Slum health: diseases of neglected populations.

BackgroundUrban slums, like refugee communities, comprise a social cluster that engenders a distinct set of health problems. With 1 billion people currently estimated to live in such communities, this neglected population has become a major reservoir for a wide spectrum of health conditions that the formal health sector must deal with.DiscussionUnlike what occurs with refugee populations, the formal health sector becomes aware of the health problems of slum populations relatively late in the course of their illnesses. As such, the formal health sector inevitably deals with the severe and end-stage complications of these diseases at a substantially greater cost than what it costs to manage non-slum community populations. Because of the informal nature of slum settlements, and cultural, social, and behavioral factors unique to the slum populations, little is known about the spectrum, burden, and determinants of illnesses in these communities that give rise to these complications, especially of those diseases that are chronic but preventable. In this article, we discuss observations made in one slum community of 58,000 people in Salvador, the third largest city in Brazil, to highlight the existence of a spectrum and burden of chronic illnesses not likely to be detected by the formal sector health services until they result in complications or death. Lack of health-related data from slums could lead to inappropriate and unrealistic allocation of health care resources by the public and private providers. Similar misassumptions and misallocations are likely to exist in other nations with large urban slum populations.SummaryContinued neglect of ever-expanding urban slum populations in the world could inevitably lead to greater expenditure and diversion of health care resources to the management of end-stage complications of diseases that are preventable. A new approach to health assessment and characterization of social-cluster determinants of health in urban slums is urgently needed

Short-Chained Oligo(Ethylene Oxide)-Functionalized Gold Nanoparticles: Realization Of Significant Protein Resistance

Protein corona formed on nanomaterial surfaces play an important role in the bioavailability and cellular uptake of nanomaterials. Modification of surfaces with oligoethylene glycols (OEG) are a common way to improve the resistivity of nanomaterials to protein adsorption. Short-chain ethylene oxide (EO) oligomers have been shown to improve the protein resistance of planar Au surfaces. We describe the application of these EO oligomers for improved protein resistance of 30 nm spherical gold nanoparticles (AuNPs). Functionalized AuNPs were characterized using UV-Vis spectroscopy, dynamic light scattering (DLS), and zeta potential measurements. Capillary electrophoresis (CE) was used for separation and quantitation of AuNPs and AuNP-protein mixtures. Specifically, nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) was employed for the determination of equilibrium and rate constants for binding between citrate-stabilized AuNPs and two model proteins, lysozyme and fibrinogen. Semi-quantitative CE analysis was carried out for mixtures of EO-functionalized AuNPs and proteins, and results demonstrated a 2.5-fold to 10-fold increase in protein binding resistance to lysozyme depending on the AuNP surface functionalization and a 15-fold increase in protein binding resistance to fibrinogen for both EO oligomers examined in this study

The multiple junction edge illuminated solar cell

The multiple junction edge illuminated solar cell was devised for high voltage low current applications. Devices to be flight tested in early 1974 with 96 series connected PNN+ junctions in a 2 cm X 2.3 cm size deliver 36 volts at 1 milliampere. Test data of M-J cells fabricated with resistivities of 10, 50, 100, 200, 450, and 1000 ohm cm silicon are presented and problem areas are discussed. An additional potential application of the M-J cell lies in ultilization of its high intensity performance that has been demonstrated at levels in excess of 100 AMO suns

After #MeToo: Perceptions of Sexual Harassment In and Out of the Workplace

The purpose of this study is to identify perceptions of sexual harassment in the workplace and non-workplace settings. Following the “Me Too” movement, the issue of what constitutes sexual harassment in workplace environments underwent intense speculation. Confusion about the behaviors that equate to sexual harassment not only delays making progress toward eliminating it, but risks the well-being of citizens, employees, and their organizations. Individuals who experience sexual harassment are thrust into states of psychological distress and are known to experience fear, negative moods, and a lowered satisfaction with life in general. Additionally, exhibiting behaviors of sexual harassment in the workplace has a debilitating effect on work groups and individual employees by creating hostile work environments. As a result, employees experience decreased job satisfaction and managers may notice the increased salience of turnover cues. Examining contrasting perceptions of sexual harassment in work and non-work settings articulates the need for better informed public and organizational policy. Seeking to phase out phrases such as “I didn’t know that was sexual harassment,” this study explores the existing gap between what is perceived to be sexual harassment by the individual and what is sexual harassment. Further, it examines the discrepancies between perceptions of sexual harassment in work settings versus non-work settings and seeks to inform organizations and the public about the perceptions surrounding sexual harassment. Our research questions were addressed with a survey taken by students from a southeastern college in the United States

Sizes and shapes of 10-Ma Distal fall pyroclasts in the Ogallala gGroup, Nebraska

Size distributions of distal ashfall particles from correlated 10-Ma layers in Nebraska, measured using laser diffraction methods, are lognormal with mode diameters of ∼90 mm. This ashfall is ∼100% bubble-wall shards of rhyolite glass and apparently represents a distal ashfall from an eruption 1400 km away. Measured terminal velocities of these ash particles are 0.2–18 cm/s, consistent with Stokes Law settling of spherical particles with diameters of 9–50 mm. Surface area of the ash particles, measured with gas adsorption, is 20–30 times the surface area of equivalent Stokes spheres. These results highlight the effects of shape and atmospheric drag in distal ashfalls. They also highlight atmospheric transport and fallout of distal ashfall particles, because these deposits resemble many other ashfalls preserved in the Great Plains of North America throughout the Tertiary and Quaternary. Because the ashfalls preserve major mammalian death assemblages, they demonstrate that deposits with modes of optical diameters 1100 mm are still hazardous by aerodynamic definitions of lung disease risk and include particles substantially within hazardous PM10 ranges. The aerodynamically fine particle size may lead to substantial aeolian redistribution, causing local thicknesses of 12 m. Overall, the ashfall thicknesses observed are at least several times larger than would be expected based on exponential thinning from the volcano. Shape measurements of distal ash particles may be necessary to assess risk. The possible health risks in the central United States from a future rhyolitic eruption in the western United States may be significant

Differences in the Prevalence of Non-Communicable Disease between Slum Dwellers and the General Population in a Large Urban Area in Brazil.

Residents of urban slums are at greater risk for disease than their non-slum dwelling urban counterparts. We sought to contrast the prevalences of selected non-communicable diseases (NCDs) between Brazilian adults living in a slum and the general population of the same city, by comparing the age and sex-standardized prevalences of selected NCDs from a 2010 survey in Pau da Lima, Salvador Brazil, with a 2010 national population-based telephone survey. NCD prevalences in both populations were similar for hypertension (23.6% (95% CI 20.9⁻26.4) and 22.9% (21.2⁻24.6), respectively) and for dyslipidemia (22.7% (19.8⁻25.5) and 21.5% (19.7⁻23.4)). Slum residents had higher prevalences of diabetes mellitus (10.1% (7.9⁻12.3)) and of overweight/obesity (46.5% (43.1⁻49.9)), compared to 5.2% (4.2⁻6.1) and 40.6% (38.5⁻42.8) of the general population in Salvador. Fourteen percent (14.5% (12.1⁻17.0)) of slum residents smoked cigarettes compared to 8.3% (7.1⁻9.5) of the general population in Salvador. The national telephone survey underestimated the prevalence of diabetes mellitus, overweight/obesity, and smoking in the slum population, likely in part due to differential sampling inside and outside of slums. Further research and targeted policies are needed to mitigate these inequalities, which could have significant economic and social impacts on slum residents and their communities

A Comparative Study of Magnetic Fields in the Solar Photosphere and Chromosphere at Equatorial and Polar Latitudes

Besides their own intrinsic interest, correct interpretation of solar surface magnetic field observations is crucial to our ability to describe the global magnetic structure of the solar atmosphere. Photospheric magnetograms are often used as lower boundary conditions in models of the corona, but not data from the nearly force-free chromosphere. National Solar Observatory's (NSO) Synoptic Optical Long-term Investigations of the Sun VSM (Vector Spectromagnetograph) produces full-disk line-of-sight magnetic flux images deriving from both photospheric and chromospheric layers on a daily basis. In this paper, we investigate key properties of the magnetic field in these two layers using more than five years of VSM data. We find from near-equatorial measurements that the east-west inclination angle of most photospheric fields is less than about 12{\deg}, while chromospheric fields expand in all directions to a significant degree. Using a simple stereoscopic inversion, we find evidence that photospheric polar fields are also nearly radial but that during 2008 the chromospheric field in the south pole was expanding superradially. We obtain a spatially resolved polar photospheric flux distribution up to 80{\deg} latitude whose strength increases poleward approximately as cosine(colatitude) to the power 9-10. This distribution would give a polar field strength of 5-6 G. We briefly discuss implications for future synoptic map construction and modeling

Quantitative shape measurements of distal volcanic ash

Large-scale volcanic eruptions produce fine ash (\u3c 200 μm) which has a long atmospheric residence time (1 hour or more) and can be transported great distances from the volcanic source, thus, becoming a hazard to aircraft and public health. Ash particles have irregular shapes, so data on particle shape, size, and terminal velocities are needed to understand how the irregular-shaped particles affect transport processes and radiative transfer measurements. In this study, a methodology was developed to characterize particle shapes, sizes , and terminal velocities for three ash samples of different compositions. The shape and size of 2,500 particles from 1) distal fallout (~100 km) of the October 14, 1974 Fuego eruption (basaltic), 2) the secondary maxima (~250 km) of the August 18, 1992 Spurr eruption (andesitic), and 3) the Miocene Ash Hollow member, Nebraska (rhyolitic) were measured using image analysis techniques. Samples were sorted into 10 to 19 terminal velocity groups (0.6-59.0 cm/s) using an air elutriation device. Grain size distributions for the samples were measured using laser diffraction. Aspect ratio, feret diameter, and perimeter measurements were found to be the most useful descriptors of how particle shape affects terminal velocity. These measurement values show particle shape differs greatly from a sphere (commonly used in models and algorithms). The diameters of ash particles were 10-120% larger than ideal spheres at the same terminal velocity, indicating that irregular particle shape greatly increases drag. Gas-adsorption derived surface areas are 1 to 2 orders of magnitude higher than calculated surface areas based on measured dimensions and simple geometry, indicating that particle shapes are highly irregular. Correction factors for surface area were derived from the ash sample measurements so that surface areas calculated by assuming spherical particle shapes can be corrected to reflect more realistic values