in vitro preliminary evidences on the antioxidant properties of biogenic amines

Antioxidant properties of the principal biogenic amines were determined in vitro by four analytical methods—Folin Ciocalteu, DPPH, enzymatic and inhibition of lipid peroxidation—in order to avoid possible measuring-method linked mistakes. Different results are obtained, depending on the parameters that each of them measures. The combination of the data indicates that all examined amines show antioxidant characteristics: in particular, tyramine, serotonin, L-norepinephrine, (-)-epinephrine and dopamine owing to their (poly)phenolic structure too, while aliphatic polyamines-spermine, spermidine, putrescine and cadaverine-histamine, melatonin and tryptamine appear to act specifically on the oxygen-consuming species involved in the lipid peroxidation of polyunsaturated fatty acids

Interventions in overcrowding of emergency departments: an overview of systematic reviews

OBJECTIVE: To present an overview of systematic reviews on throughput interventions to solve the overcrowding of emergency departments. METHODS: Electronic searches for reviews published between 2007 and 2018 were made on PubMed, Cochrane Library, EMBASE, Health Systems Evidence, CINAHL, SciELO, LILACS, Google Scholar and the CAPES periodicals portal. Data of the included studies was extracted into a pre-formatted sheet and their methodological quality was assessed using AMSTAR 2 tool. Eventually, 15 systematic reviews were included for the narrative synthesis. RESULTS: The interventions were grouped into four categories: (1) strengthening of the triage service; (2) strengthening of the ED’s team; (3) creation of new care zones; (4) change in ED’s work processes. All studies observed positive effect on patient’s length of stay, expect for one, which had positive effect on other indicators. According to AMSTAR 2 criteria, eight revisions were considered of high or moderate methodological quality and seven, low or critically low quality. There was a clear improvement in the quality of the studies, with an improvement in focus and methodology after two decades of systematic studies on the subject. CONCLUSIONS: Despite some limitations, the evidence presented on this overview can be considered the cutting edge of current scientific knowledge on the topic

Public policies to strengthen higher education in Mexico City: teaching experiences in the educational model of the Instituto de Estudios Superiores Rosario Castellanos

El objetivo del trabajo es exponer los aspectos principales que llevaron a la creación del Instituto de Estudios Superiores Rosario Castellanos (IESRC) a partir de la reciente política pública impulsada en materia educativa en la Ciudad de México (CDMX) en mayo de 2019. El artículo comunica también la experiencia docente en un modelo educativo que modifica las estrategias de enseñanza para conducir al estudiante a egresar con un perfil basado en la interdisciplina que le permita una labor activa, producti va y asertiva en diversas problemáticas sociales. En este modelo se tiene como eje y centro al estudiante. Finalmente, se muestran algunas características del modelo educativo a partir del uso de las tecnologías y las herramientas digitales que hoy día deben apoyar la educación en el marco de los nuevos retos que el aprendizaje en ambientes de hibridualidad demanda.The goal of this paper is to expose the main aspects that allowed the creation of the Instituto de Estudios Superiores Rosario Castellanos (IESRC) based on the recent public policy promoted in education in Mexico City (CDMX) in May 2019. The article also communicates the teaching experience in an educational model that modifies didactic strategies to lead the student to graduate with a profile molded in interdisciplinarity that allows active, productive and assertive work in various social problems. In this model, the student is the axis and center. Finally, some characteristics of the educational model are shown based on the use of technologies and digital tools that today must support education within the framework of the new challenges that learning in hybrid-duality environments demands.O objetivo deste trabalho é apresentar os principais aspectos que levaram à criação do Instituto de Estudos Superiores Rosario Castellanos (IESRC) com base na recente política pública promovida em matéria educacional na Cidade do México (CDMX) em maio de 2019. O artigo também comunica a experiência docente em um modelo educacional que modifica estratégias de ensino para levar o aluno a se formar com um perfil baseado na interdisciplinaridade que permite um trabalho ativo, produtivo e assertivo em diversos problemas sociais. Neste modelo, o aluno é o eixo e o centro. Por fim, são apresentadas algumas características do modelo educacional baseado no uso de tecnologias e ferramentas digitais que hoje devem apoiar a educação no quadro dos novos desafios que a aprendizagem em ambientes híbridos exige

Antioxidant properties and chemical composition relationship of Europeans and Brazilians propolis

The antioxidant activity of ethanol extracts of propolis, bee glue, of various climate and orographic characteristics, col- lected from Italy, Brazil and Russia, was evaluated measuring their inhibitory action on peroxidation of linoleic acid, radical scavenging ability towards 2,2’-diphenyl-1-picrylhydrazyl, total phenolic content and reducing capacity by en- zymatic and Folin method respectively. Propolis samples were chemically characterized by HPLC-MS/MS in order to find a possible correlation between antioxidant activity and polyphenols composition and quantification. The results obtained indicate that Italian and Russian propolis samples have similar polyphenolic composition and, as a consequence, almost similar antioxidant activity, while Brazilian propolis evidence lower polyphenolic and antioxidant characteristics. Climate and orography reasons of these differences are also suggested

Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes.

The antioxidant activities of trans-resveratrol (trans-3,5,4′-trihydroxystilbene) and trans-piceid (trans-5,4′- dihydroxystilbene-3-O-β-D-glucopyranoside), its more widespread glycosilate derivative, have been compared measuring their inhibitory action on peroxidation of linoleic acid (LA) and the radical scavenging ability towards different free radicals (such as DPPH) and radical initiators. It has been found that the two stilbenes have similar antioxidant capacity, while the comparison with BHT (2,6-di-tert-butyl-4-methylphenol) and α-tocopherol (vitamin E, vit. E), taken as reference, points out a slower but prolonged protective action against lipid peroxidation. Furthermore, piceid appears more efficacious than resveratrol as a consequence of the reaction of the latter with its radical form. The DSC profiles of phosphatidylcholine liposomes of various chain lengths, and EPR measurements of spin labelled liposomes demonstrated that the susceptible hydroxyl group of these compounds are located in the\ud lipid region of the bilayer close to the double bonds of polyunsatured fatty acids, making these stilbenes particularly suitable for the prevention and control of the lipid peroxidation of the membranes

A case study for the handling of data in a skimming control system

This work focuses on the architectural, methodological and technological aspect of handling huge amounts of data. In this summary we particularly focus our attention on the description of a special system built to support large scale data access. The work comes from the need to develop a special purpose skimming control system; this system has been designed as a collaboration between the Stanford Linear Accelerator Center (SLAC, USA), and the Istituto Nazionale di Fisica Nucleare (INFN, National Istitute of Nuclear Physic, Padua, Italy). The goal was to provide the handle of more than 10^7 files, representing Physics data collected by the BaBar experiment