32,566 research outputs found
PQCD Analysis of Parton-Hadron Duality
We propose an extraction of the running coupling constant of QCD in the
infrared region from experimental data on deep inelastic inclusive scattering
at Bjorken x -> 1. We first attempt a perturbative fit of the data that extends
NLO PQCD evolution to large x values and final state invariant mass, W, in the
resonance region. We include both target mass corrections and large x
resummation effects. These effects are of order O(1/Q^2), and they improve the
agreement with the Q^2 dependence of the data. Standard analyses require the
presence of additional power corrections, or dynamical higher twists, to
achieve a fully quantitative fit. Our analysis, however, is regulated by the
value of the strong coupling in the infrared region that enters through large x
resummation effects, and that can suppress, or absorb, higher twist effects.
Large x data therefore indirectly provide a measurement of this quantity that
can be compared to extractions from other observables.Comment: 10 pages, 3 figure
General tooth boundary conditions for equation free modelling
We are developing a framework for multiscale computation which enables models
at a ``microscopic'' level of description, for example Lattice Boltzmann, Monte
Carlo or Molecular Dynamics simulators, to perform modelling tasks at
``macroscopic'' length scales of interest. The plan is to use the microscopic
rules restricted to small "patches" of the domain, the "teeth'', using
interpolation to bridge the "gaps". Here we explore general boundary conditions
coupling the widely separated ``teeth'' of the microscopic simulation that
achieve high order accuracy over the macroscale. We present the simplest case
when the microscopic simulator is the quintessential example of a partial
differential equation. We argue that classic high-order interpolation of the
macroscopic field provides the correct forcing in whatever boundary condition
is required by the microsimulator. Such interpolation leads to Tooth Boundary
Conditions which achieve arbitrarily high-order consistency. The high-order
consistency is demonstrated on a class of linear partial differential equations
in two ways: firstly through the eigenvalues of the scheme for selected
numerical problems; and secondly using the dynamical systems approach of
holistic discretisation on a general class of linear \textsc{pde}s. Analytic
modelling shows that, for a wide class of microscopic systems, the subgrid
fields and the effective macroscopic model are largely independent of the tooth
size and the particular tooth boundary conditions. When applied to patches of
microscopic simulations these tooth boundary conditions promise efficient
macroscale simulation. We expect the same approach will also accurately couple
patch simulations in higher spatial dimensions.Comment: 22 page
Modelling and simulation framework for reactive transport of organic contaminants in bed-sediments using a pure java object - oriented paradigm
Numerical modelling and simulation of organic contaminant reactive transport in the environment is being increasingly
relied upon for a wide range of tasks associated with risk-based decision-making, such as prediction of contaminant
profiles, optimisation of remediation methods, and monitoring of changes resulting from an implemented remediation
scheme. The lack of integration of multiple mechanistic models to a single modelling framework, however, has
prevented the field of reactive transport modelling in bed-sediments from developing a cohesive understanding of
contaminant fate and behaviour in the aquatic sediment environment. This paper will investigate the problems involved
in the model integration process, discuss modelling and software development approaches, and present preliminary
results from use of CORETRANS, a predictive modelling framework that simulates 1-dimensional organic contaminant
reaction and transport in bed-sediments
A microgravity isolation mount
The design and preliminary testing of a system for isolating microgravity sensitive payloads from spacecraft vibrational and impulsive disturbances is discussed. The Microgravity Isolation Mount (MGIM) concept consists of a platform which floats almost freely within a limited volume inside the spacecraft, but which is constrained to follow the spacecraft in the long term by means of very weak springs. The springs are realized magnetically and form part of a six degree of freedom active magnetic suspension system. The latter operates without any physical contact between the spacecraft and the platform itself. Power and data transfer is also performed by contactless means. Specifications are given for the expected level of input disturbances and the tolerable level of platform acceleration. The structural configuration of the mount is discussed and the design of the principal elements, i.e., actuators, sensors, control loops and power/data transfer devices are described. Finally, the construction of a hardware model that is being used to verify the predicted performance of the MGIM is described
Self-consistent simulations of a von K\'arm\'an type dynamo in a spherical domain with metallic walls
We have performed numerical simulations of boundary-driven dynamos using a
three-dimensional non-linear magnetohydrodynamical model in a spherical shell
geometry. A conducting fluid of magnetic Prandtl number Pm=0.01 is driven into
motion by the counter-rotation of the two hemispheric walls. The resulting flow
is of von K\'arm\'an type, consisting of a layer of zonal velocity close to the
outer wall and a secondary meridional circulation. Above a certain forcing
threshold, the mean flow is unstable to non-axisymmetric motions within an
equatorial belt. For fixed forcing above this threshold, we have studied the
dynamo properties of this flow. The presence of a conducting outer wall is
essential to the existence of a dynamo at these parameters. We have therefore
studied the effect of changing the material parameters of the wall (magnetic
permeability, electrical conductivity, and thickness) on the dynamo. In common
with previous studies, we find that dynamos are obtained only when either the
conductivity or the permeability is sufficiently large. However, we find that
the effect of these two parameters on the dynamo process are different and can
even compete to the detriment of the dynamo. Our self-consistent approach allow
us to analyze in detail the dynamo feedback loop. The dynamos we obtain are
typically dominated by an axisymmetric toroidal magnetic field and an axial
dipole component. We show that the ability of the outer shear layer to produce
a strong toroidal field depends critically on the presence of a conducting
outer wall, which shields the fluid from the vacuum outside. The generation of
the axisymmetric poloidal field, on the other hand, occurs in the equatorial
belt and does not depend on the wall properties.Comment: accepted for publication in Physical Review
Mannitol for acute traumatic brain injury.
BACKGROUND: Mannitol is sometimes dramatically effective in reversing acute brain swelling, but its effectiveness in the on-going management of severe head injury remains open to question. There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it might cause reverse osmotic shifts that increase intracranial pressure. OBJECTIVES: To assess the effects of different mannitol therapy regimens, of mannitol compared to other intracranial pressure (ICP) lowering agents, and to quantify the effectiveness of mannitol administration given at other stages following acute traumatic brain injury. SEARCH STRATEGY: The review drew on the search strategy for the Injuries Group as a whole. We checked reference lists of trials and review articles, and contacted authors of trials. SELECTION CRITERIA: Randomised trials of mannitol, in patients with acute traumatic brain injury of any severity. The comparison group could be placebo-controlled, no drug, different dose, or different drug. Trials where the intervention was started more than eight weeks after injury, and cross-over trials were excluded. DATA COLLECTION AND ANALYSIS: The reviewers independently rated quality of allocation concealment and extracted the data. Relative risks (RR) and 95% confidence intervals (CI) were calculated for each trial on an intention to treat basis. MAIN RESULTS: Overall there were few eligible trials. In the pre-operative management of patients with acute intracranial haemorrhage the administration of high-dose mannitol resulted in reduced mortality (RR=0.55; 95%CI 0.36, 0.84) and reduced death and severe disability (RR=0.58; 95%CI 0.45, 0.74) when compared with conventional-dose mannitol. One trial compared ICP-directed therapy to 'standard care' (RR for death= 0.83; 95%CI 0.47,1.46). One trial compared mannitol to pentobarbital (RR for death = 0.85; 95% CI 0.52, 1.38). No trials compared mannitol to other ICP-lowering agents. One trial tested the effectiveness of pre-hospital administration of mannitol against placebo (RR for death=1.75; 95% CI 0.48, 6.38). REVIEWER'S CONCLUSIONS: High-dose mannitol appears to be preferable to conventional-dose mannitol in the pre-operative management of patients with acute intracranial haematomas. However, there is little evidence about the use of mannitol as a continuous infusion in patients with raised intracranial pressure in patients who do not have an operable intracranial haematoma. Mannitol therapy for raised ICP may have a beneficial effect on mortality when compared to pentobarbital treatment. ICP-directed treatment shows a small beneficial effect compared to treatment directed by neurological signs and physiological indicators. There are insufficient data on the effectiveness of pre-hospital administration of mannitol to preclude either a harmful or a beneficial effect on mortality
Sickle cell disease in Sierra Leone: a neglected problem
Background: Sickle cell disease (SCD) is common in Sierra Leone although its exact prevalence, incidence and clinical spectrum are unknown.Methods: Using a statistical package, StatsDirect (Altrincham, United Kingdom) we analyzed the demographic characteristics, presentations, acute events, treatments and clinical outcomes in a cohort of SCD patients attending sickle cell clinics in Freetown, Sierra Leone between February 2007 and August 2010.Results: There were 446 patients, median age of 13 years. Of these, 435 were homozygotes (HbSS), median age 13 years also. There were 248 females, median age 12.5 and 198 males, median age 14, resulting in a male:female ratio of 0.79. Eleven (2.4%) were Sickle Cell-HbC disease, median age 14 years. Patients demonstrated many of the typical features of SCD. The most common reason for hospital admission was bone pain crisis associated with an infection, followed by severe anemia. Aseptic necrosis of the femoral head, leg ulcers, septic osteomyelitis and gallstones were seen in 0.22% of patients, but strokes and acute chest syndrome were not observed. The death rate was 2.51/100 patient years observation with an estimated mean survival of 3.6 years (CI 3.2-3.7). Severe anemia was implicated in the death of 8 patients (50%), whereas only 2 deaths (12.5%) were attributable to bone pain crisis. One death (6.25%) was associated with pregnancy complicated by severe anemia and another with an adverse blood transfusion event.Conclusion: The clinical outcomes in this series highlight the need for a more comprehensive provision of care for SCD patients in Sierra Leone.Keywords: Sickle cell disease, Sierra Leone, survival, anaemia, haemoglobinopath
Newly Discovered Bright z~9-10 Galaxies and Improved Constraints on Their Prevalence Using the Full CANDELS Area
We report the results of an expanded search for z~9-10 candidates over the
~883 arcmin^2 CANDELS+ERS fields. This study adds 147 arcmin^2 to the search
area we consider over the CANDELS COSMOS, UDS, and EGS fields, while expanding
our selection to include sources with bluer J_{125}-H_{160} colors than our
previous J_{125}-H_{160}>0.5 mag selection. In searching for new z~9-10
candidates, we make full use of all available HST, Spitzer/IRAC, and
ground-based imaging data. As a result of our expanded search and use of
broader color criteria, 3 new candidate z~9-10 galaxies are identified. We also
find again the z=8.683 source previously confirmed by Zitrin+2015. This brings
our sample of probable z~9-11 galaxy candidates over the CANDELS+ERS fields to
19 sources in total, equivalent to 1 candidate per 47 arcmin^2 (1 per 10
WFC3/IR fields). To be comprehensive, we also discuss 28 mostly lower
likelihood z~9-10 candidates, including some sources that seem to be reliably
at z>8 using the HST+IRAC data alone, but which the ground-based data show are
much more likely at z<4. One case example is a bright z~9.4 candidate COS910-8
which seems instead to be at z~2. Based on this expanded sample, we obtain a
more robust LF at z~9 and improved constraints on the volume density of bright
z~9 and z~10 galaxies. Our improved z~9-10 results again reinforce previous
findings for strong evolution in the UV LF at z>8, with a factor of ~10
evolution seen in the luminosity density from z~10 to z~8.Comment: 22 pages, 12 figures, 6 tables, accepted for publication in the
Astrophysical Journa
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