Evaluación estructural sismorresistente para mejorar la construcción de viviendas informales en Ciudadela Chalaca Mz. P, Callao 2020

El presente trabajo de investigación tuvo como objetivo principal determinar la relación entre Evaluación estructural sismorresistente y Viviendas Informales en Ciudadela Chalaca Mz. P, Callao para mejorar la construcción de esa zona, debido a que se implementó edificaciones sin supervisión ni mano de obra calificada, ya que los ciudadanos no cuentan con recursos suficientes para realizarlo. Por las cuales, tomamos como población todas las viviendas abarcadas en la Mz. P, 3 de estas viviendas como muestra y 1 vivienda en el muestreo, realizando estudios de ensayos de laboratorio a la vivienda, ya que su suelo es similar en todas las edificaciones de esa zona. Mediante los ensayos SUCS y Corte Directo elaborados por medio del laboratorio de Mecánica de Suelos JCH S.A.C., obtuvimos como resultado un tipo de perfil de suelo S2 y a su vez dos clasificaciones de suelo: Arena Limosa con un CH: 15.1% y Arena Limosa Pobremente Gravada con un CH: 16.8%. En el análisis de resultados obtuvimos que el asentamiento rápido < al asentamiento tolerable como indica la norma NTP E.030

Uma Breve História do Coraçao Artificial

Como o tratamento farmacológico da insuficiência cardíaca nao tem atingido o sucesso esperado em um grande número de pacientes, outras alternativas nao farmacológicas foram desenvolvidas neste período, como forma de tratamento destes graves pacientes. Uma delas é relacionada a utilizaçao de suporte circulatório por dispositivos implantáveis, que é o motivo de discussao neste artigo

Uma Breve História do Coraçao Artificial

Como o tratamento farmacológico da insuficiência cardíaca nao tem atingido o sucesso esperado em um grande número de pacientes, outras alternativas nao farmacológicas foram desenvolvidas neste período, como forma de tratamento destes graves pacientes. Uma delas é relacionada a utilizaçao de suporte circulatório por dispositivos implantáveis, que é o motivo de discussao neste artigo

Morphophysiological aspects of the digestive tract in IV stage larvae of Bradysia impatiens (Diptera: Sciaridae).

The morphological, cytological and physiological aspects of the digestive tract of the siarid Bradysia impatiens fourth-instar larvae were studied using bright-field microscopy. The division of the digestive tract into the stomodeum (foregut), the mesenteron (midgut) and the proctodeum (hindgut) was observed; the second of which being composed of endocrine, regenerative, column-shaped cells. The larvae did not present a crop; hence digestion of the bolus occurs in the midgut. They have two well-developed gastric caeca, where it can be assumed that great nutrient absorption takes place. The peritrophic membrane is type II, with a pore size that allows the passage of molecules up to 150 kDa, and which divides the midgut into two regions: the endoperitrophic and ectoperitrophic spaces. There are four Malpighian tubules present. The midgut has a pH gradient ranging from mildly alkaline in the foregut to neutral in the caeca and hindgut. It has a recirculation mechanism stretching from the endoperitrophic to the ectoperitrophic space and vice versa, which improves digestion and optimizes enzyme production. The morphophysiological features observed in B. impatiens larvae confirm that these organisms are well-adapted detritivores. Additionally, the peritrophic membrane protects the midgut from pathogenic agents

Epigenetic mechanisms and posttranslational Modifications in systemic lupus erythematosus

The complex physiology of eukaryotic cells is regulated through numerous mechanisms, including epigenetic changes and posttranslational modifications. The wide-ranging diversity of these mechanisms constitutes a way of dynamic regulation of the functionality of proteins, their activity, and their subcellular localization as well as modulation of the di erential expression of genes in response to external and internal stimuli that allow an organism to respond or adapt to accordingly. However, alterations in these mechanisms have been evidenced in several autoimmune diseases, including systemic lupus erythematosus (SLE). The present review aims to provide an approach to the current knowledge of the implications of these mechanisms in SLE pathophysiology

The Effect of the Stretch-Shortening Cycle in the Force–Velocity Relationship and Its Association With Physical Function in Older Adults With COPD

This study aimed to evaluate the effect of the stretch-shortening cycle (SSC) on different portions of the force–velocity (F–V) relationship in older adults with and without chronic obstructive pulmonary disease (COPD), and to assess its association with physical function. The participants were 26 older adults with COPD (79 ± 7 years old; FEV1 = 53 ± 36% of predicted) and 10 physically active non-COPD (77 ± 4 years old) older adults. The F–V relationship was evaluated in the leg press exercise during a purely concentric muscle action and compared with that following an eccentric muscle action at 10% intervals of maximal unloaded shortening velocity (V0). Vastus lateralis (VL) muscle thickness, pennation angle (PA), and fascicle length (FL) were assessed by ultrasound. Habitual gait speed was measured over a 4-m distance. COPD subjects exhibited lower physical function and concentric maximal muscle power (Pmax) values compared with the non-COPD group (both p &lt; 0.05). The SSC increased force and power values among COPD participants at 0–100 and 1–100% of V0, respectively, while the same was observed among non-COPD participants only at 40–90 and 30–90% of V0, respectively (all p &lt; 0.05). The SSC induced greater improvements in force, but not power, among COPD compared with non-COPD subjects between 50 and 70% of V0 (all p &lt; 0.05). Thus, between-group differences in muscle power were not statistically significant after the inclusion of the SSC (p &gt; 0.05). The SSC-induced potentiation at 50–100% of V0 was negatively associated with physical function (r = -0.40–0.50), while that observed at 80–100% of V0 was negatively associated with VL muscle thickness and PA (r = -0.43–0.52) (all p &lt; 0.05). In conclusion, older adults with COPD showed a higher SSC-induced potentiation compared with non-COPD subjects, which eliminated between-group differences in muscle power when performing SSC muscle actions. The SSC-induced potentiation was associated with lower physical function, VL muscle thickness, and VL PA values. The SSC-induced potentiation may help as a compensatory mechanism in those older subjects with a decreased ability to produce force/power during purely concentric muscle actions

The effect of the stretch-shortening cycle in the force–velocity relationship and its association with physical function in older adults with COPD

This study aimed to evaluate the effect of the stretch-shortening cycle (SSC) on different portions of the force–velocity (F–V) relationship in older adults with and without chronic obstructive pulmonary disease (COPD), and to assess its association with physical function. The participants were 26 older adults with COPD (79 ± 7 years old; FEV1 = 53 ± 36% of predicted) and 10 physically active non-COPD (77 ± 4 years old) older adults. The F–V relationship was evaluated in the leg press exercise during a purely concentric muscle action and compared with that following an eccentric muscle action at 10% intervals of maximal unloaded shortening velocity (V0). Vastus lateralis (VL) muscle thickness, pennation angle (PA), and fascicle length (FL) were assessed by ultrasound. Habitual gait speed was measured over a 4-m distance. COPD subjects exhibited lower physical function and concentric maximal muscle power (Pmax) values compared with the non-COPD group (both p 0.05). The SSC-induced potentiation at 50–100% of V0 was negatively associated with physical function (r = -0.40–0.50), while that observed at 80–100% of V0 was negatively associated with VL muscle thickness and PA (r = -0.43–0.52

ENE-COVID nationwide serosurvey served to characterize asymptomatic infections and to develop a symptom-based risk score to predict COVID-19

Objectives: To characterize asymptomatic SARS-CoV-2 infections and develop a symptom-based risk score useful in primary healthcare. Study design and setting: Sixty-one thousand ninty-two community-dwelling participants in a nationwide population-based serosurvey completed a questionnaire on COVID-19 symptoms and received an immunoassay for SARS-CoV-2 IgG antibodies between April 27 and June 22, 2020. Standardized prevalence ratios for asymptomatic infection were estimated across participant characteristics. We constructed a symptom-based risk score and evaluated its ability to predict SARS-CoV-2 infection. Results: Of all, 28.7% of infections were asymptomatic (95% CI 26.1-31.4%). Standardized asymptomatic prevalence ratios were 1.19 (1.02-1.40) for men vs. women, 1.82 (1.33-2.50) and 1.45 (0.96-2.18) for individuals <20 and ≥80 years vs. those aged 40-59, 1.27 (1.03-1.55) for smokers vs. nonsmokers, and 1.91 (1.59-2.29) for individuals without vs. with case contact. In symptomatic population, a symptom-based score (weights: severe tiredness = 1; absence of sore throat = 1; fever = 2; anosmia/ageusia = 5) reached standardized seroprevalence ratio of 8.71 (7.37-10.3), discrimination index of 0.79 (0.77-0.81), and sensitivity and specificity of 71.4% (68.1-74.4%) and 74.2% (73.1-75.2%) for a score ≥3. Conclusion: The presence of anosmia/ageusia, fever with severe tiredness, or fever without sore throat should serve to suspect COVID-19 in areas with active viral circulation. The proportion of asymptomatics in children and adolescents challenges infection control.The ENE-COVID study was supported by the Spanish Ministry of Health, the Institute of Health Carlos III, and the Spanish National Health System. The funders were in- volved in the study logistics, but they had no role in study design or in the collection, analysis, interpretation of data, or the decision to submit the article for publicationS