Normative data for Lezak's Tinkertoy test in healthy Italian adults

The Tinkertoy test is a tool for the neuropsychological assessment of executive functions and a predictor of employability. Originally a children's toy comprising pieces to assemble freely, the TinkerToy Test examines organizational abilities, planning, and response flexibility. It allows subjects to use their own initiative and does not force them to choose from a series of predetermined alternatives. Tinkertoy test normative values were collected from 256 neurologically healthy Italian subjects. Multivariable analysis showed sex and education to have significant confounding effects. Adjusted and inferential cut-off points were determined and converted into equivalent scores, applying a distribution-free technique

Un’ epica bibliografia visiva della storia della distruzione dei libri

The Singapore Pavilion, set up as part of the 59th edition of the Art Exhibition La Biennale di Venezia, hosts the work of artist Shubigi Rao, a threefold multidisciplinary installation comprising a book, a video and a paper maze built around the theme of books destruction. They are part of a decade-long project under the title Pulp: A Short Biography of the Banished Book. Starting in 2014, it has brought the artist to visit archives and libraries all around the world and to meet women and men who daily dedicate themselves to defending books and cultures on the margins. Here we present the works exhibited in Venice (2022) and the three books that have already been published (2016, 2018, 2022) out of the five scheduled.Il Padiglione di Singapore, allestito nell’ambito della 59. edizione della Biennale d’Arte di Venezia, ospita l’opera dell’artista Shubigi Rao, una triplice installazione multidisciplinare che comprende un libro, un film e un labirinto di carta costruiti intorno al tema della distruzione dei libri. Fanno parte di un progetto decennale dal titolo Pulp: A Short Biography of the Banished Book. Iniziato nel 2014, ha portato l’artista a visitare archivi e biblioteche in tutto il mondo e a incontrare donne e uomini che quotidianamente si spendono per difendere i libri e le culture ai margini. In questo contesto presentiamo le opere esposte a Venezia (2022) e i tre dei cinque libri previsti che sono già stati pubblicati (2016, 2018, 2022)

Un’ epica bibliografia visiva della storia della distruzione dei libri

Il Padiglione di Singapore, allestito nell’ambito della 59. edizione della Biennale d’Arte di Venezia, ospita l’opera dell’artista Shubigi Rao, una triplice installazione multidisciplinare che comprende un libro, un film e un labirinto di carta costruiti intorno al tema della distruzione dei libri. Fanno parte di un progetto decennale dal titolo Pulp: A Short Biography of the Banished Book. Iniziato nel 2014, ha portato l’artista a visitare archivi e biblioteche in tutto il mondo e a incontrare donne e uomini che quotidianamente si spendono per difendere i libri e le culture ai margini. In questo contesto presentiamo le opere esposte a Venezia (2022) e i tre dei cinque libri previsti che sono già stati pubblicati (2016, 2018, 2022)

Editorial

In questo numero la rivista «Bibliothecae.it» si offre come sede di pubblicazione degli atti del convegno internazionale Periodici bibliografici tra passato e futuro che si è tenuto presso la Biblioteca Universitaria di Bologna nelle giornate del 22 e 23 febbraio 2018. 1 Studiosi italiani e stranieri sono intervenuti per approfondire in modo organico la conoscenza del periodico bibliografico come genere, sia da un punto di vista storico, con attenzione alle sue declinazioni e implicazioni letterarie, bibliografiche, editoriali e biblioteconomiche, sia da un punto di vista professionale, con riguardo alle sue manifestazioni attuali e ai suoi risvolti pubblicistici, scientifici, economici e commerciali.In this issue the journal "Bibliothecae.it" is offered as the venue for the publication of the proceedings of the international conference "Bibliographical Journals between past and future" ( University Library of Bologna on 22-23 February 2018). Italian scholars and foreigners have intervened to deepen the knowledge of the periodical bibliography as a genre in an organic way, both from a historical point of view, with attention to its declinations and literary implications, bibliographies, editorials and librarians, both from a professional point of view, with regard to its current manifestations and its public, scienti fi c, economic and commercial aspects

Focal adhesion molecules as potential target of lead toxicity in NRK-52E cell line

AbstractIn this study, we investigated the influence of inorganic lead (Pb(II)), an environmental pollutant having nephrotoxic action, on the focal adhesion (FA) organization of a rat kidney epithelial cell line (NRK-52E). In particular, we evaluated the effects of the metal on the recruitment of paxillin, focal adhesion kinase, vinculin and cytoskeleton proteins at the FAs complexes. We provided evidences that, in proliferating NRK-52E cell cultures, low concentrations of Pb(II) affect the cell adhesive ability and stimulate the disassembly of FAs, thus inhibiting the integrin-activated signalling. These effects appeared to be strictly associated to the Pb-induced arrest of cell cycle at G0/G1 phase also proved in this cell line

The societal burden of chronic liver diseases: results from the COME study.

OBJECTIVE: Chronic liver diseases (CLDs) impose a significant socioeconomic burden on patients and the healthcare system, but to what extent remains underexplored. We estimated costs and health-related-quality-of-life (HRQoL) among patients with CLDs at different stages and with different aetiologies. DESIGN: A cost-of-illness study was conducted. Direct costs, productivity loss and HRQoL were estimated in patients with chronic hepatitis, cirrhosis hepatocellular carcinoma (HCC) or where orthotopic liver transplantation (OLT) had been performed, for hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection, or in those with liver disease from other causes. Patients were retrospectively observed for 6 months. The societal perspective was adopted to calculate costs. RESULTS: In total, 1088 valid patients (median age=59.5 years, 60% men) were enrolled. 61% had chronic hepatitis, 20% cirrhosis, 8% HCC and 12% underwent OLT. HCV infection was identified in 52% and HBV infection in 29% of the patients. Adjusted mean direct costs increased from €3000/patient-month in HBV infected patients with OLT. Antiviral treatment was the cost driver in patients with hepatitis, while hospital costs were the driver in the other subgroups. Absenteeism increased from HBV-infected patients with hepatitis (0.7 day/patient-month) to patients with OLT with other aetiologies (3.7 days/patient-month). HRQoL was on average more compromised in cirrhosis and patients with HCC, than in hepatitis and patients with OLT. HBV-infected patients generated higher direct costs, patients with other aetiologies generated the highest productivity loss and HCV-infected patients reported the worst HRQoL levels. CONCLUSIONS: The present study can be considered a benchmark for future research and to guide policies aimed at maximising the cost-effective of the interventions