Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation

first_pagesettingsOrder Article Reprints Open AccessArticle Metabolic Disturbance of High-Saturated Fatty Acid Diet in Cognitive Preservation by Antonio Rivas-Domínguez 1ORCID,Himan Mohamed-Mohamed 2,Margarita Jimenez-Palomares 3ORCID,Victoria García-Morales 3ORCID,Laura Martinez-Lopez 1,Manuel Luis Orta 1,Juan José Ramos-Rodriguez 2,*,†ORCID andBeatriz Bermudez-Pulgarin 1,† 1 Department of Cellular Biology, University of Seville, 41009 Seville, Spain 2 Department of Physiology, Faculty of Health Sciences (Ceuta), University of Granada, 51001 Ceuta, Spain 3 Department of Biomedicine, Biotechnology and Public Health, University of Cádiz, 11003 Cádiz, Spain * Author to whom correspondence should be addressed. † These authors contributed equally to this work. Int. J. Mol. Sci. 2023, 24(9), 8042; https://doi.org/10.3390/ijms24098042 Received: 31 March 2023 / Revised: 16 April 2023 / Accepted: 26 April 2023 / Published: 28 April 2023 (This article belongs to the Special Issue Research on Neural and Cognitive Molecular Mechanisms of Memory and Executive Control) Download Browse Figures Review Reports Versions Notes Abstract Aging continues to be the main cause of the development of Alzheimer’s, although it has been described that certain chronic inflammatory pathologies can negatively influence the progress of dementia, including obesity and hyperlipidemia. In this sense, previous studies have shown a relationship between low-density lipoprotein receptor (LDLR) and the amyloid-beta (Aβ) binding activity, one of the main neuropathological features of Alzheimer’s disease (AD). LDLR is involved in several processes, including lipid transport, regulation of inflammatory response and lipid metabolism. From this perspective, LDLR−/− mice are a widely accepted animal model for the study of pathologies associated with alterations in lipid metabolism, such as familial hypercholesterolemia, cardiovascular diseases, metabolic syndrome, or early cognitive decline. In this context, we induced hyperlipidemia in LDLR−/− mice after feeding with a high-saturated fatty acid diet (HFD) for 44 weeks. LDLR−/−-HFD mice exhibited obesity, hypertriglyceridemia, higher glucose levels, and early hepatic steatosis. In addition, HFD increased plasmatic APOE and ubiquitin 60S levels. These proteins are related to neuronal integrity and health maintenance. In agreement, we detected mild cognitive dysfunctions in mice fed with HFD, whereas LDLR−/−-HFD mice showed a more severe and evident affectation. Our data suggest central nervous system dysfunction is associated with a well-established metabolic syndrome. As a late consequence, metabolic syndrome boots many behavioral and pathological alterations recognized in dementia, supporting that the control of metabolic parameters could improve cognitive preservation and prognosis.Junta de Andalucía, Spain, grant number P18-RT-3324P20-01061 from Junta de Andalucía, SpainPID2019- 110960GB-I00 from the Ministry of Science and Innovation, Spai

Embedded neural network for real-time animal behavior classification

Recent biological studies have focused on understanding animal interactions and welfare. To help biolo- gists to obtain animals’ behavior information, resources like wireless sensor networks are needed. More- over, large amounts of obtained data have to be processed off-line in order to classify different behaviors.There are recent research projects focused on designing monitoring systems capable of measuring someanimals’ parameters in order to recognize and monitor their gaits or behaviors. However, network unre- liability and high power consumption have limited their applicability.In this work, we present an animal behavior recognition, classification and monitoring system based ona wireless sensor network and a smart collar device, provided with inertial sensors and an embeddedmulti-layer perceptron-based feed-forward neural network, to classify the different gaits or behaviorsbased on the collected information. In similar works, classification mechanisms are implemented in aserver (or base station). The main novelty of this work is the full implementation of a reconfigurableneural network embedded into the animal’s collar, which allows a real-time behavior classification andenables its local storage in SD memory. Moreover, this approach reduces the amount of data transmittedto the base station (and its periodicity), achieving a significantly improving battery life. The system hasbeen simulated and tested in a real scenario for three different horse gaits, using different heuristics andsensors to improve the accuracy of behavior recognition, achieving a maximum of 81%.Junta de Andalucía P12-TIC-130

ACTA DE LA ASAMBLEA DE LA SECCIÓN DE PSICOANÁLISIS DE LA ASOCIACIÓN ESPAÑOLA DE NEUROPSIQUIATRÍA. Acuerdos de la Asamblea de las XII Jornadas

Sin resume

Reconocimiento, medición, presentación, información a revelar y tratamiento tributario del contrato de opción de venta de maíz blanco, utilizado por las Asociaciones Privadas de Interés Social del departamento de San Vicente, a implementarse en el año 2019.

La presente investigación está enfocada en proponer una guía de aplicación sobre el Reconocimiento, medición, presentación, información a revelar y el tratamiento tributario del contrato de opción de venta de maíz blanco, utilizado por las asociaciones privadas de interés social del departamento de San Vicente. La idea de una guía surge debido a que en El Salvador existe una limitada cantidad de información sobre las opciones financieras en cuanto al tratamiento financiero respecta. Es por ello que, como grupo de investigación se tomó como referente el contrato de opción de venta negociado en BOLPROS como objeto de estudio, si bien es cierto que no se cuenta con un mercado de derivados financieros en nuestro país, su naturaleza lo convierte en un instrumento financiero cuyo tratamiento es diferente al de los instrumentos financieros básicos. El primer capítulo contiene los fundamentos teóricos del contrato de opción de venta, las asociaciones y la comercialización del maíz blanco en El Salvador. El capítulo dos muestra el planteamiento del problema de investigación y la metodología empleada para la recopilación de datos que fundamentan la situación actual de los sujetos de estudio. El tercer capítulo presenta la situación actual de los sujetos de investigación. En este se muestra como las asociaciones realizan el tratamiento financiero y tributario de las operaciones que surgen del contrato de opción de venta; así como, las conclusiones y recomendaciones producto de los instrumentos administrados a las asociaciones privadas de interés social. En el cuarto capítulo se plantea una guía de aplicación que contiene las políticas contables basadas en la normativa financiera que deben aplicar las asaciones privadas de interés social; así como el tratamiento tributario del contrato de opción de venta de maíz blanco. También contiene el desarrollo de un caso práctico fundamentado en la política contable propuesta, con la finalidad de que los estados financieros muestren fielmente la realidad económica de las asociaciones que utilizan este tipo de contrato

The Role of DNA Damage Response in Dysbiosis-Induced Colorectal Cancer

The high incidence of colorectal cancer (CRC) in developed countries indicates a predominant role of the environment as a causative factor. Natural gut microbiota provides multiple benefits to humans. Dysbiosis is characterized by an unbalanced microbiota and causes intestinal damage and inflammation. The latter is a common denominator in many cancers including CRC. Indeed, in an inflammation scenario, cellular growth is promoted and immune cells release Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), which cause DNA damage. Apart from that, many metabolites from the diet are converted into DNA damaging agents by microbiota and some bacteria deliver DNA damaging toxins in dysbiosis conditions as well. The interactions between diet, microbiota, inflammation, and CRC are not the result of a straightforward relationship, but rather a network of multifactorial interactions that deserve deep consideration, as their consequences are not yet fully elucidated. In this paper, we will review the influence of dysbiosis in the induction of DNA damage and CRC.Junta de Andalucía P18-RT-332

Design and Construction for Hydroxides Based Air Conditioning System with Solar Collectors for Confined Roofs

In this chapter, the methodology to determinate heat load is revised and presented. The main parameters must be fixed as function of climatization, internal thermic conditions (comfort, temperature, and humid) and the activities. According with literature, the roof structural requirements were checked. These are an important parameter because it represents the limits to the system such as load by devices (weight of equipment), orientation in solar systems (operating conditions), and building materials. The method of calculation of solar available is shown; the aim is to achieve the major collection of solar energy. Finally, the plate heat exchangers can be fabricated in gasketed, welded or module welded design characterized by the model in which the flow channels for the two heat exchanging media are sealed. The kind of exchanger is suitable depending on your requirements. The thermodynamic method of calculation of sizing the exchangers is reviewed. The aim of this section is to find the suitable devices for the operation of air-conditioning absorption system based on hydroxide

SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome

The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at frst patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confrmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n= 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the fnal multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age≥ 70 years, SpO2, neutrophils > 7.5 × ­103 /µL, lactate dehydrogenase≥ 300 U/L, and C-reactive protein≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome

Construcción de la guía didáctico-interactiva de la asignatura “didáctica general” fase II del proyecto “implementación de la docencia de la asignatura didáctica general en studium mediante la construcción de distintos tipos de objetos de aprendizaje"

Memoria ID12-0116. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome

The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at first patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confirmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n = 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥ 7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the final multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age ≥ 70 years, SpO2, neutrophils > 7.5 × 103/µL, lactate dehydrogenase ≥ 300 U/L, and C-reactive protein ≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome