Procrastinación académica y estrés académico en estudiantes universitarios violentados de Piura, 2022

La presente investigación tuvo como finalidad determinar la relación entre la procrastinación académica y el estrés académico en estudiantes universitarios violentados. Para esto la investigación se realizó bajo un enfoque cuantitativo, con un diseño no experimental, transversal, de alcance correlacional, aplicando instrumentos debidamente validados a una muestra de 377 estudiantes de una universidad privada de Piura. En conclusión, se determinó la asociación entre la procrastinación académica y el estrés académico en estudiantes universitarios violentados de Piura, encontrándose que sí existe relación entre ambas variables con un grado de correlación del 23% (0.227) y un nivel de significancia estadística de 0.000 (< 0.05)

Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing.

It is critical to identify biomarkers and functional networks associated with aggressive thyroid cancer to anticipate diseaseprogression and facilitate personalized patient management. We performed miRNome sequencing of 46 thyroid tumorsenriched with advanced disease patients with a median follow-up of 96 months. MiRNome profiles correlated with tumor-specific histopathological and molecular features, such as stromal cell infiltration and tumor driver mutation. Differentialexpression analysis revealed a consistent hsa-miR-139-5p downexpression in primary carcinomas from patients withrecurrent/metastatic disease compared to disease-free patients, sustained in paired local metastases and validated in publiclypost-print1,62 M

Recensiones [Revista de Historia Económica Año XVII Primavera-Verano 1999 n. 2 pp. 465-494]

Editada en la Fundación Empresa PúblicaE. Torres Villanueva. Ramón de la Sota, 1857-1936. Un empresario vasco (Por Mercedes Cabrera).-- S. López García y J. M. Valdaliso (eds). ¿Que inventen ellos? Tecnología, empresa y cambio económico en la España contemporánea (Por José M.Ortiz-Villajes).-- J. M. Zaratiegui. Caballeros y empresarios. El hombre de negocios Victoriano (Por Juan Manuel Mates Barco).-- M. Arroyo Huguet. La industria del gas en Barcelona, 1841-1933 (Por Carlos Larrinaga Rodríguez).-- M. Seoane. El burgués maldito. La historia secreta de José Ber Gelbard (Por Raúl García Heras).-- J. A. Miranda Encarnación. La industria del calzado en España (1860-1959) (Por Mar Cebrián).-- J. M. Valdaliso. La navegación regular de cabotaje en España en los siglos XIX y XX (Por Richard Sicotte).-- J. R. Modesto Alapont. A ús i costum de bon llamador L'arrendament de terres a l'Horta de Valencia, 1780-1860 (Por Ricardo Robledo).-- I. Iriarte Goñi. Bienes comunales y capitalismo agrario en Navarra, 1855-1935 (Por Antonio Miguel Linares).-- T. Tortella. Los primeros billetes españoles: las «cédulas» del Banco de San Carlos (1782-1829) (Por Pablo Martín Aceña)Publicad

El papel del farmacéutico en la cistitis

La infección del tracto urinario (ITU), con sus múltiples presentaciones clínicas, está entre las enfermedades infecciosas más frecuentes, tanto en pacientes ambulatorios como en pacientes hospitalizados. Esta patología suele afectar más a las mujeres debido a sus condiciones anatómicas y hormonales. Existen diversas estrategias para la prevención de estas infecciones, en las cuales jugará un papel muy importante el consejo farmacéutico en la farmacia comunitaria. En cuanto al tratamiento, existen distintos cuadros clínicos que requerirán diferentes duraciones de terapia antibiótica. Tanto el exceso como el defecto deberán evitarse. A lo largo de este trabajo hablaremos de los síntomas, antecedentes, prevención y tratamiento de estas infecciones, centrándonos sobre todo en la cistitis recurrente y en el uso de las plantas medicinales para su profilaxis

Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells

Pheochromocytomas and paragangliomas (PPGLs) with activated pseudohypoxic pathways are associated with an immature catecholamine phenotype and carry a higher risk for metastasis. For improved understanding of the underlying mechanisms we investigated the impact of hypoxia and pseudohypoxia on catecholamine biosynthesis in pheochromocytoma cells naturally lacking Hif2α (MPC and MTT) or expressing both Hif1α and Hif2α (PC12). Cultivation under extrinsic hypoxia or in spheroid culture (intrinsic hypoxia) increased cellular dopamine and norepinephrine contents in all cell lines. To distinguish further between Hif1α- and Hif2α-driven effects we expressed Hif2α in MTT and MPC-mCherry cells (naturally lacking Hif2α). Presence of Hif2α resulted in similarly increased cellular dopamine and norepinephrine under hypoxia as in the control cells. Furthermore, hypoxia resulted in enhanced phosphorylation of tyrosine hydroxylase (TH). A specific knockdown of Hif1α in PC12 diminished these effects. Pseudohypoxic conditions, simulated by expression of Hif2α under normoxia resulted in increased TH phosphorylation, further stimulated by extrinsic hypoxia. Correlations with PPGL tissue data led us to conclude that catecholamine biosynthesis under hypoxia is mainly mediated through increased phosphorylation of TH, regulated as a short-term response (24-48 h) by HIF1α. Continuous activation of hypoxia-related genes under pseudohypoxia leads to a HIF2α-mediated phosphorylation of TH (permanent status).Funding: This research was funded by the Deutsche Forschungsgemeinschaft (DFG) within the CRC/Transregio205/1 (project number: 314061271-TRR 205), Project No. B12 (N.B. and G.E.), Project No. B10 (S.R., J.P. and M.U.)and Project No. S01 (A.W., C.G. and M.P.) “The Adrenal: Central Relay in Health and Disease“, and by theParadi erence Foundation (N.B., I.P., S.R. and G.E.).S

Multiclassifier Systems for Predicting Neurological Outcome of Patients with Severe Trauma and Polytrauma in Intensive Care Units

[EN]This paper presents an ensemble based classification proposal for predicting neurological outcome of severely traumatized patients. The study comprises both the whole group of patients and a subgroup containing those patients suffering traumatic brain injury (TBI). Data was gathered from patients hospitalized in the Intensive Care Unit (ICU) of the University Hospital in Salamanca. Predictive models were induced from both epidemiologic and clinical variables taken at the emergency room and along the stay in the ICU. The large number of variables leads to a low accuracy in the classifiers even when feature selection methods are used. In addition, the presence of a much larger number of instances of one of the classes in the subgroup of TBI patients produces a significantly lesser precision for the minority class

Agriculture, Forestry and Other Land Use (AFOLU)

Agriculture, Forestry, and Other Land Use (AFOLU) is unique among the sectors considered in this volume, since the mitigation potential is derived from both an enhancement of removals of greenhouse gases (GHG), as well as reduction of emissions through management of land and livestock (robust evidence; high agreement). The land provides food that feeds the Earth’s human population of ca. 7 billion, fibre for a variety of purposes, livelihoods for billions of people worldwide, and is a critical resource for sustainable development in many regions. Agriculture is frequently central to the livelihoods of many social groups, especially in developing countries where it often accounts for a significant share of production. In addition to food and fibre, the land provides a multitude of ecosystem services; climate change mitigation is just one of many that are vital to human well-being (robust evidence; high agreement). Mitigation options in the AFOLU sector, therefore, need to be assessed, as far as possible, for their potential impact on all other services provided by land. [Section 11.1

Missed clinical clues in patients with pheochromocytoma/paraganglioma discovered by imaging

CONTEXT: Pheochromocytomas and paragangliomas (PPGLs) are rare but potentially harmful tumors that can vary in their clinical presentation. Tumors may be found due to signs and symptoms, as part of a hereditary syndrome or following an imaging procedure. OBJECTIVE: To investigate potential differences in clinical presentation between PPGLs discovered by imaging (iPPGLs), symptomatic cases (sPPGLs) and those diagnosed during follow-up because of earlier disease/known hereditary mutations (fPPGL). DESIGN: Prospective study protocol, which has enrolled patients from 6 European centers with confirmed PPGLs. SETTING AND PATIENTS: Data were analyzed from 235 patients (37% iPPGLs, 36% sPPGLs, 27% fPPGLs) and compared for tumor volume, biochemical profile, mutation status, presence of metastases and self-reported symptoms. RESULTS: iPPGL patients were diagnosed at a significantly higher age than fPPGLs (p<0.001), found to have larger tumors (p=0.003) and higher metanephrine and normetanephrine levels at diagnosis (p=0.021). Significantly lower than in sPPGL, there was a relevant number of self-reported symptoms in iPPGL (2.9 vs. 4.3 symptoms, p<0.001). In 16.2% of iPPGL, mutations in susceptibility genes were detected, although this proportion was lower than in fPPGL (60.9%) and sPPGL (21.5%). CONCLUSIONS: Patients with PPGLs detected by imaging were older, have higher tumor volume and more excessive hormonal secretion in comparison to those found as part of a surveillance program. Presence of typical symptoms indicates that in a relevant proportion of those patients the PPGL diagnosis had been delayed. Précis: Pheochromocytoma/paraganglioma discovered by imaging are often symptomatic and carry a significant proportion of germline mutations in susceptibility genes.The research leading to these results has received funding from the following sources: The Seventh Framework Programme (FP7/2007–2013) under grant agreement n° 259735 awarded to F B, H T and G E. The study has further been supported by the Deutsche Forschungsgemeinschaft (DFG) within the CRC/Transregio 205/1 ‘The Adrenal: Central Relay in Health and Disease’ to M F, M R, J L, G E, and F B. The authors are grateful to all patients who participated in this research and to Christina Brugger, Katharina Langton and Denise Kaden for excellent technical assistance.S

Genetic and clinical characterization of a novel FH founder mutation in families with hereditary leiomyomatosis and renal cell cancer syndrome

Common ancestor; Hereditary leiomyomatosis; Renal cell cancerAvantpassat comú; Leiomiomatosi hereditària; Càncer de cèl·lules renalsAncestro común; Leiomiomatosis hereditaria; Cáncer de células renalesBackground Hereditary leiomyomatosis and renal cell cancer syndrome is a rare autosomal dominant hereditary syndrome. Previously, we published the largest cohort of FH mutation carriers in Spain and observed a highly recurrent missense heterozygous variant, FH(NM_000143.4):c.1118A > G p.(Asn373Ser), in 104 individuals from 31 apparently unrelated families. Here, we aimed to establish its founder effect and characterize the associated clinical phenotype. Results Haplotype analysis confirmed that families shared a common haplotype (32/38 markers) spanning 0.61–0.82 Mb, indicating this recurrent variant was inherited from a founder ancestor. Cutaneous and uterine leiomyomatosis were diagnosed in 64.6% (64/99) and 98% (50/51) of patients, respectively, and renal cell cancer was present in 10.4% (10/96). The pathogenic FH_c.1118A > G variant is a Spanish founder mutation that originated 12–26 generations ago. We estimate that the variant may have appeared between 1370 and 1720. Individuals carrying this founder mutation had similar frequency of renal cell cancer and a higher frequency of renal cysts and leiomyomas than those in other cohorts of this syndrome. Conclusions In the Spanish province of Alicante there is a high prevalence of HLRCC because of the founder mutation FH c.1118A > G; p.(Asn373Ser). The characterization of founder mutations provides accurate and specific information regarding their penetrance and expressivity. In individuals with suspected HLRCC from the province of Alicante, genetic testing by direct analysis of the founder FH c.1118A > G; p.(Asn373Ser) mutation may be a faster and more efficient diagnostic tool compared with complete gene sequencing.Project founded by Spanish Society of Medical Oncology Foundation (FSEOM). SEOM + 1 Grant (UGP-19-428)