338 research outputs found
Generalised Einstein Relation for Hot Brownian Motion
The Brownian motion of a hot nanoparticle is described by an effective Markov
theory based on fluctuating hydrodynamics. Its predictions are scrutinized over
a wide temperature range using large-scale molecular dynamics simulations of a
hot nanoparticle in a Lennard-Jones fluid. The particle positions and momenta
are found to be Boltzmann distributed according to distinct effective
temperatures and . For we
derive a formally exact theoretical prediction and establish a generalised
Einstein relation that links it to directly measurable quantities
Puckering Free Energy of Pyranoses: an NMR and Metadynamics--Umbrella Sampling Investigation
We present the results of a combined metadynamics--umbrella sampling
investigation of the puckered conformers of pyranoses described using the
gromos 45a4 force field. The free energy landscape of Cremer--Pople puckering
coordinates has been calculated for the whole series of alpha and beta
aldohexoses, showing that the current force field parameters fail in
reproducing proper puckering free energy differences between chair conformers.
We suggest a modification to the gromos 45a4 parameter set which improves
considerably the agreement of simulation results with theoretical and
experimental estimates of puckering free energies. We also report on the
experimental measurement of altrose conformers populations by means of NMR
spectroscopy, which show good agreement with the predictions of current
theoretical models
Hot Brownian Motion
We derive the generalized Markovian description for the non-equilibrium
Brownian motion of a heated particle in a simple solvent with a
temperature-dependent viscosity. Our analytical results for the generalized
fluctuation-dissipation and Stokes-Einstein relations compare favorably with
measurements of laser-heated gold nano-particles and provide a practical
rational basis for emerging photothermal technologies.Comment: 10 pages, 5 figure
Survey of the Moths (Lepidoptera) Inhabiting the Funk Bottoms Wildlife Area, Wayne and Ashland Counties, Ohio
Author Institution: Department of Entomology, Ohio Agricultural Research and Development Center, The Ohio State UniversityIn 1995, the Funk Bottoms Wildlife Area was the subject of an ongoing series of insect surveys intended to establish benchmark information on arthropod diversity of wetlands in northeast Ohio. This article concentrates on the moths which were collected at ultraviolet light traps within the Funk Bottoms Wildlife Area. A companion report will follow focusing on the Coleoptera along with several orders of aquatic insects. 3252 specimens were identified to 306 species in 19 families. These species are classified as follows: Abundant = 34; Locally Abundant = 1; Common = 257; Locally Common = 2; Uncommon = 10; Rare = 1; and Special Interest = 1
Pharmacological and Parenteral Nutrition-Based Interventions in Microvillus Inclusion Disease
Microvillus inclusion disease (MVID) is a rare inherited and invariably fatal enteropathy, characterized by severe intractable secretory diarrhea and nutrient malabsorption. No cure exists, and patients typically die during infancy because of treatment-related complications. The need for alternative treatment strategies is evident. Several pharmacological interventions with variable successes have been tried and reported for individual patients as part of their clinical care. Unfortunately, these interventions and their outcomes have remained hidden in case reports and have not been reviewed. Further, recent advances regarding MVID pathogenesis have shed new light on the outcomes of these pharmacological interventions and offer suggestions for future clinical research and trials. Hence, an inventory of reported pharmacological interventions in MVID, their rationales and outcomes, and a discussion of these in the light of current knowledge is opportune. Together with a discussion on MVID-specific pharmacokinetic, -dynamic, and -genetic concerns that pose unique challenges regarding pharmacological strategies, we envision that this paper will aid researchers and clinicians in their efforts to develop pharmacological interventions to combat this devastating disease
A two-species continuum model for aeolian sand transport
Starting from the physics on the grain scale, we develop a simple continuum
description of aeolian sand transport. Beyond popular mean-field models, but
without sacrificing their computational efficiency, it accounts for both
dominant grain populations, hopping (or "saltating") and creeping (or
"reptating") grains. The predicted stationary sand transport rate is in
excellent agreement with wind tunnel experiments simulating wind conditions
ranging from the onset of saltation to storms. Our closed set of equations thus
provides an analytically tractable, numerically precise, and computationally
efficient starting point for applications addressing a wealth of phenomena from
dune formation to dust emission.Comment: 23 pages, 9 figure
Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model
Patients suffering from gastrointestinal mucositis often receive parenteral nutrition as nutritional support. However, the absence of enteral nutrition might not be beneficial for the intestine. We aimed to determine the feasibility of minimal enteral feeding (MEF) administration in a methotrexate (MTX)-induced mucositis rat model and thereby determine the effect of MEF on recovery. Male Wistar rats were attached to swivel systems from day 1 to 5 after 45 mg/kg MTX IV injection. The MTX group continued ad libitum feeding, and the MTX + MEF group continued ad libitum feeding and received from day 1 to 5 continuously MEF. MEF consisted of 20 % of their normal caloric intake. We measured body weight, intake, and plasma citrulline. At day 10, the rats were terminated and villus and crypt length were measured. The administration of MEF caused no increased severity of mucositis phenotype, with comparable caloric intake, body weight, and plasma citrulline during mucositis. The recovery of plasma citrulline levels was not different between both groups. At day 7 and 8, the MTX + MEF group gained significantly more weight (p <0.05 and p <0.01, respectively), and at day 8 and 9 the total caloric intake was significantly increased (p <0.01 and p <0.05, respectively) compared to the MTX group. At day 10, the rats from the MTX + MEF group showed a significant increase in jejunal villus length compared to the MTX group (p <0.05). This is the first study in which the feasibility of MEF administration during chemotherapy-induced mucositis was determined. This study indicates that MEF administration is feasible during mucositis and suggests that MEF accelerates recovery after MTX-induced mucositis
A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior
While males and females largely share the same genome and nervous system, they
differ profoundly in reproductive investments and require distinct behavioral,
morphological and physiological adaptations. How can the nervous system, while
bound by both developmental and biophysical constraints, produce these sexdifferences in behavior? Here we uncover a novel dimorphism in Drosophila
melanogaster that allows deployment of completely different behavioral repertoires in
males and females with minimum changes to circuit architecture. Sexual differentiation
of only a small number of higher-order neurons in the brain leads to a change in
connectivity related to the primary reproductive needs of both sexes - courtship pursuit
in males and communal oviposition in females. This study explains how an apparently
similar brain generates distinct behavioral repertoires in the two sexes and presents a
fundamental principle of neural circuit organization that may be extended to other
species
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