Knowledge diffusion and geographical proximity: a multi-relational networks approach

AbstractIn the literature on innovation and organizational learning, there is a wide consensus about the relevance of learning activities. Specifically, they occur both individually (as producers will increase their knowledge simply "by doing") and collectively (as producers and other stakeholders involved will learn "by interacting"). Therefore, in these studies, the focus on informal learning has become increasingly evident with recognition that informal learning predominates in smaller and locally-operating firms, and large corporations alike. The aim of the study is twofold; firstly to understand the link between formal networks and informal learning and secondly to investigate if the information exchanged in the network between firms and institutions is altered by content. Through a case study in Foggia, southern Italy, we have investigated how knowledge flows among small organic food firms and related supporting institutions. The core finding of the study was that the existence of networks is necessary to promote informal knowledge flows, yet not sufficient by itself. In conclusion, several obstacles had to be removed before producers gained from the positive effects of geographical clustering and proximity

Negotiating voices through embodied semiosis: the co-construction of a science text

This article presents a rich description of an everyday, paired learner interaction in class. In contributing to debates on collaborative classroom interaction, this article presents a micro-analysis of the work of embodied modes employed in face-to-face interaction. Through ethnographically-contextualised Multimodal Discourse Analysis (EC-MDA) , a partial understanding of the ways in which two learners interact through embodied semiosis is reached. The originality of this article lies with the insights gained from multimodal discourse analysis which show how (in textual terms), even in a less creative space, learners negotiate personal, individual ‘ownness’ alongside academic genres in the co-construction of a science text. Three key aspects to paired classroom interaction are identified, namely: multiple voices, multimodal inference and modal synchrony. Through exploring the intricacies of social interaction, we can recognise the detailed multimodal contributions of individuals engaged in collaborative construction of text

An evidence map of the effect of Tai Chi on health outcomes.

BackgroundThis evidence map describes the volume and focus of Tai Chi research reporting health outcomes. Originally developed as a martial art, Tai Chi is typically taught as a series of slow, low-impact movements that integrate the breath, mind, and physical activity to achieve greater awareness and a sense of well-being.MethodsThe evidence map is based on a systematic review of systematic reviews. We searched 11 electronic databases from inception to February 2014, screened reviews of reviews, and consulted with topic experts. We used a bubble plot to graphically display clinical topics, literature size, number of reviews, and a broad estimate of effectiveness.ResultsThe map is based on 107 systematic reviews. Two thirds of the reviews were published in the last five years. The topics with the largest number of published randomized controlled trials (RCTs) were general health benefits (51 RCTs), psychological well-being (37 RCTs), interventions for older adults (31 RCTs), balance (27 RCTs), hypertension (18 RCTs), fall prevention (15 RCTs), and cognitive performance (11 RCTs). The map identified a number of areas with evidence of a potentially positive treatment effect on patient outcomes, including Tai Chi for hypertension, fall prevention outside of institutions, cognitive performance, osteoarthritis, depression, chronic obstructive pulmonary disease, pain, balance confidence, and muscle strength. However, identified reviews cautioned that firm conclusions cannot be drawn due to methodological limitations in the original studies and/or an insufficient number of existing research studies.ConclusionsTai Chi has been applied in diverse clinical areas, and for a number of these, systematic reviews have indicated promising results. The evidence map provides a visual overview of Tai Chi research volume and content.Systematic review registrationPROSPERO CRD42014009907

The Effects of 16-Week Exercising Program on Inflammatory Markers in Human Milk

The purpose of this study is to determine the effects of a 16-week exercise program on inflammatory cytokines in human milk. The human milk samples were collected from 2003-2010 during two postpartum breastfeeding exercise interventions, the Breastfeeding for Healthy Infants and Postpartum (Be HIP) and Be HIP Too

Being clouds, pulling teeth and using their breadloaves : a multimodal micro-analysis of instantiations of child-to-child interaction in classroom contexts.

This study examines the ways in which children communicate and collaborate with one another whilst working on curriculum tasks in an educational setting. It uses an approach to methodology founded on Linguistic Anthropology and Linguistic Ethnography and informed by a social-semiotic theory of communication, drawing upon field notes and video-recorded data from a class of nine and ten year olds at a Sheffield primary school. A framework informed by sociolinguistic theory and multimodal analyses of communication has been devised to analyse the data in such a way that the many and varied modes of meaning-making employed by the children are considered. The purpose of the study is to gain a deeper understanding of the ways in which children creatively employ semiotic resources in their face-to-face spontaneous interactions. The main findings of the study are that modes of meaning-making are integral to the communicative activity and work in coordination with each other. Features which have been noted in linguistic studies of interaction can be seen in this multimodal study and could be classed as features of multimodal communication rather than linguistic features. In addition, child-to-child classroom meaning-making is intersubjective and collaborative. Knowledge can be presented through any chosen mode and can be developed collaboratively through multiple modes. The study has implications for pedagogy in that educationalists need to be aware of the multimodal nature of children's interactions, recognise the value of the semiotic work of pupils and ensure opportunities for meaning-making using multiple modes are planned for. The implications for future research are that methodological approaches need to take account of the use of all modes in interactions in order to gain a thicker description of what is taking place than could be achieved with a language-dominant approach

Nanofluid optical property characterization: towards efficient direct absorption solar collectors

Suspensions of nanoparticles (i.e., particles with diameters < 100 nm) in liquids, termed nanofluids, show remarkable thermal and optical property changes from the base liquid at low particle loadings. Recent studies also indicate that selected nanofluids may improve the efficiency of direct absorption solar thermal collectors. To determine the effectiveness of nanofluids in solar applications, their ability to convert light energy to thermal energy must be known. That is, their absorption of the solar spectrum must be established. Accordingly, this study compares model predictions to spectroscopic measurements of extinction coefficients over wavelengths that are important for solar energy (0.25 to 2.5 μm). A simple addition of the base fluid and nanoparticle extinction coefficients is applied as an approximation of the effective nanofluid extinction coefficient. Comparisons with measured extinction coefficients reveal that the approximation works well with water-based nanofluids containing graphite nanoparticles but less well with metallic nanoparticles and/or oil-based fluids. For the materials used in this study, over 95% of incoming sunlight can be absorbed (in a nanofluid thickness ≥10 cm) with extremely low nanoparticle volume fractions - less than 1 × 10-5, or 10 parts per million. Thus, nanofluids could be used to absorb sunlight with a negligible amount of viscosity and/or density (read: pumping power) increase

Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury.

Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the beneficial effects of therapeutic hypothermia are due to preserved autophagy and mitophagy. Under general anesthesia, the left anterior descending coronary artery of 19 female farm pigs was occluded for 90 minutes with consecutive reperfusion. 30 minutes after reperfusion, we performed pericardial irrigation with warm or cold saline for 60 minutes. Myocardial tissue analysis was performed one and four weeks after infarction. Therapeutic hypothermia induced a significant increase in autophagic flux, mitophagy, mitochondrial mass and function in the myocardium after infarction. Cell stress, apoptosis, inflammation as well as fibrosis were reduced, with significant preservation of systolic and diastolic function four weeks post infarction. We found similar biochemical changes in human samples undergoing open chest surgery under hypothermic conditions when compared to the warm. These results suggest that autophagic flux and mitophagy are important mechanisms implicated in cardiomyocyte recovery after myocardial infarction under hypothermic conditions. New therapeutic strategies targeting these pathways directly could lead to improvements in prevention of heart failure

Risk of Sequelae after Chlamydia trachomatis Genital Infection in Women

Chlamydia trachomatis infection, the most common reportable disease in the United States, can lead to pelvic inflammatory disease (PID), infertility, ectopic pregnancy, and chronic pelvic pain. Although C. trachomatis is identified among many women who receive a diagnosis of PID, the incidence and timing of PID and longterm sequelae from an untreated chlamydial infection have not been fully determined. This article examines evidence reviewed as part of the Centers for Disease Control and Prevention Chlamydia Immunology and Control Expert Advisory Meeting; 24 reports were included.We found no prospective studies directly assessing risk of long-term reproductive sequelae, such as infertility, after untreated C. trachomatis infection. Several studies assessed PID diagnosis after untreated chlamydial infection, but rates varied widely, making it difficult to determine an overall estimate. In high-risk settings, 2%-5% of untreated women developed PID within the ∼2-week period between testing positive for C. trachomatis and returning for treatment. However, the rate of PID progression in the general, asymptomatic population followed up for longer periods appeared to be low. According to the largest studies, after symptomatic PID of any cause has occurred, up to 18% of women may develop infertility. In several studies, repeated chlamydial infection was associated with PID and other reproductive sequelae, although it was difficult to determine whether the risk per infection increased with each recurrent episode. The present review critically evaluates this body of literature and suggests future research directions. Specifically, prospective studies assessing rates of symptomatic PID, subclinical tubal damage, and long-term reproductive sequelae after C. trachomatis infection; better tools to measure PID and tubal damage; and studies on the natural history of repeated chlamydial infections are neede

Dialogic Teaching : Evaluation Report and Executive Summary

The aim of the intervention was to raise levels of engagement and attainment across English, maths, and science in primary schools by improving the quality of teacher and pupil talk in the classroom. The approach, termed ‘dialogic teaching’, emphasises dialogue through which pupils learn to reason, discuss, argue, and explain in order to develop their higher order thinking as well as their articulacy. The intervention was developed and delivered by a team from the Cambridge Primary Review Trust (CPRT) and the University of York. Year 5 teachers in 38 schools, and a teacher mentor from each school, received resources and training from the delivery team, and then implemented the intervention over the course of the autumn and spring terms in the 2015/2016 school year. Following the intervention, pupils were tested in English, mathematics, and science. This efficacy trial compared the 38 schools (2,492 pupils) in which the intervention took place with 38 control schools (2,466 pupils). During the intervention, the evaluation team also carried out a survey and interviews with a sample of teachers, mentors, and heads, plus case-study visits to three intervention schools