Vaginal yeasts in the era of "over the counter" antifungals

OBJECTIVE: To establish whether there has been any rise in the prevalence of non-albicans Candida species isolated from vaginal swabs since the introduction of “over the counter” antifungal treatments. METHOD: A retrospective review looking at all positive vaginal yeast isolates collected from women attending one genitourinary medicine clinic during the 6 year period from 1993 to 1998 inclusive. All positive vaginal yeast isolates were included, regardless of whether or not the patients were symptomatic. Isolates from HIV positive women were excluded from the analysis. RESULT: No increase in non-albicans vaginal yeast isolates was shown during the period studied. The proportion of non-albicans yeasts remained constant at approximately 5% of the total yeasts isolated. The most common non-albicans yeast isolated was C glabrata. CONCLUSION: There is no evidence from this study to suggest that the increasing use of “over the counter” antifungal treatment has selected for atypical, possibly inherently azole resistant, strains of vaginal yeasts in HIV seronegative women

Relationship between perceptual learning in speech and statistical learning in younger and older adults

Within a few sentences, listeners learn to understand severely degraded speech such as noise-vocoded speech. However, individuals vary in the amount of such perceptual learning and it is unclear what underlies these differences. The present study investigates whether perceptual learning in speech relates to statistical learning, as sensitivity to probabilistic information may aid identification of relevant cues in novel speech input. If statistical learning and perceptual learning (partly) draw on the same general mechanisms, then statistical learning in a non-auditory modality using non-linguistic sequences should predict adaptation to degraded speech. In the present study, 73 older adults (aged over 60 years) and 60 younger adults (aged between 18 and 30 years) performed a visual artificial grammar learning task and were presented with sixty meaningful noise-vocoded sentences in an auditory recall task. Within age groups, sentence recognition performance over exposure was analyzed as a function of statistical learning performance, and other variables that may predict learning (i.e., hearing, vocabulary, attention switching control, working memory and processing speed). Younger and older adults showed similar amounts of perceptual learning, but only younger adults showed significant statistical learning. In older adults, improvement in understanding noise-vocoded speech was constrained by age. In younger adults, amount of adaptation was associated with lexical knowledge and with statistical learning ability. Thus, individual differences in general cognitive abilities explain listeners' variability in adapting to noise-vocoded speech. Results suggest that perceptual and statistical learning share mechanisms of implicit regularity detection, but that the ability to detect statistical regularities is impaired in older adults if visual sequences are presented quickly

Adult age effects in auditory statistical learning

Statistical learning plays a key role in language processing, e.g., for speech segmentation. Older adults have been reported to show less statistical learning on the basis of visual input than younger adults. Given age-related changes in perception and cognition, we investigated whether statistical learning is also impaired in the auditory modality in older compared to younger adults and whether individual learning ability is associated with measures of perceptual (i.e., hearing sensitivity) and cognitive functioning in both age groups. Thirty younger and thirty older adults performed an auditory artificial-grammar-learning task to assess their statistical learning ability. In younger adults, perceptual effort came at the cost of processing resources required for learning. Inhibitory control (as indexed by Stroop colornaming performance) did not predict auditory learning. Overall, younger and older adults showed the same amount of auditory learning, indicating that statistical learning ability is preserved over the adult life span

History of the Tromsø ionosphere heating facility

We present the historical background of the construction of a major ionospheric heating facility, “Heating”, near Tromsø, Norway, in the 1970s by the Max Planck Institute for Aeronomy; we also detail the facility’s subsequent operational history to the present. Heating was built next to the European Incoherent Scatter Scientific Association (EISCAT) incoherent scatter (IS) radar facility and in a region with a multitude of diagnostic instruments used to study the auroral region. The facility was transferred to EISCAT in January 1993 and continues to provide new discoveries in plasma physics and ionospheric and atmospheric science to this day. It is expected that Heating will continue operating along with the new generation of IS radar, called EISCAT_3D, when it is commissioned in the near future

Cavitating Langmuir Turbulence in the Terrestrial Aurora

Langmuir cavitons have been artificially produced in the earth's ionosphere, but evidence of naturally-occurring cavitation has been elusive. By measuring and modeling the spectra of electrostatic plasma modes, we show that natural cavitating, or strong, Langmuir turbulence does occur in the ionosphere, via a process in which a beam of auroral electrons drives Langmuir waves, which in turn produce cascading Langmuir and ion-acoustic excitations and cavitating Langmuir turbulence. The data presented here are the first direct evidence of cavitating Langmuir turbulence occurring naturally in any space or astrophysical plasma.Comment: 4 pages, 4 figures, published in PRL on 9 March 2012 http://link.aps.org/doi/10.1103/PhysRevLett.108.10500

Mesospheric observations with the EISCAT UHF radar during polar cap absorption events: <br>3. Comparison with simultaneous EISCAT VHF measurements

International audienceMesospheric observations were obtained by the EISCAT UHF and VHF radars during the solar proton event of March 1990. We present the first comparison of incoherent-scatter spectral measurements from the middle mesosphere using simultaneous, co-located observations by the two radars. VHF spectra observed with a vertical antenna were found to be significantly narrower than model predictions, in agreement with earlier UHF results. For antenna pointing directions that were significantly away from the vertical, the wider VHF radar beam gave rise to broadening of the observed spectra due to vertical shears in the horizontal wind. In this configuration, UHF spectral measurements were found to be more suitable for aeronomical applications. Both radar systems provide consistent and reliable estimates of the neutral wind. Spectral results using both the multipulse and pulse-to-pulse schemes were intercompared and their suitability for application to combined mesosphere ? lower thermosphere studies investigated

High-latitude artificial aurora using the EISCAT high-gain HF facility

The EISCAT high-frequency (HF) transmitter facility at Ramfjord, Norway, has been used to accelerate F-region electrons sufficiently to excite the oxygen atoms and nitrogen molecules, resulting in optical emissions at 630, 557.7 and 427.8 nm. During O-mode transmissions at 5.423 MHz, using 630 MW effective radiated power, in the hours after sunset on 12 November 2001 several new observations were made, including: (1) The first high-latitude observation of an HF induced optical emission at 427.8 nm and (2) Optical rings being formed at HF on followed by their collapse into a central blob. Both discoveries remain unexplained with current theories