862 research outputs found
Clinical investigation of an outbreak of alveolitis and asthma in a car engine manufacturing plant
Background Exposure to metal working fluid (MWF) has been associated with outbreaks of EAA in the US, with bacterial contamination of MWF being a possible cause, but was uncommon in the UK. Twelve workers developed extrinsic allergic alveolitis (EAA) in a car engine manufacturing plant in the UK, presenting clinically between December 2003 and May 2004. This paper reports the subsequent epidemiological investigation of the whole workforce. This had three aims:-
• To measure the extent of the outbreak by identifying other workers who may have developed EAA or other work-related respiratory diseases.
• To provide case-detection so that those affected can be treated.
• To provide epidemiological data to identify the cause of the outbreak.
Methods The outbreak was investigated in a three-phase cross-sectional survey of the workforce.
Phase I A respiratory screening questionnaire was completed by 808/836 workers (96.7%) in May 2004.
Phase II 481 employees with at least one respiratory symptom on screening and 50 asymptomatic controls were invited for investigation at the factory in June 2004. This included a questionnaire, spirometry and clinical opinion. 454/481(94.4%) responded along with 48/50(96%) controls. Workers were identified who needed further investigation and serial measurements of peak expiratory flow (PEF).
Phase III 162 employees were seen at the Birmingham Occupational Lung Disease clinic. 198 employees returned PEF records, including 141 of the 162 who attended for clinical investigation. Case definitions for diagnoses were agreed.
Results 87 workers (10.4% of workforce) met case definitions for occupational lung disease, comprising EAA(19), occupational asthma(74) and humidifier fever(7). 12 workers had more than one diagnosis. The peak onset of work-related breathlessness was Spring 2003. The proportion of workers affected was higher for those using metal working fluid (MWF) from a large sump(27.3%) compared with working all over the manufacturing area (7.9%) (OR=4.39,p<0.001). Two workers had positive specific provocation tests to the used but not the unused MWF solution.
Conclusions Extensive investigation of the outbreak of EAA detected a large number of affected workers, not only with EAA but also occupational asthma. This is the largest reported outbreak in Europe. Mist from used MWF is the likely cause. In workplaces using MWF, there is a need to carry out risk assessments, to monitor and maintain fluid quality, to control mist and to carry out respiratory health surveillance
Results of the First Coincident Observations by Two Laser-Interferometric Gravitational Wave Detectors
We report an upper bound on the strain amplitude of gravitational wave bursts
in a waveband from around 800Hz to 1.25kHz. In an effective coincident
observing period of 62 hours, the prototype laser interferometric gravitational
wave detectors of the University of Glasgow and Max Planck Institute for
Quantum Optics, have set a limit of 4.9E-16, averaging over wave polarizations
and incident directions. This is roughly a factor of 2 worse than the
theoretical best limit that the detectors could have set, the excess being due
to unmodelled non-Gaussian noise. The experiment has demonstrated the viability
of the kind of observations planned for the large-scale interferometers that
should be on-line in a few years time.Comment: 11 pages, 2 postscript figure
Effects of sea temperature and stratification changes on seabird breeding success
As apex predators in marine ecosystems, seabirds may primarily experience climate change impacts indirectly, via changes to their food webs. Observed seabird population declines have been linked to climate-driven oceanographic and food web changes. However, relationships have often been derived from relatively few colonies and consider only sea surface temperature (SST), so important drivers, and spatial variation in drivers, could remain undetected. Further, explicit climate change projections have rarely been made, so longer-term risks remain unclear. Here, we use tracking data to estimate foraging areas for eleven black-legged kittiwake (Rissa tridactyla) colonies in the UK and Ireland, thus reducing reliance on single colonies and allowing calculation of colony-specific oceanographic conditions. We use mixed models to consider how SST, the potential energy anomaly (indicating density stratification strength) and the timing of seasonal stratification influence kittiwake productivity. Across all colonies, higher breeding success was associated with weaker stratification before breeding and lower SSTs during the breeding season. Eight colonies with sufficient data were modelled individually: higher productivity was associated with later stratification at three colonies, weaker stratification at two, and lower SSTs at one, whilst two colonies showed no significant relationships. Hence, key drivers of productivity varied among colonies. Climate change projections, made using fitted models, indicated that breeding success could decline by 21 – 43% between 1961-90 and 2070-99. Climate change therefore poses a longer-term threat to kittiwakes, but as this will be mediated via availability of key prey species, other marine apex predators could also face similar threats
Coulomb Gauge QCD, Confinement, and the Constituent Representation
Quark confinement and the genesis of the constituent quark model are examined
in nonperturbative QCD in Coulomb gauge. We employ a self-consistent method to
construct a quasiparticle basis and to determine the quasiparticle interaction.
The results agree remarkably well with lattice computations. They also
illustrate the mechanism by which confinement and constituent quarks emerge,
provide support for the Gribov-Zwanziger confinement scenario, clarify several
perplexing issues in the constituent quark model, and permit the construction
of an improved model of low energy QCD.Comment: 43 pages, 14 figures, revtex, uses psfig.st
Confronting Finsler space-time with experiment
Within all approaches to quantum gravity small violations of the Einstein
Equivalence Principle are expected. This includes violations of Lorentz
invariance. While usually violations of Lorentz invariance are introduced
through the coupling to additional tensor fields, here a Finslerian approach is
employed where violations of Lorentz invariance are incorporated as an integral
part of the space-time metrics. Within such a Finslerian framework a modified
dispersion relation is derived which is confronted with current high precision
experiments. As a result, Finsler type deviations from the Minkowskian metric
are excluded with an accuracy of 10^{-16}.Comment: To be published in General Relativity and Gravitatio
Completion of Advance Directives: Do Social Work Preadmission Interviews Make a Difference?
Objectives: This study tests the efficacy of a preadmission, educational interview on advance directives, in this case, health care proxies (HCPs) offered to elective, orthopedic patients. Method: Using a quasi-experimental design, participants (n = 54) are assigned to either treatment group (who received the educational interview, conducted by a social worker, over and above the federally mandated written information on HCPs) or comparison group (who received the written information only). Results: Logistic regression analysis indicates there is a statistically significantly higher probability that a patient would sign an HCP if assigned to the treatment group than if assigned to the comparison condition. Conclusion: Benefits of educating patients about HCPs as part of routine social work practice are outlined
Statistical Theory of Spin Relaxation and Diffusion in Solids
A comprehensive theoretical description is given for the spin relaxation and
diffusion in solids. The formulation is made in a general
statistical-mechanical way. The method of the nonequilibrium statistical
operator (NSO) developed by D. N. Zubarev is employed to analyze a relaxation
dynamics of a spin subsystem. Perturbation of this subsystem in solids may
produce a nonequilibrium state which is then relaxed to an equilibrium state
due to the interaction between the particles or with a thermal bath (lattice).
The generalized kinetic equations were derived previously for a system weakly
coupled to a thermal bath to elucidate the nature of transport and relaxation
processes. In this paper, these results are used to describe the relaxation and
diffusion of nuclear spins in solids. The aim is to formulate a successive and
coherent microscopic description of the nuclear magnetic relaxation and
diffusion in solids. The nuclear spin-lattice relaxation is considered and the
Gorter relation is derived. As an example, a theory of spin diffusion of the
nuclear magnetic moment in dilute alloys (like Cu-Mn) is developed. It is shown
that due to the dipolar interaction between host nuclear spins and impurity
spins, a nonuniform distribution in the host nuclear spin system will occur and
consequently the macroscopic relaxation time will be strongly determined by the
spin diffusion. The explicit expressions for the relaxation time in certain
physically relevant cases are given.Comment: 41 pages, 119 Refs. Corrected typos, added reference
Coulomb gauge approach to (qqg)over-bar hybrid mesons
An effective Coulomb gauge Hamiltonian, H-eff, is used to calculate the light ( u (u) over barg), strange ( s (s) over barg) and charmed (c (c) over barg) hybrid meson spectra. For the same two parameter H-eff providing glueball masses consistent with lattice results and a good description of the observed u, d, s and c quark mesons, a large-scale variational treatment predicts that the lightest hybrid has J(PC) = 0(++) and mass 2.1 GeV. The lightest exotic 1(-+) state is just above 2.2 GeV, near the upper limit of lattice and flux tube predictions. These theoretical formulations all indicate that the observed 1(-+) pi(1)(1600) and, more clearly, pi(1)(1400) are not hybrid states. The Coulomb gauge approach further predicts that in the strange and charmed sectors, respectively, the ground state hybrids have 1(+-) with masses 2.1 and 3.8 GeV, while the. rst exotic 1( +) states are at 2.4 and 4.0 GeV. Finally, using our hybrid wavefunctions and the Franck-Condon principle, a novel experimental signature is presented to assist heavy hybrid meson searches
Internal representations of smell in the Drosophila brain
Recent advances in sensory neuroscience using Drosophila olfaction as a model system have revealed brain maps representing the external world. Once we understand how the brain's built-in capability generates the internal olfactory maps, we can then elaborate how the brain computes and makes decision to elicit complex behaviors. Here, we review current progress in mapping Drosophila olfactory circuits and discuss their relationships with innate olfactory behaviors
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
- …