Shaping Metrics for HEI Cultural Engagement - Knowledge Transfer

An application was submitted to the Arts and Humanities Research Council (AHRC) for support for a project that would identify and define activities deemed relevant to Knowledge Transfer (KT) - Cultural Engagement (CE), and propose appropriate means to evaluate them. It was acknowledged from the outset that efforts at agreeing “metrics” for the impact of such activities had been attempted before, albeit with limited success. (One such notable example has been lately provided by the Higher Education and Business Community Interaction Survey (HEBCIS) which has collected some data on social, community, and cultural engagement for some years; however, the robustness and consistency of the data for these purposes have often been questioned.

An Imaging Infrared (IIR) seeker using a microprogrammed processor

A recently developed Imaging Infrared Seeker uses a microprogrammed processor to perform gimbal servo control and system interface while performing the seeker functions of automatic target detection, acquisition, and tracking. The automatic detection mode requires up to 80% of the available capability of a high performance microprogrammed processor. Although system complexity was increased significantly, this approach can be cost effective when the basic computation capacity is already available

Shaping Metrics for HEI Cultural Engagement - Knowledge Transfer

An application was submitted to the Arts and Humanities Research Council (AHRC) for support for a project that would identify and define activities deemed relevant to Knowledge Transfer (KT) - Cultural Engagement (CE), and propose appropriate means to evaluate them. It was acknowledged from the outset that efforts at agreeing “metrics” for the impact of such activities had been attempted before, albeit with limited success. (One such notable example has been lately provided by the Higher Education and Business Community Interaction Survey (HEBCIS) which has collected some data on social, community, and cultural engagement for some years; however, the robustness and consistency of the data for these purposes have often been questioned.

Consumer-oriented Drug Information Service Needs Assessment

Federal legislation that has been introduced to amend the Social Security Act in order to provide for coverage of cognitive pharmacist services under the Medicare program in medically underserved communities. In the rural state of Arkansas this legislation would be well-received because a large portion of the state meets the criteria of a health professional shortage area. Considering the growing interest of using telecommunications as an alternative means of delivering healthcare services to medically underserved rural areas, a pharmacist-staffed consumer-oriented drug information service was explored. Over a 5-day period, 473 face-to-face consumer surveys were conducted in pharmacy and non-pharmacy settings in an urban cluster population center that serves the surrounding rural area. The survey was designed to determine whether or not consumers had a perceived need for a drug information service that was independent from and supplemental to services provided by their pharmacist. Results reveal that 71% of participants surveyed did not perceive a need for medication information that was supplemental to that provided by their pharmacist. When queried regarding the likelihood of using a drug information service if one was available their response was neutral, and they became less likely if a fee was associated with the service. While the results are not conclusive and cannot be generalized as to whether a consumer-oriented drug information service would contribute to improving patient care, the survey suggests that this telepharmacy service is not perceived as being needed by the public

A zeta function approach to the relation between the numbers of symmetry planes and axes of a polytope

A derivation of the Ces\`aro-Fedorov relation from the Selberg trace formula on an orbifolded 2-sphere is elaborated and extended to higher dimensions using the known heat-kernel coefficients for manifolds with piecewise-linear boundaries. Several results are obtained that relate the coefficients, $b_i$, in the Shephard-Todd polynomial to the geometry of the fundamental domain. For the 3-sphere we show that $b_4$ is given by the ratio of the volume of the fundamental tetrahedron to its Schl\"afli reciprocal.Comment: Plain TeX, 26 pages (eqn. (86) corrected

High-throughput sequencing reveals a simple model of nucleosome energetics

We use nucleosome maps obtained by high-throughput sequencing to study sequence specificity of intrinsic histone-DNA interactions. In contrast with previous approaches, we employ an analogy between a classical one-dimensional fluid of finite-size particles in an arbitrary external potential and arrays of DNA-bound histone octamers. We derive an analytical solution to infer free energies of nucleosome formation directly from nucleosome occupancies measured in high-throughput experiments. The sequence-specific part of free energies is then captured by fitting them to a sum of energies assigned to individual nucleotide motifs. We have developed hierarchical models of increasing complexity and spatial resolution, establishing that nucleosome occupancies can be explained by systematic differences in mono- and dinucleotide content between nucleosomal and linker DNA sequences, with periodic dinucleotide distributions and longer sequence motifs playing a secondary role. Furthermore, similar sequence signatures are exhibited by control experiments in which genomic DNA is either sonicated or digested with micrococcal nuclease in the absence of nucleosomes, making it possible that current predictions based on high-throughput nucleosome positioning maps are biased by experimental artifacts.Comment: 36 pages, 13 figure

Long-Term Stability of Visual Pattern Selective Responses of Monkey Temporal Lobe Neurons

Many neurons in primate inferotemporal (IT) cortex respond selectively to complex, often meaningful, stimuli such as faces and objects. An important unanswered question is whether such response selectivity, which is thought to arise from experience-dependent plasticity, is maintained from day to day, or whether the roles of individual cells are continually reassigned based on the diet of natural vision. We addressed this question using microwire electrodes that were chronically implanted in the temporal lobe of two monkeys, often allowing us to monitor activity of individual neurons across days. We found that neurons maintained their selectivity in both response magnitude and patterns of spike timing across a large set of visual images throughout periods of stable signal isolation from the same cell that sometimes exceeded two weeks. These results indicate that stimulus-selectivity of responses in IT is stable across days and weeks of visual experience

Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes.

addresses: Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, B3H 1X5, Canada. [email protected]: PMCID: PMC2428068types: Journal Article; Research Support, Non-U.S. Gov'tOpen Access Article. This is a copy of an article published in Current Biology © Elsevier. Current Biology is available online at: http://www.sciencedirect.com/science/journal/09609822Blastocystis is a unicellular stramenopile of controversial pathogenicity in humans. Although it is a strict anaerobe, Blastocystis has mitochondrion-like organelles with cristae, a transmembrane potential and DNA. An apparent lack of several typical mitochondrial pathways has led some to suggest that these organelles might be hydrogenosomes, anaerobic organelles related to mitochondria. We generated 12,767 expressed sequence tags (ESTs) from Blastocystis and identified 115 clusters that encode putative mitochondrial and hydrogenosomal proteins. Among these is the canonical hydrogenosomal protein iron-only [FeFe] hydrogenase that we show localizes to the organelles. The organelles also have mitochondrial characteristics, including pathways for amino acid metabolism, iron-sulfur cluster biogenesis, and an incomplete tricarboxylic acid cycle as well as a mitochondrial genome. Although complexes I and II of the electron transport chain (ETC) are present, we found no evidence for complexes III and IV or F1Fo ATPases. The Blastocystis organelles have metabolic properties of aerobic and anaerobic mitochondria and of hydrogenosomes. They are convergently similar to organelles recently described in the unrelated ciliate Nyctotherus ovalis. These findings blur the boundaries between mitochondria, hydrogenosomes, and mitosomes, as currently defined, underscoring the disparate selective forces that shape these organelles in eukaryotes

Optically Selected BL Lacertae Candidates from the Sloan Digital Sky Survey Data Release Seven

We present a sample of 723 optically selected BL Lac candidates from the SDSS DR7 spectroscopic database encompassing 8250 deg^2 of sky; our sample constitutes one of the largest uniform BL Lac samples yet derived. Each BL Lac candidate has a high-quality SDSS spectrum from which we determine spectroscopic redshifts for ~60% of the objects. Redshift lower limits are estimated for the remaining objects utilizing the lack of host galaxy flux contamination in their optical spectra; we find that objects lacking spectroscopic redshifts are likely at systematically higher redshifts. Approximately 80% of our BL Lac candidates match to a radio source in FIRST/NVSS, and ~40% match to a ROSAT X-ray source. The homogeneous multiwavelength coverage allows subdivision of the sample into 637 radio-loud BL Lac candidates and 86 weak-featured radio-quiet objects. The radio-loud objects broadly support the standard paradigm unifying BL Lac objects with beamed radio galaxies. We propose that the majority of the radio-quiet objects may be lower-redshift (z<2.2) analogs to high-redshift weak line quasars (i.e., AGN with unusually anemic broad emission line regions). These would constitute the largest sample of such objects, being of similar size and complementary in redshift to the samples of high-redshift weak line quasars previously discovered by the SDSS. However, some fraction of the weak-featured radio-quiet objects may instead populate a rare and extreme radio-weak tail of the much larger radio-loud BL Lac population. Serendipitous discoveries of unusual white dwarfs, high-redshift weak line quasars, and broad absorption line quasars with extreme continuum dropoffs blueward of rest-frame 2800 Angstroms are also briefly described.Comment: 24 pages, 14 figures, 8 tables. Accepted for publication in A