The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells. Thymic precursors express both CD8 and CD4, and it has been suggested that the intracellular signals generated by CD8 or CD4 binding to class I or II MHC, respectively, might influence the fate of uncommitted cells. Here we test the notion that intracellular signaling by CD4 directs the development of thymocytes to a CD4 lineage. A hybrid protein consisting of the CD8 extracellular and transmembrane domains and the cytoplasmic domain of CD4 (CD884) should bind class I MHC but deliver a CD4 intracellular signal. We find that expression of a hybrid CD884 protein in thymocytes of transgenic mice leads to the development of large numbers of class I MHC-specific, CD4 lineage T cells. We discuss these results in terms of current models for CD4 and CD8 lineage commitment

An Acoustic Technique for the Noninvasive in-Situ Measurement of Crystal Size and Solution Concentration

We demonstrated the use of acoustic measurements for tracking potassium dihydrogen phosphate (KDP) crystal growth. Both KDP solution concentration and KDP crystal size can be found by using information derived from acoustic wave propagation in the solution. Acoustic measurements show good correlation to conductivity measurements for KDP solution concentration

Magnetohydrodynamic scaling: From astrophysics to the laboratory

During the last few years, considerable progress has been made in simulating astrophysical phenomena in laboratory experiments with high-power lasers. Astrophysical phenomena that have drawn particular interest include supernovae explosions; young supernova remnants; galactic jets; the formation of fine structures in late supernovae remnants by instabilities; and the ablation-driven evolution of molecular clouds. A question may arise as to what extent the laser experiments, which deal with targets of a spatial scale of ∼100 μm and occur at a time scale of a few nanoseconds, can reproduce phenomena occurring at spatial scales of a million or more kilometers and time scales from hours to many years. Quite remarkably, in a number of cases there exists a broad hydrodynamic similarity (sometimes called the “Euler similarity”) that allows a direct scaling of laboratory results to astrophysical phenomena. A discussion is presented of the details of the Euler similarity related to the presence of shocks and to a special case of a strong drive. Constraints stemming from the possible development of small-scale turbulence are analyzed. The case of a gas with a spatially varying polytropic index is discussed. A possibility of scaled simulations of ablation front dynamics is one more topic covered in this paper. It is shown that, with some additional constraints, a simple similarity exists. © 2001 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71174/2/PHPAEN-8-5-1804-1.pd

Strategic signalling and awards: Investigation into the first decade of AIS best publications awards

Professional organizations for academics such as the Academy of Management and Association for Information Systems (AIS) create best publications awards to honour and promote exemplary contributions that align with the core values and priorities of their distinct fields. Despite the strategic importance of awards, researchers rarely investigate meaningful patterns implicit in the contribution characteristics of award-winning articles. We conduct a reconstructive study of the 10-year history of the AIS Best Publications Awards by outlining a framework that reveals contribution characteristics, demographic patterns, and citation histories of the award-winning articles. Comparing the AIS results to a complete sample of MIS Quarterly paper-of-the-year articles (1993–2015) demonstrates consistent patterns implicit in IS articles that win best publications awards. We develop a model that explains both how these awards shape patterns and discusses what changes might be needed as the field confronts new realities. Our analyses reinforce the importance of taking strategic actions to support the continuous development of the field and advance literature on change and evolving trends in academic fields

Modified Bell-Plesset Effect with Compressibility: Application to Double-Shell Ignition Target Designs

The effect of spherical convergence on the fluid stability of collapsing and expanding bubbles was originally treated by Bell [Los Alamos Scientific Laboratory Report No. LA-1321 (1951)] and Plesset [J. Appl. Phys. 25, 96 (1954)]. The additional effect of fluid compressibility was also considered by Bell but was limited to the case of nonzero density on only one side of a fluid interface. A more general extension is developed which considers distinct time-dependent uniform densities on both sides of an interface in a spherically converging geometry. A modified form of the velocity potential is used that avoids an unphysical divergence at the origin [Goncharov et al., Phys. Plasmas 7, 5118 (2000); Lin et al., Phys. Fluids 14, 2925 (2002)]. Two consequences of this approach are that an instability proposed by Plesset for an expanding bubble in the limit of large interior density is now absent and application to inertial confinement fusion studies of stability becomes feasible. The model is applied to a proposed ignition double-shell target design [Amendt et al., Phys. Plasmas 9, 2221 (2002)] for the National Ignition Facility [Paisner et al., Laser Focus World 30, 75 (1994)] for studying the stability of the inner surface of an imploding high-Z inner shell. Application of the Haan [Phys. Rev. A 39, 5812 (1989)] saturation criterion suggests that ignition is possible

Predicting the safety and efficacy of butter therapy to raise tumour pHe: an integrative modelling study

Background: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidity through systemic buffers significantly inhibits development and growth of metastases in mouse xenografts.\ud \ud Methods: We apply and extend a previously developed mathematical model of blood and tumour buffering to examine the impact of oral administration of bicarbonate buffer in mice, and the potential impact in humans. We recapitulate the experimentally observed tumour pHe effect of buffer therapy, testing a model prediction in vivo in mice. We parameterise the model to humans to determine the translational safety and efficacy, and predict patient subgroups who could have enhanced treatment response, and the most promising combination or alternative buffer therapies.\ud \ud Results: The model predicts a previously unseen potentially dangerous elevation in blood pHe resulting from bicarbonate therapy in mice, which is confirmed by our in vivo experiments. Simulations predict limited efficacy of bicarbonate, especially in humans with more aggressive cancers. We predict buffer therapy would be most effectual: in elderly patients or individuals with renal impairments; in combination with proton production inhibitors (such as dichloroacetate), renal glomular filtration rate inhibitors (such as non-steroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitors), or with an alternative buffer reagent possessing an optimal pK of 7.1–7.2.\ud \ud Conclusion: Our mathematical model confirms bicarbonate acts as an effective agent to raise tumour pHe, but potentially induces metabolic alkalosis at the high doses necessary for tumour pHe normalisation. We predict use in elderly patients or in combination with proton production inhibitors or buffers with a pK of 7.1–7.2 is most promising

DC Link Stabilized Field Oriented Control of Electric Propulsion Systems

Induction motor based electric propulsion systems can be used in a wide variety of applications including locomotives, hybrid electric vehicles, and ships. Field oriented control of these drives is attractive since it allows the torque to be tightly and nearly instantaneously controlled. However, such systems can be prone to negative impedance instability of the DC link. This paper examines this type of instability and sets forth a readily implemented albeit nonlinear control strategy to mitigate this potential problem

Numerical simulation of supernova-relevant laser-driven hydro experiments on OMEGA

In ongoing experiments performed on the OMEGA laser [J. M. Soures et al., Phys. Plasmas 5, 2108 (1996)] at the University of Rochester Laboratory for Laser Energetics, nanosecond laser pulses are used to drive strong blast waves into two-layer targets. Perturbations on the interface between the two materials are unstable to the Richtmyer–Meshkov instability as a result of shock transit and the Rayleigh–Taylor instability during the deceleration-phase behind the shock front. These experiments are designed to produce a strongly shocked interface whose evolution is a scaled version of the unstable hydrogen–helium interface in core-collapse supernovae such as SN 1987A. The ultimate goal of this research is to develop an understanding of the effect of hydrodynamic instabilities and the resulting transition to turbulence on supernovae observables that remain as yet unexplained. The authors are, at present, particularly interested in the development of the Rayleigh–Taylor instability through the late nonlinear stage, the transition to turbulence, and the subsequent transport of material within the turbulent region. In this paper, the results of numerical simulations of two-dimensional (2D) single and multimode experiments are presented. These simulations are run using the 2D Arbitrary Lagrangian Eulerian radiation hydrodynamics code CALE [R. T. Barton, Numerical Astrophysics (Jones and Bartlett, Boston, 1985)]. The simulation results are shown to compare well with experimental radiography. A buoyancy-drag model captures the behavior of the single-mode interface, but gives only partial agreement in the multimode cases. The Richtmyer–Meshkov and target decompression contributions to the perturbation growth are both estimated and shown to be significant. Significant dependence of the simulation results on the material equation of state is demonstrated, and the prospect of continuing the experiments to conclusively demonstrate the transition to turbulence is discussed. © 2004 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71253/2/PHPAEN-11-7-3631-1.pd