Optimization of Differential Diagnosis of Inflammatory Bowel Diseases Based on an Integrated Assessment of Oral Mucosa Status

n/

Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry

OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc). METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers. RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group. CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies

Mass Media

ISSN:1867-932

Pathogenetic Aspects of Oral Cavity Lesions in Inflammatory Gastrointestinal Tract Diseases

Despite the similarity of many pathogenetic lesions of the gastrointestinal tract and the oral cavity, there remain unresolved issues related to the etiology and pathogenesis of dental diseases associated with inflammatory bowel diseases.Aim. Analysis and systematization of literature data on the problem of combined diseases of the oral cavity and the gastrointestinal tract.Key findings. Severe recurrent inflammatory bowel disease and the close relationship of all levels of the digestive tube create prerequisites for the development of pathological processes in the oral cavity. Despite the extensive symptoms of oral manifestations of inflammatory bowel disease, aphthous stomatitis is considered more often than other diseases. There are different opinions about the involvement of the oral mucosa in the pathological process in inflammatory bowel disease. Some authors consider the defeat of the mouth in terms of the specific localization of Crohn’s disease, others see in it only extraintestinal manifestations of the disease, along with changes in the skin, joints and eyes. Immunohistochemical studies allow you to answer individual questions of pathogenesis.Conclusion. The presented analysis of publications confirms the morphofunctional unity of various parts of the digestive system, which determines the complex mechanisms of the development of combined diseases

Pathogenetic Aspects of Oral Cavity Lesions in Inflammatory Gastrointestinal Tract Diseases

Despite the similarity of many pathogenetic lesions of the gastrointestinal tract and the oral cavity, there remain unresolved issues related to the etiology and pathogenesis of dental diseases associated with inflammatory bowel diseases.Aim. Analysis and systematization of literature data on the problem of combined diseases of the oral cavity and the gastrointestinal tract.Key findings. Severe recurrent inflammatory bowel disease and the close relationship of all levels of the digestive tube create prerequisites for the development of pathological processes in the oral cavity. Despite the extensive symptoms of oral manifestations of inflammatory bowel disease, aphthous stomatitis is considered more often than other diseases. There are different opinions about the involvement of the oral mucosa in the pathological process in inflammatory bowel disease. Some authors consider the defeat of the mouth in terms of the specific localization of Crohn’s disease, others see in it only extraintestinal manifestations of the disease, along with changes in the skin, joints and eyes. Immunohistochemical studies allow you to answer individual questions of pathogenesis.Conclusion. The presented analysis of publications confirms the morphofunctional unity of various parts of the digestive system, which determines the complex mechanisms of the development of combined diseases

Turnover of mineral elements in the ecosystem of native herbaceous-bilberry spruce forest in the middle taiga subzone (Komi Republic)

The contents of the paper aim at issues on native spruce forests in the taiga zone. It includes assessments of chemical elements local cycles in the ecosystem of middle-taiga of different ages of different herbaceous-bilberry spruce forest Piceеtum herboso-myrtillosum on podzols soils. It shows the structure of organic and mineral plant matter from of different tiers is shown. It revealed the regularities processes of consumption and return of chemical elements in the soil-vegetation system. The tree stand plays a major role in formation of the structural composition of organic matter annual production and fall in the ecosystem of old-aged spruce forest. The renewal process was marked as successful under the canopy forest. The plant phytomass accumulates 2298 kg ∙ ha–1 elements of mineral nutrition. High accumulation capacity is demonstrated by Ca, N, K and Si. To form its annual production, spruce forest tolerate 144.1 kg ∙ ha–1 mineral elements. The biological cycle rate of nutrients for spruce forest equals 7.3 years. The annual leaf waste provides the soil surface with 104.5 kg ∙ ha–1 nitrogen and ash elements. Destruction annually releases 23 kg ∙ ha–1 mineral elements from leaf fallen waste. Forest litter is the main source of nutrients. The reserve of chemical elements in organic soil layer is 1044.9 kg • ha–1. Precipitations annually enrich the soil with additional 24.5 kg ∙ ha–1 mineral elements. Transportation of mineral elements outside the limits of root layer (0–30 cm) within surface soil waters is 59.2 kg ∙ ha–1 a year