2,616 research outputs found
Arrival of the Fukushima Radioactivity Plume in North American Continental Waters
The large discharge of radioactivity into the northwest Pacific Ocean from the 2011 Fukushima Dai-ichi nuclear reactor accident has generated considerable concern about the spread of this material across the ocean to North America. We report here the first systematic study to our knowledge of the transport of the Fukushima marine radioactivity signal to the eastern North Pacific. Time series measurements of 134Cs and 137Cs in seawater revealed the initial arrival of the Fukushima signal by ocean current transport at a location 1,500 km west of British Columbia, Canada, in June 2012, about 1.3 y after the accident. By June 2013, the Fukushima signal had spread onto the Canadian continental shelf, and by February 2014, it had increased to a value of 2 Bq/m3 throughout the upper 150 m of the water column, resulting in an overall doubling of the fallout background from atmospheric nuclear weapons tests. Ocean circulation model estimates that are in reasonable agreement with our measured values indicate that future total levels of 137Cs (Fukushima-derived plus fallout 137Cs) off the North American coast will likely attain maximum values in the 3–5 Bq/m3 range by 2015–2016 before declining to levels closer to the fallout background of about 1 Bq/m3 by 2021. The increase in 137Cs levels in the eastern North Pacific from Fukushima inputs will probably return eastern North Pacific concentrations to the fallout levels that prevailed during the 1980s but does not represent a threat to human health or the environment
Boolean analysis identifies CD38 as a biomarker of aggressive localized prostate cancer.
The introduction of serum Prostate Specific Antigen (PSA) testing nearly 30 years ago has been associated with a significant shift towards localized disease and decreased deaths due to prostate cancer. Recognition that PSA testing has caused over diagnosis and over treatment of prostate cancer has generated considerable controversy over its value, and has spurred efforts to identify prognostic biomarkers to distinguish patients who need treatment from those that can be observed. Recent studies show that cancer is heterogeneous and forms a hierarchy of tumor cell populations. We developed a method of identifying prostate cancer differentiation states related to androgen signaling using Boolean logic. Using gene expression data, we identified two markers, CD38 and ARG2, that group prostate cancer into three differentiation states. Cancers with CD38-, ARG2- expression patterns, corresponding to an undifferentiated state, had significantly lower 10-year recurrence-free survival compared to the most differentiated group (CD38+ARG2+). We carried out immunohistochemical (IHC) staining for these two markers in a single institution (Stanford; n = 234) and multi-institution (Canary; n = 1326) cohorts. IHC staining for CD38 and ARG2 in the Stanford cohort demonstrated that combined expression of CD38 and ARG2 was prognostic. In the Canary cohort, low CD38 protein expression by IHC was significantly associated with recurrence-free survival (RFS), seminal vesicle invasion (SVI), extra-capsular extension (ECE) in univariable analysis. In multivariable analysis, ARG2 and CD38 IHC staining results were not independently associated with RFS, overall survival, or disease-specific survival after adjusting for other factors including SVI, ECE, Gleason score, pre-operative PSA, and surgical margins
Asymptotic Dynamics in Quantum Field Theory
A crucial element of scattering theory and the LSZ reduction formula is the
assumption that the coupling vanishes at large times. This is known not to hold
for the theories of the Standard Model and in general such asymptotic dynamics
is not well understood. We give a description of asymptotic dynamics in field
theories which incorporates the important features of weak convergence and
physical boundary conditions. Applications to theories with three and four
point interactions are presented and the results are shown to be completely
consistent with the results of perturbation theory.Comment: 18 pages, 3 figure
Starcounts Redivivus. IV. Density Laws Through Photometric Parallaxes
In an effort to more precisely define the spatial distribution of Galactic
field stars, we present an analysis of the photometric parallaxes of 70,000
stars covering nearly 15 square degrees in seven Kapteyn Selected Areas. We
address the affects of Malmquist Bias, subgiant/giant contamination,
metallicity and binary stars upon the derived density laws. The affect of
binary stars is the most significant. We find that while the disk-like
populations of the Milky Way are easily constrained in a simultaneous analysis
of all seven fields, no good simultaneous solution for the halo is found. We
have applied halo density laws taken from other studies and find that the
Besancon flattened power law halo model (c/a=0.6, r^-2.75) produces the best
fit to our data. With this halo, the thick disk has a scale height of 750 pc
with an 8.5% normalization to the old disk. The old disk scale height is
280-300 pc. Corrected for a binary fraction of 50%, these scale heights are 940
pc and 350-375 pc, respectively. Even with this model, there are systematic
discrepancies between the observed and predicted density distributions. Our
model produces density overpredictions in the inner Galaxy and density
underpredictions in the outer Galaxy. A possible solution is modeling the
stellar halo as a two-component system in which the halo has a flattened inner
distribution and a roughly spherical, but substructured outer distribution.
Further reconciliation could be provided by a flared thick disk, a structure
consistent with a merger origin for that population. (Abridged)Comment: 66 pages, accepted to Astrophysical journal, some figures compresse
Record Maximum Oscillation Frequency in C-face Epitaxial Graphene Transistors
The maximum oscillation frequency (fmax) quantifies the practical upper bound
for useful circuit operation. We report here an fmax of 70 GHz in transistors
using epitaxial graphene grown on the C-face of SiC. This is a significant
improvement over Si-face epitaxial graphene used in the prior high frequency
transistor studies, exemplifying the superior electronics potential of C-face
epitaxial graphene. Careful transistor design using a high {\kappa} dielectric
T-gate and self-aligned contacts, further contributed to the record-breaking
fmax
Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge
We previously generated a panel of human monoclonal antibodies (mAbs) against Zika virus (ZIKV) and identified one, ZIKV-116, that shares germline usage with mAbs identified in multiple donors. Here we show that ZIKV-116 interferes with ZIKV infection at a post-cellular attachment step by blocking viral fusion with host membranes. ZIKV-116 recognizes the lateral ridge of envelope protein domain III, with one critical residue varying between the Asian and African strains responsible for differential binding affinity and neutralization potency (E393D). ZIKV-116 also binds to and cross-neutralizes some dengue virus serotype 1 (DENV1) strains, with genotype-dependent inhibition explained by variation in a domain II residue (R204K) that potentially modulates exposure of the distally located, partially cryptic epitope. The V-J reverted germline configuration of ZIKV-116 preferentially binds to and neutralizes an Asian ZIKV strain, suggesting that this epitope may optimally induce related B cell clonotypes. Overall, these studies provide a structural and molecular mechanism for a cross-reactive mAb that uniquely neutralizes ZIKV and DENV1
Attention on Weak Ties in Social and Communication Networks
Granovetter's weak tie theory of social networks is built around two central
hypotheses. The first states that strong social ties carry the large majority
of interaction events; the second maintains that weak social ties, although
less active, are often relevant for the exchange of especially important
information (e.g., about potential new jobs in Granovetter's work). While
several empirical studies have provided support for the first hypothesis, the
second has been the object of far less scrutiny. A possible reason is that it
involves notions relative to the nature and importance of the information that
are hard to quantify and measure, especially in large scale studies. Here, we
search for empirical validation of both Granovetter's hypotheses. We find clear
empirical support for the first. We also provide empirical evidence and a
quantitative interpretation for the second. We show that attention, measured as
the fraction of interactions devoted to a particular social connection, is high
on weak ties --- possibly reflecting the postulated informational purposes of
such ties --- but also on very strong ties. Data from online social media and
mobile communication reveal network-dependent mixtures of these two effects on
the basis of a platform's typical usage. Our results establish a clear
relationships between attention, importance, and strength of social links, and
could lead to improved algorithms to prioritize social media content
Mass-Losing Semiregular Variable Stars in Baade's Windows
By cross-correlating the results of two recent large-scale surveys, the
general properties of a well defined sample of semi-regular variable stars have
been determined. ISOGAL mid-infrared photometry and MACHO lightcurves are
assembled for approximately 300 stars in the Baade's Windows of low extinction
towards the Galactic bulge. These stars are mainly giants of late M spectral
type, evolving along the asymptotic giant branch (AGB). They are found to
possess a wide and continuous distribution of pulsation periods and to obey an
approximate log~period -- bolometric magnitude relation or set of such
relations.
Approximate mass-loss rates in the range of 1e-8 to 5e-7 M_sun per year are
derived from ISOGAL mid-infrared photometry and models of stellar spectra
adjusted for the presence of optically-thin circumstellar silicate dust.
Mass-loss rates depend on luminosity and pulsation period. Some stars lose mass
as rapidly as short-period Miras but do not show Mira-like amplitudes. A period
of 70 days or longer is a necessary but not a sufficient condition for mass
loss to occur.
For AGB stars in the mass-loss ranges that we observe, the functional
dependence of mass-loss rate on temperature and luminosity is found to be in
agreement with recent theoretical predictions. If we include our mass-loss
rates with a sample of extreme mass-losing AGB stars in the Large Magellanic
Cloud, we get the general result for AGB stars that mass-loss rate is
proportional to luminosity^{2.7}, valid for AGB stars with 10^{-8} to 10^{-4}
M_sun per year (Abridged).Comment: to appear in The Astrophysical Journal, 51 pages, 9 figures, 3
tables; table 1 will be available in machine-readable format at the
electronic Ap
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