Fractal initial conditions and natural parameter values in hybrid inflation

We show that the initial field values required to produce inflation in the two fields original hybrid model, and its supergravity F-term extension, do not suffer from any fine-tuning problem, even when the fields are restricted to be sub-planckian and for almost all potential parameter values. This is due to the existence of an initial slow-roll violating evolution which has been overlooked so far. Due to the attractor nature of the inflationary valley, these trajectories end up producing enough accelerated expansion of the universe. By numerically solving the full non-linear dynamics, we show that the set of such successful initial field values is connected, of dimension two and possesses a fractal boundary of infinite length exploring the whole field space. We then perform a Monte-Carlo-Markov-Chain analysis of the whole parameter space consisting of the initial field values, field velocities and potential parameters. We give the marginalised posterior probability distributions for each of these quantities such that the universe inflates long enough to solve the usual cosmological problems. Inflation in the original hybrid model and its supergravity version appears to be generic and more probable by starting outside of the inflationary valley. Finally, the implication of our findings in the context of the eternal inflationary scenario are discussed.Comment: 16 pages, 16 figures, uses RevTeX. Lyapunov exponents and references added, matches published versio

Les villes-usines face à la problématique environnementale : réflexions à partir de l’exemple de l’agglomération dunkerquoise

Fortement dépendantes de secteurs industriels en déclin ou disparus, les villes-usines sont confrontées depuis quelques années à des problématiques de reconversion et de (ré)attractivité. Dans ce cadre, la dimension environnementale, largement sacrifiée pendant les années de croissance, constitue un enjeu majeur, renforcé encore par la perspective de la transition écologique et sociale. Dans cet article, nous tentons de formuler quelques pistes de réflexion pour esquisser les contours d’une articulation de ces villes-usines à une reconsidération du rôle et de l’importance de l’environnement naturel dans le développement territorial. Pour cela, nous prenons appui sur l’exemple du territoire urbano-industriel de l’agglomération dunkerquoise, dont nous tirons des enseignements mis en perspective avec le cas particulier des villes-usines.Highly dependent on declining or disappeared industrial sectors, company towns have been faced in recent years with problems of renovation and (re)attractiveness. In this context, the environmental dimension, which was largely surrendered during the years of growth, is a major challenge, further reinforced by the perspective of ecological and social transition. In this article, our main objective is to expose some avenues for reflection to outline the contours of an articulation of these company towns with a reconsideration of the role and importance of the natural environment in their territorial development. In fact, we use the example of the urban-industrial territory of Dunkerque (France), from which we draw lessons put into perspective with the particular case of factory towns.Die von rückläufigen oder schwindenden Industriebereichen stark abhängigen Fabrikstädte sind seit einigen Jahren mit Problemen der Umstellung und (Wieder-) Attraktivität konfrontiert. In diesem Zusammenhang stellt die Umweltdimension, die in den Jahren des Wachstums weitgehend geopfert wurde, eine große Herausforderung dar, die durch die Aussicht auf einen ökologischen und sozialen Wandel noch verstärkt wird. In diesem Artikel versuchen wir, einige Gedankengänge zu formulieren, um die Konturen einer Artikulation dieser Fabrikstädte zu skizzieren und die Rolle und Bedeutung der natürlichen Umwelt für die territoriale Entwicklung zu überdenken. Dafür stützen wir uns auf das Beispiel des städtischen Industriegebiets der Agglomeration Dünkirchen, aus dem wir Lehren ziehen, die mit dem besonderen Fall der Fabrikenstädte in Beziehung gesetzt werden

Laminar–turbulent intermittency in pipe flow for an Herschel–Bulkley fluid: Radial receptivity to finite-amplitude perturbations

We investigate the laminar-to-turbulent transition for non-Newtonian Herschel–Bulkley fluids that exhibit either a shear-thinning or shear-thickening behavior. The reduced-order model developed in this study also includes the effect of yield-stress for the fluid. Within our model framework, we investigate how the Newtonian dynamics change when significant non-Newtonian effects are considered either via the flow index n or the yield-stress τ0 or both. We find that an increase in τ0 as well as a decrease in n lead to a delayed transition if a perturbation of the given turbulent intensity is injected at various radial locations. As the radial position of the injection for the perturbation is varied in this study, our reduced-order model allows for the investigation of the flow receptivity to the finite-amplitude perturbations and to their radial position of inception. We observe that, for a given mean flow profile, the same perturbation becomes more prone to induce turbulence the closer it approaches the wall because of its initial amplitude being relatively higher with respect to the local mean flow. An opposite trend is found when the perturbation amplitude is rescaled on the local mean flow

New evidence of a mitochondrial genetic background paradox: Impact of the J haplogroup on the A3243G mutation

International audienceBackground: The A3243G mutation in the tRNALeu gene (UUR), is one of the most common pathogenic mitochondrial DNA (mtDNA) mutations in France, and is associated with highly variable and heterogeneous disease phenotypes. To define the relationships between the A3243G mutation and mtDNA backgrounds, we determined the haplogroup affiliation of 142 unrelated French patients – diagnosed as carriers of the A3243G mutation – by control-region sequencing and RFLP survey of their mtDNAs. Results: The analysis revealed 111 different haplotypes encompassing all European haplogroups, indicating that the 3243 site might be a mutational hot spot. However, contrary to previous findings, we observed a statistically significant underepresentation of the A3243G mutation on haplogroup J in patients (p = 0.01, OR = 0.26, C.I. 95%: 0.08–0.83), suggesting that might be due to a strong negative selection at the embryo or germ line stages. Conclusion: Thus, our study supports the existence of mutational hotspot on mtDNA and a "haplogroup J paradox," a haplogroup that may increase the expression of mtDNA pathogenic mutations, but also be beneficial in certain environmental contexts

OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background

<p>Abstract</p> <p>Background</p> <p>Leber's hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA) are the most frequent forms of hereditary optic neuropathies. LHON is associated with mitochondrial DNA (mtDNA) mutations whereas ADOA is mainly due to mutations in the OPA1 gene that encodes a mitochondrial protein involved in the mitochondrial inner membrane remodeling. A striking influence of mtDNA haplogroup J on LHON expression has been demonstrated and it has been recently suggested that this haplogroup could also influence ADOA expression. In this study, we have tested the influence of mtDNA backgrounds on OPA1 mutations.</p> <p>Methods</p> <p>To define the relationships between OPA1 mutations and mtDNA backgrounds, we determined the haplogroup affiliation of 41 French patients affected by OPA1-related ADOA by control-region sequencing and RFLP survey of their mtDNAs.</p> <p>Results</p> <p>The comparison between patient and reference populations did not revealed any significant difference.</p> <p>Conclusion</p> <p>Our results argue against a strong influence of mtDNA background on ADOA expression. These data allow to conclude that OPA1 could be considered as a "severe mutation", directly responsible of the optic atrophy, whereas OPA1-negative ADOA and LHON mutations need an external factor(s) to express the pathology (i.e. synergistic interaction with mitochondrial background).</p

Mutation Rate Switch inside Eurasian Mitochondrial Haplogroups: Impact of Selection and Consequences for Dating Settlement in Europe

R-lineage mitochondrial DNA represents over 90% of the European population and is significantly present all around the planet (North Africa, Asia, Oceania, and America). This lineage played a major role in migration “out of Africa” and colonization in Europe. In order to determine an accurate dating of the R lineage and its sublineages, we analyzed 1173 individuals and complete mtDNA sequences from Mitomap. This analysis revealed a new coalescence age for R at 54.500 years, as well as several limitations of standard dating methods, likely to lead to false interpretations. These findings highlight the association of a striking under-accumulation of synonymous mutations, an over-accumulation of non-synonymous mutations, and the phenotypic effect on haplogroup J. Consequently, haplogroup J is apparently not a Neolithic group but an older haplogroup (Paleolithic) that was subjected to an underestimated selective force. These findings also indicated an under-accumulation of synonymous and non-synonymous mutations localized on coding and non-coding (HVS1) sequences for haplogroup R0, which contains the major haplogroups H and V. These new dates are likely to impact the present colonization model for Europe and confirm the late glacial resettlement scenario

The DESI survey validation : results from visual inspection of bright galaxies, luminous red galaxies, and emission line galaxies

Funding: TWL was supported by the Ministry of Science and Technology (MOST 111-2112-M-002-015-MY3), the Ministry of Education, Taiwan (MOE Yushan Young Scholar grant NTU-110VV007), National Taiwan University research grants (NTU CC-111L894806, NTU- 111L7318), and NSF grant AST-1911140. DMA acknowledges the Science Technology and Facilities Council (STFC) for support through grant code ST/T000244/1. This research is supported by the Director, Office of Science, Office of High Energy Physics of the U.S. Department of Energy under Contract No. DE–AC02–05CH11231, and by the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility under the same contract; additional support for DESI is provided by the U.S. National Science Foundation, Division of Astronomical Sciences under Contract No. AST-0950945 to the NSF’s National Optical-Infrared Astronomy Research Laboratory; the Science and Technologies Facilities Council of the United Kingdom; the Gordon and Betty Moore Foundation; the Heising-Simons Foundation; the French Alternative Energies and Atomic Energy Commission (CEA); the National Council of Science and Technology of Mexico (CONACYT); the Ministry of Science and Innovation of Spain (MICINN), and by the DESI Member Institutions: https://www.desi.lbl.gov/ collaborating-institutions.The Dark Energy Spectroscopic Instrument (DESI) Survey has obtained a set of spectroscopic measurements of galaxies for validating the final survey design and target selections. To assist these tasks, we visually inspect (VI) DESI spectra of approximately 2,500 bright galaxies, 3,500 luminous red galaxies, and 10,000 emission line galaxies, to obtain robust redshift identifications. We then utilize the VI redshift information to characterize the performance of the DESI operation. Based on the VI catalogs, our results show that the final survey design yields samples of bright galaxies, luminous red galaxies, and emission line galaxies with purity greater than 99%. Moreover, we demonstrate that the precision of the redshift measurements is approximately 10 km/s for bright galaxies and emission line galaxies and approximately 40 km/s for luminous red galaxies. The average redshift accuracy is within 10 km/s for the three types of galaxies. The VI process also helps to improve the quality of the DESI data by identifying spurious spectral features introduced by the pipeline. Finally, we show examples of unexpected real astronomical objects, such as Lyman α emitters and strong lensing candidates, identified by VI. These results demonstrate the importance and utility of visually inspecting data from incoming and upcoming surveys, especially during their early operation phases.Publisher PDFPeer reviewe