The Age, Metallicity and Alpha-Element Abundance of Galactic Globular Clusters from Single Stellar Population Models

Establishing the reliability with which stellar population parameters can be measured is vital to extragalactic astronomy. Galactic GCs provide an excellent medium in which to test the consistency of Single Stellar Population (SSP) models as they should be our best analogue to a homogeneous (single) stellar population. Here we present age, metallicity and $\alpha$-element abundance measurements for 48 Galactic globular clusters (GCs) as determined from integrated spectra using Lick indices and SSP models from Thomas, Maraston & Korn, Lee & Worthey and Vazdekis et al. By comparing our new measurements to independent determinations we are able to assess the ability of these SSPs to derive consistent results -- a key requirement before application to heterogeneous stellar populations like galaxies. We find that metallicity determinations are extremely robust, showing good agreement for all models examined here, including a range of enhancement methods. Ages and $\alpha$-element abundances are accurate for a subset of our models, with the caveat that the range of these parameters in Galactic GCs is limited. We are able to show that the application of published Lick index response functions to models with fixed abundance ratios allows us to measure reasonable $\alpha$-element abundances from a variety of models. We also examine the age-metallicity and [$\alpha$/Fe]-metallicity relations predicted by SSP models, and characterise the possible effects of varied model horizontal branch morphology on our overall results.Comment: 22 pages, 19 figures, accepted for publication in MNRA

Preparation of core-crosslinked linear-dendritic copolymer micelles with enhanced stability and their application for drug solubilisation

In this study we explore the preparation of core-crosslinked micelles of linear-dendritic methoxy-poly(ethylene glycol) (MPEG)-copoly(ester-sulfide) (PES) polymers to improve the stability of such polymeric micelle systems against premature disintegration and drug release. A series of MPEG-PES copolymers were synthesised via stepwise reactions of acetylation and thiol-ene photoreaction. Surface tension measurement showed that the copolymers with ethenyl surface groups could self-associate in dilute aqueous solutions to form micelles. Crosslinking within the micelle cores in the presence of dithioerythritol (DTT) linker was initiated under UV radiation. The formation of core-crosslinked micelles was confirmed by HPLC in combination with charged aerosol detection (CAD). The copolymers were found to readily hydrolyse under acidic conditions due to the ester-containing dendrons. Drug solubilisation capacities of the micellar solutions were determined using griseofulvin as a poorly water-soluble model drug. The solubility of griseofulvin showed a 10-fold enhancement in 1% w/v micelle solution and increased with the concentration of the copolymers. Drug release studies indicated that a more sustained release of griseofulvin was achieved for the core-crosslinked micelles compared to the non-crosslinked micelles, attributable to greater stability of the crosslinked core structure. The findings of this study present a new pathway towards developing biodegradable polymeric nanocarriers

Determination of folding reversibility of lysozyme crystals using microcalorimetry

Ye

Effect of mechanical denaturation on surface free energy of protein powders

yesGlobular proteins are important both as therapeutic agents and excipients. However, their fragile native conformations can be denatured during pharmaceutical processing, which leads to modification of the surface energy of their powders and hence their performance. Lyophilized powders of hen egg-white lysozyme and β-galactosidase from Aspergillus oryzae were used as models to study the effects of mechanical denaturation on the surface energies of basic and acidic protein powders, respectively. Their mechanical denaturation upon milling was confirmed by the absence of their thermal unfolding transition phases and by the changes in their secondary and tertiary structures. Inverse gas chromatography detected differences between both unprocessed protein powders and the changes induced by their mechanical denaturation. The surfaces of the acidic and basic protein powders were relatively basic, however the surface acidity of β-galactosidase was higher than that of lysozyme. Also, the surface of β-galactosidase powder had a higher dispersive energy compared to lysozyme. The mechanical denaturation decreased the dispersive energy and the basicity of the surfaces of both protein powders. The amino acid composition and molecular conformation of the proteins explained the surface energy data measured by inverse gas chromatography. The biological activity of mechanically denatured protein powders can either be reversible (lysozyme) or irreversible (β-galactosidase) upon hydration. Our surface data can be exploited to understand and predict the performance of protein powders within pharmaceutical dosage forms

Summer 1973

What Happens to Herbicides in the Environmen? (page 3) Agricultural Chelates--What They Are, What They Do (6) Turfgrass Cultivars (9) Vandalism on the Golf Course (13) Massachusetts Seed laws (20

Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis.

BackgroundBudesonide foam, a rectally administered, second-generation corticosteroid with extensive hepatic first-pass metabolism, is efficacious for the treatment of mild-to-moderate ulcerative proctitis and ulcerative proctosigmoiditis.AimThe aim of this study was to comprehensively assess the safety and pharmacokinetic profile of budesonide foam.MethodsData from five phase III studies were pooled to further evaluate safety, including an open-label study (once-daily treatment for 8 weeks), an active-comparator study (once-daily treatment for 4 weeks), and two placebo-controlled studies and an open-label extension study (twice-daily treatment for 2 weeks, then once daily for 4 weeks). Data from the placebo-controlled studies and two phase I studies (i.e., patients with mild-to-moderate ulcerative colitis and healthy volunteers) were pooled to evaluate the pharmacokinetics of budesonide foam.ResultsA similar percentage of patients reported adverse events in the budesonide foam and placebo groups, with the majority of adverse events being mild or moderate in intensity (93.3 vs 96.0%, respectively). Adverse events occurred in 41.4 and 36.3% of patients receiving budesonide foam and placebo, respectively. Mean morning cortisol concentrations remained within the normal range for up to 8 weeks of treatment; there were no clinically relevant effects of budesonide foam on the hypothalamic-pituitary-adrenal axis. Population pharmacokinetic analysis demonstrated low systemic exposure after budesonide foam administration.ConclusionsThis integrated analysis demonstrated that budesonide foam for the induction of remission of distal ulcerative colitis is safe overall, with no clinically relevant effects on the hypothalamic-pituitary-adrenal axis

It Takes a Village: Open Source Software Sustainability

This Guidebook is designed to serve as a practical reference source to help open source software programs serving cultural and scientific heritage organizations plan for long-term sustainability, ensuring that commitment and resources will be available at levels sufficient for the software to remain viable and effective as long as it is needed. One of the most significant themes of this Guidebook is that sustainability is not a linear process, with set beginning and end points. Program sustainability shifts and evolves over time across a number of phases and facets. The phases speak to where a program is in its lifecycle: getting started, growing, or stable but not static. The facets describe the different components of sustainability, each of which is critical to overall program health, but may have different timelines, goals, and resource needs. The facets deemed most critical by the Guidebook’s authors and contributors are: Governance, Technology, Resources (Financial and Human), and Community Engagement. Sections of the Guidebook will: define the phases and facets of sustainability; identify goals, characteristics, and common roadblocks for each phase in each facet; provide guidance for moving an OSS program to the next phase in a given facet, with the understanding that the same program may be in different phases along different facets of sustainability; and highlight case studies and additional resources to help a program’s research and decision-making process. The Guidebook is intended for a broad audience. While certain paths may be of more interest than others, we would recommend reading through each of the facets before returning to the one that aligns most closely with a specific role, e.g., governance for a program manager, technology for a technical lead, engagement for a community manager, or resources for an administrator. The worksheet in Appendix A can help identify the specific phase a program is in along each facet. The open source landscape is wide and varied. Bringing open source programs serving cultural and scientific heritage together under one shared umbrella can provide us all with the power to better advocate for our needs, develop shared sustainability strategies, and provide our communities with the information needed to assess and contribute to the sustainability of the programs they depend on

What Range Herbivores Eat -- and Why

12 pp., 4 figures, 1 table, 8 illustrations, resource listDifferent range animals have different diets. Some eat grass, some eat browse (leaves from woody plants) and forbs (wildflowers, weeds, etc.), and some eat all three. The differences in their diets allow many types of range animals to co-exist on the same range. Understanding the diets of range herbivores allows the landowner to use the rangeland resource more wisely

Understanding Forage Intake in Range Animals

6 pp., 2 tables, 5 graphsForage intake is as important as forage quality. This publication explains the factors affecting forage intake. Available in Spanish as E-100S

Why Range Forage Quality Changes

8 pp., 6 illustrations, 1 tableRange plants vary in nutritional quality. Forage quality is determined by the plant part eaten, plant age, season, soils and range sites, stocking rates, and other factors. Periods of high animal nutritional demand must match periods of high forage quality and supply