151 research outputs found
Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis
Background: People with cystic fibrosis, who are chronically colonised with the organism Pseudomonas aeruginosa, often require multiple courses of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations. The properties of aminoglycosides suggest that they could be given in higher doses less often.
Objectives: To assess the effectiveness and safety of once-daily versus multiple-daily dosing of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations in cystic fibrosis.
Search methods: We searched the Cystic Fibrosis Specialist Register held at the Cochrane Cystic Fibrosis and Genetic Disorders Group’s editorial base, comprising references identified from comprehensive electronic database searches, handsearching relevant journals and handsearching abstract books of conference proceedings.
Date of the most recent search: 25 November 2013.
Selection criteria: All randomised controlled trials, whether published or unpublished, in which once-daily dosing of aminoglycosides has been compared with multiple-daily dosing in terms of efficacy or toxicity or both, in people with cystic fibrosis.
Data collection and analysis: The two authors independently selected the studies to be included in the review and assessed the risk of bias of each study. Data were independently extracted by each author. Authors of the included studies were contacted for further information. As yet unpublished data were obtained for one of the included studies.
Main results: Fifteen studies were identified for possible inclusion in the review. Four studies reporting results from a total of 328 participants were included in this review. All studies compared once-daily dosing with thrice-daily dosing. One study had a low risk of bias for all criteria assessed; the remaining three included studies had a high risk of bias from blinding, but for other criteria were judged to have either an unclear or a low risk of bias.
There was no significant difference between treatment groups in: forced expiratory volume at one second, mean difference 0.33 (95% confidence interval -2.81 to 3.48); forced vital capacity, mean difference 0.29 (95% confidence interval -6.58 to 7.16); % weight for height, mean difference -0.82 (95% confidence interval -3.77 to 2.13); body mass index, mean difference 0.00 (95% confidence interval -0.42 to 0.42); or in the incidence of ototoxicity, relative risk 0.56 (95% confidence interval 0.04 to 7.96). The percentage change in creatinine significantly favoured once-daily treatment in children, mean difference -8.20 (95% confidence interval -15.32 to -1.08), but showed no difference in adults, mean difference 3.25 (95% confidence interval -1.82 to 8.33).
Authors’ conclusions: Once- and three-times daily aminoglycoside antibiotics appear to be equally effective in the treatment of pulmonary exacerbations of cystic fibrosis. There is evidence of less nephrotoxicity in children
Kinematics of Magnetic Bright Features in the Solar Photosphere
Convective flows are known as the prime means of transporting magnetic fields
on the solar surface. Thus, small magnetic structures are good tracers of the
turbulent flows. We study the migration and dispersal of magnetic bright
features (MBFs) in intergranular areas observed at high spatial resolution with
Sunrise/IMaX. We describe the flux dispersal of individual MBFs as a diffusion
process whose parameters are computed for various areas in the quiet Sun and
the vicinity of active regions from seeing-free data. We find that magnetic
concentrations are best described as random walkers close to network areas
(diffusion index, gamma=1.0), travelers with constant speeds over a
supergranule (gamma=1.9-2.0), and decelerating movers in the vicinity of flux
emergence and/or within active regions (gamma=1.4-1.5). The three types of
regions host MBFs with mean diffusion coefficients of 130 km^2/s, 80-90 km^2/s,
and 25-70 km^2/s, respectively. The MBFs in these three types of regions are
found to display a distinct kinematic behavior at a confidence level in excess
of 95%.Comment: 8 pages, 4 figure
Solar Coronal Loops Associated with Small-scale Mixed Polarity Surface Magnetic Fields
How and where are coronal loops rooted in the solar lower atmosphere? The
details of the magnetic environment and its evolution at the footpoints of
coronal loops are crucial to understanding the processes of mass and energy
supply to the solar corona. To address the above question, we use
high-resolution line-of-sight magnetic field data from the Imaging Magnetograph
eXperiment instrument on the SUNRISE balloon-borne observatory and coronal
observations from the Atmospheric Imaging Assembly onboard the Solar Dynamics
Observatory of an emerging active region. We find that the coronal loops are
often rooted at the locations with minor small-scale but persistent
opposite-polarity magnetic elements very close to the larger dominant polarity.
These opposite-polarity small-scale elements continually interact with the
dominant polarity underlying the coronal loop through flux cancellation. At
these locations we detect small inverse Y-shaped jets in chromospheric Ca II H
images obtained from the SUNRISE Filter Imager during the flux cancellation.
Our results indicate that magnetic flux cancellation and reconnection at the
base of coronal loops due to mixed polarity fields might be a crucial feature
for the supply of mass and energy into the corona.Comment: Published in the Astrophysical Journal Supplement Serie
Bright points in the quiet Sun as observed in the visible and near-UV by the balloon-borne observatory Sunrise
Bright points (BPs) are manifestations of small magnetic elements in the
solar photosphere. Their brightness contrast not only gives insight into the
thermal state of the photosphere (and chromosphere) in magnetic elements, but
also plays an important role in modulating the solar total and spectral
irradiance. Here we report on simultaneous high-resolution imaging and
spectropolarimetric observations of BPs using Sunrise balloon-borne observatory
data of the quiet Sun at disk center. BP contrasts have been measured between
214 nm and 525 nm, including the first measurements at wavelengths below 388
nm. The histograms of the BP peak brightness show a clear trend toward broader
contrast distributions and higher mean contrasts at shorter wavelengths. At 214
nm we observe a peak brightness of up to five times the mean quiet-Sun value,
the highest BP contrast so far observed. All BPs are associated with a magnetic
signal, although in a number of cases it is surprisingly weak. Most of the BPs
show only weak downflows, the mean value being 240 m/s, but some display strong
down- or upflows reaching a few km/s.Comment: Accepted for publication in The Astrophysical Journal Letters on
September 08 201
Fully resolved quiet-Sun magnetic flux tube observed with the Sunrise IMaX instrument
Until today, the small size of magnetic elements in quiet Sun areas has
required the application of indirect methods, such as the line-ratio technique
or multi-component inversions, to infer their physical properties. A consistent
match to the observed Stokes profiles could only be obtained by introducing a
magnetic filling factor that specifies the fraction of the observed pixel
filled with magnetic field. Here, we investigate the properties of a small
magnetic patch in the quiet Sun observed with the IMaX magnetograph on board
the balloon-borne telescope Sunrise with unprecedented spatial resolution and
low instrumental stray light. We apply an inversion technique based on the
numerical solution of the radiative transfer equation to retrieve the
temperature stratification and the field strength in the magnetic patch. The
observations can be well reproduced with a one-component, fully magnetized
atmosphere with a field strength exceeding 1 kG and a significantly enhanced
temperature in the mid- to upper photosphere with respect to its surroundings,
consistent with semi-empirical flux tube models for plage regions. We therefore
conclude that, within the framework of a simple atmospheric model, the IMaX
measurements resolve the observed quiet-Sun flux tube.Comment: Accepted for publication in The Astrophysical Journal Letters on Aug
11 201
Sunrise: instrument, mission, data and first results
The Sunrise balloon-borne solar observatory consists of a 1m aperture Gregory
telescope, a UV filter imager, an imaging vector polarimeter, an image
stabilization system and further infrastructure. The first science flight of
Sunrise yielded high-quality data that reveal the structure, dynamics and
evolution of solar convection, oscillations and magnetic fields at a resolution
of around 100 km in the quiet Sun. After a brief description of instruments and
data, first qualitative results are presented. In contrast to earlier
observations, we clearly see granulation at 214 nm. Images in Ca II H display
narrow, short-lived dark intergranular lanes between the bright edges of
granules. The very small-scale, mixed-polarity internetwork fields are found to
be highly dynamic. A significant increase in detectable magnetic flux is found
after phase-diversity-related reconstruction of polarization maps, indicating
that the polarities are mixed right down to the spatial resolution limit, and
probably beyond.Comment: accepted by ApJ
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