Generating analysis topology using virtual topology operators

AbstractVirtual topology operations have been utilized to generate an analysis topology definition suitable for downstream mesh generation. Detailed descriptions are provided for virtual topology merge and split operations for all topological entities, where virtual decompositions are robustly linked to the underlying geometry. Current virtual topology technology is extended to allow the virtual partitioning of volume cells. A valid description of the topology, including relative orientations, is maintained which enables downstream interrogations to be performed on the analysis topology description, such as determining if a specific meshing strategy can be applied to the virtual volume cells. As the virtual representation is a true non-manifold description of the sub-divided domain the interfaces between cells are recorded automatically. Therefore, the advantages of non-manifold modelling are exploited within the manifold modelling environment of a major commercial CAD system without any adaptation of the underlying CAD model. A hierarchical virtual structure is maintained where virtual entities are merged or partitioned. This has a major benefit over existing solutions as the virtual dependencies here are stored in an open and accessible manner, providing the analyst with the freedom to create, modify and edit the analysis topology in any preferred sequence

Parametric design velocity computation for CAD-based design optimization using adjoint methods

This paper presents an efficient optimization process, where the parameters defining the features in a feature-based CAD model are used as design variables. The process exploits adjoint methods for the computation of gradients, and as such the computational cost is essentially independent of the number of design variables, making it ideal for optimization in large design spaces. The novelty of this paper lies in linking the adjoint surface sensitivity information with geometric sensitivity values, referred to as design velocities, computed for CAD models created in commercial CAD systems (e.g. CATIA V5 or Siemens NX)

The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.

Blocking the bioactivity of allergens is conceptually attractive as a small-molecule therapy for allergic diseases but has not been attempted previously. Group 1 allergens of house dust mites (HDM) are meaningful targets in this quest because they are globally prevalent and clinically important triggers of allergic asthma. Group 1 HDM allergens are cysteine peptidases whose proteolytic activity triggers essential steps in the allergy cascade. Using the HDM allergen Der p 1 as an archetype for structure-based drug discovery, we have identified a series of novel, reversible inhibitors. Potency and selectivity were manipulated by optimizing drug interactions with enzyme binding pockets, while variation of terminal groups conferred the physicochemical and pharmacokinetic attributes required for inhaled delivery. Studies in animals challenged with the gamut of HDM allergens showed an attenuation of allergic responses by targeting just a single component, namely, Der p 1. Our findings suggest that these inhibitors may be used as novel therapies for allergic asthma

Investigation of attentional bias in obsessive compulsive disorder with and without depression in visual search

Copyright: © 2013 Morein-Zamir et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedWhether Obsessive Compulsive Disorder (OCD) is associated with an increased attentional bias to emotive stimuli remains controversial. Additionally, it is unclear whether comorbid depression modulates abnormal emotional processing in OCD. This study examined attentional bias to OC-relevant scenes using a visual search task. Controls, non-depressed and depressed OCD patients searched for their personally selected positive images amongst their negative distractors, and vice versa. Whilst the OCD groups were slower than healthy individuals in rating the images, there were no group differences in the magnitude of negative bias to concern-related scenes. A second experiment employing a common set of images replicated the results on an additional sample of OCD patients. Although there was a larger bias to negative OC-related images without pre-exposure overall, no group differences in attentional bias were observed. However, OCD patients subsequently rated the images more slowly and more negatively, again suggesting post-attentional processing abnormalities. The results argue against a robust attentional bias in OCD patients, regardless of their depression status and speak to generalized difficulties disengaging from negative valence stimuli. Rather, post-attentional processing abnormalities may account for differences in emotional processing in OCD.Peer reviewedFinal Published versio

Decomposing complex thin-walled CAD models for hexahedral-dominant meshing

AbstractThis paper describes an automatic method for identifying thin-sheet regions (regions with large lateral dimensions relative to the thickness) for complex thin walled components, with a view to using this information to guide the hex meshing process. This fully automated method has been implemented in a commercial CAD system (Siemens NX) and is based on the interrogation and manipulation of face pairs, which are sets of opposing faces bounding thin-sheet regions. Careful consideration is given to the mapping, merging and intersection of face pairs to generate topologies suitable for sweep meshing thin-sheet regions, and for treating the junctions between adjacent thin-sheet regions. The quality of the resulting hexahedral mesh is considered when making decisions on the generation and positioning of the cutting surfaces required to isolate thin-sheet regions. The resulting decomposition delivers a substantial step towards automatic hexahedral meshing for complex thin-walled geometries. It is proposed that hexahedral meshes be applied to the identified thin-sheet regions by quad meshing one of the faces bounding the thin-sheet region and sweeping it through the thickness to create hexahedral elements