Evolução teórica sobre tesauro: estudo diacrônico das publicações de Dagobert Soergel (1972-2017)

Study on theoretical evolution about thesaurus according to the discourse of researcher Dagobert Soergel. Thesaurus are tools for controlling vocabulary, information representation and retrieval, used in indexing. The aim of the study was to analyze Soergel's discourse in his articles on the construction, functions, maintenance, technologies and uses of thesaurus, using Bardin's content analysis methodology. The Soergel's publications analyzed are marked by proposals of these aspects of thesaurus, theoretical and methodological, in relation to different technologies. The analyzed articles show that the researcher is innovative and accompanies trends, which point to the elaboration, use and improvement of thesaurus.Estudio de la evolución de la teoría acerca de los tesauros en el pensamiento del investigador Dagobert Soergel. Se analizó el discurso de Soergel en artículos que publicó sobre tesauros mediante la metodología del análisis de contenido de Bardin en muestra diacrónica. En particular se analizaron las categorías de construcción, funciones, mantenimiento, tecnologías y usos de los tesauros. Los artículos analizados muestran que Soergel se preocupa de los avances científicos y metodológicos de los tesauros en diferentes entornos tecnológicos. El investigador es innovador y sigue las tendencias sobre construcción, funciones, mantenimiento, tecnologías y usos de los tesauros, que apuntan a su desarrollo estructurado y su uso en nuevos ambientes tecnológicos y con interoperabilidadEstudo de la evolución teórica acerca de los tesauros según el discurso del investigador Dagobert Soergel. Los tesauros son instrumentos de control de vocabulario, representación y recuperación de la información, utilizados en la indización. El reto fue de analizar el discurso de Soergel en sus artículos sobre la construcción, funciones, mantenimiento, tecnologías y usos de tesauros, utilizando la metodología de análisis de contenido de Bardin. Las publicaciones analizadas de Soergel están marcadas por la proposición de estos aspectos, teóricos y metodológicos, cuánto a los tesauros frente a diferentes tecnologías. Los artículos analizados muestran que el investigador es innovador y acompaña tendencias, que apuntan a la elaboración, utilización y mejora de los tesauros

Complete Genome Sequence of a thermotolerant sporogenic lactic acid bacterium, Bacillus coagulans strain 36D1

Bacillus coagulans is a ubiquitous soil bacterium that grows at 50-55 °C and pH 5.0 and ferments various sugars that constitute plant biomass to L (+)-lactic acid. The ability of this sporogenic lactic acid bacterium to grow at 50-55 °C and pH 5.0 makes this organism an attractive microbial biocatalyst for production of optically pure lactic acid at industrial scale not only from glucose derived from cellulose but also from xylose, a major constituent of hemicellulose. This bacterium is also considered as a potential probiotic. Complete genome sequence of a representative strain, B. coagulans strain 36D1, is presented and discussed

Bioavailability of the Polyphenols: Status and Controversies

The current interest in polyphenols has been driven primarily by epidemiological studies. However, to establish conclusive evidence for the effectiveness of dietary polyphenols in disease prevention, it is useful to better define the bioavailability of the polyphenols, so that their biological activity can be evaluated. The bioavailability appears to differ greatly among the various phenolic compounds, and the most abundant ones in our diet are not necessarily those that have the best bioavailability profile. In the present review, we focus on the factors influencing the bioavailability of the polyphenols. Moreover, a critical overview on the difficulties and the controversies of the studies on the bioavailability is discussed

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients