(Liquid + liquid) equilibria of polymer-salt aqueous two-phase systems for laccase partitioning : UCON 50-HB-5100 with potassium citrate and (sodium or potassium) formate at 23 ºC

Aqueous two-phase systems (ATPS) are recognized as very suitable techniques for the recovery of target solutes in biological applications. Three new phase diagrams of (UCON 50-HB-5100 + potassium citrate + water), (UCON 50-HB-5100 + sodium formate + water), and (UCON 50-HB-5100 + potassium formate + water) systems were measured at 23 C. The binodal curves were successfully described using the empirical equation suggested by Merchuk and co-workers. The reliability of the tie-line data experimentally determined was evaluated using the equations reported by Othmer–Tobias and Bancroft and satisfactory linearity was obtained for all ATPS. Among the salts studied, potassium citrate proved to be the most effective in ATPS formation, providing the largest heterogeneous region. Besides, the effect of both anions and cations in the size of the heterogeneous region and in the slope of the tie-lines has been compared. For the same salts and conditions, the heterogeneous region using UCON as the phase-forming polymer is larger than using polyethylene glycol. Furthermore, laccase partition in the UCON-salt ATPS was studied and it was found that in all cases enzyme partition occurred preferably to the bottom phase (salt-rich phase). Laccase concentration in the salt-rich phase was approximately 2-fold that in the top phase, thus UCON-salt ATPS can be a suitable biphasic system for laccase extraction.This work is supported by project PEst-C/EQB/LA0020/2011, financed by FEDER through COMPETE - Programa Operacional Factores de Competitividade and by FCT - Fundacao para a Ciencia e a Tecnologia, Portugal. SCS and OR acknowledge financial support of FCT (Ph.D. grant SFRH/BD/43439/2008) and Programme Ciencia 2007 (FCT), respectively. EL acknowledges financial support of Ministerio de Educacion y Ciencia of Spain (doctoral fellowship EX2009-0404

Combination of DROOL rules and Protégé knowledge bases in the ONTO-H annotation tool

ONTO-H is a semi-automatic collaborative tool for the semantic annotation of documents, built as a Protégé 3.0 tab plug-in. Among its multiple functionalities aimed at easing the document annotation process, ONTO-H uses a rule-based system to create cascading annotations out from a single drag and drop operation from a part of a document into an already existing concept or instance of the domain ontology being used for annotation. It also gives support to the detection of name conflicts and instance duplications in the creation of the annotations. The rule system runs on top of the open source rule engine DROOLS and is connected to the domain ontology used for annotation by means of an ad-hoc programmed Java proxy

Masa fúngica intracardiaca en un paciente prematuro extremo

There are few reports on intracardiac fungal masses, especially in the pediatric population. We present the case of an extremely premature patient who, after being hospitalized since birth in an intensive care unit, developed fungal masses in the right atrium, which, due to their size, location and resistance to medical treatment, required surgical excision. For this reason, at the slightest suspicion of systemic candidiasis in pediatric patients, it is mandatory to include an echocardiogram in the defocalization examinations to rule out endocarditis and thus avoid the development of intracardiac fungal masses. Therefore, early detection for timely medical management may avoid the surgical approach associated with a high risk of morbidity and mortality in extremely premature patients.Existen pocos reportes sobre masas fúngicas intracardiacas, sobretodo en la población pediátrica. Presentamos el caso de un paciente prematuro extremo que, al permanecer hospitalizado desde su nacimiento en una unidad de cuidados intensivos desarrolló masas fúngicas en atrio derecho, las cuales, por su tamaño, ubicación y resistencia al tratamiento médico, necesitaron de exéresis quirúrgica. Por tal motivo, ante la mínima sospecha de candidiasis sistémica en pacientes pediátricos, es mandatorio incluir en los exámenes de desfocalización un ecocardiograma para descartar endocarditis y así evitar el desarrollo de masas fúngicas intracardiacas. Por lo tanto, la detección precoz para un manejo médico oportuno puede evitar el abordaje quirúrgico que se asocia a un alto riesgo de morbimortalidad en pacientes prematuros extremos

Lattice dynamics of Sb2Te3 at high pressures

We report an experimental and theoretical lattice dynamics study of antimony telluride (Sb 2Te 3) up to 26 GPa together with a theoretical study of its structural stability under pressure. Raman-active modes of the low-pressure rhombohedral (R-3m) phase were observed up to 7.7 GPa. Changes of the frequencies and linewidths were observed around 3.5 GPa where an electronic topological transition was previously found. Raman-mode changes evidence phase transitions at 7.7, 14.5, and 25GPa. The frequencies and pressure coefficients of the new phases above 7.7 and 14.5 GPa agree with those calculated for the monoclinic C2/m and C2/c structures recently observed at high pressures in Bi 2Te 3 and also for the C2/m phase in the case of Bi 2Se 3 and Sb 2Te 3. Above 25 GPa no Raman-active modes are observed in Sb 2Te 3, similarly to the case of Bi 2Te 3 and Bi 2Se 3. Therefore, it is possible that the structure of Sb 2Te 3 above 25 GPa is the same disordered bcc phase already found in Bi 2Te 3 by x-ray diffraction studies. Upon pressure release, Sb 2Te 3 reverts back to the original rhombohedral phase after considerable hysteresis. Raman- and IR-mode symmetries, frequencies, and pressure coefficients in the different phases are reported and discussed. © 2011 American Physical Society.This work has been done under financial support from Spanish MICINN under Project Nos. MAT2010-21270-C04-03/04 and CSD-2007-00045 and supported by the Ministry of Education, Youth and Sports of the Czech Republic (MSM 0021627501). E. P.-G. acknowledges the financial support of the Spanish MEC under a FPI fellowship. Supercomputer time has been provided by the Red Espanola de Supercomputacion (RES) and the MALTA cluster.Gomis Hilario, O.; Vilaplana Cerda, RI.; Manjón Herrera, FJ.; Rodríguez-Hernández, P.; Pérez-González, E.; Muñoz, A.; Kucek, V.... (2011). 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Journal of Applied Physics, 102(6), 064503. doi:10.1063/1.2778737Kim, M. S., Cho, S. H., Hong, S. K., Roh, J. S., & Choi, D. J. (2008). Crystallization characteristics of nitrogen-doped Sb2Te3 films for PRAM application. Ceramics International, 34(4), 1043-1046. doi:10.1016/j.ceramint.2007.09.078Anderson, T. L., & Krause, H. B. (1974). Refinement of the Sb2Te3 and Sb2Te2Se structures and their relationship to nonstoichiometric Sb2Te3−y Se y compounds. Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, 30(5), 1307-1310. doi:10.1107/s0567740874004729Zhang, H., Liu, C.-X., Qi, X.-L., Dai, X., Fang, Z., & Zhang, S.-C. (2009). Topological insulators in Bi2Se3, Bi2Te3 and Sb2Te3 with a single Dirac cone on the surface. Nature Physics, 5(6), 438-442. doi:10.1038/nphys1270Hasan, M. Z., & Kane, C. L. (2010). Colloquium: Topological insulators. Reviews of Modern Physics, 82(4), 3045-3067. doi:10.1103/revmodphys.82.3045Moore, J. E. (2010). 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Effect of Pressure on the Energy Gap of Bi2Te3. Journal of Applied Physics, 32(9), 1733-1735. doi:10.1063/1.1728426Khvostantsev, L. G., Orlov, A. I., Abrikosov, N. K., & Ivanova, L. D. (1980). Thermoelectric properties and phase transition in Sb2Te3 under hydrostatic pressure up to 9 GPa. Physica Status Solidi (a), 58(1), 37-40. doi:10.1002/pssa.2210580103Sakai, N., Kajiwara, T., Takemura, K., Minomura, S., & Fujii, Y. (1981). Pressure-induced phase transition in Sb2Te3. Solid State Communications, 40(12), 1045-1047. doi:10.1016/0038-1098(81)90248-9Khvostantsev, L. G., Orlov, A. I., Abrikosov, N. K., & Ivanova, L. D. (1985). Kinetic Properties and Phase Transitions in Sb2Te3 under Hydrostatic Pressure up to 9 GPa. physica status solidi (a), 89(1), 301-309. doi:10.1002/pssa.2210890132Thonhauser, T., Scheidemantel, T. J., Sofo, J. O., Badding, J. V., & Mahan, G. D. (2003). Thermoelectric properties ofSb2Te3under pressure and uniaxial stress. Physical Review B, 68(8). doi:10.1103/physrevb.68.085201Thonhauser, T. (2004). Influence of negative pressure on thermoelectric properties of Sb2Te3. Solid State Communications, 129(4), 249-253. doi:10.1016/j.ssc.2003.10.006Einaga, M., Tanabe, Y., Nakayama, A., Ohmura, A., Ishikawa, F., & Yamada, Y. (2010). New superconducting phase of Bi2Te3under pressure above 11 GPa. Journal of Physics: Conference Series, 215, 012036. doi:10.1088/1742-6596/215/1/012036Zhang, J. L., Zhang, S. J., Weng, H. M., Zhang, W., Yang, L. X., Liu, Q. Q., … Jin, C. Q. (2010). Pressure-induced superconductivity in topological parent compound Bi2Te3. Proceedings of the National Academy of Sciences, 108(1), 24-28. doi:10.1073/pnas.1014085108Jacobsen, M. K., Kumar, R. S., Cornelius, A. L., Sinogeiken, S. V., Nico, M. F., Elert, M., … Nguyen, J. (2008). 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Semiconductors, 31(3), 276-278. doi:10.1134/1.1187126Polian, A., Gauthier, M., Souza, S. M., Trichês, D. M., Cardoso de Lima, J., & Grandi, T. A. (2011). Two-dimensional pressure-induced electronic topological transition in Bi2Te3. Physical Review B, 83(11). doi:10.1103/physrevb.83.113106Vilaplana, R., Santamaría-Pérez, D., Gomis, O., Manjón, F. J., González, J., Segura, A., … Kucek, V. (2011). Structural and vibrational study of Bi2Se3under high pressure. Physical Review B, 84(18). doi:10.1103/physrevb.84.184110Richter, W., & Becker, C. R. (1977). A Raman and far-infrared investigation of phonons in the rhombohedral V2–VI3 compounds Bi2Te3, Bi2Se3, Sb2Te3 and Bi2(Te1−xSex)3 (0 <x < 1), (Bi1−ySby)2Te3 (0 <y < 1). Physica Status Solidi (b), 84(2), 619-628. doi:10.1002/pssb.2220840226Sosso, G. C., Caravati, S., & Bernasconi, M. (2009). Vibrational properties of crystalline Sb2Te3from first principles. Journal of Physics: Condensed Matter, 21(9), 095410. doi:10.1088/0953-8984/21/9/095410Dagens, L. (1978). Phonon anomaly near a Fermi surface topological transition. Journal of Physics F: Metal Physics, 8(10), 2093-2113. doi:10.1088/0305-4608/8/10/010Dagens, L., & Lopez-Rios, C. (1979). Thermodynamic properties of a metal near a Fermi surface topological transition: the anomalous electron-phonon interaction contribution. Journal of Physics F: Metal Physics, 9(11), 2195-2216. doi:10.1088/0305-4608/9/11/011Goncharov, A. ., & Struzhkin, V. . (2003). Pressure dependence of the Raman spectrum, lattice parameters and superconducting critical temperature of MgB2: evidence for pressure-driven phonon-assisted electronic topological transition. Physica C: Superconductivity, 385(1-2), 117-130. doi:10.1016/s0921-4534(02)02311-0Antonangeli, D., Farber, D. L., Said, A. H., Benedetti, L. R., Aracne, C. M., Landa, A., … Klepeis, J. E. (2010). Shear softening in tantalum at megabar pressures. Physical Review B, 82(13). doi:10.1103/physrevb.82.132101Santamaría-Pérez, D., Vegas, A., Muehle, C., & Jansen, M. (2011). Structural behaviour of alkaline sulfides under compression: High-pressure experimental study on Cs2S. The Journal of Chemical Physics, 135(5), 054511. doi:10.1063/1.3617236Vilaplana, R., Gomis, O., Manjón, F. J., Segura, A., Pérez-González, E., Rodríguez-Hernández, P., … Kucek, V. (2011). High-pressure vibrational and optical study of Bi2Te3. Physical Review B, 84(10). doi:10.1103/physrevb.84.104112Larson, P. (2006). Effects of uniaxial and hydrostatic pressure on the valence band maximum inSb2Te3: An electronic structure study. Physical Review B, 74(20). doi:10.1103/physrevb.74.205113Lošťák, P., Beneš, L., Civiš, S., & Süssmann, H. (1990). Preparation and some physical properties of Bi2−xInxSe3 single crystals. Journal of Materials Science, 25(1), 277-282. doi:10.1007/bf00544220Horák, J., Quayle, P. C., Dyck, J. S., Drašar, Č., Lošt’ák, P., & Uher, C. (2008). Defect structure of Sb2−xCrxTe3 single crystals. Journal of Applied Physics, 103(1), 013516. doi:10.1063/1.2826940Piermarini, G. J., Block, S., & Barnett, J. D. (1973). Hydrostatic limits in liquids and solids to 100 kbar. Journal of Applied Physics, 44(12), 5377-5382. doi:10.1063/1.1662159Errandonea, D., Meng, Y., Somayazulu, M., & Häusermann, D. (2005). Pressure-induced transition in titanium metal: a systematic study of the effects of uniaxial stress. Physica B: Condensed Matter, 355(1-4), 116-125. doi:10.1016/j.physb.2004.10.030Syassen, K. (2008). Ruby under pressure. High Pressure Research, 28(2), 75-126. doi:10.1080/08957950802235640Hohenberg, P., & Kohn, W. (1964). Inhomogeneous Electron Gas. Physical Review, 136(3B), B864-B871. doi:10.1103/physrev.136.b864Kresse, G., & Hafner, J. (1993). Ab initiomolecular dynamics for liquid metals. Physical Review B, 47(1), 558-561. doi:10.1103/physrevb.47.558Kresse, G., & Hafner, J. (1994). Ab initiomolecular-dynamics simulation of the liquid-metal–amorphous-semiconductor transition in germanium. Physical Review B, 49(20), 14251-14269. doi:10.1103/physrevb.49.14251Kresse, G., & Furthmüller, J. (1996). Efficiency of ab-initio total energy calculations for metals and semiconductors using a plane-wave basis set. Computational Materials Science, 6(1), 15-50. doi:10.1016/0927-0256(96)00008-0Kresse, G., & Furthmüller, J. (1996). Efficient iterative schemes forab initiototal-energy calculations using a plane-wave basis set. Physical Review B, 54(16), 11169-11186. doi:10.1103/physrevb.54.11169Blöchl, P. E. (1994). Projector augmented-wave method. Physical Review B, 50(24), 17953-17979. doi:10.1103/physrevb.50.17953Kresse, G., & Joubert, D. (1999). From ultrasoft pseudopotentials to the projector augmented-wave method. Physical Review B, 59(3), 1758-1775. doi:10.1103/physrevb.59.1758Perdew, J. P., Ruzsinszky, A., Csonka, G. I., Vydrov, O. A., Scuseria, G. E., Constantin, L. A., … Burke, K. (2008). Restoring the Density-Gradient Expansion for Exchange in Solids and Surfaces. Physical Review Letters, 100(13). doi:10.1103/physrevlett.100.136406Mujica, A., Rubio, A., Muñoz, A., & Needs, R. J. (2003). High-pressure phases of group-IV, III–V, and II–VI compounds. Reviews of Modern Physics, 75(3), 863-912. doi:10.1103/revmodphys.75.863Blanco, M. A., Francisco, E., & Luaña, V. (2004). GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model. Computer Physics Communications, 158(1), 57-72. doi:10.1016/j.comphy.2003.12.001Cardona, M. (2004). Phonon widths versus pressure. High Pressure Research, 24(1), 17-23. doi:10.1080/08957950310001635819Cardona, M. (2004). Effects of pressure on the phonon–phonon and electron–phonon interactions in semiconductors. physica status solidi (b), 241(14), 3128-3137. doi:10.1002/pssb.200405202Ulrich, C., Mroginski, M. A., Goñi, A. R., Cantarero, A., Schwarz, U., Muñoz, V., & Syassen, K. (1996). Vibrational Properties of InSe under Pressure: Experiment and Theory. physica status solidi (b), 198(1), 121-127. doi:10.1002/pssb.2221980117Kulibekov, A. M., Olijnyk, H. P., Jephcoat, A. P., Salaeva, Z. Y., Onari, S., & Allakhverdiev, K. R. (2003). Raman scattering under pressure and the phase transition in ɛ-GaSe. physica status solidi (b), 235(2), 517-520. doi:10.1002/pssb.200301613Cheng, W., & Ren, S.-F. (2011). Phonons of single quintuple Bi2Te3and Bi2Se3films and bulk materials. Physical Review B, 83(9). doi:10.1103/physrevb.83.094301Buga, S. G., Serebryanaya, N. R., Dubitskiy, G. A., Semenova, E. E., Aksenenkov, V. V., & Blank, V. D. (2011). Structure and electrical properties of Sb2Te3and Bi0.4Sb1.6Te3metastable phases obtained by HPHT treatment. High Pressure Research, 31(1), 86-90. doi:10.1080/08957959.2010.52342

Nivel de seguridad de las redes de área local en algunas instituciones públicas que funcionan en la ciudad de Santiago, provincia de Veraguas.

In order to determine the level of security in the local area networks in some public institutions in Santiago, Veraguas, a survey was applied to the network administrators of 15 government entities between the months of June and July 2016; this survey contains 16 items, of which 37,5% were closed questions and 62,5% were open questions. 93,33% of the institutions met technical criteria such as the set of functions and administrative processes, that were developed on the network, the number of collaborators-users, and the existing technologies; judgments that were proposed and validated as references of the results. As a conclusive aspect, it was determined that the institutions under study have a deficient level of Security in their Local Area Networks established by the order of 40,31%; associated with its low protection capacity and network operating condition which requires a better performance of the security administration.Con la finalidad de determinar el nivel de seguridad en las redes de área local en algunas instituciones públicas en Santiago de Veraguas, se aplicó a los administradores de las redes de 15 entidades gubernamentales, entre los meses de junio a julio de 2016, una encuesta que contiene 16 ítems, de los cuales el 37,5% fueron preguntas cerradas y el 62,5% abiertas. El 93,33% de las instituciones cumplieron con criterios técnicos como: el conjunto de funciones y procesos administrativos que se desarrollan sobre la red, la cantidad de colaboradores-usuarios y las tecnologías existentes; juicios que fueron propuestos y validados como referentes de los resultados. Como aspecto concluyente, se determinó que las instituciones objeto de estudio, cuentan con un deficiente nivel de seguridad en sus redes de área local establecido por el orden del 40,31%; asociado a su poca capacidad de protección y condición de funcionamiento de la red; lo que requiere de un mejor desempeño de la administración de la seguridad

Efecto antiinflamatorio de la izalpinina derivada de Chromolaena leivensis: edema de la pata inducido por λ-carragenina y modelo in silico

El flavonoide izalpinina se aisló de las partes aéreas de Chromolaena leivensis. Su determinación estructural se llevó a cabo mediante técnicas espectroscópicas de EM y RMN (1H, 13C). Se evaluó el efecto antiinflamatorio de este compuesto en un modelo de edema plantar inducido por carragenina en ratas. La inflamación de la pata se midió a intervalos de una hora durante siete horas tras la administración de -carragenano. Se evaluaron los niveles séricos de creatina quinasa (CK), obteniéndose resultados estadísticamente significativos con los tratamientos a dosis de 10 mg/kg (* p < 0,01) y 20 mg/kg (** p < 0,005). El efecto antiinflamatorio del compuesto se evaluó mediante pletismografía, y los resultados mostraron diferencias significativas en las tres concentraciones (10 mg/kg, 20 mg/kg, 40 mg/kg) en la primera y tercera hora tras el tratamiento. * p < 0,05; ** p < 0,001; **** p < 0,0001 frente al grupo de control negativo tratado con vehículo (DMSO). Por último, los análisis de acoplamiento molecular revelan que la izalpinina tiene una fuerte afinidad de unión con cinco proteínas diana implicadas en el proceso inflamatorio. El análisis mediante dinámica molecular permitió demostrar que los complejos ligando-proteína presentan una estabilidad aceptable, con valores de RMSD dentro del rango permitido.The flavonoid izalpinin was isolated from the aerial parts of Chromolaena leivensis. Its structural determination was carried out using MS and NMR spectroscopic techniques (1H, 13C). This compound was evaluated for its anti-inflammatory effect in a rat model on -carrageenan-induced plantar edema. Paw inflammation was measured at one-hour intervals for seven hours following the administration of -carrageenan. Serum creatine kinase (CK) levels were evaluated, obtaining statistically significant results with the treatments at doses of 10 mg/kg (* p < 0.01) and 20 mg/kg (** p < 0.005). The anti-inflammatory effect of the compound was evaluated by using plethysmography, and the results showed significant differences at the three concentrations (10 mg/kg, 20 mg/kg, 40 mg/kg) in the first and third hours after treatment. * p < 0.05; ** p < 0.001; **** p < 0.0001 vs. the negative control group treated with vehicle (DMSO). Lastly, molecular docking analyses reveal that izalpinin has a strong binding affinity with five target proteins involved in the inflammatory process. The analysis using molecular dynamics allowed demonstrating that the ligand–protein complexes present acceptable stability, with RMSD values within the allowed range

Percepción de la ciberseguridad: : ciberdelitos, normas legales y políticas de seguridad

The objective of the study is to establish a relationship between cybersecurity, cybercrimes, current legal regulations and cybersecurity policies associated with electronic and computer media in Panama, an online form was applied remotely during the months of June-July year 2022, to the faculty coordinators and professors who belong to the School of Informatics for Educational and Business Management in eight academic units, and who have specialized studies in the area of ??Administration of Information Centers, Auditing and Security of Information Systems. A percentage 92.59% responded to this instrument, which compiled the results of the years of academic benefits and services, teaching category and academic-professional training in the specialty area, as well as information related to cybersecurity policies and backups of important information. As a conclusive aspect, it was determined that 96.96% of the respondents fully agree that teaching actions are required in terms of cybersecurity policies applied to the use and management of computer equipment, technological resources and digital media.Con el objetivo de establecer una relación entre la ciberseguridad, los ciberdelitos, las normas legales vigentes y las políticas de ciberseguridad asociados a los medios electrónicos e informáticos en Panamá, se aplicó un formulario en línea de manera remota durante los meses de junio-julio del año 2022, a los coordinadores de facultad y profesores que pertenecen a la Escuela de Informática para la Gestión Educativa y Empresarial en ocho unidades académicas, que cuentan con estudios especializados en el área de Administración de Centros de Información, Auditoría y Seguridad de Sistemas de Información. El 92.59% respondieron dicho instrumento, el cual recopiló los resultados de los años de prestaciones y servicios académicos, categoría docente y la formación académico-profesional en el área de especialidad, así como información relacionada con políticas de ciberseguridad y respaldos de información importante. Como aspecto concluyente, se determinó que el 96.96% de los encuestados está totalmente de acuerdo que se requieren de acciones de docencia en materia de políticas de ciberseguridad aplicadas al uso y manejo de los equipos informáticos, recursos tecnológicos y medios de comunicación digital

Cu(ii) and Zn(ii) complexes with a poly-functional ligand derived from o-vanillin and thiophene. Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells

The interaction of a poly-functional ligand derived from o-vanillin and 2-thiophenemethylamine (oVATPNH2) with transition metal ions Cu(II) and Zn(II) leads to the formation of stable coordination compounds, namely [Cu(oVATPNH2)2] and [Zn(oVATPNH2)2]. Their crystal structures have been determined by X-ray diffraction methods. Two molecules of the deprotonated ligand acting in a bidentate fashion build a nearly square planar environment around Cu(II) and a distorted tetrahedral coordination arrangement for Zn(II). The complexes were characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance and solution UV-vis and EPR. Their thermal behavior has been analyzed by means of TGA and DTA. DFT theoretical studies, using computational methods based on DFT, were employed to assist the interpretation and assignment of spectroscopic data. Cytotoxicity assays against two human breast cancer cell lines, namely MCF-7 and MDA-MB-231, revealed an enhancement of the effectiveness of the complexes as compared with both the ligand and the free metal ions. The results for the copper compound are promising, as its cytotoxic effect was stronger than the reference metallodrug cisplatin in both cancer cell lines tested.CONICET-CCT-La Plata (PIP 0651 and 0034), ANPCyT (PICT 2016-1574) and UNLP (11/X-473) (Argentina) and also by Consejerı´a de Educacio´n CyL and FFEDER BU076U16, BU022G18 and Ministerio de Economı´a y Competitividad CTQ2016-75023-C2-1-P and CTQ2015-70371- REDT MetDrugs Network (Spai

Recomendaciones dirigidas a los familiares responsables del cuidado domiciliario de un paciente diagnosticado con Covid-19

The crisis that is causing the disease called COVID-19 is severely affecting the health system of many countries, which require alternative measures to care this large number of patients who are not able to be treated at medical centers. This is the reason why home care is considered an alternative, for which it must be very rigorous with the care of the sick person, since if it is not done in a proper way, the other members of the family home are under risk of contamination, which would increase the saturation of the health system. Indications such as the stay of the patient in one place, the use of protective barriers when entering this area, or the constant sanitization of hands, among other measures, can lead to the success of this type of actions, favoring the prompt recovery of the patient and the preservation of the health of the other members at home.La crisis que está ocasionando la enfermedad denominada COVID-19 está afectando severamente al sistema sanitario de diversos países, lo que obliga a tomar medidas alternativas para poder atender a una gran cantidad de pacientes que no pueden acceder a los centros de atención médica. Es por esta razón que se considera como una alternativa la atención domiciliaria para lo cual se debe ser muy riguroso en el cuidado de la persona afectada con COVID 19, ya que, si esto no se realiza de forma adecuada, los demás integrantes del hogar corren el riesgo de contaminarse, lo que incrementaría la saturación de los establecimientos de salud. Indicaciones como la permanencia del enfermo en un solo lugar, el uso de barreras de protección cuando se ingresa a esta área o la constante práctica de la higiene de manos, entre otras medidas, puede encaminar al éxito de este tipo de atención favoreciendo la pronta recuperación del paciente y la preservación de la salud de los demás habitantes del hogar.A atual crise que está causando a doença denominada COVID-19 está afetando gravemente o sistema de saúde de vários países, o que requer outras medidas a serem tomadas para poder atender este grande número de pacientes fora dos centros hospitalares. É por isso que a assistência domiciliar é considerada uma alternativa, para a qual deve ser muito rigorosa com o cuidado do doente, pois se não for realizada de forma adequada os demais membros do domicílio correm o risco de contaminar o que aumentaria a saturação das unidades de saúde. Indicações como a permanência do paciente em um único local, o uso de barreiras protetoras na entrada nesta área ou a prática constante de higienização das mãos, entre outras medidas, podem levar ao sucesso desse tipo de atendimento, favorecendo uma recuperação rápida do paciente e a preservação da saúde dos demais habitantes. &nbsp