Child homicide: generating victim and suspect risk profiles

Purpose – In England and Wales, on average one child every week is a victim of homicide. The purpose of this paper is to explore whether different victim-risk profiles and suspect variables can be differentiated for specific victim ages. Design/methodology/approach – This paper presents a preliminary analysis of more than 1,000 child homicides committed in England and Wales between 1996 and 2013, from data provided through the Homicide Index. Statistical techniques such as cluster analysis were used to identify specific victim-risk profiles and to analyse suspect variables according to the age of victim. Findings – The findings present a clearer picture of the risk-age relationship in child homicide, whereby several specific risk profiles are identified for specific child ages, comprised of crime variables including; likely victim and suspect demographics, the most likely circumstances of the homicide and methods of killing. Using similar techniques, a number of tentative clusters of suspects implicated in child homicide are also described and analysed, with suggestions of further analysis that might prove of value. Practical implications – The practical implications cannot be understated. For those professionals working in the fields of child protection and criminal investigation the identification of risk profiles promises to provide a back-cloth with which to practice when confronted with complex and distressing child homicide scenarios. This research promises most to those currently training in related professions. Originality/value – Although the statistical level of risk has been linked with the age of a child (with younger children being most vulnerable to killing by a parent or step-parent and older children most vulnerable to killing by acquaintances and strangers), extant research is yet to progress beyond the identification of broad age-risk categories. The paper concludes with a discussion of the likely implications for those charged with reducing and investigating child homicide and outlines the possibility of future research

Experiments for satellite and material recovery from orbit. Volume I - Summary Final report

Experiment missions for OSO satellite rendezvous, capture, material retrieval, refurbishment, and extravehicular operation wor

Experiments for Satellite and Material Recovery from Orbit. Volume III - Experiment Missions Final Report

Experiment missions for OSO satellite rendezvous, capture, material recovery, refurbishment, and extravehicular operation wor

Remotely triggered scaffolds for controlled release of pharmaceuticals

Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery. Incorporation of the unique properties of HNPs into thermally responsive scaffolds holds great potential for future biomedical applications. Here we successfully fabricated smart scaffolds based on thermo-responsive poly(N-isopropylacrylamide) (pNiPAM). Nanoparticles providing localized trigger of heating when irradiated with a short laser burst were found to give rise to remote control of bulk polymer shrinkage. Gold-coated iron oxide nanoparticles were synthesized using wet chemical precipitation methods followed by electrochemical coating. After subsequent functionalization of particles with allyl methyl sulfide, mercaptodecane, cysteamine and poly(ethylene glycol) thiol to enhance stability, detailed biological safety was determined using live/dead staining and cell membrane integrity studies through lactate dehydrogenase (LDH) quantification. The PEG coated HNPs did not show significant cytotoxic effect or adverse cellular response on exposure to 7F2 cells (p < 0.05) and were carried forward for scaffold incorporation. The pNiPAM-HNP composite scaffolds were investigated for their potential as thermally triggered systems using a Q-switched Nd:YAG laser. These studies show that incorporation of HNPs resulted in scaffold deformation after very short irradiation times (seconds) due to internal structural heating. Our data highlights the potential of these hybrid-scaffold constructs for exploitation in drug delivery, using methylene blue as a model drug being released during remote structural change of the scaffold

Structure of Micro-instabilities in Tokamak Plasmas: Stiff Transport or Plasma Eruptions?

Solutions to a model 2D eigenmode equation describing micro-instabilities in tokamak plasmas are presented that demonstrate a sensitivity of the mode structure and stability to plasma profiles. In narrow regions of parameter space, with special plasma profiles, a maximally unstable mode is found that balloons on the outboard side of the tokamak. This corresponds to the conventional picture of a ballooning mode. However, for most profiles this mode cannot exist and instead a more stable mode is found that balloons closer to the top or bottom of the plasma. Good quantitative agreement with a 1D ballooning analysis is found provided the constraints associated with higher order profile effects, often neglected, are taken into account. A sudden transition from this general mode to the more unstable ballooning mode can occur for a critical flow shear, providing a candidate model for why some experiments observe small plasma eruptions (Edge Localised Modes, or ELMs) in place of large Type I ELMs.Comment: 11 pages, 3 figure

Experiments for satellite and material recovery from orbit. Volume II - Technical Final report

Experiment missions for OSO satellite rendezvous, capture, material retrieval, refurbishment, and extravehicular operation wor

The olive biophenols oleuropein and hydroxytyrosol selectively reduce proliferation, influence the cell cycle, and induce apoptosis in pancreatic cancer cells

Current chemotherapy drugs for pancreatic cancer only offer an increase in survival of up to six months. Additionally, they are highly toxic to normal tissues, drastically affecting the quality of life of patients. Therefore, the search for novel agents, which induce apoptosis in cancer cells while displaying limited toxicity towards normal cells, is paramount. The olive biophenols, oleuropein, hydroxytyrosol and tyrosol, have displayed cytotoxicity towards cancer cells without affecting non-tumorigenic cells in cancers of the breast and prostate. However, their activity in pancreatic cancer has not been investigated. Therefore, the aim of this study was to determine the anti-pancreatic cancer potential of oleuropein, hydroxytyrosol and tyrosol. Pancreatic cancer cells (MIA PaCa-2, BxPC-3, and CFPAC-1) and non-tumorigenic pancreas cells (HPDE) were treated with oleuropein, hydroxytyrosol and tyrosol to determine their effect on cell viability. Oleuropein displayed selective toxicity towards MIA PaCa-2 cells and hydroxytyrosol towards MIA PaCa-2 and HPDE cells. Subsequent analysis of Bcl-2 family proteins and caspase 3/7 activation determined that oleuropein and hydroxytyrosol induced apoptosis in MIA PaCa-2 cells, while oleuropein displayed a protective effect on HPDE cells. Gene expression analysis revealed putative mechanisms of action, which suggested that c-Jun and c-Fos are involved in oleuropein and hydroxytyrosol induced apoptosis of MIA PaCa-2 cells