Estudo fitoquímico e avaliação ds atividades biológicas das cascas de Celtis Iguanaea (jacq.) Sargent Ulmaceae

Orientadora : Profa. Dra. Marilis Dallarmi MiguelCo-orientador: Prof. Dr. Obdulio Gomes MiguelDissertação (Mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas. Defesa: Curitiba,31/03/2010Bibliografia: fls. 103-108Área de concentração: Insumos, medicamentos e correlatosResumo: A especie Celtis iguanaea e popularmente conhecida como esporao de galo ou grao de galo. As folhas sao utilizadas pela populacao para o tratamento de dores no corpo e no peito, para reumatismo, asma, colicas, ma digestao e como diuretico, as raizes sao utilizadas para infeccoes urinarias e as cascas para a febre. O presente trabalho objetivou contribuir para o estudo fitoquimico, antioxidante, alelopatico, antimicrobiano e de toxicidade das cascas de Celtis iguanaea. O extrato etanolico foi submetido a particao com os solventes hexano, cloroformio e acetato de etila. As substancias - sitosterol (esteroide), a friedelina e o epifriedelinol (triterpenos) foram isolados da fracao hexano e a substancia -trans-p-coumaroiltiramina uma amida inibidora da enzima acetilcolinesterase, foi isolada da fracao cloroformio. As substancias foram identificadas por meio de metodos espectroscopicos de RMN de 1H e 13C. A fracao cloroformio apresentou uma atividade antioxidante equivalente a da rutina e a fracao acetato de etila equivalente a 60 % da atividade da vitamina C. O extrato bruto na concentracao de 0,1 mg apresentou atividade alelopatica, inibindo o crescimento do hipocotilo em 34,97 % e estimulando o crescimento da radicula em 29,64 % de Lactuca sativa. No ensaio de toxicidade frente a Artemia salina apresentou uma LC50 superior a 1000 ƒÊ/mL, e nao apresentou atividade antibacteriana significante frente as cepas testadas.Abstract: The specie Celtis iguanaea, is popularly known as esporao de galo and grao de galo . The leaves are used by the population to treat body and chest aches, rheumatism, asthma, colic, poor digestion and as diuretic, the roots are used for urinary tract infections and barks are used for fever. This work aimed to contribute to antioxidant, allelopathic, antimicrobial and toxicity activities and phytochemical study of Celtis iguanaea barks. Ethanolic extract was submitted to partition with hexane, chloroform and ethyl acetate. Tree substances, -sytosterol (steroid), friedelin and epifriedelinol (triterpenes) were isolated from the hexane fraction, and N-trans-pcoumaroyltiramine, an amide inhibitor of the enzyme acethylcolinesterase, was isolated from the chloroform fraction and all these substances were identified by using spectroscopic methods,1H and 13C NMR. The chloroform fractions demonstrated antioxidant activity equivalent of the rutine and the ethyl acetate fraction equivalent for 60 % of the activit of the vitamin C. The extract ethanolic in 0,1 mg concentration showed allelopathic activity inhibiting the hypocotyls growth in 34,97 % and stimulating the growth of radicle in 29,64 % of Lactuca sativa. The toxicity was tested front the Artemia salina, that showed a LC50 values greater than 1000 ƒÊg/ml, and did not present antimicrobial activity significant front the cepas tested

Il pluralismo dell'informazione nell'era digitale. Applicazione del Media Pluralism Monitor nell'Unione Europea, in Albania, Montenegro, Repubblica della Macedonia del Nord, Serbia e Turchia nell'anno 2021. Paese : Italia

This report presents the results of the implementation of the Media Pluralism Monitor for the year 2021 (MPM2022) in Italy. The MPM is a holistic tool geared at assessing the risks to media pluralism in EU member states and selected candidate countries (32 European countries in total, including Albania, Montenegro, the Republic of North Macedonia, Serbia, and Turkey). The MPM takes into account legal, political and economic variables that are relevant to analysing the levels of plurality of media systems in a democratic society. The Media Pluralism Monitor has been implemented, on a regular basis, by the Centre for Media Pluralism and Media Freedom, since 2013/2014.The Centre for Media Pluralism and Media Freedom is co-financed by the European Unio

Test on the effects of reconstituted soil on emergency speed and root growth in maize

Summary Reconstitution is a pedotechnique to counter land degradation and desertification. The reconstitution, patented by the research laboratory m.c.m. Ecosistemi, applies chemical-mechanical actions to a mixture of degraded soil and matrices (such as waste sludge) in order to produce reconstituted soil, a very high fertility soil. This paper is about a pot study in a greenhouse to investigate how reconstituted soil affects emergence speed and seminal roots development of Zea mays L. seedlings, in comparison with a Technosol. 200 seedlings are monitored up to the 16th day after the seeding. The emergence percentage is 98% on reconstituted soil and 91% on Technosol. Average length and weight of fresh seminal roots are higher on reconstituted soil

UMA EXPERIÊNCIA COM UM INSTRUMENTO DE AVALIAÇÃO DO DESEMPENHO ORAL NO ÂMBITO DA DISCIPLINA DE CÁLCULO

Considerando que a avaliação em disciplinas matemáticas no âmbito do Ensino Superior ainda segue moldes ditos tradicionais, este artigo analisa uma experiência envolvendo a utilização deum instrumento de avaliação do desempenho oral, elencando suas potencialidades para a promoção de oportunidades de aprendizagem, bem como algumas de suas limitações. Para tal, realiza-se uma pesquisa qualitativa de cunho interpretativo, considerando a transcrição do diálogo de três grupos deestudantes de Cálculo Diferencial e Integral que analisam resoluções de dois limites de funções reais de uma variável real. Como conclusões, apontam-se as possibilidades oferecidas pelo instrumento para os estudantes produzirem argumentos e transmitirem sua compreensão ao trabalhar de maneiradialógica, diferentemente de trabalhar apenas no contexto escrito. Algumas limitações incluíram a divisão na fala entre os integrantes e o tratamento “mecânico” dos critérios, bem como dificuldadesem expressar oralmente alguns aspectos de notação

Bevacizumab and temozolomide in secondary gliomatosis from gemistocytic astrocytoma: a case report

Gliomatosis cerebri is a rare diffuse glioma with a growth pattern consisting of exceptionally extensive infiltration of the CNS with involvement of at least three lobes. It may appear de novo (primary gliomatosis) or result from the spreading of a focal glioma (secondary gliomatosis). Bevacizumab is a monoclonal antibody anti-VEGF active against recurrent high grade gliomas after standard therapy. We report the case of a 41-year-old man with a secondary gliomatosis treated with bevacizumab and temozolomide who responded and the response lasted 17 months. Moreover, we focus on the side effects (hypertension, deep vein thrombosis) induced by bevacizumab and their effective treatments

Temozolomide as salvage treatment for recurrent intracranial ependymomas of the adult: a retrospective study

BACKGROUND: Few data are available on temozolomide (TMZ) in ependymomas. We investigated the response, survival, and correlation with MGMT promoter methylation in a cohort of patients with adult intracranial ependymoma receiving TMZ as salvage therapy after failure of surgery and radiotherapy. PATIENTS AND METHODS: We retrieved clinical information from the institutional database and follow-up visits, and response to TMZ on MRI was evaluated according to the MacDonald criteria. RESULTS: Eighteen patients (median age, 42 y), with either WHO grade III (10) or grade II (8) ependymoma were evaluable. Tumor location at diagnosis was supratentorial in 11 patients and infratentorial in 7. Progression before TMZ was local in 11 patients, local and spinal in 6 patients, and spinal only in one patient. A median of 8 cycles of TMZ (1–24) was administered. Response to TMZ consisted of complete response (CR) in one (5%) patient, partial response (PR) in 3 (17%) patients, stable disease (SD) in 7 (39%) patients, and progressive disease (PD) in 7 (39%) patients. Maximum response occurred after 3, 10, 14, and 15 cycles, respectively, with neurological improvement in 2 patients. All 4 responding patients were chemotherapy naïve. Both anaplastic (2) and grade II (2) tumors responded. Median progression-free survival and overall survival were 9.69 months (95% CI, 3.22–30.98) and 30.55 months (95% CI, 12.85–52.17), respectively. MGMT methylation was available in 11 patients and was not correlated with response or outcome. CONCLUSION: TMZ has a role in recurrent chemo-naïve adult patients with intracranial ependymoma, regardless of tumor grade and MGMT methylation. We suggest that, after failure of surgery and radiotherapy, TMZ should be considered as a possible first-line treatment for recurrent ependymoma

Caminhos para a pesquisa sociológica

Review of PAUGAM, Serge (Org.) A pesquisa sociológica. Petrópolis: Editora Vozes, 2015.Resenha de PAUGAM, Serge (Org.) A pesquisa sociológica. Petrópolis: Editora Vozes, 2015

IMUNOLOGIA

O Sistema Imunológico evoluiu para nos proteger dos patógenos, esses podem ser patógenos intracelulares que infectam as células individualmente; ou patógenos extracelulares, que dividem-se no sangue nos tecidos ou nas cavidades do organismo. Os dois tipos de patógenos requerem respostas imunes diferentes. A inflamação é uma resposta ao dano tecidual pois permite que anticorpos, moléculas do sistema complemento e leucócitos entrem no tecido no local da infecção. Os linfócitos também são necessários para reconhecer e destruir células infectadas nos tecidos, além de contar com a presença de neutófilos, responsáveis pela fagocitação de bactérias e demais microorganismos. O Sistema Imunológico é passível de falhas, podendo resultar em imunodeficiência, hipersensibilidade ou desregulação que leva a doenças autoimunes

Better survival of patients with oligo- compared with polymetastatic cancers: a systematic review and meta-analysis of 173 studies

Background: The modern concept of oligometastatic (OM) state has been initially developed to describe patients with a low burden of disease and with a potential for cure with local ablative treatments. We systematically assessed the risk of death and relapse of oligometastatic (OM) cancers compared to cancers with more diffuse metastatic spread, through a meta-analysis of published data. Methods: PubMed, the Cochrane Library, and EMBASE were searched for studies reporting prognosis of patients with OM solid tumors. Risk of death and relapse were extracted and pooled to provide an adjusted hazard ratio with a 95% confidence interval (HR 95%CI). The primary outcome of the study refers to overall mortality in OM vs. polymetastatic (PM) patients. Results. Mortality and relapse associated with OM state in patients with cancer were evaluated among 104,234 participants (n=173 studies). Progression-free survival was better in patients with OM disease (hazard ratio [HR] = 0.62, 95% CI 0.57–0.68; P <.001; n=69 studies). Also, OM cancers were associated with a better OS (HR = 0.65, 95% CI 0.62-0.68; P<.01; n=161 studies). In colorectal (CRC), breast, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) the reduction in the risk of death for OM patients were 35, 38, 30 and 42%, respectively. Conclusions. Patients with oligometastases have a significantly better prognosis than those with more widespread stage IV tumors. We suggest that a treatment strategy that involves bot the primary and the metastases should be identified at the time of diagnosis