Size-Dependent Surface Plasmon Dynamics in Metal Nanoparticles

We study the effect of Coulomb correlations on the ultrafast optical dynamics of small metal particles. We demonstrate that a surface-induced dynamical screening of the electron-electron interactions leads to quasiparticle scattering with collective surface excitations. In noble-metal nanoparticles, it results in an interband resonant scattering of d-holes with surface plasmons. We show that this size-dependent many-body effect manifests itself in the differential absorption dynamics for frequencies close to the surface plasmon resonance. In particular, our self-consistent calculations reveal a strong frequency dependence of the relaxation, in agreement with recent femtosecond pump-probe experiments.Comment: 8 pages + 4 figures, final version accepted to PR

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

RAD51 is an ATP-dependent recombinase, recruited by BRCA2 to mediate DNA double-strand breaks repair through homologous recombination and represents an attractive cancer drug target. Herein, we applied for the first-time protein-templated dynamic combinatorial chemistry on RAD51 as a hit identification strategy. Upon design of N-acylhydrazone-based dynamic combinatorial libraries, RAD51 showed a clear templating effect, amplifying 19 N-acylhydrazones. Screening against the RAD51-BRCA2 protein-protein interaction via ELISA assay afforded 10 inhibitors in the micromolar range. Further 19F NMR experiments revealed that 7 could bind RAD51 and be displaced by BRC4, suggesting an interaction in the same binding pocket of BRCA2. These results proved not only that ptDCC could be successfully applied on full-length oligomeric RAD51, but also that it could address the need of alternative strategies toward the identification of small-molecule PPI inhibitors

Electromagnetic compatibility of implantable neurostimulators to RFID emitters

<p>Abstract</p> <p>Background</p> <p>The objective of this study is to investigate electromagnetic compatibility (EMC) of implantable neurostimulators with the emissions from radio frequency identification (RFID) emitters.</p> <p>Methods</p> <p>Six active implantable neurostimulators with lead systems were tested for susceptibility to electromagnetic fields generated by 22 RFID emitters. These medical devices have been approved for marketing in the U.S. for a number of intended uses that include: epilepsy, depression, incontinence, Parkinsonian tremor and pain relief. Each RFID emitter had one of the following carrier frequencies: 125 kHz, 134 kHz, 13.56 MHz, 433 MHz, 915 MHz and 2.45 GHz</p> <p>Results</p> <p>The test results showed the output of one of the implantable neurostimulators was inhibited by 134 kHz RFID emitter at separation distances of 10 cm or less. The output of the same implantable neurostimulator was also inhibited by another 134 kHz RFID emitter at separation distances of 10 cm or less and also showed inconsistent pulsing rate at a separation distance of 15 cm. Both effects occurred during and lasted through out the duration of the exposure.</p> <p>Conclusions</p> <p>The clinical significance of the effects was assessed by a clinician at the U.S. Food and Drug Administration. The effects were determined to be clinically significant only if they occurred for extended period of time. There were no observed effects from the other 5 implantable neurostimulators or during exposures from other RFID emitters.</p

Size-dependent Correlation Effects in Ultrafast Optical Dynamics of Metal Nanoparticles

We study the role of collective surface excitations in the electron relaxation in small metal particles. We show that the dynamically screened electron-electron interaction in a nanoparticle contains a size-dependent correction induced by the surface. This leads to new channels of quasiparticle scattering accompanied by the emission of surface collective excitations. We calculate the energy and temperature dependence of the corresponding rates, which depend strongly on the nanoparticle size. We show that the surface-plasmon-mediated scattering rate of a conduction electron increases with energy, in contrast to that mediated by a bulk plasmon. In noble-metal particles, we find that the dipole collective excitations (surface plasmons) mediate a resonant scattering of d-holes to the conduction band. We study the role of the latter effect in the ultrafast optical dynamics of small nanoparticles and show that, with decreasing nanoparticle size, it leads to a drastic change in the differential absorption lineshape and a strong frequency dependence of the relaxation near the surface plasmon resonance. The experimental implications of our results in ultrafast pump-probe spectroscopy are also discussed.Comment: 29 pages including 6 figure

Ultrafast optical generation of coherent phonons in CdTe1-xSex quantum dots

We report on the impulsive generation of coherent optical phonons in CdTe0.68Se0.32 nanocrystallites embedded in a glass matrix. Pump probe experiments using femtosecond laser pulses were performed by tuning the laser central energy to resonate with the absorption edge of the nanocrystals. We identify two longitudinal optical phonons, one longitudinal acoustic phonon and a fourth mode of a mixed longitudinal-transverse nature. The amplitude of the optical phonons as a function of the laser central energy exhibits a resonance that is well described by a model based on impulsive stimulated Raman scattering. The phases of the coherent phonons reveal coupling between different modes. At low power density excitations, the frequency of the optical coherent phonons deviates from values obtained from spontaneous Raman scattering. This behavior is ascribed to the presence of electronic impurity states which modify the nanocrystal dielectric function and, thereby, the frequency of the infrared-active phonons

Molards as an analogue for ejecta-ice interactions on Mars

International audience&lt;p&gt;The 125-km-diameter Hale impact crater is located in the southern hemisphere of Mars and has been dated to 1 Ga (Early to Middle Amazonian; Jones et al., 2011). It is thought to have penetrated the martian cryosphere, because it hosts landforms indicating volatile mobilisation post-impact: its ejecta are lobate and bear channels, and the interior is pervasively pitted and hosts alluvial fans (Collins-May et al. 2020; El-Maarry et al., 2013; Jones et al., 2011; Tornabene et al., 2012). Here, we test the hypothesis that conical mounds found within the ejecta are &amp;#8220;molards&amp;#8221; by comparing them to terrestrial analogues. Molards are conical mounds of debris resulting from the degradation of blocks of ice-rich material which have been mobilised by a landslide and are found in periglacial environments (Morino et al., 2019).&lt;/p&gt;&lt;p&gt;Our study area (240x180 km) is in the South-East part of the Hale impact crater ejecta (36&amp;#176;&amp;#8211;39&amp;#176;S, 36&amp;#176;&amp;#8211;31&amp;#176;W). We analyse the spatial and topographic distribution of the conical mounds using orbital images from 25 cm/pixel to 15 m/pixel and measure their height, width and slope using 1 m/pixel elevation data. We then compare them to conical mounds on the deposits of the 2010 Mount Meager debris avalanche, Canada (Roberti et al. 2017) and of the 2000 Paatuut landslide in western Greenland (Dahl-Jensen et al. 2004).&lt;/p&gt;&lt;p&gt;The conical mounds of the Hale impact crater are located at the distal boundary of the thickest part of the ejecta blanket, which reflects the spatial distribution of mounds along the distal parts of the terminal lobe of the Mount Meager debris avalanche. Furthermore, mounds in the Hale impact crater have comparable shapes and flank slopes to molards in the Mount Meager and Paatuut case studies, but are one order of magnitude bigger. This size difference is consistent with the flow-depth that transported the blocks also being one order of magnitude bigger than on Earth.&lt;/p&gt;&lt;p&gt;We infer that conical mounds near the Hale impact crater are a result of fragmented blocks of ice-cemented regolith produced by the impact and transported by the ejecta flows, and finally degraded into cones of debris (molards) by the loss of interstitial ice. Our interpretation supports the prevailing hypothesis that the Hale impact event penetrated the martian cryosphere and further provides important constraints on the rheology of martian ejecta deposits that can be tested by future studies and in other locations on Mars.&lt;/p&gt;&lt;p&gt;We acknowledge financial support for the PERMOLARDS project from French National Research Agency (ANR-19-CE01-0010).&lt;/p&gt

Thioflavine-T and Congo Red reveal the polymorphism of insulin amyloid fibrils when probed by polarization-resolved fluorescence microscopy.

International audienceAmyloid fibrils are protein misfolding structures that involve a β-sheet structure and are associated with the pathologies of various neurodegenerative diseases. Here we show that Thioflavine-T and Congo Red, two major dyes used to image fibrils by fluorescence assays, can provide deep structural information when probed by means of polarization-resolved fluorescence microscopy. Unlike fluorescence anisotropy or fluorescence detected linear dichroism imaging, this technique allows to retrieve simultaneously both mean orientation and orientation dispersion of the dye, used here as a reporter of the fibril structure. We have observed that insulin amyloid fibrils exhibit a homogeneous behavior over the fibrils' length, confirming their structural uniformity. In addition, these results reveal the existence of various structures among the observed fibrils' population, in spite of a similar aspect when imaged with conventional fluorescence microscopy. This optical nondestructive technique opens perspectives for in vivo structural analyses or high throughput screening