Cyber-physical systems (CPS) in supply chain management: from foundations to practical implementation

Abstract Since 2015 developments such as Industry 4.0 and cyber-physical production systems on the technology side, and approaches such as flexible and smart manufacturing systems hold great potential. These in turn give rise to special requirements that the production planning, control and monitoring, among others, needing a paradigm shift to exploit the full potential of these methods and techniques. Starting from foundations in Cyber Physical Systems (CPS), building upon definitions and findings reported by literature, a practical example of innovative Cyber Physical Supply Chain Planning System (CPS2) is provided. The paper clarifies the advantages of cyber-physical systems in the production planning, controlling and monitoring perspective with respect to manufacturing, logistics and related planning practices. A set of basic features of CPS2 systems are discussed and addressed by contextualizing service orientation architecture and microservices components with respect to supply chain management collaboration and cooperation practices. The identification of specific technologies behind those functions, within the developed research, provides some practical insight if the interesting CPS2 potential

Sex attribution, gender identity and quality of life in disorders of sex development due to 45,X/46,XY mosaicism: methods for clinical and psychosocial assessment.

The choice of sex in newborns with genital ambiguity is challenging. Information concerning the satisfaction of subjects with disorders of sex development from childhood to adulthood is required in order to address sex attribution policies. This study focuses on the methods that enable clinicians to investigate the alignment of phenotypes with gender identity and quality of life in people with disorders of this kind. These methods are presented as tools for studying a cohort of ten subjects with 45,X/46,XY mosaicism examined between 1985 and 2014 in the Department of Pediatric Endocrinology, Regina Margherita Children's Hospital, Turin: five children and five young adults, four reared as females and six as males. Clinical outcome was assessed by means of a clinical scoring system considering height, genital appearance, gonads and pubertal development. The Gender Identity Questionnaire for Children and the World Health Organization Quality of Life assessment were adopted. The four male children strongly identified with their assigned sex: male attribution was satisfactory until pubertal age. In young adults the clinical scores ranged between 55-65% for both genders. In the young male, the reduced sexual activity and the poor body image perception strongly affected his quality of life. The clinical scores of the two young female adults (60% for both) were not balanced with their quality of life scores (87.5% and 68.75% respectively): individual traits and social-familial context should be investigated in order to explain these differences. Clinical and psychosocial assessment in people with disorders of sex development is mandatory in order to plan care procedures; a detailed analysis requires adequate tools. Clinical scoring system, Gender Identity Questionnaire for Children and World Health Organization Quality of Life assessment can be used to investigate the alignment of physical phenotype with gender identity and quality of life