802 research outputs found

    Psychological stress factors and salivary cortisol in nursing students throughout their training

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    OBJECTIVE: to analyze psychological stress factors and salivary cortisol concentration in nursing undergraduates throughout their training. METHOD: a cross-sectional, analytical, and comparative study carried out in an evening course using a sociodemographic questionnaire, an Instrument to Assess Stress in Nursing Students, and salivary cortisol analysis. The study included descriptive and comparative analyses and a multiple linear regression model. RESULTS: 187 participants answered the questionnaires, and 129 had their cortisol quantified. The domains Practical Activities Execution, Professional Communication, and Professional Training represented the stress factors with the highest mean values for 3rd, 4th, and 5th-year students compared to 1st and 2nd year. For the 5th year, it was the domains Professional Communication and Professional Training compared to the 3rd year and Environment compared to the 1st and 3rd year. A significant result was obtained between the times of cortisol collections for males (p < 0.0001), females (p < 0.0001), and for 1st (p = 0.0319) 2nd (p = 0.0245), and 5th (p < 0.0001) years. CONCLUSION: Students in years 3 through 5 had higher exposure to stressors, and there were adjustments in cortisol production rhythmicity for students in years 1, 2, and 5

    Apocynin Dietary Supplementation Delays Mouse Ovarian Ageing

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    Advanced maternal age is associated with higher infertility rates, pregnancy-associated complications, and progeny health issues. The ovary is considered the main responsible for these consequences due to a continuous decay in follicle number and oocyte quality. Intracellular imbalance between oxidant molecules and antioxidant mechanisms, in favour of the former, results in oxidative stress (OS) that is believed to contribute to ovarian ageing. This work is aimed at evaluating whether an age-related increase in ovarian OS, inflammation, and fibrosis may contribute to tissue dysfunction and whether specific antioxidant supplementation with a NADPH oxidase inhibitor (apocynin) could ameliorate them. Mice aged 8-12 weeks (reproductively young) or 38-42 weeks (reproductively aged) were employed. Aged mice were divided into two groups, with one receiving apocynin (5 mM) in the drinking water, for 7 weeks, upon which animals were sacrificed and their ovaries collected. Ovarian structure was similar at both ages, but the ovaries from reproductively aged mice exhibited lipofuscin deposition, enhanced fibrosis, and a significant age-related reduction in primordial and primary follicle number when compared to younger animals. Protein carbonylation and nitration, and markers of OS were significantly increased with age. Moreover, mRNA levels of inflammation markers, collagens, metalloproteinases (MMPs), and tissue inhibitor MMPs (TIMPs) were upregulated. Expression of the antifibrotic miRNA29c-3p was significantly reduced. Apocynin supplementation ameliorated most of the age-related observed changes, sometimes to values similar to those observed in young females. These findings indicate that there is an age-related increase in OS that plays an important role in enhancing inflammation and collagen deposition, contributing to a decline in female fertility. Apocynin supplementation suggests that the imbalance can be ameliorated and thus delay ovarian ageing harmful effects.info:eu-repo/semantics/publishedVersio

    A CFD based approach for determination of ammonia concentration profile and flux from poultry houses with natural ventilation

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    The understanding of concentration and emissions distribution of gases such as ammonia (NH3) in agricultural installations is of growing importance due to its effect on health and productivity of animals and workers. The objective of this study was to use validated Computational Fluid Dynamics (CFD) model as a tool to predict NH3 concentration distribution and mass fluxes in a non-insulated broiler chicken installation with natural ventilation, typically found in subtropical and tropical contries. Results from this study indicated that simulation with CFD can be used to predict NH3 concentration distribution and mass flux inside similar installations with incident winds from different directions of entrance at the lateral opening of the installation. The most direct application of the proposed mode would be to help improving the existing buildings and also to help in the conception of new ones, and may also apply the model to help in the development of NH3 emission inventories

    Divergência genética em feijão-caupi em três regiões do Estado do Tocantins a partir de características agronômicas.

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    O objetivo do trabalho foi avaliar a dissimilaridade genética entre genótipos de feijão-caupi cultivado em três regiões distintas do Estado do Tocantins. O delineamento experimental utilizado foi em bloco casualizados com quatro repetições usando vinte genótipos experimentais, sendo quatro cultivares e dezesseis linhagens. Os acessos são divergentes, demonstrando variabilidade moderada, com formação de quatro grupos distintos. O genótipo MNC03-737F-11 foi o mais dissimilar em relação aos demais.CONAC 2012. Disponível em: http://www.conac2012.org/resumos/pdf/203b.pdf. Acesso em: 07 ago. 2013

    Clusters of functional status in COPD: an exploratory analysis

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    Functional status is highly meaningful to the daily life of people with COPD but is often overlooked by treatmentoptions. Understanding its heterogeneity, might contribute to better personalised care. We aimed to explore clustersof functional status in people with COPD. Lung function, impact of the disease, activity-related dyspnoea and functional status were collected cross-sectionally.The 6-minute walk test, 1-minute sit-to-stand test, quadriceps maximum voluntary contraction and handgrip musclestrength were used to group individuals to clusters (K-means clustering). Total within cluster sum of squares wascomputed for different values of k and the optimum number of clusters was defined as the inflexion point on thecurve. Differences between clusters were explored using ANOVA and post-hoc multiple pairwise comparisons. 127 people with COPD (82% male, 68±8 years, FEV1 56±20 %pred) were included in the analysis. 4 clusters werefound (Fig. 1): ‘over-achievers’ (Cluster 2, n=30); ‘achievers’ (Cluster 1, n=28); ‘partial-achievers’ (Cluster 4, n=39);‘non-achievers’ (Cluster 3, n=29). Our 4 clusters of functional status may guide tailored treatment regimens to improve this highly meaningful outcome.Cluster validity, their behaviour over time and differential response to treatment needs further investigation.publishe

    Qualidade Sanitária E Germinação De Sementes De Butia Capitata Tratadas Com Bactericida E Fungicida

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    Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Propagation of “coquinho-azedo” (Butia capitata) is limited due to dormancy and high incidence of fungi in its seeds. The aim of this study was to evaluate the effect of treating “coquinho-azedo” seeds with different concentrations of bactericide and/or fungicide on the incidence of fungi and on the germination of seeds. Thus, B. capitata seeds were immersed in four doses of the bactericide kasugamycin (0, 1.5, 3.0 and 4.5 mL/L) and/or in four concentrations of the fungicide carbendazim+ thiram (0, 2.92, 5.84 e 8.75 mL/ Kg), totaling 16 treatments. After the treatments, the operculum was removed from the seeds, which were placed on trays containing autoclaved sand, covered with transparent plastic film and kept in the nursery. In the germination test, treatments were distributed in randomized block design, factorial arrangement of 4×4 (bactericidal doses × fungicide doses), with four replicates of 50 seeds per plot. For the test of seed health quality, the Blotter test was employed in completely randomized design, using 20 replicates and 10 seeds. Health quality and germination were evaluated at 15 and 40 days after the treatment of seeds, respectively. There was no interaction between the bactericide and the fungicide on germination and control of fungi associated with seeds. However, there was an effect of fungicide concentrations on the evaluated parameters. We observed a negative correlation between the concentrations of the fungicide carbendazim + thiram and fungal incidence, and a positive correlation between the fungicide concentrations and seed germination. Therefore, fungicide treatment reduces the fungal incidence and provides better germination of B. capitata seeds. © 2016, Universidade Estadual Paulista (UNESP). All rights reserved.424303307CNPq, Conselho Nacional de Desenvolvimento Científico e TecnológicoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
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