Modelling Immunological Memory

Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. Although the theory appears valid, we suggest that there are a common set of reasons why immunological memory models are a useful support tool; not conclusive in themselves

Geometric phases and anholonomy for a class of chaotic classical systems

Berry's phase may be viewed as arising from the parallel transport of a quantal state around a loop in parameter space. In this Letter, the classical limit of this transport is obtained for a particular class of chaotic systems. It is shown that this ``classical parallel transport'' is anholonomic --- transport around a closed curve in parameter space does not bring a point in phase space back to itself --- and is intimately related to the Robbins-Berry classical two-form.Comment: Revtex, 11 pages, no figures

Modelling Immunological Memory

Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then use the same system to evaluate the predicted effects of a theory of immunological memory. The resulting model has not been explored before in artificial immune systems research, and we compare the simulated in silico output with in vivo measurements. Although the theory appears valid, we suggest that there are a common set of reasons why immunological memory models are a useful support tool; not conclusive in themselves

Toward the End of Time

The null-brane space-time provides a simple model of a big crunch/big bang singularity. A non-perturbative definition of M-theory on this space-time was recently provided using matrix theory. We derive the fermion couplings for this matrix model and study the leading quantum effects. These effects include particle production and a time-dependent potential. Our results suggest that as the null-brane develops a big crunch singularity, the usual notion of space-time is replaced by an interacting gluon phase. This gluon phase appears to constitute the end of our conventional picture of space and time.Comment: 31 pages, reference adde

Take it or leave it: prefrontal control in recreational cocaine users.

Though stimulant drugs such as cocaine are considered highly addictive, some individuals report recreational use over long periods without developing dependence. Difficulties in response inhibition have been hypothesized to contribute to dependence, but previous studies investigating response inhibition in recreational cocaine users have reported conflicting results. Performance on a stop-signal task was examined in 24 recreational cocaine users and 32 healthy non-drug using control participants matched for age, gender and verbal intelligence during functional magnetic resonance imaging scanning. The two groups were further matched on traumatic childhood histories and the absence of family histories of addiction. Results revealed that recreational cocaine users did not significantly differ from controls on any index of task performance, including response execution and stop-signal reaction time, with the latter averaging 198 ms in both groups. Functional magnetic resonance imaging analyses indicated that, compared with controls, stopping in the recreational users was associated with increased activation in the pre-supplementary motor area but not the right inferior frontal cortex. Thus, findings imply intact response inhibition abilities in recreational cocaine users, though the distinct pattern of accompanying activation suggests increased recruitment of brain areas implicated in response inhibition. This increased recruitment could be attributed to compensatory mechanisms that enable preserved cognitive control in this group, possibly relating to their hypothetical resilience to stimulant drug dependence. Such overactivation, alternatively, may be attributable to prolonged cocaine use leading to neuroplastic adaptations.This work was funded by a Medical Research Council (MRC) research grant to KDE, ETB and TWR (G0701497) and was conducted within the Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK, which is supported by a joint award from the MRC and the Wellcome Trust; Both KDE and PSJ were supported by the MRC, SM was supported by a Wellcome Trust grant (089589/Z/09/Z) awarded to TW Robbins.This is the final version of the article. It first appeared from NPG via http://dx.doi.org/10.1038/tp.2015.8

A Synchrotron-Based Study of the Mary Rose Iron Cannonballs

Post‐excavation iron corrosion may be accelerated by the presence of Cl^{-} , leading to conservation methods designed to remove Cl. This study exploits a unique opportunity to assess 35 years of conservation applied to cast‐iron cannon shot excavated from the Mary Rose. A combination of synchrotron X‐ray powder diffraction (SXPD), absorption spectroscopy (XAS), and fluorescence (XRF) mapping have been used to characterise the impact of conservation on the crystalline corrosion products, chlorine distribution, and speciation. The chlorinated phase akaganeite, β‐FeO(OH,Cl), was found on shot washed in corrosion inhibitor Hostacor IT with or without an additional reduction stage. No chlorinated phases were observed on the surface of shot stored in sodium sesquicarbonate (Na_{2}CO_{3}/NaHCO_{3}); however, hibbingite, β‐Fe_{2}(OH)_{3}Cl, was present in metal pores. It is proposed that surface β‐FeO(OH,Cl) formed in the early stages of active conservation owing to oxidation of β‐Fe_{2}(OH)_{3}Cl at near‐neutral pH

Matrix String Description of Cosmic Singularities in a Class of Time-dependent Solutions

A large class of time-dependent solutions with 1/2 supersymmetry were found previously. These solutions involve cosmic singularities at early time. In this paper, we study if matrix string description of the singularities in these solutions with backgrounds is possible and present several examples where the solutions can be described well in the perturbative picture.Comment: 12 pages, v2: typos corrected, a ref. adde

Time-Dependent Warping, Fluxes, and NCYM

We describe the supergravity solutions dual to D6-branes with both time-dependent and time-independent B-fields. These backgrounds generalize the Taub-NUT metric in two key ways: they have asymmetric warp factors and background fluxes. In the time-dependent case, the warping takes a novel form. Kaluza-Klein reduction in these backgrounds is unusual, and we explore some of the new features. In particular, we describe how a localized gauge-field emerges with an analogue of the open string metric and coupling. We also describe a gravitational analogue of the Seiberg-Witten map. This provides a framework in supergravity both for studying non-commutative gauge theories, and for constructing novel warped backgrounds.Comment: 32 pages, LaTeX, references adde