Evolutionary testing supported by slicing and transformation

Evolutionary testing is a search based approach to the automated generation of systematic test data, in which the search is guided by the test data adequacy criterion. Two problems for evolutionary testing are the large size of the search space and structural impediments in the implementation of the program which inhibit the formulation of a suitable fitness function to guide the search. In this paper we claim that slicing can be used to narrow the search space and transformation can be applied to the problem of structural impediments. The paper presents examples of how these two techniques have been successfully employed to make evolutionary testing both more efficient and more effective

Making waves in education

Making Waves in Education is a book of a collaborative nature, being a collection of chapters written by undergraduates studying B.A. Hons in Education at the Universities of Plymouth and York. Thirteen chapters, each from a different student, cover topics from learning theories to sex education, home education and autism. The chapters are well-organised and written, and they cover key topics in an accessible and thoughtful way. The chapters are generally well - referenced and present critical and balanced arguments. Many use hard statistics in an effective way to back up their points and all include bibliographies as indeed one expects from a serious publication. The collection therefore addresses itself to a wide readership of anyone interested in education, and students and teachers/trainers in HE in particula

The reconstructed Indonesian warm pool sea surface temperatures from tree rings and corals: Linkages to Asian monsoon drought and El Niño–Southern Oscillation

[ 1] The west Pacific warm pool is the heat engine for the globe's climate system. Its vast moisture and heat exchange profoundly impact conditions in the tropics and higher latitudes. Here, September - November sea surface temperature (SST) variability is reconstructed for the warm pool region (15 degrees S - 5 degrees N, 110 - 160 degrees E) surrounding Indonesia using annually resolved teak ring width and coral delta O-18 records. The reconstruction dates from A. D. 1782 - 1992 and accounts for 52% of the SST variance over the most replicated period. Significant correlations are found with El Nino - Southern Oscillation (ENSO) and monsoon indices at interannual to decadal frequency bands. Negative reconstructed SST anomalies coincide with major volcanic eruptions, while other noteworthy extremes are at times synchronous with Indian and Indonesian monsoon drought, particularly during major warm ENSO episodes. While the reconstruction adds to the sparse network of proxy reconstructions available for the tropical Indo-Pacific, additional proxies are needed to clarify how warm pool dynamics have interacted with global climate in past centuries to millennia.</p

Maps & Apps: Mobile Media Marketing Education for Food and Farm Entrepreneurs

With an increasing number of consumers using smartphones, tablets, and other mobile devices to find and interact with local businesses, Ohio State University Extension developed a new curriculum aimed at improving market access for food and farm entrepreneurs. The literature review, curriculum framework, and lessons learned shared in this article can be used by Extension professionals to improve their own online presence, as well as by educators working with entrepreneurs and community leaders

Transformative Processes in Environmental Education: A Case Study

This paper presents a case study on the severely degraded Boksburg Lake’s (Gauteng, South Africa) social–ecological system, and on an environmental-education initiative that aimed to support the lake’s transformation with a view to its improved social and ecological well-being. In this case study, three key characteristics of the initiative which appeared to support the transformative process are discussed, namely:1. Learning was aligned with the local social–ecological context;2. Human-to-human and human-to-ecological connections were encouraged; and3. The youth played a key role in initiating and effecting transformation.Apparent consequences of this particular environmental-education approach include: local people becoming involved and invested in an environmental-education process that was highly meaningful to them; a deeper connection being nurtured among participating stakeholders, as well as between the youth and Boksburg Lake; a collective identity being adopted to bring about change; knowledge of Boksburg Lake’s social– ecological system being strengthened; acknowledgement of personal culpability in the lake’s degradation; many of the youths changing their negative environmental practices; and local stakeholders, including the youth, engaging in collective action to reclaim Boksburg Lake. Furthermore, a range of new practices emerged from the Schools for a Sustainable Environment (SSE) initiative. The literature is drawn on to explain the possible consequences of this initiative. Through this paper, it is hoped that environmentaleducation practitioners will be provided with useful conceptual tools to support their work

The Context of Sexual Risk Behaviour Among Men Who Have Sex with Men Seeking PrEP, and the Impact of PrEP on Sexual Behaviour.

There are still important gaps in our understanding of how people will incorporate PrEP into their existing HIV prevention strategies. In this paper, we explore how PrEP use impacted existing sexual risk behaviours and risk reduction strategies using qualitative data from the PROUD study. From February 2014 to January 2016, we conducted 41 in-depth interviews with gay, bisexual and other men who have sex with men (GBMSM) enrolled in the PROUD PrEP study at sexual health clinics in England. The interviews were conducted in English and were audio-recorded. The recordings were transcribed, coded and analysed using framework analysis. In the interviews, we explored participants' sexual behaviour before joining the study and among those using or who had used PrEP, changes to sexual behaviour after starting PrEP. Participants described the risk behaviour and management strategies before using PrEP, which included irregular condom use, sero-sorting, and strategic positioning. Participants described their sexual risk taking before initiating PrEP in the context of the sexualised use of drugs, geographical spaces linked with higher risk sexual norms, and digitised sexual networking, as well as problematic psychological factors that exacerbated risk taking. The findings highlight that in the main, individuals who were already having frequent condomless sex, added PrEP to the existing range of risk management strategies, influencing the boundaries of the 'rules' for some but not all. While approximately half the participants reduced other risk reduction strategies after starting PrEP, the other half did not alter their behaviours. PrEP provided an additional HIV prevention option to a cohort of GBMSM at high risk of HIV due to inconsistent use of other prevention options. In summary, PrEP provides a critical and necessary additional HIV prevention option that individuals can add to existing strategies in order to enhance protection, at least from HIV. As a daily pill, PrEP offers protection in the context of the sex cultures associated with sexualised drug use, digitised sexual applications and shifting social norms around sexual fulfilment and risk taking. PrEP can offer short or longer-term options for individuals as their sexual desires change over their life course offering protection from HIV during periods of heightened risk. PrEP should not be perceived or positioned in opposition to the existing HIV prevention toolkit, but rather as additive and as a tool that can and is having a substantial impact on HIV

Precast Concrete Pavement Systems

Precast concrete pavement is becoming a favorable option to restore the functional and structural capacity of high-truck-volume traffic pavement. INDOT has a pilot project designed and constructed successfully in 2018. This session introduces the technology to practicing engineers

Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth

Co-infections alter the host immune response but how the systemic and local processes at the site of infection interact is still unclear. The majority of studies on co-infections concentrate on one of the infecting species, an immune function or group of cells and often focus on the initial phase of the infection. Here, we used a combination of experiments and mathematical modelling to investigate the network of immune responses against single and co-infections with the respiratory bacterium Bordetella bronchiseptica and the gastrointestinal helminth Trichostrongylus retortaeformis. Our goal was to identify representative mediators and functions that could capture the essence of the host immune response as a whole, and to assess how their relative contribution dynamically changed over time and between single and co-infected individuals. Network-based discrete dynamic models of single infections were built using current knowledge of bacterial and helminth immunology; the two single infection models were combined into a co-infection model that was then verified by our empirical findings. Simulations showed that a T helper cell mediated antibody and neutrophil response led to phagocytosis and clearance of B. bronchiseptica from the lungs. This was consistent in single and co-infection with no significant delay induced by the helminth. In contrast, T. retortaeformis intensity decreased faster when co-infected with the bacterium. Simulations suggested that the robust recruitment of neutrophils in the co-infection, added to the activation of IgG and eosinophil driven reduction of larvae, which also played an important role in single infection, contributed to this fast clearance. Perturbation analysis of the models, through the knockout of individual nodes (immune cells), identified the cells critical to parasite persistence and clearance both in single and co-infections. Our integrated approach captured the within-host immuno-dynamics of bacteria-helminth infection and identified key components that can be crucial for explaining individual variability between single and co-infections in natural populations