Descripción de la metodología y los resultados obtenidos en un estudio prospectivo europeo sobre seguridad de la inmunoterapia en la práctica clínica habitual

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Pediatría. Fecha de lectura: 14-11-201

Cultural Historical Psychology and the Reset of History

The authors argue that, in the research trajectory of cultural historical psychology, there are nuclear aspects of Vygotsky’s theory that have been insufficiently considered. Three of these aspects are herein discussed: the intense and rapid changes to mediational processes and their influence on human psyche; meaningful findings on neuroplasticity that require a neuropsychological approach; and, perhaps most importantly, the need for cultural historical approach, and for psychology at large, to return to the study of the direction and meaning of human life

Algunas propuestas innovadoras de Muhammad Yunus para combatir la pobreza y otras carencias socioeconomicas

Aunque son numerosas las iniciativas innovadoras para financiar los programas de desarrollo de los países menos desarrollados (recargos sobre los billetes aéreos, tasa sobre las transacciones financieras, lotería solidaria..), la gestión de los microcréditos por el Banco Grameen fundado por Muhammad Yunus, es probablemente la que ha tenido mayor difusión y aceptación.Academia Andaluza de Ciencia RegionalInstituto de Desarrollo Regional-UG

Bayesian methods in the field of rehabilitation

Brief report[Abstract] Bayesian techniques, as an alternative method of statistical analysis in rehabilitation studies, have some advantages such as handling small sample sizes, allowing incorporation of previous experience of the researchers or clinicians, being suitable for different kinds of studies, and managing highly complex models. These characteristics are important in rehabilitation research. In the present article, the Bayesian approach is displayed through three examples in previously analyzed data with traditional or frequentist methods. The studies used as examples have small sample sizes and show that the Bayesian procedures enhance the statistical information of the results. The Bayesian credibility interval includes the true value of the corresponding parameter diminishing uncertainty about the treatment effect. In addition, the Bayes factor value quantifies the evidence provided by the data in favor of the alternative hypothesis as opposed to the null hypothesis. Bayesian inference could be an interesting and adaptable alternative statistical method for physical medicine and rehabilitation applications

An EAACI “European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI)”: the methodology:the methodology

At present, there is no European report on clinically relevant systemic reactions due to the regular use of allergen immunotherapy (AIT), administered either subcutaneously or sublingually (SCIT and SLIT, respectively) outside clinical trials. Using an electronic survey and a “harmonised terminology” according to MedDRA, we aimed to prospectively collect systemic adverse reactions due to AIT from real life clinical settings. Under the framework of the EAACI, a team of European specialists in AIT, pharmacovigilance, epidemiology and drugs regulation set up a web-based prospective pilot survey to be conducted in three European countries (France, Germany and Spain). A designated “national coordinator” was responsible for following ethics requirements relative to each country and to select at least 30 doctors per country. Patients were recruited the same day they received their first dose of either SCIT or SLIT. Patient inclusion criteria were: adults and children, with IgE mediated pollen, house dust mite, Alternaria, and/or animal dander respiratory allergies who will initiate AIT. A list of 31 symptoms terms were extracted from the MedDRA (Medical Dictionary for Regulatory Activities) dictionary to harmonize the reporting of all adverse systemic reactions in this survey. The SurveyMonkey® online instrument was used by participant doctors to submit information directly to a blinded central database. Three questionnaires were generated: i) the Doctor Questionnaire, ii) the Patient Questionnaire and iii) the Adverse Reaction Questionnaire. A handbook and a mistake report form were given to each doctor. In this paper, we describe the methodology followed

Model-Assisted Bird Monitoring Based on Remotely Sensed Ecosystem Functioning and Atlas Data

Urgent action needs to be taken to halt global biodiversity crisis. To be effective in the implementation of such action, managers and policy-makers need updated information on the status and trends of biodiversity. Here, we test the ability of remotely sensed ecosystem functioning attributes (EFAs) to predict the distribution of 73 bird species with different life-history traits. We run ensemble species distribution models (SDMs) trained with bird atlas data and 12 EFAs describing different dimensions of carbon cycle and surface energy balance. Our ensemble SDMs—exclusively based on EFAs—hold a high predictive capacity across 71 target species (up to 0.94 and 0.79 of Area Under the ROC curve and true skill statistic (TSS)). Our results showed the life-history traits did not significantly affect SDM performance. Overall, minimum Enhanced Vegetation Index (EVI) and maximum Albedo values (descriptors of primary productivity and energy balance) were the most important predictors across our bird community. Our approach leverages the existing atlas data and provides an alternative method to monitor inter-annual bird habitat dynamics from space in the absence of long-term biodiversity monitoring schemes. This study illustrates the great potential that satellite remote sensing can contribute to the Aichi Biodiversity Targets and to the Essential Biodiversity Variables framework (EBV class “Species distribution”)Fieldwork campaigns were carried out within the project “Estudios sobre a biodiversidade do Macizo Central Galego. Lugar de Importancia Comunitaria” (PGIDT99PXI20002B) and “Caracterización de los vertebrados del LIC Macizo Central e Bidueiral de Montederramo”, code: 2008-CE227”, funded by SAYFOR S.L. This work also received funding from Xunta de Galicia through the grant to structure and consolidate competitive research groups of Galicia (ED431B 2018/36). A.R. was funded by the Xunta de Galicia, Spain (post-doctoral fellowship ED481B2016/084-0). S.A.-C. was financially supported by PORBIOTA—E-Infraestrutura Portuguesa de Informação e Investigação em Biodiversidade (POCI-01-0145-FEDER-022127)S

Influence of denitrifiers abundance on N2O emissions in long term tillage system under a rainfed legume crop

Current studies about nitrous oxide (N2O) emissions from legume crops have raised considerable doubt, observing a high variability between sites (0.03-7.09 kg N2O–N ha−1 y -1) [1]. This high variability has been associated to climate and soil conditions, legume species and soil management practices (e.g. conservation or conventional tillage). Conservation tillage (i.e. no tillage (NT) and minimum tillage (MT)) has spread during the last decades because promotes several positive effects (increase of soil organic content, reduction of soil erosion and enhancement of carbon (C) sequestration). However, these benefits could be partly counterbalanced by negative effects on the release of N2O emissions. Among processes responsible for N2O production and consumption in soils, denitrification plays an importantrole both in tilled and no-tilled ropping systems [2]. Recently, amplification of functional bacterial genes involved in denitrification is being used to examine denitrifiers abundance and evaluate their influence on N2O emissions. NirK and nirS are functional genes encoding the cytochrome cd1 and copper nitrite reductase, which is the key enzyme regulating the denitrification process

Catalytic conversion of 5-hydroxymethylfurfural (5-HMF) over Pd-Ru/FAU zeolite catalysts.

We present this study on FAU-type zeolites were prepared varying the Si/Al ratio (4, 5 and 6) and crystallization time (4, 6 and 8 h) to produce a highly pure and homogeneous material with enhanced surface area values. Bimetallic Pd-Ru and Pt-Ru (0.5 wt.% of each metal) were impregnated onto the zeolites matrix by the incipient wetness impregnation method. The materials were characterized by X-ray diffraction (XRD), nitrogen physisorption, Fourier Transform Infrared spectroscopy (FT-IR), Scattering Electronic Microscopy (SEM), Scattering and Transmission Microscopy (STEM), temperature-programmed desorption (TPD), temperature-programmed desorption (TPR) and Inductively Couples Plasma- Mass Spectrometer (ICP-MS). Results indicated that using lower Si/Al ratios favored the catalytic activity. Also, the longest crystallization time had a positive effect on surface area, homogeneous particle size distribution and crystallinity. The catalytic performance in the esterification of 5-hydroxymethylfurfural (5-HMF) to produce 5-acetoxymethylfurfural (AcMF) was investigated. The maximum 5-HMF conversion of 87.28 % was achieved using pure zeolite with relation Si/Al = 5, and 8 h of crystallization. Pd-Ru supported onto same zeolite showed a conversion of 84.22 %. The highest selectivity towards AcMF of 71.29 % with pure zeolite Si/Al = 5 and 8 h of crystallization was achieved, followed by Pd-Ru/FAU with Si/Al = 5 and 8 h of crystallization, achieving 60.42 %. Finally, results shown that the interaction between the properties of zeolitic support and the metallic species, specifically Pd, had a positive effect in the catalytic process the pristine zeolite showed improved catalytic characteristics related to its acid strength

Situación de lluvias torrenciales en Santa Cruz de Tenerife el 31 de marzo de 2002. Análisis de los factores meteorológicos relevantes

Ponencia presentada en: 1er Encuentro sobre Meteorología y Atmósfera de Canarias, celebrado en el Puerto de la Cruz, los días 12,13 y 14 de noviembre de 2003. El encuentro estuvo organizado por el Centro Meteorológico Territorial en Canarias Occidental, con la colaboración del Observatorio Atmosférico de Izaña y del Grupo de Física de la Atmósfera de la Facultad de Física (Universidad de La Laguna)Durante la tarde del 31 de marzo de 2002 se produjeron lluvias torrenciales en la ciudad de Santa Cruz de Tenerife, que ocasionaron 8 muertos y cuantiosos daños materiales. Las precipitaciones que llegaron a acumular cantidades de 204, 1 mm en menos de 3 horas, estuvieron asociadas con estructuras convectivas que presentaron dos características fundamentales: por un lado, fueron muy eficientes en la producción de precipitación y, por otro, fueron cuasiestacionarias, permaneciendo ancladas y afectando a prácticamente el mismo lugar de manera continuada. Con objeto de conocer e intentar comprender y explicar los fenómenos meteorológicos que provocaron las lluvias torrenciales, se han analizado todos los datos disponibles. Del estudio realizado se concluye que los desarrollos convectivos fueron consecuencia de la combinación de diferentes factores, entre los que destacan la inestabilidad atmosférica existente, el forzamiento asociado con una perturbación mesoescalar y la convergencia del viento en niveles bajos, resultado a su vez de la interacción del flujo general con la marcada orografía de la isla de Tenerife

Effect of fluid emissions in the acoustic response on the seabed of the Gulf of Cádiz

Advances in remotely-sensed techniques have revolutionized mapping methods and our understanding of the seabed environment. In particular, multibeam backscatter data nowadays allows developing quantitative studies on the composition of the seafloor, which represents an important baseline for habitat mapping. Usually, the acoustic response is considered as a direct proxy of sediment texture, but seepage could affect significantly this relationship. A multibeam data set from the Gulf of Cádiz, was grouped using an ISO-cluster analysis and results were compared with 80 ground-truthing stations taken inside and outside cold seepage areas. Results show significant differences between the acoustic response of sediments with the same texture depending on the presence/absence of fluid emissions. Understanding this relationship is necessary to make image-based backscatter classification that allows the production of sediment and habitat maps in areas with extensive fluid emissions such as the Gulf of Cádiz.Versión del edito