Uranium Resource Evaluation Amarillo Quadrangle Texas

Uranium resources of the Amarillo Quadrangle, Texas, were evaluated, using criteria established for the National Uranium Evaluation (NURE) program, to a depth of 1500 m (5,000 ft) using available surface and subsurface information. No surface uranium occurrences were reported in the literature. Areas of anomalous radioactivity, interpreted from an aerial radiometric survey, and geochemical anomalies, interpreted from hydrogeochemical and stream-sediment reconnaissance, were investigated. No uranium occurrences were located during a detailed rock sampling program. Areas of uranium favorability in the subsurface were evaluated using driller's log descriptions and gamma-ray well logs. On the basis of subsurface data, five areas of uranium favorability were delineated within the quadrangle. Two areas in the Triassic Dockum Group are in sand-rich facies. Two areas are in thick arkosic alluvial fan and fluvial facies of Early Permian and Pennsylvanian age. Early Permian arkosic strata cover the greatest area. One favorable area along and northeast of the Amarillo Uplift is characterized by abundant gamma-ray log anomalies that are concentrated in Wolfcampian (Early Permian) and older strata. Geologic units considered unfavorable are all Pleistocene strata, all the Tertiary Ogallala Formation, most of the Triassic Dockum Group, all post-Wolfcampian Permian strata, and parts of Lower Permian (Wolfcampian) and Pennsylvanian rock units. Recommendations for improving the reliability of this evaluation include drilling test holes for detailed subsurface information.Bureau of Economic Geolog

Interdisciplinary palimpsest: visual representations of coastal change combining digital craft and geomorphology

From rocks to clay, a shared interest in natural materials and their physical transformation provided the initial common ground for an interdisciplinary art-geoscience collaborative project that also opened up a novel and engaging public communication channel. Scientific data collected for a location-based geomorphology mapping project was collaboratively re-interpreted and re-presented as a craft installation by using digital technologies and hand-crafted processes. The project explored how creative practice can uncover and broaden narratives, layering interpretations whilst respecting and embracing the need for accurate visual representation of scientific data. As the practice-based element of a broader digital craft PhD research programme, the project effectively demonstrated an enlarged field of practice for digital craft. The collaboration resulted in a large-scale, porcelain panelled, wall-mounted installation for public exhibition and has led to subsequent significant unforeseen developments in the scope and outlook of research work undertaken by the collaborators. This paper reflects on the synergies between disciplines that were uncovered and how project challenges were met. We conclude that the project work acted as a ‘boundary object’ for the two collaborating parties, able to represent different values and fulfil different objectives for each party at the same time, while also moving forward practice for both

Retinal ganglion cells adapt to ionic stress in experimental glaucoma

IntroductionIdentification of early adaptive and maladaptive neuronal stress responses is an important step in developing targeted neuroprotective therapies for degenerative disease. In glaucoma, retinal ganglion cells (RGCs) and their axons undergo progressive degeneration resulting from stress driven by sensitivity to intraocular pressure (IOP). Despite therapies that can effectively manage IOP many patients progress to vision loss, necessitating development of neuronal-based therapies. Evidence from experimental models of glaucoma indicates that early in the disease RGCs experience altered excitability and are challenged with dysregulated potassium (K+) homeostasis. Previously we demonstrated that certain RGC types have distinct excitability profiles and thresholds for depolarization block, which are associated with sensitivity to extracellular K+.MethodsHere, we used our inducible mouse model of glaucoma to investigate how RGC sensitivity to K+ changes with exposure to elevated IOP.ResultsIn controls, conditions of increased K+ enhanced membrane depolarization, reduced action potential generation, and widened action potentials. Consistent with our previous work, 4 weeks of IOP elevation diminished RGC light-and current-evoked responses. Compared to controls, we found that IOP elevation reduced the effects of increased K+ on depolarization block threshold, with IOP-exposed cells maintaining greater excitability. Finally, IOP elevation did not alter axon initial segment dimensions, suggesting that structural plasticity alone cannot explain decreased K+ sensitivity.DiscussionThus, in response to prolonged IOP elevation RGCs undergo an adaptive process that reduces sensitivity to changes in K+ while diminishing excitability. These experiments give insight into the RGC response to IOP stress and lay the groundwork for mechanistic investigation into targets for neuroprotective therapy

Development of X-43A Mach 10 Leading Edges

The nose leading edge of the Hyper-X Mach 10 vehicle was orginally anticipated to reach temperatures near 4000 F at the leading-edge stagnation line. A SiC coated carbon/carbon (C/C) leading-edge material will not survive that extreme temperature for even a short duration single flight. To identify a suitable leading edge for the Mach 10 vehicle, arc-jet testing was performed on thirteen leading-edge segments fabricated from different material systems to evaluate their performance in a simulated flight environment. Hf, Zr, Si, and Ir based materials, in most cases as a coating on C/C, were included in the evaluation. Afterwards, MER, Tucson, AZ was selected as the supplier of the flight vehicle leading edges. The nose and the vertical and horizontal tail leading edges were fabricated out of a 3:1 biased high thermal conductivity C/C. The leading edges were coated with a three layer coating comprised of a SiC conversion of the top surface of the C/C, followed by a chemical vapor deposited layer of SiC, followed by a thin chemical vapor deposited layer of HfC. This paper will describe the fabrication of the Mach 10 C/C leading edges and the testing performed to validate performance

Young people doing dance doing gender: relational analysis and thinking intersectionally

Scraton (1992) asserts in her conclusion to ‘Shaping up to Womanhood’ that feminist analysis of PE (and sport and leisure more broadly) needs to engage more directly with masculinity as a means to understanding the ‘dynamics of gender’. Focusing on young people’s involvement in recreational dance, this paper demonstrates how some of those dynamics of gender are played out, reproduced and resisted by both boys and girls who participate at community based dance organisations. Selective data in the form of research frames are incorporated to illustrate how gender is constructed, enacted and embodied by young people engaged in recreational dance. Masculine and feminine hegemonies are highlighted and demonstrate that gender is both relational and intersectional. This contributes to ongoing analysis of masculinities and femininities as practices and processes imbued with complex power relations for young people

Task-related modulation of anterior theta and posterior alpha EEG reflects top-down preparation

<p>Abstract</p> <p>Background</p> <p>Prestimulus EEG alpha activity in humans has been considered to reflect ongoing top-down preparation for the performance of subsequent tasks. Since theta oscillations may be related to poststimulus top-down processing, we investigated whether prestimulus EEG theta activity also reflects top-down cognitive preparation for a stimulus.</p> <p>Results</p> <p>We recorded EEG data from 15 healthy controls performing a color and shape discrimination task, and used the wavelet transformation to investigate the time course and power of oscillatory activity in the signals. We observed a relationship between both anterior theta and posterior alpha power in the prestimulus period and the type of subsequent task.</p> <p>Conclusions</p> <p>Since task-differences were reflected in both theta and alpha activities prior to stimulus onset, both prestimulus theta (particularly around the anterior region) and prestimulus alpha (particularly around the posterior region) activities may reflect prestimulus top-down preparation for the performance of subsequent tasks.</p

The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice

Impaired insulin signalling is increasingly thought to contribute to Alzheimer's disease (AD). The ε4 isoform of the APOE gene is the greatest genetic risk factor for sporadic, late onset AD, and is also associated with risk for type 2 diabetes mellitus (T2DM). Neuropathological studies reported the highest number of AD lesions in brain tissue of ε4 diabetic patients. However other studies assessing AD pathology amongst the diabetic population have produced conflicting reports and have failed to show an increase in AD-related pathology in diabetic brain. The thiazolidinediones (TZDs), peroxisome proliferator-activated receptor gamma agonists, are peripheral insulin sensitisers used to treat T2DM. The TZD, pioglitazone, improved memory and cognitive functions in mild to moderate AD patients. Since it is not yet clear how apoE isoforms influence the development of T2DM and its progression to AD, we investigated amyloid beta and tau pathology in APOE knockout mice, carrying human APOEε3 or ε4 transgenes after diet-induced insulin resistance with and without pioglitazone treatment.Male APOE knockout, APOEε3-transgenic and APOEε4-transgenic mice, together with background strain C57BL6 mice were kept on a high fat diet (HFD) or low fat diet (LFD) for 32 weeks, or were all fed HFD for 32 weeks and during the final 3 weeks animals were treated with pioglitazone or vehicle.All HFD animals developed hyperglycaemia with elevated plasma insulin. Tau phosphorylation was reduced at 3 epitopes (Ser396, Ser202/Thr205 and Thr231) in all HFD, compared to LFD, animals independent of APOE genotype. The introduction of pioglitazone to HFD animals led to a significant reduction in tau phosphorylation at the Ser202/Thr205 epitope in APOEε3 animals only. We found no changes in APP processing however the levels of soluble amyloid beta 40 was reduced in APOE knockout animals treated with pioglitazone

Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition

Evidence shows that the endocannabinoid system modulates the addictive properties of nicotine. In the present study, we hypothesized that spontaneous withdrawal resulting from removal of chronically implanted transdermal nicotine patches is regulated by the endocannabinoid system. A 7-day nicotine dependence procedure (5.2 mg/rat/day) elicited occurrence of reliable nicotine abstinence symptoms in Wistar rats. Somatic and affective withdrawal signs were observed at 16 and 34 hours following removal of nicotine patches, respectively. Further behavioral manifestations including decrease in locomotor activity and increased weight gain also occurred during withdrawal. Expression of spontaneous nicotine withdrawal was accompanied by fluctuation in levels of the endocannabinoid anandamide (AEA) in several brain structures including the amygdala, the hippocampus, the hypothalamus and the prefrontal cortex. Conversely, levels of 2-arachidonoyl-sn-glycerol were not significantly altered. Pharmacological inhibition of fatty acid amide hydrolase (FAAH), the enzyme responsible for the intracellular degradation of AEA, by URB597 (0.1 and 0.3 mg/kg, i.p.), reduced withdrawal-induced anxiety as assessed by the elevated plus maze test and the shock-probe defensive burying paradigm, but did not prevent the occurrence of somatic signs. Together, the results indicate that pharmacological strategies aimed at enhancing endocannabinoid signaling may offer therapeutic advantages to treat the negative affective state produced by nicotine withdrawal, which is critical for the maintenance of tobacco use