34 research outputs found

    A Cross-Sectional Study: Determining Factors of Functional Independence and Quality of Life of Patients One Month after Having Suffered a Stroke

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    Loss of quality of life (QoL) and functional independence are two of the most common consequences of suffering a stroke. The main objective of this research is to study which factors are the greatest determinants of functional capacity and QoL a month after suffering a stroke so that they can be considered in early interventions

    Reliability and Validity of the Motor Activity Log (MAL-30) Scale for Post-Stroke Patients in a Spanish Sample

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    The validation of assessment instruments is of great importance when they are applied in clinical and healthcare settings, since their safe and reliable use is essential for the application of appropriate and high-quality treatments. The motor activity log (MAL-30) is an instrument widely used by professionals in the clinic, which has been validated in different countries, languages and populations. The aim of this study was to determine the reliability and validity of the MAL-30 scale for post-stroke patients in a Spanish sample.This research was funded by the CaixaBank Foundation (CAIXA-UBU002)

    Memoria del IV Coloquio Internacional sobre Diversidad Cultural y Estudios Regionales

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    Esta memoria del IV Coloquio Internacional sobre Diversidad Cultural y Estudios Regionales: Escenarios de la heterogeneidad, memorias y culturas, realizada por el Centro de Investigaciones sobre Diversidad Cultural y Estudios Regionales, CIDICER, en 2016, compila las ponencias presentadas, las cuales se organizan por ejes temáticos, en 7 apartados: Culturas, Identidades e Imaginarios, Literatura Cultura e Identidades, Estéticas de la Heterogeneidad, Pluriculturalidad y Grupos Minoritarios, Diversidad Cultural e Identidades, Literatura, Identidades y Género.UCR::Sedes Regionales::Sede de Occidente::Recinto San Ramón::Centro de Investigaciones sobre Diversidad Cultural y Estudios Regionales (CIDICER

    Anti-Spike antibodies 3 months after SARS-CoV-2 mRNA vaccine booster dose in patients on hemodialysis: the prospective SENCOVAC study

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    Background: Patients on hemodialysis are at high-risk for complications derived from coronavirus disease 2019 (COVID-19). The present analysis evaluated the impact of a booster vaccine dose and breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on humoral immunity 3 months after the booster dose. Methods: This is a multicentric and prospective study assessing immunoglobulin G anti-Spike antibodies 6 and 9 months after initial SARS-CoV-2 vaccination in patients on hemodialysis that had also received a booster dose before the 6-month assessment (early booster) or between the 6- and 9-month assessments (late booster). The impact of breakthrough infections, type of vaccine, time from the booster and clinical variables were assessed. Results: A total of 711 patients [67% male, median age (range) 67 (20-89) years] were included. Of these, 545 (77%) received an early booster and the rest a late booster. At 6 months, 64 (9%) patients had negative anti-Spike antibody titers (3% of early booster and 29% of late booster patients, P =. 001). At 9 months, 91% of patients with 6-month negative response had seroconverted and there were no differences in residual prevalence of negative humoral response between early and late booster patients (0.9% vs 0.6%, P =. 693). During follow-up, 35 patients (5%) developed breakthrough SARS-CoV-2 infection. Antibody titers at 9 months were independently associated with mRNA-1273 booster (P =. 001), lower time from booster (P =. 043) and past breakthrough SARS-CoV-2 infection (P <. 001). Conclusions: In hemodialysis patients, higher titers of anti-Spike antibodies at 9 months were associated with mRNA-1273 booster, lower time from booster and past breakthrough SARS-CoV-2 infectionThe present project has been supported by Fresenius Medical Care, Diaverum, Vifor Pharma, Vircell, Fundación Renal Iñigo Álvarez de Toledo and ISCIII FEDER funds RICORS2040 (RD21/0005

    Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

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    The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

    Pasados y presente. Estudios para el profesor Ricardo García Cárcel

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    Ricardo García Cárcel (Requena, 1948) estudió Historia en Valencia bajo el magisterio de Joan Reglà, con quien formó parte del primer profesorado de historia moderna en la Universidad Autónoma de Barcelona. En esta universidad, desde hace prácticamente cincuenta años, ha desarrollado una extraordinaria labor docente y de investigación marcada por un sagaz instinto histórico, que le ha convertido en pionero de casi todo lo que ha estudiado: las Germanías, la historia de la Cataluña moderna, la Inquisición, las culturas del Siglo de Oro, la Leyenda Negra, Felipe II, Felipe V, Austrias y Borbones, la guerra de la Independencia, la historia cultural, los mitos de la historia de España... Muy pocos tienen su capacidad para reflexionar, ordenar, analizar, conceptualizar y proponer una visión amplia y llena de matices sobre el pasado y las interpretaciones historiográficas. A su laboriosidad inimitable se añade una dedicación sin límites en el asesoramiento de alumnos e investigadores e impulsando revistas, dosieres, seminarios o publicaciones colectivas. Una mínima correspondencia a su generosidad lo constituye este volumen a manera de ineludible agradecimiento

    Análisis morfométrico de los peces del grupo labialis, género Profundulus (Cyprinodontiformes: Profundulidae), en Chiapas, México Morphometric analysis of the fish included in the labialis group, genus Profundulus (Cyprinodontiformes: Profundulidae), in Chiapas, Mexico

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    Se presentan los resultados de la comparación morfométrica de las especies del "complejo labialis", del género Profundulus, basada en 11 medidas tradicionales y 21 cruzadas. Mediante el análisis de componentes principales y agrupamiento se demostró que Profundulus labialis y P. candalarius muestran un patrón morfológico semejante, caracterizado por mayor altura del cuerpo, menor longitud del hocico, y menor longitud y ancho de la boca; mientras que P. hildebrandi presenta características diferentes. El análisis de varianza mostró 14 medidas morfométricas estadísticamente significativas que permiten separar, por lo menos, a una de las tres especies y además corroboran su validez taxonómica. Las relaciones de similitud establecidas en este análisis concuerdan con las relaciones filogenéticas propuestas por otros autores. Las diferencias encontradas en medidas relacionadas con estructuras tróficas y de la altura del cuerpo podrían estar relacionadas con aspectos ecológicos o asociaciones con distintos hábitats.Results of morphometrical comparison of the species of the "labialis complex", of the genus Profundulus, based on 11 traditional and 21 crossed measures, are herein presented. Through the principal components and cluster analyses we have found that Profundulus labialis and P. candalarius show a similar morphological pattern, characterized by the greater altitude, the shorter snout, and the shorter length and width of the mouth; while P. hildebrandi has the opposite characteristics. The analysis of variance showed 14 statistically different measures that allow to recognize at least one of the three species, and they also corroborate their taxonomical validity. The results of the present analyses of similarities are congruent with the phylogenetic relationships proposed by other authors. Some measurements associated to trophic structures seem to vary according to ecological conditions

    RE<sub>0.01</sub>Sr<sub>0.99</sub>Co<sub>0.5</sub>Fe<sub>0.5</sub>O<sub>3</sub> (RE = La, Pr, and Sm) Cathodes for SOFC

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    This study focuses on the synthesis, characterization, and study of new perovskite-type materials as cathodes in SOFC. The doped perovskites were successfully synthesized with high purity. The electrochemical performance of these materials was extensively examined through the characterization of I-V-P and EIS curves at the three temperatures, 750, 800, and 850 °C, where it reveals a substantial reduction in total resistances, accompanied by an impressive increase in power densities. The cell featuring La0.01Sr0.99Co0.5Fe0.5O3 exhibited the most commendable electrochemical properties at each temperature, following which were SrCo0.5Fe0.5O3, Pr0.01Sr0.99Co0.5Fe0.5O3, and Sm0.01Sr0.99Co0.5Fe0.5O3

    A Cross-Sectional Study: Determining Factors of Functional Independence and Quality of Life of Patients One Month after Having Suffered a Stroke

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    (1) Background: loss of quality of life (QoL) and functional independence are two of the most common consequences of suffering a stroke. The main objective of this research is to study which factors are the greatest determinants of functional capacity and QoL a month after suffering a stroke so that they can be considered in early interventions. (2) Methods: a cross-sectional study was conducted which sample consisted of 81 people who had previously suffered a stroke. The study population was recruited at the time of discharge from the Neurology Service and Stroke Unit of the hospitals of Burgos and Córdoba, Spain, through a consecutive sampling. Data were collected one month after participants experienced a stroke, and the main study variables were quality of life, measured with the Stroke-Specific Quality of Life Measure (NEWSQOL), and functional independence, measured with the Functional Independence Measure-Functional Assessment Measure (FIM-FAM). (3) Results: the factors associated with a worse QoL and functional capacity one month after having suffered a stroke were living in a different dwelling than the usual flat or house (p p p p = 0.048). (4) Conclusions: the type of dwelling, age, cognitive ability and functional capacity of the affected upper limb are determining aspects in functional independence and QoL during the first weeks after a stroke
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