LAP6/WVU system outline

Operating manual for additional memory for PDP 12 and LINC 8 computer

Surgical Care of the Lower Extremity in Rheumatoid Arthritis

One of the most important things for the physician to recognize in referring a patient to the orthopedic surgeon for treatment of rheumatoid arthritis is the goal of surgical correction. The primary goal in surgical treatment of diseased joints in the lower extremity is relief of pain. Some pain-free patients have such severe deformities that a surgical procedure may be undertaken in order to improve and restore function, accepting certain calculated risks; however, to improve function surgically in a pain-free joint requires complete and full understanding on the part of the patient as well as the physician

Cryptic diversity and database errors challenge non-indigenous species surveys: An illustration with Botrylloides spp. in the English Channel and Mediterranean Sea

Molecular tools have been extensively used in recent decades to examine biological invasion processes, and are increasingly being adopted as efficient tools to support non-indigenous species surveys, notably through barcoding approaches, i.e., the use of a reference sequence specific to a given species to validate its identification. The technique is easy to use but requires reliable reference sequences to be available in public databases. In addition, the increasing discovery of cryptic species in marine taxa may complicate taxonomic assignment. We illustrate these two issues in the ascidian genus Botrylloides, in which at least three global marine invaders have been recognized, including B. violaceus and B. diegensis. We obtained COI sequences from >750 colonies of Botrylloides spp. sampled in W Europe or provided by expert colleagues from other regions. Phylogenetic trees clearly distinguished our targeted taxa [i.e., B. violaceus, B. diegensis and B. leachii (native)]. They also revealed another discrete lineage apparently related to a recently described eastern Mediterranean species. By examining public databases, we found sequences of B. diegensis erroneously assigned to B. leachii. This observation has major implications as the introduced B. diegensis can be misidentified as a putatively native species. We also checked published sequences of the genus Botrylloides in the Mediterranean Sea, complemented with new samples. Based on our custom reference database, all published sequences of B. leachii corresponded to B. diegensis, although this NIS has hardly been reported at all in the Mediterranean region. Such database errors are unfortunate, as the barcoding approach is a powerful tool to identify the recognized Botrylloides species currently present in European seas. This is of particular importance because a trait often used during field assessment, i.e., single-color vs. two-color colonies, is misleading to distinguish B. violaceus and B. diegensis respectively: a substantial proportion of the single-color morph are actually B. diegensis in both the Mediterranean Sea and the English Channel. Altogether, this study exemplifies the advantages and disadvantages of molecular barcoding in NIS surveys and studies. The limitations that were identified are all easy to resolve once proper vouchers and collections are set up

Radicchio : chemistry composition during refrigerated storage

El radicchio (Cichorium intybus, L.) tipo Chioggia o Veneciano -también llamado endibia roja- pertenece a la familia de la achicoria. Por sus óptimas características nutricionales: vitaminas y calcio, y buenas características organolépticas: textura firme, es incorporable en una amplia gama de comidas o industrializable. Sus hojas tienen acciones digestiva, depurativa y diurética estimulando la función hepática. Procedente del NE de Italia ha comenzado a difundirse debido a su adaptabilidad a diferentes condiciones de clima y suelo. El presente trabajo tuvo como objetivo determinar la variación de la composición química en cámara frigorífica a 0 °C y 90 % HR. Los análisis realizados fueron: • sólidos solubles • pH • vitamina C • acidez • ß-carotenos • cenizas • humedad • azúcares • caracteres organolépticos Sólo se observaron variaciones en los contenidos de vitamina C y ß-carotenos, que disminuyeron durante la conservación frigorífica manteniendo sin cambios notables las características organolépticas. Consecuentemente, el valor nutritivo del radicchio evolucionó favorablemente durante la conservación frigorífica, si bien hubo pérdida de vitamina por oxidación.The study of radicchio consisted in analytical determinations, to stablish the chemistry composition of this vegetable during storage in refrigerating room to 0 °C and 90 % RH. The radicchio (Cichorium intybus L.), also known as "red endive", belongs to the group of chicory and represented an exclusivity of the NE of Italy, till many years ago. This vegetable was considered important by its good nutritive characteristics (rich in vitamins, calcium), its firm texture, adaptability to different climate conditions and soils. The leaves have digestive, depurative action, estimulates the hepatic function and they are diuretic. Owing to its organoleptic characteristics, it permits to obtain a great variety of meals and can industrialize of different ways. The analysis done were: organoleptic characteristics, soluble solids, vitamin C, ß-carotenes, moisture, pH, acidity, ashes, sugars. It was observed variations in the vitamin C and ßcarotenes content, because they decrease during refrigerated storage; the organoleptic characteristics were maintained in very good conditions. Finally, we can say that radicchio envolved favorably respect its nutritive value during refrigerated storage, although there was vitamin losses by oxidation.Fil: Bauzá, Mónica. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Guinle, Viviana C.. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Roby, Héctor R.. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Winter, Patricia L.. Universidad Nacional de Cuyo. Facultad de Ciencias Agraria

Inclusive Human Intention Prediction with Wearable Sensors: Machine Learning Techniques for the Reaching Task Use Case †

Human intentions prediction is gaining importance with the increase of human-robot interaction challenges in several contexts, like industrial and clinical. This paper compares Linear Discriminant Analysis (LDA) and Random Forest (RF) performance in predicting the intention of moving towards a target during reaching movements, on ten subjects wearing four electromagnetic sensors. LDA and RF prediction accuracy is compared with respect to observation-sample dimension and noise presence, training and prediction time. Both algorithms achieved good accuracy, which improves as the sample dimension increases, although LDA presents better results for the current dataset

Human Dermal Microvascular Endothelial Cells Produce Matrix Metalloproteinases in Response to Angiogenic Factors and Migration

Matrix metalloproteinases (MMPs) are a family of inducible enzymes that degrade extracellular matrix components, allowing cells to traverse connective tissue structures efficiently. Specific tissue inhibitors (TIMPs) function as physiologic inhibitors of MMP activity. Because neovascularization may require various proteinases, we characterized the profile of metalloenzyme production by microvascular endothelial cells (MEC) and the modulation of expression by phorbol esters (PMA) and by the physiologically relevant cytokines tumor necrosis factor-α (TNF-α), basic fibroblast growth factor, and interferon-γ. MMP expression by MEC and large-vessel human umbilical vein endothelial cells (HUVEC) was determined by enzyme-linked immunosorbent assay, immunoprecipitation, Northern hybridization, and transfection assays. Constitutive expression of MMPs by endothelial cells was low. PMA stimulated the production of collagenase, stromelysin, 92-kDa gelatinase, and TIMP-1 in both endothelial cell types. TIMP-2 was constitutively expressed by MEC and HUVEC, but was down-regulated by PMA. TNF-α induced an endothelial-cell-specific up-regulation of collagenase with a concomitant inhibition of PMA-induced TIMP-1 up-regulation, a response that is distinct from that of fibroblasts. Interferon-γ up-regulated TIMP-1 production by MEC and blocked PMA and TNT-induced up-regulation of collagenase. Northern hybridization assays showed pretranslational control of PMA-, basic fibroblast growth factor-, and TNF-α–induced MM.P expression. Collagenase-promoter CAT constructs containing 2.28 kb of the 5' region of the collagenase gene demonstrated transcriptional regulation. The potential physiologic relevance of such regulation was shown in an in vitro migration assay. MEC were stimulated to migrate by wounding and exposure to TNF-α. Collagenase mRNA was prominently expressed by the migrating cells, as shown by in situ hybridization. In sum, MEC have a unique profile of MMP expression and regulation compared with other cell types, which may be important for wound healing and angiogenesis, particularly during the early phase of migration

Access to Care and Cardiovascular Disease Prevention: A Cross-Sectional Study in 2 Latino Communities.

Cardiovascular disease (CVD) is the leading killer of Americans. CVD is understudied among Latinos, who have high levels of CVD risk factors. This study aimed to determine whether access to health care (ie, insurance status and having a usual source of care) is associated with 4 CVD prevention factors (ie, health care utilization, CVD screening, information received from health care providers, and lifestyle factors) among Latino adults and to evaluate whether the associations depended on CVD clinical risk/disease.Data were collected as part of a community-engaged food environment intervention study in East Los Angeles and Boyle Heights, CA. Logistic regressions were fitted with insurance status and usual source of care as predictors of the 4 CVD prevention factors while controlling for demographics. Analyses were repeated with interactions between self-reported CVD clinical risk/disease and access to care measures.Access to health care significantly increased the odds of CVD prevention. Having a usual source of care was associated with all factors of prevention, whereas being insured was only associated with some factors of prevention. CVD clinical risk/disease did not moderate any associations.Although efforts to reduce CVD risk among Latinos through the Affordable Care Act could be impactful, they might have limited impact in curbing CVD among Latinos, via the law's expansion of insurance coverage. CVD prevention efforts must expand beyond the provision of insurance to effectively lower CVD rates

Review of upper limb kinematics after cervical spinal cord injury: Implications for rehabilitation

IntroductionThe aim of this literature review is to provide a clear understanding of motor control and kinematic changes during open-chain upper limb (UL) movements after tetraplegia.MethodUsing data from MEDLINE between 1966 and August 2014, we investigated kinematic UL studies after tetraplegia.ResultsWe included fourteen control case and three series case studies with a total of 161 SCI participants and 126 healthy control participants. SCI participants efficiently perform a broad range of tasks with their UL This is achieved by effective scapulothoracic and glenohumeral compensation which provide a dynamic mechanical coupling between the shoulder and elbow joints thus palliating elbow extension despite triceps brachii paralysis. The mechanism is incomplete, however, since C5-C6 SCI individuals are forced to reduce overhead workspace to keep the elbow extended and to maintain the mechanical dynamic interaction between the shoulder and elbow. Furthermore, motion slowing is a clear kinematic characteristic, caused by:– decreased strength;– triceps brachii paralysis disrupting normal agonist-antagonist co-contraction;– accuracy requirements at movement endpoint;– grasping.Grasping requires a prolonged deceleration phase during transport to ensure hand placement with respect to the to-be-grasped object then wrist extension during grasping to elicit either whole hand or lateral grip. Contrary to the normal pattern, where grasping is prepared during the transport phase, SCI individuals transport the wrist in flexion leading to passive finger opening that did not attest a grip preparation particularly if object size is greater than maximal grip aperture. The pattern (wrist flexed then extended) indicates that reaching and grasping are performed consecutively suggesting that these two phases are independent. Elbow extension restoration causes increased elbow stiffness resulting in increased movement velocity, reduced need for glenohumeral compensation, and overall improved motor control.ConclusionRehabilitation and surgical restoration should take these kinematic characteristics into account to reinforce proximal and distal compensations allowing elbow extension and grasp using tenodesis and consequently favoring greater autonomy of individuals after SCI

Influenza-like illness in acute myocardial infarction patients during the winter wave of the influenza A H1N1 pandemic in London: a case-control study.

OBJECTIVE: To investigate recent respiratory and influenza-like illnesses (ILIs) in acute myocardial infarction patients compared with patients hospitalised for acute non-vascular surgical conditions during the second wave of the 2009 influenza A H1N1 pandemic. DESIGN: Case-control study. SETTING: Coronary care unit, acute cardiology and acute surgical admission wards in a major teaching hospital in London, UK. PARTICIPANTS: 134 participants (70 cases and 64 controls) aged ≥40 years hospitalised for acute myocardial infarction and acute surgical conditions between 21 September 2009 and 28 February 2010, frequency-matched for gender, 5-year age-band and admission week. PRIMARY EXPOSURE: ILI (defined as feeling feverish with either a cough or sore throat) within the last month. SECONDARY EXPOSURES: Acute respiratory illness within the last month not meeting ILI criteria; nasopharyngeal and throat swab positive for influenza virus. RESULTS: 29 of 134 (21.6%) participants reported respiratory illness within the last month, of whom 13 (9.7%) had illnesses meeting ILI criteria. The most frequently reported category for timing of respiratory symptom onset was 8-14 days before admission (31% of illnesses). Cases were more likely than controls to report ILI-adjusted OR 3.17 (95% CI 0.61 to 16.47)-as well as other key respiratory symptoms, and were less likely to have received influenza vaccination-adjusted OR 0.46 (95% CI 0.19 to 1.12)-although the differences were not statistically significant. No swabs were positive for influenza virus. CONCLUSIONS: Point estimates suggested that recent ILI was more common in patients hospitalised with acute myocardial infarction than with acute surgical conditions during the second wave of the influenza A H1N1 pandemic, and influenza vaccination was associated with cardioprotection, although the findings were not statistically significant. The study was underpowered, partly because the age groups typically affected by acute myocardial infarction had low rates of infection with the pandemic influenza strain compared with seasonal influenza

Garlic cv. colorado : post-harvest handling

Para mantener la calidad de los ajos, evitando principalmente las pérdidas postcosecha por brotación, ataque de agentes patógenos y evaporación de agua, se consideraron distintas modalidades de conservación: tradicional, a campo en caballete; en galpón y en frigorífico a 10, 0 y -3 °C. El ensayo duró 9 meses a partir de la cosecha. Durante el mismo se analizaron los bulbos colocados en cada modalidad de conservación, comparando: % de defectos, índice de brotación, color, pérdida de peso, sólidos totales, humedad, cenizas, acidez, pH y sólidos solubles. • Porcentaje de defectos: al noveno mes y temperaturas de 0 °C y -3 °C, presentaban 70 y 62 %, respectivamente, de ajo en buenas condiciones. • Índice visual de superación de dormición: al séptimo mes y -3 °C la media fue 34,56 %. A 0 °C, 83,33 %. • Peso: su pérdida fue menor en los últimos meses de conservación a -3 °C. En consecuencia, para un período corto de conservación (hasta 3 meses, dependiendo de las condiciones ambientales) son utilizables las modalidades campo o galpón. Para períodos más largos, es conveniente usar refrigeración a 0 °C, o mejor -3 °C, condición en la cual los ajos no brotaron.Different storage modalities were considered: traditional (field conditions); in shed and cold storage room to 10 °C, 0 °C and -3 °C, in order to maintain the garlics with high quality avoiding the post-harvest losses owing to budding, pathogens damage and water evaporation. The study had a duration of 9 months after harvest, and the bulbs belong to every storage modality were analyzed, comparing: % of defect, budding index, color, weight loss, total solids, moisture, ashes, acidity, pH, soluble solids. • Respect % of deffects: it is differentiated the modalities to 0 °C and -3 °C, which at the ninth month from harvest presented 70 and 62 % respectively of garlic in good conditions. • Dormancy overcome visual index: where the storage to -3 °C presented to seventh month a mean of 34,56 %, while to 0 °C was of 83,33 %. • Weight: in the last months of storage, the modality -3 °C was which shows the least loss. We can conclude that for short periods of storage (till 3 month, depending of weather conditions) are possible to use the sheld or field modalities and for longer periods is convenient to use cold storage, temperatures of 0 °C or better -3 °C, in which case budding was not observed.Fil: Giménez, Adriana B.. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Araniti, Elena V. . Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Guinle, Viviana C.. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Roby, Héctor R.. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Llera, Joaquín. Universidad Nacional de Cuyo. Facultad de Ciencias AgrariasFil: Winter, Patricia. Universidad Nacional de Cuyo. Facultad de Ciencias Agraria