (AER) output of a 64x64 pixels silicon retinomorphic system. Two different scenarios are presented in order to achieve the maximum frequency of light changes for a pixel sensor and the maximum frequency of requested directions on the output AER. Results obtained are 100 Hz and 1.66 MHz in each case respectively. We have tested the upper spin limit and found it to be approximately 6000rpm (revolutions per minute) and in some cases with high light contrast lost events do not exist.Ministerio de Ciencia e Innovación TEC2009-10639- C04-0

Ontologies in medicinal chemistry: current status and future challenges

[Abstract] Recent years have seen a dramatic increase in the amount and availability of data in the diverse areas of medicinal chemistry, making it possible to achieve significant advances in fields such as the design, synthesis and biological evaluation of compounds. However, with this data explosion, the storage, management and analysis of available data to extract relevant information has become even a more complex task that offers challenging research issues to Artificial Intelligence (AI) scientists. Ontologies have emerged in AI as a key tool to formally represent and semantically organize aspects of the real world. Beyond glossaries or thesauri, ontologies facilitate communication between experts and allow the application of computational techniques to extract useful information from available data. In medicinal chemistry, multiple ontologies have been developed during the last years which contain knowledge about chemical compounds and processes of synthesis of pharmaceutical products. This article reviews the principal standards and ontologies in medicinal chemistry, analyzes their main applications and suggests future directions.Instituto de Salud Carlos III; FIS-PI10/02180Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo; 209RT0366Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; CN2012/217Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; CN2011/034Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; CN2012/21

Model predictive current control of grid-connected neutral-point-clamped converters to meet low-voltage ride-through requirements

The low-voltage ride through (LVRT) requirement demands the wind power plants to remain connected to the grid in the presence of grid voltage dips, actively helping the network overall control to keep network voltage and frequency stable. Wind power technology points to increase power ratings. Hence, multilevel converters, as for example, neutral-point-clamped (NPC) converters, are well suited for this application. Predictive current control presents similar dynamic response and reference tracking than other well-established control methods, but working at lower switching frequencies. In this paper, the predictive current control is applied to the grid-side NPC converter as part of a wind energy conversion system, in order to fulfill the LVRT requirements. DC-link neutral-point balance is also achieved by means of the predictive control algorithm, which considers the redundant switching states of the NPC converter. Simulation and experimental results confirm the validity of the proposed control approach.Postprint (author’s final draft

Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes

Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium-based technology and the standard copper-catalyzed azide–alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonalThis research received financial support from the Spanish MINECO (SAF2016-76689-R, CTQ2017-84767-P and PID2019-106184GB-I00, and a FPU predoctoral Fellowship to AGG), the Xunta de Galicia (ED431C 2017/19, 2015-CP082, Centro Singular de Investigación de Galicia accreditation 2019–2022, ED431G 2019/03), the ERDF, and the ERC (Adv. Grant No. 340055). The Orfeo-Cinqa network (CTQ2016-81797-REDC) is also acknowledgedS

Laboratory and telescope demonstration of the TP3-WFS for the adaptive optics segment of AOLI

AOLI (Adaptive Optics Lucky Imager) is a state-of-art instrument that combines adaptive optics (AO) and lucky imaging (LI) with the objective of obtaining diffraction limited images in visible wavelength at mid- and big-size ground-based telescopes. The key innovation of AOLI is the development and use of the new TP3-WFS (Two Pupil Plane PositionsWavefront Sensor). The TP3-WFS, working in visible band, represents an advance over classical wavefront sensors such as the Shack-Hartmann WFS (SH-WFS) because it can theoretically use fainter natural reference stars, which would ultimately provide better sky coverages to AO instruments using this newer sensor. This paper describes the software, algorithms and procedures that enabled AOLI to become the first astronomical instrument performing real-time adaptive optics corrections in a telescope with this new type of WFS, including the first control-related results at the William Herschel Telescope (WHT)This work was supported by the Spanish Ministry of Economy under the projects AYA2011-29024, ESP2014-56869-C2-2-P, ESP2015-69020-C2-2-R and DPI2015-66458-C2-2-R, by project 15345/PI/10 from the Fundación Séneca, by the Spanish Ministry of Education under the grant FPU12/05573, by project ST/K002368/1 from the Science and Technology Facilities Council and by ERDF funds from the European Commission. The results presented in this paper are based on observations made with the William Herschel Telescope operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Special thanks go to Lara Monteagudo and Marcos Pellejero for their timely contributions

Selective Extraction of Bioactive Phenylethanoids from Digitalis obscura

Cardenolide-free extracts from Digitalis obscura showed significant antifeedant effects against the aphid Myzus persicae and this activity correlated with their phenylethanoid content. The content in phenylethanoids of Digitalis obscura has been studied. Maceration of the aerial parts of D. obscura was used for the selective extraction of the natural compound rengyolone (1) and the aglycone of cornoside (compound 3). Pure rengyolone (1) can be obtained from D. obscura in approximately 90% purity from fresh plant from the CHCl3 soluble fraction of the ethanolic extract (0.8% yield). The ethanol extraction of freshly collected D. obscura showed the presence of compound 3 as the only phenylethanoid. Compound 3 was proven to easily evolve to rengyolone. Due to this instability, and although its presence in plants has been previously reported, the spectroscopical data of 3 are reported herein for the first time. Selective mono-acetylation of compound of 3 led to the active natural compound hallerone (5). The aphid antifeedant (against Myzus persicae) and nematicidal (against root-knot nematode Meloidogyne javanica) activities of these compounds have been evaluated. Here we report for the first time on the aphid antifeedant effects of 1, 3, and 5. Additionally, the nematicidal activity of hallerone (5) is described here for the first time.MINISTERIO DE ECONOMÍA Y COMPETITIVIDADPID2019-106222RB-C32/SRA (State Research Agency, 10.13039/501100011033)PID2019- 106222RB-C31/SRA (State Research Agency, 10.13039/501100011033)ERASMUS + N◦2018-1-FR01- KA202-047892 Biocontrol E Training (BET)Unidad Asociada UGR-CSIC Bioplaguicidas: Biotecnología, síntesis y diversidad químic