Orbital Decay of the PSR J0045-7319/B Star Binary System: Age of Radio Pulsar and Initial Spin of Neutron Star

Recent timing observations of PSR J0045-7319 reveal that the neutron star/B star binary orbit is decaying on a time scale of |\Porb/\dot\Porb|=0.5 Myr, shorter than the characteristic age ($\tau_c=3$ Myr) of the pulsar (Kaspi et al.~1996a). We study mechanisms for the orbital decay. The standard weak friction theory based on static tide requires far too short a viscous time to explain the observed \dot\Porb. We show that dynamical tidal excitation of g-modes in the B star can be responsible for the orbital decay. However, to explain the observed short decay timescale, the B star must have some significant retrograde rotation with respect to the orbit --- The retrograde rotation brings lower-order g-modes, which couple much more strongly to the tidal potential, into closer ``resonances'' with the orbital motion, thus significantly enhancing the dynamical tide. A much less likely possibility is that the g-mode damping time is much shorter than the ordinary radiative damping time. The observed orbital decay timescale combined with a generic orbital evolution model based on dynamical tide can be used as a ``timer'', giving an upper limit of $1.4$ Myr for the age of the binary system since the neutron star formation. Thus the characteristic age of the pulsar is not a good age indicator. Assuming standard magnetic dipole braking for the pulsar and no significant magnetic field decay on a timescale \lo 1 Myr, the upper limit for the age implies that the initial spin of the neutron star at birth was close to its current value.Comment: AASTeX, 9 pages, 3 ps figures. ApJ Letters, in pres

Information content of the weak-charge form factor

Parity-violating electron scattering provides a model-independent determination of the nuclear weak-charge form factor that has widespread implications across such diverse areas as fundamental symmetries, nuclear structure, heavy-ion collisions, and neutron-star structure. We assess the impact of precise measurements of the weak-charge form factor of ${}^{48}$Ca and ${}^{208}$Pb on a variety of nuclear observables, such as the neutron skin and the electric-dipole polarizability. We use the nuclear Density Functional Theory with several accurately calibrated non-relativistic and relativistic energy density functionals. To assess the degree of correlation between nuclear observables and to explore systematic and statistical uncertainties on theoretical predictions, we employ the chi-square statistical covariance technique. We find a strong correlation between the weak-charge form factor and the neutron radius, that allows for an accurate determination of the neutron skin of neutron-rich nuclei. We determine the optimal range of the momentum transfer $q$ that maximizes the information content of the measured weak-charge form factor and quantify the uncertainties associated with the strange quark contribution. Moreover, we confirm the role of the electric-dipole polarizability as a strong isovector indicator. Accurate measurements of the weak-charge form factor of ${}^{48}$Ca and ${}^{208}$Pb will have a profound impact on many aspects of nuclear theory and hadronic measurements of neutron skins of exotic nuclei at radioactive-beam facilities.Comment: 10 pages, 4 figure

Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep

Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of intravenously (IV) administered tramadol and its active metabolite O-desmethyltramadol (M1) and to assess the mechanical antinociceptive effects in sheep. In a prospective, randomized, blinded study, six healthy adult sheep were given 4 and 6\u2009mg/kg tramadol and saline IV in a cross-over design with a 2-week wash-out period. At predetermined time points blood samples were collected and physiological parameters and mechanical nociceptive threshold (MNT) values were recorded. The analytical determination of tramadol and M1 was performed using high performance liquid chromatography. Pharmacokinetic parameters fitted a two- and a non-compartmental model for tramadol and M1, respectively. Normally distributed data were analysed by a repeated mixed linear model. Plasma concentration vs. time profiles of tramadol and M1 were similar after the two doses. Tramadol and M1 plasma levels decreased rapidly in the systemic circulation, with both undetectable after 6\u2009h following drug administration. Physiological parameters did not differ between groups; MNT values were not statistically significant between groups at any time point. It was concluded that although tramadol and M1 concentrations in plasma were above the human minimum analgesic concentration after both treatments, no mechanical antinociceptive effects of tramadol were reported. Further studies are warranted to assess the analgesic efficacy of tramadol in sheep

Progress towards a methodology for high throughput 3D reconstruction of soot nanoparticles via electron tomography

The aim of this work is to make progress towards the development of 3D reconstruction as a legitimate alternative to traditional 2D characterisation of soot. Time constraints are the greatest opposition to its implementation, as currently reconstruction of a single soot particle takes around 5-6 hours to complete. As such, the accuracy and detail gains are currently insufficient to challenge 2D characterisation of a representative sample (e.g. 200 particles). This work is a consideration of the optimisation of the steps included within the computational reconstruction and manual segmentation of soot particles. Our optimal process reduced the time required by over 70% in comparison to a typical procedure, whilst producing models with no appreciable decrease in quality

Intense plasma discharge source at 13.5 nm for extreme-ultraviolet lithography

Includes bibliographical references (page 36).We measured an emission of 6 mJ/pulse at 13.5 nm produced by the Li2+ Lyman-α transition excited by a fast capillary discharge, using a lithium hydride capillary. 75% of the energy emanated from a spot size of 0.6 mm. The emission is narrow band and would thus be useful in extreme-ultraviolet lithography imaging systems that use Mo:Si multilayer mirrors. The output within the bandwidth of Mo:Si mirrors was comparable with that of a laser-produced plasma (LPP), and the wall plug efficiency of 0.1% was nearly an order of magnitude better than that of a LPP

Spontaneous supercurrent induced by ferromagnetic pi-junctions

We present magnetization measurements of mesoscopic superconducting niobium loops containing a ferromagnetic (PdNi) pi-junction. The loops are prepared on top of the active area of a micro Hall-sensor based on high mobility GaAs/AlGaAs heterostructures. We observe asymmetric switching of the loop between different magnetization states when reversing the sweep direction of the magnetic field. This provides evidence for a spontaneous current induced by the intrinsic phase shift of the pi-junction. In addition, the presence of the spontaneous current near zero applied field is directly revealed by an increase of the magnetic moment with decreasing temperature, which results in half integer flux quantization in the loop at low temperatures.Comment: 4 pages, 4 figure

A mutate-and-map protocol for inferring base pairs in structured RNA

Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling. This experimental framework has been extensively revisited in the past decade with new strategies for high-throughput read-outs, chemical modification, and rapid data analysis. Recently, we have coupled the technique to high-throughput mutagenesis. Point mutations of a base-paired nucleotide can lead to exposure of not only that nucleotide but also its interaction partner. Carrying out the mutation and mapping for the entire system gives an experimental approximation of the molecules contact map. Here, we give our in-house protocol for this mutate-and-map strategy, based on 96-well capillary electrophoresis, and we provide practical tips on interpreting the data to infer nucleic acid structure.Comment: 22 pages, 5 figure

Hybridly pumped collisional soft X-ray laser in Ne-like sulphur

Includes bibliographical references (page 98).We describe an experiment demonstrating XUV amplification following collisional excitation in a discharge-created plasma waveguide irradiated by a picosecond optical laser pulse. A capillary discharge was used to generate a plasma radiation pipe with a radially concave electron density profile. Temporally resolved transmission characteristics and guiding effect have been measured. An intense short laser pulse rapidly heated the electrons, producing amplification in the 3p1S0-3s 1P1 transition of Ne-like S at 60.84 nm. The integrated gain-length product obtained within a 3 cm active medium with a laser energy of 0.46 J was ~6.8. The pump energy depletion has been analysed as well. This new, hybridly pumped soft X-ray laser with the transient gain offers a new way towards efficient tabletop coherent XUV sources

Volume extreme ultraviolet holographic imaging with numerical optical sectioning

Includes bibliographical references (pages 10622-10623).Three dimensional images were obtained using a single high numerical aperture hologram recorded in a high resolution photoresist with a table top λ = 46.9 nm laser. Gabor holograms were numerically reconstructed over a range of image planes by sweeping the propagation distance in the numerical reconstruction algorithm, allowing numerical optical sectioning. A robust three dimension image of a test object was obtained with numerical optical sectioning, providing a longitudinal resolution of approximately 2 μm and a lateral resolution of 164 nm

Interaction between galectin-3 and cystinosin uncovers a pathogenic role of inflammation in kidney involvement of cystinosis.

Inflammation is involved in the pathogenesis of many disorders. However, the underlying mechanisms are often unknown. Here, we test whether cystinosin, the protein involved in cystinosis, is a critical regulator of galectin-3, a member of the β-galactosidase binding protein family, during inflammation. Cystinosis is a lysosomal storage disorder and, despite ubiquitous expression of cystinosin, the kidney is the primary organ impacted by the disease. Cystinosin was found to enhance lysosomal localization and degradation of galectin-3. In Ctns-/- mice, a mouse model of cystinosis, galectin-3 is overexpressed in the kidney. The absence of galectin-3 in cystinotic mice ameliorates pathologic renal function and structure and decreases macrophage/monocyte infiltration in the kidney of the Ctns-/-Gal3-/- mice compared to Ctns-/- mice. These data strongly suggest that galectin-3 mediates inflammation involved in kidney disease progression in cystinosis. Furthermore, galectin-3 was found to interact with the pro-inflammatory cytokine Monocyte Chemoattractant Protein-1, which stimulates the recruitment of monocytes/macrophages, and proved to be significantly increased in the serum of Ctns-/- mice and also patients with cystinosis. Thus, our findings highlight a new role for cystinosin and galectin-3 interaction in inflammation and provide an additional mechanistic explanation for the kidney disease of cystinosis. This may lead to the identification of new drug targets to delay cystinosis progression