An empirical investigation of hypersexuality

The aim of this study was to investigate the nature of hypersexuality and the personality factors associated with the desire for and experience of high frequency sexual behavior. Participants in the study were 69 male and 93 female university students. Respondents reported on their desire for and experience of masturbation, oral sex, sexual intercourse, pornography, indecent phone calls or letters, prostitution, exhibitionism, voyeurism, as well as providing self-report measures which evaluated their levels of state and trait anxiety, depression, obsessive and compulsive symptoms and fear of intimacy. The results demonstrated that subjects who engaged in high-frequency voyeurism were more depressed than low-frequency voyeurs. Respondents in the high-frequency sexual deviant desire and behavior groups appeared to have more obsessive-compulsive symptoms in comparison to the low-frequency deviant sexual behavior and desire groups. Increased psychopathology was not associated with high-frequency non-deviant sexual behaviors and desires. This finding raised the question of whether labels such as sexual compulsion and addiction are merely pathologizing illegal sexual behavior

Deacylated tRNA Accumulation Is a Trigger for Bacterial Antibiotic Persistence Independent of the Stringent Response

Bacterial antibiotic persistence occurs when bacteria are treated with an antibiotic and the majority of the population rapidly dies off, but a small subpopulation enters into a dormant, persistent state and evades death. Diverse pathways leading to nucleoside triphosphate (NTP) depletion and restricted translation have been implicated in persistence, suggesting alternative redundant routes may exist to initiate persister formation. To investigate the molecular mechanism of one such pathway, functional variants of an essential component of translation (phenylalanyltRNA synthetase [PheRS]) were used to study the effects of quality control on antibiotic persistence. Upon amino acid limitation, elevated PheRS quality control led to significant decreases in aminoacylated tRNAPhe accumulation and increased antibiotic persistence. This increase in antibiotic persistence was most pronounced (65-fold higher) when the relA-encoded tRNA-dependent stringent response was inactivated. The increase in persistence with elevated quality control correlated with ;2-fold increases in the levels of the RNase MazF and the NTPase MazG and a 3-fold reduction in cellular NTP pools. These data reveal a mechanism for persister formation independent of the stringent response where reduced translation capacity, as indicated by reduced levels of aminoacylated tRNA, is accompanied by active reduction of cellular NTP pools which in turn triggers antibiotic persistence. IMPORTANCE Bacterial antibiotic persistence is a transient physiological state wherein cells become dormant and thereby evade being killed by antibiotics. Once the antibiotic is removed, bacterial persisters are able to resuscitate and repopulate. It is thought that antibiotic bacterial persisters may cause reoccurring infections in the clinical setting. The molecular triggers and pathways that cause bacteria to enter into the persister state are not fully understood. Our results suggest that accumulation of deacylated tRNA is a trigger for antibiotic persistence independent of the RelA-dependent stringent response, a pathway thought to be required for persistence in many organisms. Overall, this provides a mechanism where changes in translation quality control in response to physiological cues can directly modulate bacterial persistence

Geothermal well site restoration and plug and abandonment of wells, DOE Gladys McCall test site, Cameron Parish, Louisiana and DOE Willis Hulin test site, Vermillion Parish, Louisiana

A report is presented on the final phase of an energy research program conducted by the U.S. Department of Energy (DOE) involving two geothermal well sites in the State of Louisiana--the Gladys McCall site and the Willis Hulin site. The research program was intended to improve geothermal technology and to determine the efficacy of producing electricity commercially from geopressured resource sites. The final phase of the program consisted of plug and abandonment (P&A) of the wells and restoration of the well sites. Restoration involved (a) initial soil and water sampling and analysis; (b) removal and disposal of well pads, concrete, utility poles, and trash; (c) plugging of monitor and freshwater wells; and (d) site leveling and general cleanup. Restoration of the McCall site required removal of naturally occurring radioactive material (NORM), which was costly and time-consuming. Exhibits are included that provide copies of work permits and authorizations, P&A reports, and cost and salvage reports. Site locations, grid maps, and photographs are provided

Windsurfing : an extreme form of material and embodied interaction?

This paper makes reference to the development of water based board sports in the world of adventure or action games. With a specific focus on windsurfing, we use Parlebas (1999) and Warnier's (2001) theoretical interests in the praxaeology of physical learning as well as Mauss' (1935) work on techniques of the body. We also consider the implications of Csikzentimihalyi's notion of flow (1975). We argue that windsurfing equipment should not merely be seen as protection but rather as status objects through which extreme lifestyles are embodied and embodying

The City: Art and the Urban Environment

The City: Art and the Urban Environment is the fifth annual exhibition curated by students enrolled in the Art History Methods class. This exhibition draws on the students’ newly developed expertise in art-historical methodologies and provides an opportunity for sustained research and an engaged curatorial experience. Working with a selection of paintings, prints, and photographs, students Angelique Acevedo ’19, Sidney Caccioppoli ’21, Abigail Coakley ’20, Chris Condon ’18, Alyssa DiMaria ’19, Carolyn Hauk ’21, Lucas Kiesel ’20, Noa Leibson ’20, Erin O’Brien ’19, Elise Quick ’21, Sara Rinehart ’19, and Emily Roush ’21 carefully consider depictions of the urban environment in relation to significant social, economic, artistic, and aesthetic developments. [excerpt]https://cupola.gettysburg.edu/artcatalogs/1029/thumbnail.jp

Courant-Dorfman algebras and their cohomology

We introduce a new type of algebra, the Courant-Dorfman algebra. These are to Courant algebroids what Lie-Rinehart algebras are to Lie algebroids, or Poisson algebras to Poisson manifolds. We work with arbitrary rings and modules, without any regularity, finiteness or non-degeneracy assumptions. To each Courant-Dorfman algebra (\R,\E) we associate a differential graded algebra \C(\E,\R) in a functorial way by means of explicit formulas. We describe two canonical filtrations on \C(\E,\R), and derive an analogue of the Cartan relations for derivations of \C(\E,\R); we classify central extensions of \E in terms of H^2(\E,\R) and study the canonical cocycle \Theta\in\C^3(\E,\R) whose class $[\Theta]$ obstructs re-scalings of the Courant-Dorfman structure. In the nondegenerate case, we also explicitly describe the Poisson bracket on \C(\E,\R); for Courant-Dorfman algebras associated to Courant algebroids over finite-dimensional smooth manifolds, we prove that the Poisson dg algebra \C(\E,\R) is isomorphic to the one constructed in \cite{Roy4-GrSymp} using graded manifolds.Comment: Corrected formulas for the brackets in Examples 2.27, 2.28 and 2.29. The corrections do not affect the exposition in any wa

Circumstellar Na I and Ca II lines in type IIP supernovae and SN 1998S

We study a possibility of detection of circumstellar absorption lines of Na I D$_{1,2}$ and Ca II H,K in spectra of type IIP supernovae at the photospheric epoch. The modelling shows that the circumstellar lines of Na I doublet will not be seen in type IIP supernovae for moderate wind density, e.g., characteristic of SN 1999em, whereas rather pronounced Ca II lines with P Cygni profile should be detectable. A similar model is used to describe Na I and Ca II circumstellar lines seen in SN 1998S, type IIL with a dense wind. We show that line intensities in this supernova are reproduced, if one assumes an ultraviolet excess, which is caused primarily by the comptonization of supernova radiation in the shock wave.Comment: To be published in Astronomy Letter

2d Gauge Theories and Generalized Geometry

We show that in the context of two-dimensional sigma models minimal coupling of an ordinary rigid symmetry Lie algebra $\mathfrak{g}$ leads naturally to the appearance of the "generalized tangent bundle" $\mathbb{T}M \equiv TM \oplus T^*M$ by means of composite fields. Gauge transformations of the composite fields follow the Courant bracket, closing upon the choice of a Dirac structure $D \subset \mathbb{T}M$ (or, more generally, the choide of a "small Dirac-Rinehart sheaf" $\cal{D}$), in which the fields as well as the symmetry parameters are to take values. In these new variables, the gauge theory takes the form of a (non-topological) Dirac sigma model, which is applicable in a more general context and proves to be universal in two space-time dimensions: A gauging of $\mathfrak{g}$ of a standard sigma model with Wess-Zumino term exists, \emph{iff} there is a prolongation of the rigid symmetry to a Lie algebroid morphism from the action Lie algebroid $M \times \mathfrak{g}\to M$ into $D\to M$ (or the algebraic analogue of the morphism in the case of $\cal{D}$). The gauged sigma model results from a pullback by this morphism from the Dirac sigma model, which proves to be universal in two-spacetime dimensions in this sense.Comment: 22 pages, 2 figures; To appear in Journal of High Energy Physic