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La conservación preventiva de las obras de arte

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The Role of Hip Joint Clearance Discrepancy as Other Clinical Predictor of Reinjury and Injury Severity in Hamstring Tears in Elite Athletes

[EN] Hamstring tear injuries (HTI) are the most prevalent injuries in athletes, with high reinjury rates. To prevent reinjury and reduce the severity of injuries, it is essential to identify potential risk factors. Hip characteristics are fundamental to optimal hamstring function. We sought to investigate the role of hip joint clearance discrepancy (JCD) as a risk factor for HTI and a clinical predictor of risk of reinjury and injury severity. A cross-sectional, retrospective study was performed with elite athletes (n = 100) who did (n = 50) and did not (n = 50) have a history of injury. X-rays were taken to assess JCD. We reviewed muscular lesions historial, and health records for the previous 5 years. Significant differences were found in injury severity (p = 0.026; ŋ2p = 0.105) and a number of injuries (p = 0.003; ŋ2p = 0.172). The multivariate analysis data indicated that JCD was significantly associated with the number of injuries and their severity (p &lt; 0.05). In the stepwise regression model, JCD variability explained 60.1% of the number of injuries (R2 0.601) and 10.5% of injury severity (R2 0.0105). These results suggest that JCD could play an important role as a risk factor for HTI and also as a clinical predictor of reinjury and injury severityS

Sub-250 fs, 650 kW Peak Power Harmonic Mode-Locked Fiber Laser with InN-based SESAM

43rd. European Conference on Optical Communication (ECOC 2017), Gothemburg, 17-21 Sept.We demonstrate ultrafast harmonically mode-locked fiber lasing in up to 6-km-long rings at 1.56μm with InN SESAM. Fundamental mode-locking with pulse width of 239fs, pulse energy of 155nJ and peak power of 650kW is achieved with a 1-km-long cavity.European CommissionMinisterio de Economía y CompetitividadComunidad de Madri

Role of organic cation transporter 3 (OCT3) in the response of hepatocellular carcinoma to tyrosine kinase inhibitors

Impaired function of organic cation transporter 1 (OCT1) in hepatocellular carcinoma (HCC) has been associated with unsatisfactory response to sorafenib. However, some patients lacking OCT1 at the plasma membrane (PM) of HCC cells still respond to sorafenib, suggesting that another transporter may contribute to take up this drug. The aim of this study was to investigate whether OCT3 could contribute to the uptake of sorafenib and other tyrosine kinase inhibitors (TKIs) and whether OCT3 determination can predict HCC response to sorafenib. Cells overexpressing OCT3 were used to determine the ability of this carrier to transport sorafenib. Immunostaining of OCT3 was performed in HCC samples obtained in the TRANSFER study. Considering the intensity of staining and the number of OCT3-positive cells, tumors were classified as having absent, weak, moderate, or strong OCT3 expression and were also categorized according to the presence or absence of PM staining. Functional in vitro studies revealed that OCT3 is also able to mediate sorafenib uptake. Other TKIs, such as regorafenib, lenvatinib, and cabozantinib can also interact with this transporter. In silico studies suggested that the expression of OCT3 is better preserved in HCC than that of OCT1. In HCC samples, OCT3 was expressed at the PM of cancer cells, and its presence, detected in 26% of tumors, was associated with better outcomes in patients treated with sorafenib. In conclusion, analysis by immunohistochemistry of OCT3 in the PM of tumor cells may help to predict the response of HCC patients to sorafenib and potentially to other TKIs.Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III Junta de Castilla y Leo

Desarrollo de herramientas para mejorar la calidad del Programa de Doctorado en Fisiopatología y Farmacología

Memoria ID2022-203 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2022-2023

Español académico e inmersión universitaria del alumnado extranjero en la Universidad de Alicante

La integración académica de los estudiantes internacionales es un paso imprescindible en la internacionalización del sistema universitario. Para contribuir a ella, el objetivo de esta red ha sido la creación de una Guía académica para estudiantes internacionales, que persigue un mejor rendimiento académico de su estancia. Sus destinatarios son los estudiantes de movilidad internacional de la Facultad de Filosofía y Letras que cursan asignaturas relacionadas con la lengua y la literatura españolas. Metodológicamente, partiendo del diagnóstico de la situación tanto del alumnado extranjero como de su profesorado obtenida como resultado de una red anterior (Pastor, 2014b), hemos trabajado con las asignaturas más demandadas por este colectivo en los últimos tres años, hemos realizado entrevistas personalizadas con el profesorado que las imparte y hemos elaborado la información requerida. Así pues, ofrecemos como resultado la presente Guía, que incluye una introducción sobre la cultura académica universitaria en España, así como las fichas de las asignaturas más solicitadas, diseñadas desde la perspectiva de lo que requiere de ellas un estudiante internacional (requisitos lingüísticos, material adaptado, pautas de evaluación, comentarios de anteriores alumnos, etc.). Confiamos en facilitar con todo ello su interacción con el profesorado y el resto del alumnado e incrementar así su rendimiento y éxito académicos