Home on the Range: Factors Explaining Partial Migration of African Buffalo in a Tropical Environment

Partial migration (when only some individuals in a population undertake seasonal migrations) is common in many species and geographical contexts. Despite the development of modern statistical methods for analyzing partial migration, there have been no studies on what influences partial migration in tropical environments. We present research on factors affecting partial migration in African buffalo (Syncerus caffer) in northeastern Namibia. Our dataset is derived from 32 satellite tracking collars, spans 4 years and contains over 35,000 locations. We used remotely sensed data to quantify various factors that buffalo experience in the dry season when making decisions on whether and how far to migrate, including potential man-made and natural barriers, as well as spatial and temporal heterogeneity in environmental conditions. Using an information-theoretic, non-linear regression approach, our analyses showed that buffalo in this area can be divided into 4 migratory classes: migrants, non-migrants, dispersers, and a new class that we call “expanders”. Multimodel inference from least-squares regressions of wet season movements showed that environmental conditions (rainfall, fires, woodland cover, vegetation biomass), distance to the nearest barrier (river, fence, cultivated area) and social factors (age, size of herd at capture) were all important in explaining variation in migratory behaviour. The relative contributions of these variables to partial migration have not previously been assessed for ungulates in the tropics. Understanding the factors driving migratory decisions of wildlife will lead to better-informed conservation and land-use decisions in this area

IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation

ABSTRACTImmune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients. Targeting suppressive mechanisms acting on innate immune cells could significantly improve the incidence of clinical response by facilitating a multi-lineage response against the tumor involving both adaptive and innate immune systems. Here, we show that intra-tumoral interleukin (IL)-38 expression is a feature of a large frequency of head and neck, lung and cervical squamous cancers and correlates with reduced immune cell numbers. We generated IMM20324, an antibody that binds human and mouse IL-38 proteins and inhibits the binding of IL-38 to its putative receptors, interleukin 1 receptor accessory protein-like 1 (IL1RAPL) and IL-36R. In vivo, IMM20324 demonstrated a good safety profile, delayed tumor growth in a subset of mice in an EMT6 syngeneic model of breast cancer, and significantly inhibited tumor expansion in a B16.F10 melanoma model. Notably, IMM20324 treatment resulted in the prevention of tumor growth following re-implantation of tumor cells, indicating the induction of immunological memory. Furthermore, exposure of IMM20324 correlated with decreased tumor volume and increased levels of intra-tumoral chemokines. Together, our data suggest that IL-38 is expressed in a high frequency of cancer patients and allows tumor cells to suppress anti-tumor immunity. Blockade of IL-38 activity using IMM20324 can re-activate immunostimulatory mechanisms in the tumor microenvironment leading to immune infiltration, the generation of tumor-specific memory and abrogation of tumor growth

Cancer-related fatigue in lung cancer : a research agenda : an official American Thoracic Society research statement

Background: Fatigue is the most common symptom among cancer survivors. Cancer-related fatigue (CRF) may occur at any point in the cancer care continuum. Multiple factors contribute to CRF development and severity, including cancer type, treatments, presence of other symptoms, comorbidities, and medication side effects. Clinically, increasing physical activity, enhancing sleep quality, and recognizing sleep disorders are integral to managing CRF. Unfortunately, CRF is infrequently recognized, evaluated, or treated in lung cancer survivors despite more frequent and severe symptoms than in other cancers. Therefore, increased awareness and understanding of CRF are needed to improve health-related quality of life in lung cancer survivors. Objectives: 1) To identify and prioritize knowledge and research gaps and 2) to develop and prioritize research questions to evaluate mechanistic, diagnostic, and therapeutic approaches to CRF among lung cancer survivors. Methods: We convened a multidisciplinary panel to review the available literature on CRF, focusing on the impacts of physical activity, rehabilitation, and sleep disturbances in lung cancer. We used a three-round modified Delphi process to prioritize research questions. Results: This statement identifies knowledge gaps in the 1) detection and diagnostic evaluation of CRF in lung cancer survivors; 2) timing, goals, and implementation of physical activity and rehabilitation; and 3) evaluation and treatment of sleep disturbances and disorders to reduce CRF. Finally, we present the panel’s initial 32 research questions and seven final prioritized questions. Conclusions: This statement offers a prioritized research agenda to 1) advance clinical and research efforts and 2) increase awareness of CRF in lung cancer survivors

Eogenetic Karst from the Perspective of an Equivalent Porous Medium

The porosity of young limestones experiencing meteoric diagenesis in the vicinity of their deposition (eogenetic karst) is mainly a double porosity consisting of touching-vug channels and preferred passageways lacing through a matrix of interparticle porosity. In contrast, the porosity of limestones experiencing subaerial erosion following burial diagenesis and uplift (telogenetic karst) is mainly a double porosity consisting of conduits within a network of fractures. The stark contrast between these two kinds of karst is illustrated by their position on a graph showing the hydraulic characteristics of an equivalent porous medium consisting of straight, cylindrical tubes (n-D space, where n is porosity,D is the diameter of the tubes, and logn is plotted against logD). Studies of the hydrology of small carbonate islands show that large-scale, horizontal hydraulic conductivity (K) increases by orders of magnitude during the evolution of eogenetic karst. Earlier petrologic studies have shown there is little if any change in the total porosity of the limestone during eogenetic diagenesis. The limestone of eogenetic karst, therefore, tracks horizontally inn-D space. In contrast, the path from initial sedimentary material to telogenetic karst comprises a descent on the graph with reduction ofn during burial diagenesis, then a sideways shift with increasingD due to opening of fractures during uplift and exposure, and finally an increase inD andn during development of the conduits along the fractures. Eogenetic caves are mainly limited to boundaries between geologic units and hydrologic zones: stream caves at the contact between carbonates and underlying impermeable rocks (and collapse-origin caves derived therefrom); vertical caves along platform-margin fractures; epikarst; phreatic pockets (banana holes) along the water table; and flank margin caves that form as mixing chambers at the coastal freshwater-saltwater “interface”. In contrast, the caverns of telogenetic karst are part of a system of interconnected conduits that drain an entire region. The eogenetic caves of small carbonate islands are, for the most part, not significantly involved in the drainage of the island

Radial Basis Function Neural Network with Localized Stochastic-Sensitive Autoencoder for Home-Based Activity Recognition

info:eu-repo/semantics/publishe